Lysis of fresh human solid tumors by autologous lymphocytes activated in vitro with lectins.

abstract：:BMS-214662 and BMS-225975 are tetrahydrobenzodiazepine-based farnesyltransferase inhibitors (FTIs) that have nearly identical structures and very similar pharmacological profiles associated with farnesyltransferase (FT) inhibition. Despite their similar activity against FT in vitro and in cells, these compounds differ...

journal_title：Cancer research

authors： Manne V,Lee FY,Bol DK,Gullo-Brown J,Fairchild CR,Lombardo LJ,Smykla RA,Vite GD,Wen ML,Yu C,Wong TW,Hunt JT

更新日期：2004-06-01 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TIL) are potent mediators of an antitumor response. However, their function is attenuated in solid tumors. CD8+ T-cell effector functions, such as cytokine and granzyme production, depend on cytoplasmic Ca2+, which is controlled by ion channels. In particular, Kv1.3 channels regulate th...

journal_title：Cancer research

authors： Chimote AA,Hajdu P,Sfyris AM,Gleich BN,Wise-Draper T,Casper KA,Conforti L

更新日期：2017-01-01 00:00:00

abstract：:In November 1974, in response to a mandate in the revised National Cancer Act of 1974, a plan was introduced for the formation of a Diet, Nutrition, and Cancer Program. Dr. Frank J. Rauscher, Director of the National Cancer Institute, selected a group of scientists who defined the goals of the program and recommended ...

journal_title：Cancer research

authors： Gori GB

更新日期：1975-11-01 00:00:00

abstract：:Recently, we have reported that the toxicity of the membrane-active agent valinomycin (VM) can be reduced with maintenance and/or enhancement of its antitumor activity by incorporation in liposomes (S. S. Daoud and Juliano, Cancer Res., 46:5518-5525, 1986). Since the underlying defect(s) in multidrug resistance reside...

journal_title：Cancer research

authors： Daoud SS,Juliano RL

更新日期：1989-05-15 00:00:00

abstract：:Both Src kinase and membrane type 1 matrix metalloproteinase (MT1-MMP) play critical roles in cancer invasion and metastasis. It is not clear, however, how the spatiotemporal activation of these two critical enzymes is coordinated in response to an oncogenic epithelial growth factor (EGF) stimulation. Here, we have vi...

journal_title：Cancer research

authors： Ouyang M,Huang H,Shaner NC,Remacle AG,Shiryaev SA,Strongin AY,Tsien RY,Wang Y

更新日期：2010-03-15 00:00:00

abstract：:Cell cycle arrest in G2 phase is a common response to a variety of DNA-damaging agents. The coupling between DNA damage and G2 arrest was studied in synchronized HeLa cells using camptothecin, a highly specific inhibitor of topoisomerase I that damages DNA through the formation of reversible topoisomerase I-DNA cleava...

journal_title：Cancer research

authors： Tsao YP,D'Arpa P,Liu LF

更新日期：1992-04-01 00:00:00

abstract：:Upon MYC inactivation, tumors variously undergo proliferative arrest, cellular differentiation, and apoptosis and in some cases, apparently permanently revoking tumorigenesis. In liver tumor cells, we recently showed that MYC inactivation uncovers stem cell properties and triggers differentiation, but in this case, th...

journal_title：Cancer research

authors： Shachaf CM,Felsher DW

更新日期：2005-06-01 00:00:00

abstract：:Mutated KRAS protein is a pivotal tumor driver in pancreatic cancer. However, despite comprehensive efforts, effective therapeutics that can target oncogenic KRAS are still under investigation or awaiting clinical approval. Using a specific KRAS-dependent gene signature, we implemented a computer-assisted inspection o...

journal_title：Cancer research

authors： Mottini C,Tomihara H,Carrella D,Lamolinara A,Iezzi M,Huang JK,Amoreo CA,Buglioni S,Manni I,Robinson FS,Minelli R,Kang Y,Fleming JB,Kim MP,Bristow CA,Trisciuoglio D,Iuliano A,Del Bufalo D,Di Bernardo D,Melisi D,Dra

更新日期：2019-11-01 00:00:00

abstract：:The signaling pathways that mediate the development of pancreatic ductal adenocarcinoma (PDAC) downstream of mutant Kras remain incompletely understood. Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer. Phosphorylation of rpS6 was increased in pancreatic acinar cells ...

journal_title：Cancer research

authors： Khalaileh A,Dreazen A,Khatib A,Apel R,Swisa A,Kidess-Bassir N,Maitra A,Meyuhas O,Dor Y,Zamir G

更新日期：2013-03-15 00:00:00

abstract：:The clinical management of cutaneous melanoma would benefit significantly from a better understanding of the molecular changes that occur during melanocytic progression to a melanoma phenotype. To gain unique insights into this process, we developed a three-dimensional in vitro model that allows observations of normal...

journal_title：Cancer research

authors： Seftor EA,Brown KM,Chin L,Kirschmann DA,Wheaton WW,Protopopov A,Feng B,Balagurunathan Y,Trent JM,Nickoloff BJ,Seftor RE,Hendrix MJ

更新日期：2005-11-15 00:00:00

abstract：:We have obtained evidence for the existence of genes controlling invasion and metastasis by somatic cell fusion studies. Noninvasive, nonmetastatic mouse BW5147 T-lymphoma cells were fused with invasive human T-cells. The human cells were either activated normal peripheral blood lymphocytes or leukemic T-lymphoblasts....

journal_title：Cancer research

authors： Collard JG,van de Poll M,Scheffer A,Roos E,Hopman AH,Geurts van Kessel AH,van Dongen JJ

更新日期：1987-12-15 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) is constitutively activated in many types of cancers and has been implicated in gene expression important for angiogenesis, tumor growth, progression, and metastasis. Here, we show that the NF-kappaB activator, IkappaB kinase-alpha (IKKalpha), but not IKKbeta,...

journal_title：Cancer research

authors： DeBusk LM,Massion PP,Lin PC

更新日期：2008-12-15 00:00:00

abstract：:Approximately 10% of gastric adenocarcinomas worldwide are associated with human EBV. These carcinomas generally do not express the latent membrane protein 1 (LMP1), the major known EBV oncogene. Recently, another EBV gene [ie., BARF1 (BamHI A rightward open reading frame)] was shown to have transforming and immortali...

journal_title：Cancer research

authors： zur Hausen A,Brink AA,Craanen ME,Middeldorp JM,Meijer CJ,van den Brule AJ

更新日期：2000-05-15 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:The specific activity (dpm/mg protein) of the acid-soluble nuclear material extracted from spleens or lymph nodes (but not other tissues) of tumor-bearing BALB/c mice was approximately twice that of the corresponding tissues from tumor-free mice of the same age and sex following i.p. injection of L-[U-14C]lysine. Auto...

journal_title：Cancer research

authors： Mashburn LT

更新日期：1985-05-01 00:00:00

abstract：:The glutathione transferase (GST) isoenzyme profile was determined in two human tumor cell lines, U1690 derived from a small cell lung cancer and U1810 derived from a non-small cell lung cancer. U1810 cells are 3.2-fold more resistant to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) than are U1690 cells, a finding ascri...

journal_title：Cancer research

authors： Berhane K,Hao XY,Egyházi S,Hansson J,Ringborg U,Mannervik B

更新日期：1993-09-15 00:00:00

abstract：:Trans-3,4',5-trihydroxystilbene (resveratrol), a phytoalexin present in grapes and grape products such as wine, has been identified as a chemopreventive agent. Recent studies performed with MCF-7 human breast cancer cells have demonstrated superestrogenic effects with resveratrol. In contrast, studies performed using ...

journal_title：Cancer research

authors： Bhat KP,Lantvit D,Christov K,Mehta RG,Moon RC,Pezzuto JM

更新日期：2001-10-15 00:00:00

abstract：:Glucocorticoid receptor (GR) has been shown to suppress activator protein 1 (AP-1)-mediated transcription by several molecular mechanisms. We previously showed that activation of endogenous AP-1 is essential for cellular transformation induced by oncogenes, such as v-src and c-Ha-ras. In the present study, we have ana...

journal_title：Cancer research

authors： Kameda T,Iba H

更新日期：1998-03-01 00:00:00

abstract：:Tetrachloro(d,l-trans)-1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) has been considered a prodrug which would be converted rapidly to dichloro(d,l-trans)-1,2-diaminocyclohexaneplatinum(II) [PtCl2(dach)] under physiological conditions. However, the biotransformations of tetraplatin have not been studied in detail. ...

journal_title：Cancer research

authors： Chaney SG,Gibbons GR,Wyrick SD,Podhasky P

更新日期：1991-02-01 00:00:00

abstract：:Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported to reduce cancer incidence in diabetics. There are ongoing clinical trials to evaluate its antitumor properties, which may relate to its fundamental activity as...

journal_title：Cancer research

authors： Gravel SP,Hulea L,Toban N,Birman E,Blouin MJ,Zakikhani M,Zhao Y,Topisirovic I,St-Pierre J,Pollak M

更新日期：2014-12-15 00:00:00

abstract：:Contrary to a recent suggestion, new and useful drugs for the treatment of human cancer continue to be developed although clinical trials today are more difficult and the chances for success are diminished. In the past, research at Southern Research Institute led to the development of two new classes of clinically use...

journal_title：Cancer research

authors： Montgomery JA

更新日期：1982-10-01 00:00:00

abstract：:Cancer may arise from a cancer stem/progenitor cell that shares characteristics with its normal counterpart. We report the reconstitution of the original human prostate cancer specimen from epithelial cell lines (termed HPET for human prostate epithelial/hTERT) derived from this sample. These tumors can be described i...

journal_title：Cancer research

authors： Gu G,Yuan J,Wills M,Kasper S

更新日期：2007-05-15 00:00:00

abstract：:Carcinoma cells can transition from an epithelial-to-mesenchymal differentiation state through a process known as epithelial-mesenchymal transition (EMT). The process of EMT is characterized by alterations in the pattern of gene expression and is associated with a loss of cell polarity, an increase in invasiveness, an...

journal_title：Cancer research

authors： Bogachek MV,De Andrade JP,Weigel RJ

更新日期：2015-01-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a molecularly heterogeneous cancer that is difficult to treat. Despite the role it may play in tumor progression and response to therapy, microenvironmental (stromal) heterogeneity in TNBC has not been well characterized. To address this challenge, we investigated the transcript...

journal_title：Cancer research

authors： Saleh SMI,Bertos N,Gruosso T,Gigoux M,Souleimanova M,Zhao H,Omeroglu A,Hallett MT,Park M

更新日期：2017-09-01 00:00:00

abstract：:The levels of protooncogene RNA in matched bone marrow and peripheral blood cells obtained from patients with newly diagnosed acute myelogenous leukemia were compared. While the absolute amounts of c-myc RNA in the matched specimens are similar, the levels are not correlated. In contrast, while the levels of c-fos RNA...

journal_title：Cancer research

authors： Preisler HD,Sato H,Li YQ,Stein G,Stein J

更新日期：1987-07-15 00:00:00

abstract：:Human osteosarcomas frequently show loss of alleles on chromosome 17 as well as those on chromosome 13 that harbors the retinoblastoma gene, indicating concerted operation of another tumor-suppressing gene on chromosome 17. To assign the affected gene to a defined region of chromosome 17, we performed mitotic recombin...

journal_title：Cancer research

authors： Toguchida J,Ishizaki K,Nakamura Y,Sasaki MS,Ikenaga M,Kato M,Sugimoto M,Kotoura Y,Yamamuro T

更新日期：1989-11-15 00:00:00

abstract：:The development of myeloid and lymphoid neoplasms related to overexpression of FGFR1 kinases as a result of chromosome translocations depends on the promotion of a stem cell phenotype, suppression of terminal differentiation, and resistance to apoptosis. These phenotypes are related to the stem cell leukemia/lymphoma ...

journal_title：Cancer research

authors： Hu T,Chong Y,Lu S,Wang R,Qin H,Silva J,Kitamura E,Chang CS,Hawthorn L,Cowell JK

更新日期：2018-07-01 00:00:00

abstract：:We used immunohistochemical procedures to study the cellular expression and distribution of cytokeratins (CKs) in rat 13762NF mammary adenocarcinoma cells growing at mammary fat pad sites and at spontaneous lymph node and lung sites. In order to establish CK distribution in normal rat mammary epithelia, immature, rest...

journal_title：Cancer research

authors： Lichtner RB,Julian JA,North SM,Glasser SR,Nicolson GL

更新日期：1991-11-01 00:00:00

abstract：:MTH1 helps prevent misincorporation of ROS-damaged dNTPs into genomic DNA; however, there is little understanding of how MTH1 itself is regulated. Here, we report that MTH1 is regulated by polyubiquitination mediated by the E3 ligase Skp2. In melanoma cells, MTH1 was upregulated commonly mainly due to its improved sta...

journal_title：Cancer research

authors： Wang JY,Liu GZ,Wilmott JS,La T,Feng YC,Yari H,Yan XG,Thorne RF,Scolyer RA,Zhang XD,Jin L

更新日期：2017-11-15 00:00:00

abstract：:Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the Polycomb-repressive complex 2 (PRC2) that represses gene transcription through histone H3 lysine 27 trimethylation (H3K27me3). Although EZH2 is abundantly present in various cancers, the molecular consequences leading to oncogenesis remain unclear. Her...

journal_title：Cancer research

authors： Cheng AS,Lau SS,Chen Y,Kondo Y,Li MS,Feng H,Ching AK,Cheung KF,Wong HK,Tong JH,Jin H,Choy KW,Yu J,To KF,Wong N,Huang TH,Sung JJ

更新日期：2011-06-01 00:00:00