Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia.

abstract：:The relative abundance of primary transcript and mature mRNA of the c-myc, calcyclin, S14 ribosomal protein, and rRNA genes was determined densitometrically after reverse transcriptase-polymerase chain reaction and Northern blotting analysis in resting and mitogen-stimulated lymphocytes, proliferating and terminally d...

journal_title：Cancer research

authors： Ferrari S,Tagliafico E,Manfredini R,Grande A,Rossi E,Zucchini P,Torelli G,Torelli U

更新日期：1992-01-01 00:00:00

abstract：:The s.c.-propagated murine glioma, GL-26, was established in tissue culture. The tissue culture line, with a doubling time of 36 hr, was used as the common source for all tumor cells. Suspensions of the tumor cells were transplanted intracerebrally in mice to produce an anaplastic ependymoblastoma. In vitro 51-Cr cyto...

journal_title：Cancer research

authors： Albright L,Madigan JC,Gaston MR,Houchens DP

更新日期：1975-03-01 00:00:00

abstract：:A partial-length A-myb complementary DNA recently cloned by low-stringency hybridization with a c-myb probe to complementary DNA libraries derived from human cell lines showed a high degree of homology with the DNA-binding domain of c-myb and B-myb, suggesting that A-myb also encoded a DNA-binding protein. We report h...

journal_title：Cancer research

authors： Ma XP,Calabretta B

更新日期：1994-12-15 00:00:00

abstract：:The three-dimensional structures of two carcinogens, 7-chloromethyl-12-methylbenz[a]anthracene and 7-chloromethylbenz[ai1anthracene, have been determined by X-ray crystallographic techniques. Both compounds are carcinogenic and are believed to act by alkylating DNA. However, the first has a nonplanar ring system, wher...

journal_title：Cancer research

authors： Glusker JP,Zacharias DE,Carrell HL

更新日期：1976-07-01 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably lymphangiogenic and represent a clear example of a cancer that utilizes the lymphatic vasculat...

journal_title：Cancer research

authors： Doçi CL,Mikelis CM,Lionakis MS,Molinolo AA,Gutkind JS

更新日期：2015-07-15 00:00:00

abstract：:Karyotypic and molecular genetic evidence has indicated that deletion or rearrangement of both chromosomes 3 and 13 may be important in the pathology of human small cell lung cancer (SCLC). The retinoblastoma susceptibility gene, RB, on chromosome 13 band q14, has previously been shown to be altered in SCLC [J. W. Har...

journal_title：Cancer research

authors： Hensel CH,Hsieh CL,Gazdar AF,Johnson BE,Sakaguchi AY,Naylor SL,Lee WH,Lee EY

更新日期：1990-05-15 00:00:00

abstract：:The inactivation of the tumor suppressor gene p53 has been demonstrated in a variety of human tumors. In this study, we present a p53 gene analysis of 13 uterine carcinoma cell lines. Sequencing analysis of the entire coding region revealed mutations changing the p53 amino acid composition in all six endometrial carci...

journal_title：Cancer research

authors： Yaginuma Y,Westphal H

更新日期：1991-12-15 00:00:00

abstract：:Human peripheral blood lymphocytes (PBL), obtained from patients with a variety of cancers, were incubated in vitro with phytohemagglutinin, concanavalin A, and crude or lectin-free T-cell growth factors. The lectin-activated PBL of nine patients were capable of lysing fresh autologous tumor during a 4-hr 51Cr release...

journal_title：Cancer research

authors： Mazumder A,Grimm EA,Zhang HZ,Rosenberg SA

更新日期：1982-03-01 00:00:00

abstract：:Despite studies that show the antitumor activity of Hsp90 inhibitors, such as geldanamycin (GA) and its derivative 17-allylamino-demethoxygeldanamycin (17-AAG), recent reports indicate that these inhibitors lack significant single-agent clinical activity. Resistance to Hsp90 inhibitors has been previously linked to ex...

journal_title：Cancer research

authors： McCollum AK,TenEyck CJ,Stensgard B,Morlan BW,Ballman KV,Jenkins RB,Toft DO,Erlichman C

更新日期：2008-09-15 00:00:00

abstract：:One third of the patients with estrogen receptor α (ERα)-positive breast cancer who are treated with the antiestrogen tamoxifen will either not respond to initial therapy or will develop drug resistance. Endocrine response involves crosstalk between ERα and TGFβ signaling, such that tamoxifen nonresponsiveness or resi...

journal_title：Cancer research

authors： Busch S,Sims AH,Stål O,Fernö M,Landberg G

更新日期：2015-04-01 00:00:00

abstract：:Several well characterized murine T-lymphoma cell lines were used in somatic cell hybridization experiments to study the genetic regulation of glucocorticoid-induced lysis. Cell fusions were carried out among the SL12-derived cloned lines and between the W7 and SAK8 lines all of which have functional hormone receptors...

journal_title：Cancer research

authors： Weinroth SE,MacLeod CL,Minning L,Hays EF

更新日期：1985-10-01 00:00:00

abstract：:We studied the clinical and karyotypic features of 50 patients with acute lymphoblastic leukemia, including 33 American and 17 Japanese patients, at two institutions. Clonal chromosome abnormalities were found in 39 of the 50 patients (78%) at diagnosis. Eleven patients had diploidy (N patients). Among the 39 aneuploi...

journal_title：Cancer research

authors： Kaneko Y,Rowley JD,Variakojis D,Chilcote RR,Check I,Sakurai M

更新日期：1982-07-01 00:00:00

abstract：:Proinflammatory cytokines produced in the tumor microenvironment facilitate tumor development and metastatic progression. In particular, TNF-α promotes cancer invasion and angiogenesis associated with epithelial-mesenchymal transition (EMT); however, the mechanisms underlying its induction of EMT in cancer cells remai...

journal_title：Cancer research

authors： Li CW,Xia W,Huo L,Lim SO,Wu Y,Hsu JL,Chao CH,Yamaguchi H,Yang NK,Ding Q,Wang Y,Lai YJ,LaBaff AM,Wu TJ,Lin BR,Yang MH,Hortobagyi GN,Hung MC

更新日期：2012-03-01 00:00:00

abstract：:Microsatellite instability (MSI) has been described in tumors from patients with hereditary nonpolyposis colorectal cancer, sporadic colorectal cancer, and other types of cancers. MSI is caused by the dysfunction of mismatch repairs genes. Loss of expression and mutation in one of the major mismatch repair genes, hMLH...

journal_title：Cancer research

authors： Deng G,Chen A,Hong J,Chae HS,Kim YS

更新日期：1999-05-01 00:00:00

abstract：:In this study, the mitochondrial phototoxicity of the cationic rhodacyanine MKT-077 was investigated by comparing its effects on the inhibition of mitochondrial respiration and the structural integrity of mitochondrial DNA (mtDNA) in the presence and absence of added high-intensity visible light (7.5 J/cm2). Results i...

journal_title：Cancer research

authors： Modica-Napolitano JS,Brunelli BT,Koya K,Chen LB

更新日期：1998-01-01 00:00:00

abstract：:The objective of this study was to investigate the induction of liver tumors by arylhydroxamic acids. The potential involvement of sulfate conjugation was minimized by the administration of a N-hydroxy-4-acylaminobiphenyl to female CD rats. This experimental design provided for the exposure of a target organ that has ...

journal_title：Cancer research

authors： Shirai T,Lee MS,Wang CY,King CM

更新日期：1981-06-01 00:00:00

abstract：:Two sublines, SCLC-MOA1 (MOA1) and SCLC-MOA2 (MOA2), were established from the SCLC-MO cell line, which was originally derived from an oat cell type of small cell lung carcinoma (SCLC). SCLC-MO showed typical culture morphology of SCLC, growing as tightly packed floating aggregates, while both MOA1 and MOA2 grew as a ...

journal_title：Cancer research

authors： Watanabe H,Takahashi T,Ueda R,Utsumi KR,Sato T,Ariyoshi Y,Ota K,Obata Y,Takahashi T

更新日期：1988-05-01 00:00:00

abstract：:Nkx2.8, a homeodomain transcription factor, has been characterized in liver cancer and in the developing central nervous system. We now show that this factor is also expressed in the lung, where it localizes in adults to a discrete population of tracheobronchial basal cells. To target the mouse gene, the first exon wa...

journal_title：Cancer research

authors： Tian J,Mahmood R,Hnasko R,Locker J

更新日期：2006-11-01 00:00:00

abstract：:Friend erythroleukemia cells can be induced to undergo erythroid differentiation by a variety of unrelated compounds. The fact that sodium butyrate causes reversible alterations in growth, morphology, and biochemistry in many cell systems prompted us to reexamine its pattern of induction of differentiation and to comp...

journal_title：Cancer research

authors： Friend C,Zajac-Kaye M,Holland JG,Pogo BG

更新日期：1987-01-15 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) E7 is a viral oncoprotein that is believed to play a major role in cervical neoplasia. Anti-HPV16 E7 intracellular single-chain antibodies (scFvs) were constructed to down-regulate HPV16 E7 oncoprotein in HPV DNA-containing cell lines. In these studies, we transfected anti-E7 scFvs...

journal_title：Cancer research

authors： Wang-Johanning F,Gillespie GY,Grim J,Rancourt C,Alvarez RD,Siegal GP,Curiel DT

更新日期：1998-05-01 00:00:00

abstract：:Xeroderma pigmentosum variant (XPV) patients with mutations in the DNA polymerase eta (pol eta) gene are hypersensitive to sunlight and have greatly increased susceptibility to sunlight-induced skin cancer. Consistent with the ability of Pol eta to efficiently bypass UV light-induced cyclobutane pyrimidine dimers, XPV...

journal_title：Cancer research

authors： Lin Q,Clark AB,McCulloch SD,Yuan T,Bronson RT,Kunkel TA,Kucherlapati R

更新日期：2006-01-01 00:00:00

abstract：:In order to characterize the promoting activity of the peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,463), male F344 rats which received a single 150-mg/kg dose of diethylnitrosamine (DEN) were fed 0.1% WY-14,643 or 0.05% phenobarbital in the diet for 11, 22, or 54 wk. WY-14,6...

journal_title：Cancer research

authors： Cattley RC,Popp JA

更新日期：1989-06-15 00:00:00

abstract：:We reported previously that a synthetic compound, MT-21, induced apoptosis by activating c-Jun-NH2-terminal kinase via the Krs/MST protein, which is activated by caspase-3 cleavage dependent on reactive oxygen species production. Here we examine the activation mechanism of caspase-3, an important cysteine aspartic pro...

journal_title：Cancer research

authors： Watabe M,Machida K,Osada H

更新日期：2000-09-15 00:00:00

abstract：:We present a light scattering study using angle-resolved low coherence interferometry (a/LCI) to assess nuclear morphology and subcellular structure within MCF-7 cells at several time points after treatment with chemotherapeutic agents. Although the nuclear diameter and eccentricity are not observed to change, the lig...

journal_title：Cancer research

authors： Chalut KJ,Ostrander JH,Giacomelli MG,Wax A

更新日期：2009-02-01 00:00:00

abstract：:Cancers of the upper aerodigestive tract (UADT) include malignant tumors of the oral cavity, pharynx, larynx, and esophagus and account for 6.4% of all new cancers in Europe. In the context of a multicenter case-control study conducted in 14 centers within 10 European countries and comprising 1,511 cases and 1,457 con...

journal_title：Cancer research

authors： Canova C,Hashibe M,Simonato L,Nelis M,Metspalu A,Lagiou P,Trichopoulos D,Ahrens W,Pigeot I,Merletti F,Richiardi L,Talamini R,Barzan L,Macfarlane GJ,Macfarlane TV,Holcátová I,Bencko V,Benhamou S,Bouchardy C,Kjaerheim

更新日期：2009-04-01 00:00:00

abstract：:Mice bearing the immunosuppressive plasmacytoma TEPC-183 exhibit a marked splenic hyperplasia. We have characterized these tumor-reactive splenocytes on the basis of cell surface marker expression, nonspecific esterase activity, and morphology. Although splenocyte numbers increased progressively throughout tumor growt...

journal_title：Cancer research

authors： Shanahan TC,Ceglowski WS,Havas HF

更新日期：1985-12-01 00:00:00

abstract：:Kinase inhibitors are used widely to treat various cancers, but adaptive reprogramming of kinase cascades and activation of feedback loop mechanisms often contribute to therapeutic resistance. Determining comprehensive, accurate maps of kinase circuits may therefore help elucidate mechanisms of response and resistance...

journal_title：Cancer research

authors： Olow A,Chen Z,Niedner RH,Wolf DM,Yau C,Pankov A,Lee EP,Brown-Swigart L,van 't Veer LJ,Coppé JP

更新日期：2016-04-01 00:00:00

abstract：:In vivo studies have shown that inhibitors of cyclooxygenase metabolism of arachidonic acid may diminish growth and metastasis of certain tumors. Because cyclooxygenase inhibition may increase the production of lipoxygenase products of arachidonic acid metabolism, we have investigated the effect of two such products, ...

journal_title：Cancer research

authors： Werner EJ,Walenga RW,Dubowy RL,Boone S,Stuart MJ

更新日期：1985-02-01 00:00:00

abstract：:The effects of sodium butyrate, dimethyl sulfoxide (DMSO), and retinoic acid on the growth, morphology, carcinoembryonic antigen content, cell surface membrane-associated enzyme activities, and glycoprotein profiles of a human rectal adenocarcinoma cell line (HRT-18) in culture were compared. All three agents reversib...

journal_title：Cancer research

authors： Tsao D,Morita A,Bella A Jr,Luu P,Kim YS

更新日期：1982-03-01 00:00:00

abstract：:Phorbol diester (PDE) tumor promoters have differing effects on normal and neoplastic hematopoietic cells in vitro. The effects of PDEs on cells are apparently mediated by specific cellular receptors for these ligands. The purpose of this study was to determine if the different phenotypic responses of cells of differe...

journal_title：Cancer research

authors： Weinberg JB,Misukonis MA,Goodwin BJ

更新日期：1984-03-01 00:00:00