Identification of two different surface epitopes of human ovarian epithelial carcinomas by monoclonal antibodies.

abstract：:Methyl-CpG binding domain (MBD) proteins have been shown to couple DNA methylation to transcriptional repression. This biological property suggests a role for MBD proteins in the silencing of tumor suppressor genes that are hypermethylated at their promoter CpG islands in cancer cells. Despite the demonstration of the...

journal_title：Cancer research

authors： Lopez-Serra L,Ballestar E,Fraga MF,Alaminos M,Setien F,Esteller M

更新日期：2006-09-01 00:00:00

abstract：:To determine whether expression of the XPD/ERCC2 repair gene in trichothiodystrophy (TTD) group D cells could restore mutagenesis characteristics of repair-proficient cells, we compared the UV mutagenesis of normal cells, TTD group D cells, and TTD group D cells retrovirally transduced by the wild-type XPD/ERCC2 gene ...

journal_title：Cancer research

authors： Marionnet C,Quilliet X,Benoit A,Armier J,Sarasin A,Stary A

更新日期：1996-12-01 00:00:00

abstract：:Steroid and xenobiotic receptor (SXR) or human pregnane X receptor (hPXR) has been shown to play an important role in the regulation of genes related to xenobiotic detoxification, such as cytochrome P450 3A4 and multidrug resistance gene 1. Cytochrome P450 enzymes, conjugation enzymes, and transporters are all conside...

journal_title：Cancer research

authors： Miki Y,Suzuki T,Kitada K,Yabuki N,Shibuya R,Moriya T,Ishida T,Ohuchi N,Blumberg B,Sasano H

更新日期：2006-01-01 00:00:00

abstract：:Retinoids are promising agents for cancer chemoprevention and therapy. Nuclear retinoic acid receptors (RARs; RARalpha, -beta, and -gamma) and retinoid X receptors (RXRs; RXRalpha, -beta, and -gamma) are thought to mediate most of retinoids' effects on cell growth and differentiation. Because the majority of human non...

journal_title：Cancer research

authors： Sun SY,Yue P,Dawson MI,Shroot B,Michel S,Lamph WW,Heyman RA,Teng M,Chandraratna RA,Shudo K,Hong WK,Lotan R

更新日期：1997-11-01 00:00:00

abstract：:Proliferating cell nucleolar antigen P40 is a late G1-specific protein, which was found in a variety of human tumors (A. Chatterjee, J. W. Freeman, and H. Busch. Cancer Res., 47: 1123-1129, 1987). Two overlapping complementary DNA clones for antigen P40 were isolated by immunoscreening a lambda gt11 human expression l...

journal_title：Cancer research

authors： Reddy AB,Chatterjee A,Rothblum LI,Black A,Busch H

更新日期：1989-04-01 00:00:00

abstract：:The binding of the papillomavirus E6 protein to E6AP and the induction of p53 degradation are common features of high-risk genital human papillomaviruses (HPV); cutaneous HPVs, on the other hand, lack these capacities. Nevertheless, several cutaneous HPV types of the beta-genus, such as HPV38 are associated with tumor...

journal_title：Cancer research

authors： Muench P,Probst S,Schuetz J,Leiprecht N,Busch M,Wesselborg S,Stubenrauch F,Iftner T

更新日期：2010-09-01 00:00:00

abstract：:Human bronchial carcinoma is thought to develop through progressive stages from basal cell hyperplasia to squamous metaplasia, dysplasia, carcinoma in situ, and finally invasive cancer. In this study, we used tissue microdissection to examine loss of heterozygosity of chromosomes 3p21, 5q21, and 9p21 at each stage of ...

journal_title：Cancer research

authors： Thiberville L,Payne P,Vielkinds J,LeRiche J,Horsman D,Nouvet G,Palcic B,Lam S

更新日期：1995-11-15 00:00:00

abstract：:The effects of an altered content of dietary iodine and fat on the development of N-nitrosomethylurea-induced mammary tumors in rats were studied and correlated with thyroid and pituitary function studies. In three separate experiments, animals fed a semisynthetic diet containing 11.8% fat had an earlier time of tumor...

journal_title：Cancer research

authors： Cave WT Jr,Dunn JT,MacLeod RM

更新日期：1979-03-01 00:00:00

abstract：:Retinoids have chemopreventive activity for epithelial tumors in a variety of systems, including the two-stage tumorigenesis system of mouse skin in which only the promotion stage is inhibited. We asked whether dietary vitamin A deficiency could affect the skin tumorigenic response, prior to major changes in body weig...

journal_title：Cancer research

authors： De Luca LM,Shores RL,Spangler EF,Wenk ML

更新日期：1989-10-01 00:00:00

abstract：:Despite our improved understanding of cancer, the 5-year survival rate for head and neck squamous cell carcinomas (HNSCC) patients remains relatively unchanged at 50% for the past three decades. HNSCCs often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important progno...

journal_title：Cancer research

authors： Patel V,Marsh CA,Dorsam RT,Mikelis CM,Masedunskas A,Amornphimoltham P,Nathan CA,Singh B,Weigert R,Molinolo AA,Gutkind JS

更新日期：2011-11-15 00:00:00

abstract：:Carbonic anhydrase IX (CAIX) is a membrane-associated carbonic anhydrase (CA), strongly induced by hypoxia. CAIX is overexpressed in a variety of tumor types and associated with increased metastasis and poor prognosis. An inhibitor of CAs, acetazolamide has been reported to inhibit invasion. We used RNA interference (...

journal_title：Cancer research

authors： Robertson N,Potter C,Harris AL

更新日期：2004-09-01 00:00:00

abstract：:Gastric carcinoma is one of the most common cancers and lethal malignancies worldwide. Thus far, the regulatory mechanisms of its aggressiveness are still poorly understood. To understand the pathogenesis and to develop new therapeutic strategies, it is essential to dissect the molecular mechanisms that regulate progr...

journal_title：Cancer research

authors： Yeh TS,Wu CW,Hsu KW,Liao WJ,Yang MC,Li AF,Wang AM,Kuo ML,Chi CW

更新日期：2009-06-15 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAID) are effective in suppressing the formation of colorectal tumors. However, the mechanisms underlying the antineoplastic effects of NSAIDs remain unclear. The effects of NSAIDs are incomplete, and resistance to NSAIDs is often developed. Growing evidence has indicated that th...

journal_title：Cancer research

authors： Bank A,Wang P,Du C,Yu J,Zhang L

更新日期：2008-01-01 00:00:00

abstract：:Normal bone marrow progenitors and some leukemic cells develop only a limited amount of thermotolerance. Further, once developed, thermotolerance decays at a faster rate than that normally observed in cells of nonhemopoietic origin. Thermotolerance induction and maintenance correlates with reduced levels of expression...

journal_title：Cancer research

authors： Mivechi NF,Ouyang H,Hahn GM

更新日期：1992-12-15 00:00:00

abstract：:Antiangiogenic tumor therapies have recently attracted intense interest for their broad-spectrum action, low toxicity, and, in the case of direct endothelial targeting, an absence of drug resistance. To promote tumor regression and to maintain dormancy, antiangiogenic agents need to be chronically administered. Gene t...

journal_title：Cancer research

authors： Nguyen JT,Wu P,Clouse ME,Hlatky L,Terwilliger EF

更新日期：1998-12-15 00:00:00

abstract：:Recently, we have reported that the toxicity of the membrane-active agent valinomycin (VM) can be reduced with maintenance and/or enhancement of its antitumor activity by incorporation in liposomes (S. S. Daoud and Juliano, Cancer Res., 46:5518-5525, 1986). Since the underlying defect(s) in multidrug resistance reside...

journal_title：Cancer research

authors： Daoud SS,Juliano RL

更新日期：1989-05-15 00:00:00

abstract：:Peutz-Jeghers syndrome (PJS) is characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous melanin deposition, and increased risk of cancer, mainly in the gastrointestinal tract. We examined mutations of the LKB1, beta-catenin, APC, K-ras, and p53 genes in 27 gastrointestinal hamartomatous polyps f...

journal_title：Cancer research

authors： Miyaki M,Iijima T,Hosono K,Ishii R,Yasuno M,Mori T,Toi M,Hishima T,Shitara N,Tamura K,Utsunomiya J,Kobayashi N,Kuroki T,Iwama T

更新日期：2000-11-15 00:00:00

abstract：:The anticancer agent saintopin induces DNA cleavage mediated by both topoisomerase (topo) I and topo II in vitro through stabilization of the reversible enzyme-DNA cleavable complex. We established saintopin-resistant cell lines (KB/STP-1 and KB/STP-2) from human epidermoid cancer KB cells by stepwise exposure to incr...

journal_title：Cancer research

authors： Taniguchi K,Kohno K,Kawanami K,Wada M,Kanematsu T,Kuwano M

更新日期：1996-05-15 00:00:00

abstract：:The specific activity of cyclic adenosine 3':5'-monophosphate phosphodiesterase was measured in lymphocytes isolated from the blood of normal subjects, from patients with chronic lymphocytic leukemia, and from tonsil tissue. The mean specific activity of cyclic adenosine 3':5'-monophosphate phosphodiesterase in the ly...

journal_title：Cancer research

authors： Scher NS,Quagliata F,Malathi VG,Faig D,Melton RA,Silber R

更新日期：1976-11-01 00:00:00

abstract：:p53 is regulated at multiple levels. We report here that p53, in multiple lines of human cancer cells, is down-regulated by cardiac glycoside drugs digoxin and ouabain, potent inhibitors of Na(+)/K(+)-ATPase. These drugs reduced the basal levels of p53 protein at nanomolar concentrations in a dose-, time-, and cancer ...

journal_title：Cancer research

authors： Wang Z,Zheng M,Li Z,Li R,Jia L,Xiong X,Southall N,Wang S,Xia M,Austin CP,Zheng W,Xie Z,Sun Y

更新日期：2009-08-15 00:00:00

abstract：:Ionizing radiation (IR) and concomitant angiostatin (AS) produce greater than additive local antitumor effects. We examined whether prolonged AS treatment added to IR reduces proliferation of lung metastases from LLC primary tumors. Flank tumors were treated with 40 Gy with or without AS (25 mg/kg/day). IR plus a 14-d...

journal_title：Cancer research

authors： Gorski DH,Mauceri HJ,Salloum RM,Halpern A,Seetharam S,Weichselbaum RR

更新日期：2003-01-15 00:00:00

abstract：:HeLa cells were synchronized at the G1-S boundary by double thymidine block and treated for 1 hr with varying concentrations of the antibiotic anticancer protein neocarzinostatin (NCS). Cells were then released from the block and allowed to resume their cycle. Aliquots were removed at various times in order to monitor...

journal_title：Cancer research

authors： Berry DE,Collins JM

更新日期：1980-07-01 00:00:00

abstract：:Contrary to a recent suggestion, new and useful drugs for the treatment of human cancer continue to be developed although clinical trials today are more difficult and the chances for success are diminished. In the past, research at Southern Research Institute led to the development of two new classes of clinically use...

journal_title：Cancer research

authors： Montgomery JA

更新日期：1982-10-01 00:00:00

abstract：:Inactivation of p53 signaling by mutation of p53 itself or abrogation of its normal function by other transfactors, such as MDM2, is a key event in the development of most human cancers. To identify novel regulators of p53, we have used a phenotype-based selection in which a total cDNA library in a retroviral vector h...

journal_title：Cancer research

authors： Agarwal MK,Ruhul Amin AR,Agarwal ML

更新日期：2007-01-01 00:00:00

abstract：:Morris 7777 hepatoma cells, maintained in culture for 5 days in Lewis medium supplemented with 0.1 to 0.35 mM cis-unsaturated fatty acid of the oleic (number of carbon atoms: number of double bonds, 18:1), linoleic (18:2), or arachidonic (20:4) type, were compared to similarly maintained, unsupplemented cells as to ul...

journal_title：Cancer research

authors： Abbas MK,Yoo TJ,Viles J

更新日期：1982-11-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a member of the nuclear receptor (NR) family of transcription factors with important regulatory roles in cellular growth, differentiation, and apoptosis. Using proteomic analysis, we showed expression of PPARgamma protein in a series of 260 newly diagnose...

journal_title：Cancer research

authors： Tsao T,Kornblau S,Safe S,Watt JC,Ruvolo V,Chen W,Qiu Y,Coombes KR,Ju Z,Abdelrahim M,Schober W,Ling X,Kardassis D,Meyer C,Schimmer A,Kantarjian H,Andreeff M,Konopleva M

更新日期：2010-06-15 00:00:00

abstract：:Urine from 22 patients with a variety of disseminated cancers and from an equivalent number of nonmalignant controls of similar age and sex was tested for the presence of transforming growth factor (TGF) activity as measured by the ability to promote the growth in soft agar of nontransformed indicator cells. Cancer pa...

journal_title：Cancer research

authors： Sherwin SA,Twardzik DR,Bohn WH,Cockley KD,Todaro GJ

更新日期：1983-01-01 00:00:00

abstract：:We have isolated the full-length cDNA for human ATP-binding cassette, sub-family A, member 2 transporter (ABCA2). The ORF of this cDNA encodes a protein consisting of 2436 amino acids with apparent molecular weight of M(r) 270,000. Accordingly, ABCA2 is the largest known mammalian ABC transporter described thus far. A...

journal_title：Cancer research

authors： Vulevic B,Chen Z,Boyd JT,Davis W Jr,Walsh ES,Belinsky MG,Tew KD

更新日期：2001-04-15 00:00:00

abstract：:Pathways relevant to cancer are well known to overlap with fetal development, as reflected in reactivation of embryonic genes in tumors. However, molecular evidence for this notion has gathered in piecemeal fashion, and systematic approaches have rarely been applied to gauge the extent and global characteristics of th...

journal_title：Cancer research

authors： Hu M,Shivdasani RA

更新日期：2005-10-01 00:00:00

abstract：:Nkx2.8, a homeodomain transcription factor, has been characterized in liver cancer and in the developing central nervous system. We now show that this factor is also expressed in the lung, where it localizes in adults to a discrete population of tracheobronchial basal cells. To target the mouse gene, the first exon wa...

journal_title：Cancer research

authors： Tian J,Mahmood R,Hnasko R,Locker J

更新日期：2006-11-01 00:00:00