Inhibition of human malignant neuroblastoma cell DNA synthesis by lipoxygenase metabolites of arachidonic acid.

abstract：:Chronic exposures to cadmium compounds are carcinogenic. It was hypothesized that the development of resistance to cadmium may drive carcinogenesis. This is achieved by selection of resistant cells in which the apoptotic response is significantly attenuated. The induction of cadmium resistance in rat lung epithelial c...

journal_title：Cancer research

authors： Lau AT,Chiu JF

更新日期：2007-03-01 00:00:00

abstract：:The stability of several oncoproteins, including c-Myc, is regulated by ubiquitin-dependent degradation mediated by the SCF(Fbw7) ubiquitin ligase. This activity is antagonized by the deubiquitinase Usp28, which is highly expressed in murine and human intestinal cancers. Usp28 was previously shown to interact with its...

journal_title：Cancer research

authors： Diefenbacher ME,Chakraborty A,Blake SM,Mitter R,Popov N,Eilers M,Behrens A

更新日期：2015-04-01 00:00:00

abstract：:Poly (ADP-ribose) glycohydrolase (PARG) is the main enzyme responsible for catabolism of poly (ADP-ribose) (PAR), synthesized by PARP. PARG dysfunction sensitizes certain cancer cells to alkylating agents and cisplatin by perturbing the DNA damage response. The gene mutations that sensitize cancer cells to PARG dysfun...

journal_title：Cancer research

authors： Sasaki Y,Fujimori H,Hozumi M,Onodera T,Nozaki T,Murakami Y,Ashizawa K,Inoue K,Koizumi F,Masutani M

更新日期：2019-08-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the sixth most common cancer in women worldwide and, despite advances in detection and therapies, it still represents the most lethal gynecologic malignancy in the industrialized countries. Unfortunately, still relatively little is known about the molecular events that lead to the de...

journal_title：Cancer research

authors： Iorio MV,Visone R,Di Leva G,Donati V,Petrocca F,Casalini P,Taccioli C,Volinia S,Liu CG,Alder H,Calin GA,Ménard S,Croce CM

更新日期：2007-09-15 00:00:00

abstract：:Stable variants of the human cell line, VA2-B, have been developed which are 10- to 20-fold less sensitive to the antiproliferative effects of methylglyoxal bis(guanylhydrazone) (MGBG) than the parent cell lines and which are not drug transport deficient. The lines were characterized biochemically giving particular at...

journal_title：Cancer research

authors： Kramer DL,Zychlinski L,Wiseman A,Porter CW

更新日期：1983-12-01 00:00:00

abstract：:Tumor hypoxia is associated clinically with therapeutic resistance and poor patient outcomes. One feature of tumor hypoxia is activated expression of carbonic anhydrase IX (CA9), a regulator of pH and tumor growth. In this study, we investigated the hypothesis that impeding the reuptake of bicarbonate produced extrace...

journal_title：Cancer research

authors： McIntyre A,Hulikova A,Ledaki I,Snell C,Singleton D,Steers G,Seden P,Jones D,Bridges E,Wigfield S,Li JL,Russell A,Swietach P,Harris AL

更新日期：2016-07-01 00:00:00

abstract：:The Th2 cytokines interleukin (IL)-4 and -13 are acknowledged regulators of lymphocyte proliferation and activation. They have also been well studied in the regulation of various myeloid-derived populations in tumor biology. It has become clear, however, that both cytokines can have direct effects on epithelial tumor ...

journal_title：Cancer research

authors： Hallett MA,Venmar KT,Fingleton B

更新日期：2012-12-15 00:00:00

abstract：:That ferritin, an iron storage protein, can be produced by neuroblastoma cells raises the possibility that iron may have some role in promoting tumor cell growth. To explore this possibility, we studied the effects of desferoxamine, a compound which chelates iron, on viability of CHP 126 and CHP 100, two human neurobl...

journal_title：Cancer research

authors： Blatt J,Stitely S

更新日期：1987-04-01 00:00:00

abstract：:Recent studies have shown that the Bcl-2 protein suppresses programmed cell death or apoptosis induced by a variety of stimuli including chemotherapeutic drugs. Because estrogen promotes the survival of estrogen-dependent breast cancer cells in vivo, we investigated whether estrogen might regulate levels of Bcl-2 gene...

journal_title：Cancer research

authors： Teixeira C,Reed JC,Pratt MA

更新日期：1995-09-01 00:00:00

abstract：:Several lines of evidence suggest that apoptosis dysregulation plays an important role in cancer metastasis. In this study, to explore the possibility that the mutations of death receptors are involved in the metastasis mechanism, we analyzed the death domains of Fas and tumor necrosis factor-related apoptosis-inducin...

journal_title：Cancer research

authors： Shin MS,Kim HS,Lee SH,Park WS,Kim SY,Park JY,Lee JH,Lee SK,Lee SN,Jung SS,Han JY,Kim H,Lee JY,Yoo NJ

更新日期：2001-07-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a gastrointestinal disorder of unknown etiology or cure. One complication of IBD is an increased risk for development of colon cancer. The aims of this study were to use a previously established rat model of colitis to develop a new model of colitis-associated colon cancer and ascer...

journal_title：Cancer research

authors： Santiago C,Pagán B,Isidro AA,Appleyard CB

更新日期：2007-11-15 00:00:00

abstract：:Immunostimulatory CpG oligodeoxynucleotides (ODNs) can enhance the therapeutic effect of monoclonal antibodies (mAbs) by enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Distinct classes of CpG ODNs have been found recently to stimulate different effector cell populations. We used murine cancer models t...

journal_title：Cancer research

authors： van Ojik HH,Bevaart L,Dahle CE,Bakker A,Jansen MJ,van Vugt MJ,van de Winkel JG,Weiner GJ

更新日期：2003-09-01 00:00:00

abstract：:Fusarium moniliforme (FM) is a major fungal pathogen of corn and is involved with stalk rot disease. FM is widely spread throughout the world, including the United States. Most strains of FM produce several mycotoxins, the most prominent of which is called fumonisin. Recent epidemiological studies indicated that inges...

journal_title：Cancer research

authors： Huang C,Dickman M,Henderson G,Jones C

更新日期：1995-04-15 00:00:00

abstract：:During 2007, approximately 200,000 people in the United States will be diagnosed with brain tumors. Gliomas account for 77% of primary malignant brain tumors, and the prognosis has hardly changed in the past 20 years, with only 30% of patients with malignant glioma surviving 5 years after diagnosis. Oncolytic adenovir...

journal_title：Cancer research

authors： Alonso MM,Cascallo M,Gomez-Manzano C,Jiang H,Bekele BN,Perez-Gimenez A,Lang FF,Piao Y,Alemany R,Fueyo J

更新日期：2007-09-01 00:00:00

abstract：:Cytidine dialdehyde inhibited the growth of leukemia L1210 cells in culture at a 50% inhibitory concentration of 3.5 X 10(-5) M and, when administered i.p. at 200 mg/kg daily for 5 days, increased the mean survival of L1210 tumor-bearing mice by up to 171%. Given by the s.c. or i.v. routes, the compound was ineffectiv...

journal_title：Cancer research

authors： Kinahan JJ,Pavelic ZP,Leonard RJ,Bloch A,Grindey GB

更新日期：1980-03-01 00:00:00

abstract：:The pattern of protein phosphorylation induced by phorbol-12-myristate-13-acetate (PMA) was analyzed by two-dimensional gel electrophoresis in human HL-60 leukemia cells, which are susceptible to induction of cell differentiation by PMA, and in cells from an HL-60 cell variant designated R-94 that are resistant to suc...

journal_title：Cancer research

authors： Anderson NL,Gemmell MA,Coussens PM,Murao S,Huberman E

更新日期：1985-10-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that is associated with cell growth and tumor formation. Existing catalytic inhibitors of ODC have lacked efficacy in clinical testing or displayed unacceptable toxicity. In this study, we report the identification of a...

journal_title：Cancer research

authors： Kim DJ,Roh E,Lee MH,Oi N,Lim DY,Kim MO,Cho YY,Pugliese A,Shim JH,Chen H,Cho EJ,Kim JE,Kang SC,Paul S,Kang HE,Jung JW,Lee SY,Kim SH,Reddy K,Yeom YI,Bode AM,Dong Z

更新日期：2016-03-01 00:00:00

abstract：:Alterations in cellular biochemistry which are associated with the development of resistance to cytotoxic peptides, such as tumor necrosis factor (TNF), may also be responsible for changes in the response of cells to cytotoxic agents. Culturing ME-180 cervical carcinoma cells in the presence of escalating concentratio...

journal_title：Cancer research

authors： Nishikawa K,Rosenblum MG,Newman RA,Pandita TK,Hittelman WN,Donato NJ

更新日期：1992-09-01 00:00:00

abstract：:The Aurora-A/STK15 gene encodes a kinase that is frequently amplified in cancer. Overexpression of Aurora-A in mammalian cells leads to centrosome amplification, genetic instability, and transformation. In this study, we show that Aurora-A activates nuclear factor-kappaB (NF-kappaB) via IkappaBalpha phosphorylation. I...

journal_title：Cancer research

authors： Briassouli P,Chan F,Savage K,Reis-Filho JS,Linardopoulos S

更新日期：2007-02-15 00:00:00

abstract：:The role of endogenous NO on cell survival was investigated in human melanoma cells and melanocytes. Inducible NO synthase (iNOS) was always expressed in a panel of melanoma cell lines from metastatic lesions and in normal adult melanocytes. iNOS was also detected by immunohistochemistry in melanoma cells from metasta...

journal_title：Cancer research

authors： Salvucci O,Carsana M,Bersani I,Tragni G,Anichini A

更新日期：2001-01-01 00:00:00

abstract：:Myeloid cells are capable of promoting or eradicating tumor cells and the nodal functions that contribute to their different roles are still obscure. Here, we show that mice with myeloid-specific genetic loss of the NF-κB pathway regulatory kinase IKKβ exhibit more rapid growth of cutaneous and lung melanoma tumors. I...

journal_title：Cancer research

authors： Yang J,Hawkins OE,Barham W,Gilchuk P,Boothby M,Ayers GD,Joyce S,Karin M,Yull FE,Richmond A

更新日期：2014-12-15 00:00:00

abstract：:The Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive disorder associated with immune deficiency, chromosome fragility, and increased susceptibility to lymphoid malignancies. The aim of the present study was to elucidate the potential role of the gene mutated in NBS (NBS1) in the pathogenesis and disease ...

journal_title：Cancer research

authors： Varon R,Reis A,Henze G,von Einsiedel HG,Sperling K,Seeger K

更新日期：2001-05-01 00:00:00

abstract：:Failure of cytokinesis results in tetraploidy and can increase the genomic instability frequently observed in cancer. The peptidyl-prolyl isomerase Pin1, which is deregulated in many tumors, regulates several processes, including cell cycle progression. Here, we show a novel role for Pin1 in cytokinesis. Pin1 knockout...

journal_title：Cancer research

authors： van der Horst A,Khanna KK

更新日期：2009-08-15 00:00:00

abstract：:Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells across the bone marrow endothelium (BMEC) remains a poorly understood step in metastasis. Prostate cancer cells roll on E-selectin(+) BMEC through E-selectin ligand-binding interactions under shear flow, and prostate cancer cells ex...

journal_title：Cancer research

authors： Barthel SR,Hays DL,Yazawa EM,Opperman M,Walley KC,Nimrichter L,Burdick MM,Gillard BM,Moser MT,Pantel K,Foster BA,Pienta KJ,Dimitroff CJ

更新日期：2013-01-15 00:00:00

abstract：:Chemotherapy response in patients with primary breast cancer is difficult to predict and the role of host genetic factors has not been thoroughly investigated. We hypothesized that polymorphisms in oxidative stress (OS)-related genes, including estrogen-quinone metabolizing enzymes NQO2 and GSTM1-5, may influence dise...

journal_title：Cancer research

authors： Yu KD,Huang AJ,Fan L,Li WF,Shao ZM

更新日期：2012-01-15 00:00:00

abstract：:The partial pressure of oxygen (pO2) of FSaII tumors grown in the leg of C3H mice significantly improved when the tumors were heated by immersing the tumor-bearing legs in a water bath at 41.5 degrees C for 60 min. The tumor pO2 also substantially increased when the tumor-bearing mice breathed carbogen (95% O2:5% CO2)...

journal_title：Cancer research

authors： Griffin RJ,Okajima K,Barrios B,Song CW

更新日期：1996-12-15 00:00:00

abstract：:Human hepatoma cells, HuH-6 Cl-5, were treated with 12-O-tetradecanoylphorbol-13-acetate at concentrations of 1 ng/ml to 10 micrograms/ml for 6 h in the presence of [35S]methionine. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the labeled proteins secreted into the medium showed that this t...

journal_title：Cancer research

authors： Yoneda Y,Fujiki H,Moore RE,Uchida T

更新日期：1985-05-01 00:00:00

abstract：:Genetic instability has been recognized as a hallmark of human cancers. Retinoblastoma (Rb) tumor suppressor protein has an essential role in modulating cell cycle progression. However, there is no direct evidence supporting its role in maintaining genetic stability. Here, we developed a sensitive method to examine th...

journal_title：Cancer research

authors： Zheng L,Flesken-Nikitin A,Chen PL,Lee WH

更新日期：2002-05-01 00:00:00

abstract：:We evaluated the differences in prevalence and functional activity of human estrogen receptor alpha (hER) variant mRNA between 21 normal breast tissues and 41 primary breast carcinomas using a functional assay in yeast for the hER First, we found that the presence of wild-type hER, relative to the total amount of hER,...

journal_title：Cancer research

authors： van Dijk MA,Hart AA,van 't Veer LJ

更新日期：2000-02-01 00:00:00

abstract：:The MCT-1 oncogene was originally identified from lymphoma cell lines. Herein we establish that MCT-1 is highly expressed in 85% of human diffuse large B-cell lymphomas (DLBCL) and that knocking down MCT-1 by a specific short hairpin RNA in DLBCL cells induces apoptosis, supporting a critical role for MCT-1 in DLBCL c...

journal_title：Cancer research

authors： Dai B,Zhao XF,Hagner P,Shapiro P,Mazan-Mamczarz K,Zhao S,Natkunam Y,Gartenhaus RB

更新日期：2009-10-01 00:00:00