Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis.

abstract：:Human prostate cancer has a high predisposition to metastasize to bone, resulting in the formation of osteoblastic metastases. The mechanism through which prostate cancer cells promote osteoblastic lesions is undefined. Vascular endothelial growth factor (VEGF) has been implicated as a mediator of osteoblast activity....

journal_title：Cancer research

authors： Dai J,Kitagawa Y,Zhang J,Yao Z,Mizokami A,Cheng S,Nör J,McCauley LK,Taichman RS,Keller ET

更新日期：2004-02-01 00:00:00

abstract：:Latent prostate tumors are commonly found with similar frequency in many countries and ethnic groups. In contrast, aggressive prostate cancer (PC) is significantly less prevalent among Asian men, where the intake of soy products is very high. High consumption of foods containing soy results in high plasma, urine, and ...

journal_title：Cancer research

authors： Mentor-Marcel R,Lamartiniere CA,Eltoum IE,Greenberg NM,Elgavish A

更新日期：2001-09-15 00:00:00

abstract：:We have characterized the accumulation of cisplatin (DDP) into parent and cisplatin-resistant 2008 human ovarian carcinoma cells. Accumulation of DDP at 1 h was a linear function of concentration from 0.25 to 100 microM DDP in both cell types. DDP-resistant cells that were only 3.3-fold resistant had approximately 50%...

journal_title：Cancer research

authors： Andrews PA,Velury S,Mann SC,Howell SB

更新日期：1988-01-01 00:00:00

abstract：:CX3CR1+ macrophages in the intestinal lamina propria contribute to gut homeostasis through the immunomodulatory interleukin IL10, but there is little knowledge on how these cells or the CX3CR1 receptor may affect colorectal carcinogenesis. In this study, we show that CX3CR1-deficient mice fail to resolve gut inflammat...

journal_title：Cancer research

authors： Marelli G,Erreni M,Anselmo A,Taverniti V,Guglielmetti S,Mantovani A,Allavena P

更新日期：2017-08-15 00:00:00

abstract：:Despite the initial efficacy of androgen deprivation therapy, most patients with advanced prostate cancer eventually progress to hormone-refractory prostate cancer, for which there is no curative therapy. Previous studies from our laboratory and others have shown the antiproliferative and proapoptotic effects of 3,3'-...

journal_title：Cancer research

authors： Bhuiyan MM,Li Y,Banerjee S,Ahmed F,Wang Z,Ali S,Sarkar FH

更新日期：2006-10-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of reduced relapse-free survival. Concordant expression of HMGA2 and EZH2 p...

journal_title：Cancer research

authors： El Ayachi I,Fatima I,Wend P,Alva-Ornelas JA,Runke S,Kuenzinger WL,Silva J,Silva W,Gray JK,Lehr S,Barch HC,Krutilina RI,White AC,Cardiff R,Yee LD,Yang L,O'Regan RM,Lowry WE,Seagroves TN,Seewaldt V,Krum SA,Miranda

更新日期：2019-03-01 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor that secretes various angiogenic factors. The main inhibitor of plasminogen activators, PAI-1 (SERPINE1), has been implicated in tumor progression and angiogenesis, and high PAI-1 expression has been associated with poor prognosis in MPM patients. I...

journal_title：Cancer research

authors： Takayama Y,Hattori N,Hamada H,Masuda T,Omori K,Akita S,Iwamoto H,Fujitaka K,Kohno N

更新日期：2016-06-01 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). We observed similar effects of EGCG in esophageal squamous cell carcinoma KYSE 150 cells and epide...

journal_title：Cancer research

authors： Hou Z,Sang S,You H,Lee MJ,Hong J,Chin KV,Yang CS

更新日期：2005-09-01 00:00:00

abstract：:Transforming growth factor betas (TGF-beta) play a dual role in carcinogenesis, functioning as tumor suppressors early in the process, and then switching to act as prometastatic factors in late-stage disease. We have previously shown that high molecular weight TGF-beta antagonists can suppress metastasis without the p...

journal_title：Cancer research

authors： Nam JS,Suchar AM,Kang MJ,Stuelten CH,Tang B,Michalowska AM,Fisher LW,Fedarko NS,Jain A,Pinkas J,Lonning S,Wakefield LM

更新日期：2006-06-15 00:00:00

abstract：:Chromosomal analysis of 16 rhabdomyosarcomas was done from four primary tumors and from 12 tumors after nude mouse passage. Seven tumors were alveolar; four of these had t(2;13)(q37;q14) and in two tumors it was the only structural abnormality. The other three alveolar tumors were near tetraploid with marker chromosom...

journal_title：Cancer research

authors： Wang-Wuu S,Soukup S,Ballard E,Gotwals B,Lampkin B

更新日期：1988-02-15 00:00:00

abstract：:One-week-old male and female mice of the A, BALB/c (C), and C3H/He (C3) strains and of the AC3 and CC3 F1 hybrids were treated with a single dose (300 mg/kg s.c.) of urethan and then kept without further treatment until 30 and 40 weeks (males) or 30 and 65 weeks (females). The degree of difference in susceptibility to...

journal_title：Cancer research

authors： Dragani TA,Manenti G,Della Porta G

更新日期：1991-12-01 00:00:00

abstract：:Smad3, a major intracellular mediator of TGFβ signaling, functions as both a positive and negative regulator in carcinogenesis. In response to TGFβ, the TGFβ receptor phosphorylates serine residues at the Smad3 C-tail. Cancer cells often contain high levels of the MAPK and CDK activities, which can lead to the Smad3 l...

journal_title：Cancer research

authors： Bae E,Sato M,Kim RJ,Kwak MK,Naka K,Gim J,Kadota M,Tang B,Flanders KC,Kim TA,Leem SH,Park T,Liu F,Wakefield LM,Kim SJ,Ooshima A

更新日期：2014-11-01 00:00:00

abstract：:Physical activity is defined as bodily movement due to skeletal muscle contraction that results in quantifiable energy expenditure. Both epidemiological and laboratory data indicate that the level of physical activity in which an individual engages may affect cancer risk. Exercise is distinguished from other types of ...

journal_title：Cancer research

authors： Thompson HJ

更新日期：1994-04-01 00:00:00

abstract：:The ability to accurately distinguish remaining or recurrent high-grade astrocytoma from necrosis or edema following treatment is essential to optimal patient management. Thallium 201 planar gamma-camera imaging has been shown to be helpful in detecting recurrent high-grade astrocytoma; however, due to tissue heteroge...

journal_title：Cancer research

authors： Mountz JM,Raymond PA,McKeever PE,Modell JG,Hood TW,Barthel LK,Stafford-Schuck KA

更新日期：1989-07-15 00:00:00

abstract：:Multiple copies of N-myc proto-oncogene are only rarely detected in localized neuroblastomas (NBs), and the prognostic relevance of amplification in this subset of patients is not clear. We analyzed a series of 850 children with NB admitted to a Pediatric Oncology Group NB Biology Study and identified six patients wit...

journal_title：Cancer research

authors： Cohn SL,Look AT,Joshi VV,Holbrook T,Salwen H,Chagnovich D,Chesler L,Rowe ST,Valentine MB,Komuro H

更新日期：1995-02-15 00:00:00

abstract：:Endogenous formation of N-nitrosoproline (NPRO) was demonstrated by monitoring its excretion in the urine of a male volunteer who had ingested vegetable juice, as a source of nitrate, and proline. The resulting NPRO was analyzed after derivatization by combined gas-liquid chromatography thermal energy analysis. The am...

journal_title：Cancer research

authors： Ohshima H,Bartsch H

更新日期：1981-09-01 00:00:00

abstract：:Phosphoglucose isomerase (PGI) is a multifunctional enzyme that functions in glucose metabolism as a glycolytic enzyme catalyzing an interconversion between glucose and fructose inside the cell, while it acts as cytokine outside the cell, with properties that include autocrine motility factor (AMF)-regulating tumor ce...

journal_title：Cancer research

authors： Niinaka Y,Harada K,Fujimuro M,Oda M,Haga A,Hosoki M,Uzawa N,Arai N,Yamaguchi S,Yamashiro M,Raz A

更新日期：2010-11-15 00:00:00

abstract：:The localization of biliary glycoprotein (BGP) and its mRNA in normal colonic mucosa was studied by immunohistochemistry and in situ hybridization. BGP mRNA was confined to columnar epithelial cells and expressed abundantly in the superficial mature cells and at low levels in differentiating cells in the upper crypts....

journal_title：Cancer research

authors： Frängsmyr L,Baranov V,Prall F,Yeung MM,Wagener C,Hammarström S

更新日期：1995-07-15 00:00:00

abstract：:These studies explore the effects of an epipodophyllotoxin on the membrane transport and metabolism of thymidine in Ehrlich ascites tumor cells. Uptake of 3H after exposure of cells to [3H]-thymidine is characterized by a rapid initial velocity that approximates membrane transport followed by a slower rate of uptake t...

journal_title：Cancer research

authors： Yalowich JC,Goldman ID

更新日期：1984-03-01 00:00:00

abstract：:Histone demethylase LSD1 (also known as KDM1 and AOF2) is active in various cancer cells, but its biological significance in human carcinogenesis is unexplored. In this study, we explored hypothesized interactions between LSD1 and MYPT1, a known regulator of RB1 phosphorylation. We found that MYPT1 was methylated in v...

journal_title：Cancer research

authors： Cho HS,Suzuki T,Dohmae N,Hayami S,Unoki M,Yoshimatsu M,Toyokawa G,Takawa M,Chen T,Kurash JK,Field HI,Ponder BA,Nakamura Y,Hamamoto R

更新日期：2011-02-01 00:00:00

abstract：:In eight estrogen receptor (ER)-positive breast cancer cell lines (including three sublines of MCF-7) and five ER-negative breast lines, the action of the nonsteroidal antiestrogen, tamoxifen, was studied, and the concentrations of ER and antiestrogen binding site were measured. The concentration of antiestrogen bindi...

journal_title：Cancer research

authors： Reddel RR,Murphy LC,Hall RE,Sutherland RL

更新日期：1985-04-01 00:00:00

abstract：:A series of rat 13762NF mammary adenocarcinoma cell clones and subclones of various lung metastatic potentials were examined for their abilities to degrade rat lung subendothelial matrix and purified basement membrane type IV collagen. Metastatic potentials were simultaneously determined based on the ability to form "...

journal_title：Cancer research

authors： Nakajima M,Welch DR,Belloni PN,Nicolson GL

更新日期：1987-09-15 00:00:00

abstract：:Fibroblast growth factor receptor 3 (FGFR3) plays important roles in cell proliferation, differentiation, and angiogenesis. FGFR3 is abnormally upregulated in hepatocellular carcinoma (HCC), where it correlates positively with clinicopathologic index, HCC differentiation, and advanced nuclear grade. In this study, we ...

journal_title：Cancer research

authors： Li K,Shen B,Cheng X,Ma D,Jing X,Liu X,Yang W,Peng C,Qiu W

更新日期：2016-07-15 00:00:00

abstract：:More than 500 colorectal tumors with clonal chromosomal abnormalities have been reported. Although the pattern of aberrations is nonrandom, no specific primary or secondary karyotypic abnormality has been identified. Also, the chronological order in which the aberrations appear during disease progression is not well k...

journal_title：Cancer research

authors： Höglund M,Gisselsson D,Hansen GB,Säll T,Mitelman F,Nilbert M

更新日期：2002-10-15 00:00:00

abstract：:The chemokine receptor CXCR4 plays a central role in organ-specific homing and tumor spreading and is induced by hypoxia. B lymphocytes are exposed to low oxygen tensions during their development, but the influence of hypoxia on their physiology is poorly understood. Here, we show that hypoxia is associated with up-re...

journal_title：Cancer research

authors： Piovan E,Tosello V,Indraccolo S,Masiero M,Persano L,Esposito G,Zamarchi R,Ponzoni M,Chieco-Bianchi L,Dalla-Favera R,Amadori A

更新日期：2007-09-15 00:00:00

abstract：:It is widely accepted that a major role of matrix metalloproteinases in the metastatic process is degradation of basement membrane during cancer cell invasion. We tested the hypothesis that the reduction in metastatic potential which has been demonstrated for B16F10 melanoma cells genetically engineered to overexpress...

journal_title：Cancer research

authors： Koop S,Khokha R,Schmidt EE,MacDonald IC,Morris VL,Chambers AF,Groom AC

更新日期：1994-09-01 00:00:00

abstract：:CI-921, an analogue of amsacrine with superior activity against in vivo and in vitro experimental tumor models, has been studied in 16 patients with solid tumors refractory to chemotherapy or for which conventional therapy does not exist. Thirty-nine cycles were given and doses escalated from 39 to 810 mg/m2. This tot...

journal_title：Cancer research

authors： Hardy JR,Harvey VJ,Paxton JW,Evans P,Smith S,Grove W,Grillo-Lopez AJ,Baguley BC

更新日期：1988-11-15 00:00:00

abstract：:The difficulty to dissect a complex phenotype of established malignant cells to several critical transcriptional programs greatly impedes our understanding of the malignant transformation. The genetic elements required to transform some primary human cells to a tumorigenic state were described in several recent studie...

journal_title：Cancer research

authors： Milyavsky M,Tabach Y,Shats I,Erez N,Cohen Y,Tang X,Kalis M,Kogan I,Buganim Y,Goldfinger N,Ginsberg D,Harris CC,Domany E,Rotter V

更新日期：2005-06-01 00:00:00

abstract：:Significant efforts are being devoted toward the development of effective therapeutic vaccines against cancer. Specifically, well-characterized subunit vaccines, which are designed to generate antitumor cytotoxic CD8 T-cell responses. Because CD4 T cells participate at various stages of CD8 T-cell responses, it is imp...

journal_title：Cancer research

authors： Assudani D,Cho HI,DeVito N,Bradley N,Celis E

更新日期：2008-12-01 00:00:00

abstract：:Claudin proteins form a large family of integral membrane proteins crucial for tight junction formation and function. Our previous studies have revealed that claudin-3 and claudin-4 proteins are highly overexpressed in ovarian cancer. To clarify the roles of claudins in ovarian tumorigenesis, we have generated human o...

journal_title：Cancer research

authors： Agarwal R,D'Souza T,Morin PJ

更新日期：2005-08-15 00:00:00