The diet, nutrition, and cancer program of the NCI National Cancer Program.

Abstract:

:In November 1974, in response to a mandate in the revised National Cancer Act of 1974, a plan was introduced for the formation of a Diet, Nutrition, and Cancer Program. Dr. Frank J. Rauscher, Director of the National Cancer Institute, selected a group of scientists who defined the goals of the program and recommended the appointment of a program director and of an advisory committee. These recommendations were accepted, and an Advisory Committee, reflecting a cross-section of scientific expertise, has been selected. To recommend a well-balanced program, it will be necessary for the Advisory Committee to assess the current state of the art of nutrition in cancer etiology and therapy and to be apprised of current opportunities, needs, and resources. Toward this end, a literature survey project has been initiated and two specialized workshops have been held.

journal_name

Cancer Res

journal_title

Cancer research

authors

Gori GB

subject

Has Abstract

pub_date

1975-11-01 00:00:00

pages

3545-7

issue

11 Pt. 2

eissn

0008-5472

issn

1538-7445

journal_volume

35

pub_type

杂志文章
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    abstract::Two principal virus-directed antigens have been identified on the surface of oncornavirus-infected chick embryo cells. One is identical with the major virus type-specific envelope antigen, which is a glycoprotein with a molecular weight of 85,000. The 2nd antigen (tumor-specific cell surface antigen) is specific for t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Bauer H,Kurth R,Rohrschneider L,Gelderblom H

    更新日期:1976-02-01 00:00:00

  • MK5 Regulates YAP Stability and Is a Molecular Target in YAP-Driven Cancers.

    abstract::Transcriptional regulator YAP is activated in multiple human cancers and plays critical roles in tumor initiation, progression, metastasis, and drug resistance. However, therapeutic targeting of the Hippo-YAP pathway has been challenging due to its low druggability and limited knowledge of YAP regulation in cancer. He...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-19-1339

    authors: Seo J,Kim MH,Hong H,Cho H,Park S,Kim SK,Kim J

    更新日期:2019-12-15 00:00:00

  • Nitric oxide-dependent downregulation of BRCA1 expression promotes genetic instability.

    abstract::Elevated levels of nitric oxide (NO) and reactive nitrogen species (RNS) may link inflammation to the initiation, promotion, and progression of cancer. Traditionally, this link has been thought to be mediated by the effects of NO/RNS in generating DNA damage. However, this damage also stimulates DNA repair responses w...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-12-3270

    authors: Yakovlev VA

    更新日期:2013-01-15 00:00:00

  • CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1.

    abstract::B-cell precursor acute lymphoblastic leukemia (BCP-ALL/B-precursor ALL) is characterized by a high rate of tissue infiltration. The mechanism of BCP-ALL cell extravasation is not fully understood. In the present study, we have investigated the major carrier of carbohydrate selectin ligands in the BCP-ALL cell line NAL...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-07-1459

    authors: Nonomura C,Kikuchi J,Kiyokawa N,Ozaki H,Mitsunaga K,Ando H,Kanamori A,Kannagi R,Fujimoto J,Muroi K,Furukawa Y,Nakamura M

    更新日期:2008-02-01 00:00:00

  • Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma.

    abstract::Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown. Herein, we first ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-12-2086

    authors: Zhang K,Chu K,Wu X,Gao H,Wang J,Yuan YC,Loera S,Ho K,Wang Y,Chow W,Un F,Chu P,Yen Y

    更新日期:2013-02-15 00:00:00

  • Screening prescription drugs for possible carcinogenicity: eleven to fifteen years of follow-up.

    abstract::Using computerized pharmacy records from 1969 to 1973 for a cohort of 143,574 members of the Kaiser Permanente Medical Care Program, we have been testing associations of 215 drugs or drug groups with subsequent incidence of cancer at 56 sites. This paper presents findings with follow-up through 1984. There were 227 st...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Selby JV,Friedman GD,Fireman BH

    更新日期:1989-10-15 00:00:00

  • Involvement of the Oct-1 regulatory element of the gadd45 promoter in the p53-independent response to ultraviolet irradiation.

    abstract::The gadd45 gene, a growth arrest and DNA damage (gadd)-induced gene, is transcriptionally activated by UV irradiation through two distinct pathways. One requires the sequence-specific binding of the p53 tumor suppressor protein to a responsive element within the third intron of the gadd45 gene, and the other is p53-in...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Takahashi S,Saito S,Ohtani N,Sakai T

    更新日期:2001-02-01 00:00:00

  • Increasing c-FMS (CSF-1 receptor) expression decreases retinoic acid concentration needed to cause cell differentiation and retinoblastoma protein hypophosphorylation.

    abstract::Increasing the expression of c-FMS (colony-stimulating factor 1 receptor) by introduction of a transgene reduced the concentration of retinoic acid or 1,25-dihydroxy vitamin D3 needed to cause myeloid or monocytic cell differentiation and hypophosphorylation of the retinoblastoma tumor suppressor protein (RB) typicall...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Yen A,Sturgill R,Varvayanis S

    更新日期:1997-05-15 00:00:00

  • Schwann cell-conditioned medium promotes neuroblastoma survival and differentiation.

    abstract::Neuroblastomas are histopathologically heterogeneous, ranging from immature malignant tumors to benign ganglioneuromas. The amount of Schwann cell stroma greatly increases with neuroblastoma differentiation, and these Schwann cells appear to be normal cells that infiltrate the tumor. To determine whether Schwann cells...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kwiatkowski JL,Rutkowski JL,Yamashiro DJ,Tennekoon GI,Brodeur GM

    更新日期:1998-10-15 00:00:00

  • EpCAM Signaling Promotes Tumor Progression and Protein Stability of PD-L1 through the EGFR Pathway.

    abstract::Although epithelial cell adhesion molecule (EpCAM) has previously been shown to promote tumor progression, the underlying mechanisms remain largely unknown. Here, we report that the EGF-like domain I within the extracellular domain of EpCAM (EpEX) binds EGFR, activating both AKT and MAPK signaling to inhibit forkhead ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-20-1264

    authors: Chen HN,Liang KH,Lai JK,Lan CH,Liao MY,Hung SH,Chuang YT,Chen KC,Tsuei WW,Wu HC

    更新日期:2020-11-15 00:00:00

  • Factors influencing the anticarcinogenic efficacy of selenium in dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats.

    abstract::The present study was designed to investigate the effect of selenium supplementation on dimethylbenz[a]anthracene-induced mammary tumorigenesis in female Sprague-Dawley rats fed either a 5 or 25% corn oil diet, denoted as low fat (LF) or high fat (HF), respectively. Selenium supplementation of LF and HF diets were beg...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ip C

    更新日期:1981-07-01 00:00:00

  • Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through beta1 integrin.

    abstract::Culturing DOV 13 ovarian carcinoma cells on three-dimensional collagen lattice but not on thin-layer collagen induces processing of promatrix metalloproteinase (MMP)-2 to a M(r) 62,000 form, suggesting that multivalent integrin aggregation may participate in proteinase regulation. To address the role of collagen-bindi...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Ellerbroek SM,Fishman DA,Kearns AS,Bafetti LM,Stack MS

    更新日期:1999-04-01 00:00:00

  • Overlapping gene expression in fetal mouse intestine development and human colorectal cancer.

    abstract::Pathways relevant to cancer are well known to overlap with fetal development, as reflected in reactivation of embryonic genes in tumors. However, molecular evidence for this notion has gathered in piecemeal fashion, and systematic approaches have rarely been applied to gauge the extent and global characteristics of th...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-05-0700

    authors: Hu M,Shivdasani RA

    更新日期:2005-10-01 00:00:00

  • Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain.

    abstract::Retrospective studies of breast cancer patients suggest that primary tumor Her-2 overexpression or trastuzumab therapy is associated with a devastating complication: the development of central nervous system (brain) metastases. Herein, we present Her-2 expression trends from resected human brain metastases and data fr...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-06-3316

    authors: Palmieri D,Bronder JL,Herring JM,Yoneda T,Weil RJ,Stark AM,Kurek R,Vega-Valle E,Feigenbaum L,Halverson D,Vortmeyer AO,Steinberg SM,Aldape K,Steeg PS

    更新日期:2007-05-01 00:00:00

  • Antifolates targeting purine synthesis allow entry of tumor cells into S phase regardless of p53 function.

    abstract::The class of folate antimetabolites typified by (6R)-dideazatetrahydrofolate (lometrexol, DDATHF) are specific inhibitors of de novo purine synthesis because of potent inhibition of glycinamide ribonucleotide formyltransferase (GART) but do not induce detectable levels of DNA strand breaks. As such, they are a test ca...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Bronder JL,Moran RG

    更新日期:2002-09-15 00:00:00

  • Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.

    abstract::Tumor hypoxia induces the up-regulation of a gene program associated with angiogenesis, glycolysis, adaptation to pH, and apoptosis via the hypoxia-inducible transcription factors (Hifs) 1 and 2. Disruption of this pathway has been proposed as a cancer therapy. Here, we use short interfering RNAs to compare specific i...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Sowter HM,Raval RR,Moore JW,Ratcliffe PJ,Harris AL

    更新日期:2003-10-01 00:00:00

  • Quantitative tumor cytochemistry--G.H.A. Clowes Memorial Lecture.

    abstract::Quantitative optical cytochemistry permits the determination of many different parameters in whole cells or parts of cells. Total amounts of DNA, RNA, and protein and/or the amounts of these substances in nucleus or nucleolus are examples. Techniques in this field have contributed considerably to the development of ou...

    journal_title:Cancer research

    pub_type: 历史文章,杂志文章

    doi:

    authors: Caspersson TO

    更新日期:1979-07-01 00:00:00

  • Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

    abstract::Immunosuppression may contribute to the progression of cancer. In this study we assessed the structural and functional status of T cells from tumor specimens obtained from patients with early stage non-small cell lung cancer and late-stage ovarian cancer. Although some groups have described structural alterations in t...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Woo EY,Chu CS,Goletz TJ,Schlienger K,Yeh H,Coukos G,Rubin SC,Kaiser LR,June CH

    更新日期:2001-06-15 00:00:00

  • Statistical analysis of in vivo tumor growth experiments.

    abstract::We review and compare statistical methods for the analysis of in vivo tumor growth experiments. The methods most commonly used are deficient in that they have either low power or misleading type I error rates. We propose a set of multivariate statistical modeling methods that correct these problems, illustrating their...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Heitjan DF,Manni A,Santen RJ

    更新日期:1993-12-15 00:00:00

  • Immunotoxin resistance in multidrug resistant cells.

    abstract::Multidrug resistance (MDR) can be mediated, in part, by overexpression of P-glycoprotein (P-gp) and is characterized by broad resistance to several structurally, chemically, and pharmacologically distinct chemotherapeutic compounds. It has been hypothesized that immunological approaches to cytolysis may be used to ove...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: McGrath MS,Rosenblum MG,Philips MR,Scheinberg DA

    更新日期:2003-01-01 00:00:00

  • Antitumor activity of cytidine dialdehyde and its effects on nucleotide and nucleic acid synthesis.

    abstract::Cytidine dialdehyde inhibited the growth of leukemia L1210 cells in culture at a 50% inhibitory concentration of 3.5 X 10(-5) M and, when administered i.p. at 200 mg/kg daily for 5 days, increased the mean survival of L1210 tumor-bearing mice by up to 171%. Given by the s.c. or i.v. routes, the compound was ineffectiv...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kinahan JJ,Pavelic ZP,Leonard RJ,Bloch A,Grindey GB

    更新日期:1980-03-01 00:00:00

  • Effects of bleomycin on human tongue carcinoma cells as revealed by electron microscopy.

    abstract::Five patients with tongue carcinoma were treated for 20 days with bleomycin, 15 mg/day, given by one-shot infusion through the superficial temporal artery. Specimens were taken 7, 14, and 20 days after the initial administration for light and electron microscope observations. The first alterations observed were the de...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Yasuzumi G,Hyo Y,Hoshiya T,Yasuzumi F

    更新日期:1976-10-01 00:00:00

  • Nonrandom chromosome alterations that correlate with progression to immortality in rat tracheal epithelial cells transformed with N-methyl-N'-nitro-N-nitrosoguanidine.

    abstract::Primary rat tracheal epithelial cells can be transformed in vitro by N-methyl-N'-nitro-N-nitrosoguanidine. The earliest recognizable morphological transformant is the enhanced growth variant (EGV), characterized by enhanced proliferative capacity. Transformed EGV colonies can progress to give rise to immortal cell lin...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Endo S,Nettesheim P,Oshimura M,Walker C

    更新日期:1990-02-01 00:00:00

  • Development and evaluation of the specificity of a rat monoclonal anti-idiotype antibody, WN, to an anti-B-cell lymphoma monoclonal antibody, LL2.

    abstract::Anti-idiotype monoclonal antibodies (Mabs) to mLL2, an anti-B-cell lymphoma and CD22-specific murine IgG2a-kappa Mab, were generated by hybridoma technology from splenocytes of Copenhagen rats immunized with mLL2 F(ab')2. Mab WN, an IgG2a-kappa, was selected based on its specific binding to mLL2 and not other IgG isot...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Losman MJ,Leung SO,Shih LB,Shevitz J,Shukla R,Haraga L,Goldenberg DM,Hansen HJ

    更新日期:1995-12-01 00:00:00

  • The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine.

    abstract::The base excision repair protein MED1 (also known as MBD4), an interactor with the mismatch repair protein MLH1, has a central role in the maintenance of genomic stability with dual functions in DNA damage response and repair. MED1 acts as a thymine and uracil DNA N-glycosylase on T:G and U:G mismatches that occur at ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-05-4488

    authors: Turner DP,Cortellino S,Schupp JE,Caretti E,Loh T,Kinsella TJ,Bellacosa A

    更新日期:2006-08-01 00:00:00

  • SMARCB1/INI1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas.

    abstract::Epithelioid sarcoma is a rare soft tissue neoplasm of uncertain lineage that usually arises in the distal extremities of adults, presents a high rate of recurrences and metastases and frequently poses diagnostic dilemmas. The recently reported large-cell "proximal-type" variant is characterized by increased aggressive...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-04-3050

    authors: Modena P,Lualdi E,Facchinetti F,Galli L,Teixeira MR,Pilotti S,Sozzi G

    更新日期:2005-05-15 00:00:00

  • Cellular specificity of NB70K, a putative human ovarian tumor antigen.

    abstract::We have studied the cellular expression of NB/70K, a glycoprotein proposed to be human ovarian tumor associated described previously. Analysis of cells bearing this antigen in malignant ascites shows expression in tumor cells of gynecological origin (ovarian, endometrial) and to a limited degree in breast cancer cells...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Bizzari JP,Mackillop WJ,Buick RN

    更新日期:1983-02-01 00:00:00

  • Enhancing effect of hydrocortisone on hematogenous metastasis of Ehrlich ascites tumor in mice.

    abstract::The effect of hydrocortisone on blood-borne tumor metastasis was studied in an i.v. inoculation experiment with Ehrlich hypotetraploid clone 1, Ehrlich hypotetraploid stock, and Ehrlich hyperdiploid stock tumors. The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced me...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kodama M,Kodama T

    更新日期:1975-04-01 00:00:00

  • Inhibition by parvovirus H-1 of the formation of tumors in nude mice and colonies in vitro by transformed human mammary epithelial cells.

    abstract::The formation of tumors in adult nude mice from transformed human mammary epithelial cells was drastically inhibited (greater than 80%) both after coinjection of tumoral cells and virus or after a single s.c. injection of parvovirus H-1 at the site of cell implantation prior to tumor formation. Moreover, when injected...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Dupressoir T,Vanacker JM,Cornelis JJ,Duponchel N,Rommelaere J

    更新日期:1989-06-15 00:00:00

  • Overexpression of transforming growth factor alpha overrides the glucocorticoid-mediated suppression of Con8 mammary tumor cell growth in vitro and in vivo.

    abstract::In a preceding paper (D. B. Alexander et al., Cancer Res., 53: 1808-1815, 1993), we demonstrated that the in vitro glucocorticoid inhibition of Con8 mammary tumor cell growth is accompanied by the disruption of a transforming growth factor alpha (TGF-alpha) autocrine loop. This growth suppression response functions in...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Goya L,Alexander DB,Webster MK,Kern FG,Guzman RC,Nandi S,Firestone GL

    更新日期:1993-04-15 00:00:00