Abstract:
:Emerging technologies allow broad profiling of the cancer genome for differential DNA methylation relative to benign cells. Herein, bisulfite-modified DNA from lymph nodes with either reactive hyperplasia or follicular lymphoma (FL) were analyzed using a commercial C/UpG genotyping assay. Two hundred fifty-nine differentially methylated targets (DMT) distributed among 183 unique genes were identified in FL. Comparison of matched formalin-fixed, paraffin-embedded and frozen surgical pathology replicates showed the complete preservation of the cancer methylome among differently archived tissue specimens. Analysis of the DMT profile is consistent with a pervasive epigenomic remodeling process in FL that affects predominantly nonlymphoid genes.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Killian JK,Bilke S,Davis S,Walker RL,Killian MS,Jaeger EB,Chen Y,Hipp J,Pittaluga S,Raffeld M,Cornelison R,Smith WI Jr,Bibikova M,Fan JB,Emmert-Buck MR,Jaffe ES,Meltzer PSdoi
10.1158/0008-5472.CAN-08-2984subject
Has Abstractpub_date
2009-02-01 00:00:00pages
758-64issue
3eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-08-2984journal_volume
69pub_type
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