An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer.

abstract：:Options for skin cancer treatment currently include surgery, radiotherapy, topical chemotherapy, cryosurgery, curettage, and electrodessication. Although effective, surgery is costly and unsuitable for certain patients. Radiotherapy can leave a poor cosmetic effect, and current chemotherapy is limited by low cure rate...

journal_title：Cancer research

authors： Ogbourne SM,Suhrbier A,Jones B,Cozzi SJ,Boyle GM,Morris M,McAlpine D,Johns J,Scott TM,Sutherland KP,Gardner JM,Le TT,Lenarczyk A,Aylward JH,Parsons PG

更新日期：2004-04-15 00:00:00

abstract：:Astrocytes, the most abundant type of glial cells in the brain, play critical roles in supporting neuronal development and brain function. Although astrocytes have been frequently detected in brain tumors, including medulloblastoma (MB), their functions in tumorigenesis are not clear. Here, we demonstrate that astrocy...

journal_title：Cancer research

authors： Liu Y,Yuelling LW,Wang Y,Du F,Gordon RE,O'Brien JA,Ng JMY,Robins S,Lee EH,Liu H,Curran T,Yang ZJ

更新日期：2017-12-01 00:00:00

abstract：:A series of nitrofuran-based compounds were identified as inhibitors of estrogen signaling in a cell-based, high-throughput screen of a diverse library of small molecules. These highly related compounds were subsequently found to inhibit topoisomerase II in vitro at concentrations similar to that required for the inhi...

journal_title：Cancer research

authors： Polycarpou-Schwarz M,Müller K,Denger S,Riddell A,Lewis J,Gannon F,Reid G

更新日期：2007-05-01 00:00:00

abstract：:We have analyzed genomic DNA sequences from 125 prospectively collected single unilateral primary breast carcinoma samples for the presence of alterations of c-myc, c-erbB-1, c-erbB-2, c-Ki-ras and c-Ha-ras protooncogenes. Amplification of the c-myc gene was found in 18% of the samples, and in one sample a non-germ li...

journal_title：Cancer research

authors： Garcia I,Dietrich PY,Aapro M,Vauthier G,Vadas L,Engel E

更新日期：1989-12-01 00:00:00

abstract：:We tried to purify carcinoembryonic antigen (CEA)-related antigens in normal human feces and found that, besides nonspecific cross-reacting antigen (fecal NCA), there are three other molecular species of CEA-related antigens which have been inclusively called normal fecal antigen (NFA). These were designated normal fe...

journal_title：Cancer research

authors： Kuroki M,Koga Y,Matsuoka Y

更新日期：1981-02-01 00:00:00

abstract：:Immunotoxins directed against human transferrin receptor have been evaluated in a nude mouse model of human malignant mesothelioma. Immunotoxins were constructed by linking ricin A chain to murine monoclonal antibodies reactive with the human transferrin receptor. A chain was obtained either by isolation from the pare...

journal_title：Cancer research

authors： Griffin TW,Richardson C,Houston LL,LePage D,Bogden A,Raso V

更新日期：1987-08-15 00:00:00

abstract：:An estrogen-responsive mouse Leydig cell tumor line (Tumor 124958) has been shown to contain only a low-affinity binder for estradiol in the cytosol fraction. This differed from the putative estrogen receptor in terms of its hormone-binding specificity as well as affinity. In addition, the possibility that an estrogen...

journal_title：Cancer research

authors： Maeda Y,Sato B,Noma K,Kishimoto S,Koizumi K,Aono T,Matsumoto K

更新日期：1983-09-01 00:00:00

abstract：:Tumor cell fractions isolated from tumor lines SH-3 (breast carcinoma) and RPMI-7932 (malignant melanoma) by differential centrifugations were capable of transforming lymphocytes into cytotoxic effector cells. Lymphocytes cultured alone in human AB plasma did not become cytotoxic to tumor cells. However, when cultured...

journal_title：Cancer research

authors： Sharma B

更新日期：1977-12-01 00:00:00

abstract：:Epidemiologic data and animal experiments suggest that dietary fat may influence risk of breast cancer. To determine whether intervention with a low-fat, high-carbohydrate diet would reduce breast cancer incidence in women at increased risk of the disease, we carried out a randomized controlled trial in Canada. We rec...

journal_title：Cancer research

authors： Martin LJ,Li Q,Melnichouk O,Greenberg C,Minkin S,Hislop G,Boyd NF

更新日期：2011-01-01 00:00:00

abstract：:The nucleoside analogue 1-beta-D-arabinofuranosylcytosine (ara-C) is incorporated into herpes simplex virus type 1 (HSV-1) DNA, and this correlates with inhibition of virus replication. The technique of Weigle-type reactivation (WR) was used to compare the ability of induced cellular DNA repair pathways to recognize o...

journal_title：Cancer research

authors： Bubley GJ,Crumpacker CS,Schnipper LE

更新日期：1984-05-01 00:00:00

abstract：:Persistent bronchial dysplasia is associated with increased risk of developing invasive squamous cell carcinoma (SCC) of the lung. In this study, we hypothesized that differences in gene expression profiles between persistent and regressive bronchial dysplasia would identify cellular processes that underlie progressio...

journal_title：Cancer research

authors： Merrick DT,Edwards MG,Franklin WA,Sugita M,Keith RL,Miller YE,Friedman MB,Dwyer-Nield LD,Tennis MA,O'Keefe MC,Donald EJ,Malloy JM,van Bokhoven A,Wilson S,Koch PJ,O'Shea C,Coldren C,Orlicky DJ,Lu X,Baron AE,Hickey

更新日期：2018-09-01 00:00:00

abstract：:We have previously shown that mice simultaneously infected with the murine mammary tumor virus (MuMTV) and with certain slow murine leukemia viruses (MLV) have an increased resistance to the pathological effects of both agents. Here we report that milk-transmitted MuMTV also delays the development of the acute erythro...

journal_title：Cancer research

authors： Basolo F,Toniolo A,Bistocchi M,Fontanini G,Squartini F

更新日期：1986-08-01 00:00:00

abstract：:Aberrant crypt foci (ACF) are distinct microscopic lesions of the colon thought to be the earliest identifiable precursors of colon cancer. As precursors of colon cancer, ACF may contain mutations in genes that are altered early in colorectal tumorigenesis. Candidates for these genes include APC, K-Ras, and those of t...

journal_title：Cancer research

authors： Heinen CD,Shivapurkar N,Tang Z,Groden J,Alabaster O

更新日期：1996-12-01 00:00:00

abstract：:Infection with Helicobacter pylori is a major cause of gastric cancer (GC). The association likely has been underestimated in the past due to disease-related clearance of the infection. On the other hand, only a minority of the infected individuals develop GC, and better risk stratification is therefore highly desirab...

journal_title：Cancer research

authors： Gao L,Michel A,Weck MN,Arndt V,Pawlita M,Brenner H

更新日期：2009-08-01 00:00:00

abstract：:Studies of V79-171 cells were undertaken to determine what extracellular or intracellular derivative of the drug WR-2721 is associated with radioprotection. The effect of preincubation at 23 +/- 1 degree C with WR-2721, and with derivatives of WR-2721 produced in medium containing alkaline phosphatase, upon survival o...

journal_title：Cancer research

authors： Smoluk GD,Fahey RC,Calabro-Jones PM,Aguilera JA,Ward JF

更新日期：1988-07-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a molecularly heterogeneous cancer that is difficult to treat. Despite the role it may play in tumor progression and response to therapy, microenvironmental (stromal) heterogeneity in TNBC has not been well characterized. To address this challenge, we investigated the transcript...

journal_title：Cancer research

authors： Saleh SMI,Bertos N,Gruosso T,Gigoux M,Souleimanova M,Zhao H,Omeroglu A,Hallett MT,Park M

更新日期：2017-09-01 00:00:00

abstract：:The increase of interleukin-4 (IL-4) level in tumor environment and the up-regulation of IL-4 receptor (IL-4R) on tumor cells have been long observed. However, their significance for tumor development has not been investigated. Here, we found that endogenous IL-4 promotes tumor growth because neutralizing IL-4 by 11B1...

journal_title：Cancer research

authors： Li Z,Jiang J,Wang Z,Zhang J,Xiao M,Wang C,Lu Y,Qin Z

更新日期：2008-11-01 00:00:00

abstract：:E-cadherin loss is frequently associated with ovarian cancer metastasis. Given that adhesion to the abdominal peritoneum is the first step in ovarian cancer dissemination, we reasoned that down-regulation of E-cadherin would affect expression of cell matrix adhesion receptors. We show here that inhibition of E-cadheri...

journal_title：Cancer research

authors： Sawada K,Mitra AK,Radjabi AR,Bhaskar V,Kistner EO,Tretiakova M,Jagadeeswaran S,Montag A,Becker A,Kenny HA,Peter ME,Ramakrishnan V,Yamada SD,Lengyel E

更新日期：2008-04-01 00:00:00

abstract：:Three mouse monoclonal antibodies to distinct cell surface antigens were derived from immunizations with cells of Tera-1, a human teratocarcinoma cell line, and a membrane preparation of placental tissue. The distribution of the antigens on 165 cultured lines of various human tumors and normal cells was determined by ...

journal_title：Cancer research

authors： Rettig WJ,Cordon-Cardo C,Ng JS,Oettgen HF,Old LJ,Lloyd KO

更新日期：1985-02-01 00:00:00

abstract：:Glioblastoma is the most aggressive primary brain tumor and responds poorly to currently available therapies. Transcriptomic characterization of glioblastoma has identified distinct molecular subtypes of glioblastoma. Gain-of-function alterations leading to enhanced platelet-derived growth factor (PDGF) signaling are ...

journal_title：Cancer research

authors： Rahme GJ,Zhang Z,Young AL,Cheng C,Bivona EJ,Fiering SN,Hitoshi Y,Israel MA

更新日期：2016-05-15 00:00:00

abstract：:CD26 is an antigen with key role in T-cell biology and is expressed on selected subsets of aggressive T-cell malignancies. To elucidate the role of CD26 in tumor behavior, we examine the effect of CD26 depletion by small interfering RNA transfection of T-anaplastic large cell lymphoma Karpas 299. We show that the resu...

journal_title：Cancer research

authors： Sato T,Yamochi T,Yamochi T,Aytac U,Ohnuma K,McKee KS,Morimoto C,Dang NH

更新日期：2005-08-01 00:00:00

abstract：:Autotaxin (ATX) is an exoenzyme that potently induces tumor cell motility, and enhances experimental metastasis and angiogenesis. ATX was shown recently to be identical to serum lysophospholipase D activity, producing lysophosphatidic acid (LPA) from lyso-glycerophospholipids. LPA, itself a strong chemoattractant for ...

journal_title：Cancer research

authors： Clair T,Aoki J,Koh E,Bandle RW,Nam SW,Ptaszynska MM,Mills GB,Schiffmann E,Liotta LA,Stracke ML

更新日期：2003-09-01 00:00:00

abstract：:Chronic pancreatitis, K-ras oncogene mutations, and the subsequent generation of reactive oxygen species (ROS) appear to be linked to pancreatic cancer. ROS have also been suggested to be mitogenic and capable of stimulating cell proliferation. Cells contain antioxidant enzymes to regulate steady state levels of ROS p...

journal_title：Cancer research

authors： Cullen JJ,Weydert C,Hinkhouse MM,Ritchie J,Domann FE,Spitz D,Oberley LW

更新日期：2003-03-15 00:00:00

abstract：:DNA-dependent RNA polymerase A (or 1) was purified from murine myeloma MOPC 21 by diethylaminoethyl Sephadex chromatography. Further separation from DNA polymerases, protein kinase and DNA endonuclease was accomplished by polyriboadenylate-Sepharose affinity chromatography followed by gradient centrifugation. Yields f...

journal_title：Cancer research

authors： Hall SH,Smuckler EA

更新日期：1976-03-01 00:00:00

abstract：:Complementary DNA (cDNA)-oligodeoxythmidylate-celluloses were prepared from cDNA copies of polysomal messenger RNA (mRNA) of Novikoff hepatoma, normal rat liver, and regenerating rat liver. cDNA synthesis with reverse transcriptase was approximately 46% with respect to input mRNA with oligodeoxythymidylate-cellulose p...

journal_title：Cancer research

authors： Hirsch FW,Nall KN,Hayes LC,Raju KS,Spohn WH,Busch H

更新日期：1977-10-01 00:00:00

abstract：:Caspase-8 is a proapoptotic protease that suppresses neuroblastoma metastasis by inducing programmed cell death. Paradoxically, caspase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can promote metastasis when apoptosis is compromised. Migration is enhanced by caspase-8 recru...

journal_title：Cancer research

authors： Barbero S,Mielgo A,Torres V,Teitz T,Shields DJ,Mikolon D,Bogyo M,Barilà D,Lahti JM,Schlaepfer D,Stupack DG

更新日期：2009-05-01 00:00:00

abstract：:KANSL2 is an integral subunit of the nonspecific lethal (NSL) chromatin-modifying complex that contributes to epigenetic programs in embryonic stem cells. In this study, we report a role for KANSL2 in regulation of stemness in glioblastoma (GBM), which is characterized by heterogeneous tumor stem-like cells associated...

journal_title：Cancer research

authors： Ferreyra Solari NE,Belforte FS,Canedo L,Videla-Richardson GA,Espinosa JM,Rossi M,Serna E,Riudavets MA,Martinetto H,Sevlever G,Perez-Castro C

更新日期：2016-09-15 00:00:00

abstract：:Glycolipids of murine lymphoma cell lines with low metastatic (Eb) and high metastatic (ESb) potentials have been investigated. The Eb cell line was characterized by a high quantity of gangliotriaosylceramide (Gg3), gangliotetraosylceramide (Gg4), GM1b, and a new type of disialoganglioside, termed GD1 alpha. In contra...

journal_title：Cancer research

authors： Murayama K,Levery SB,Schirrmacher V,Hakomori S

更新日期：1986-03-01 00:00:00

abstract：:The tumor suppressor protein BRCA1 localizes to sites of DNA double-strand breaks (DSB), promoting repair by homologous recombination through the recruitment of DNA damage repair proteins. In normal cells, homologous recombination largely depends on BRCA1. However, assembly of the pivotal homologous recombination regu...

journal_title：Cancer research

authors： Nakada S,Yonamine RM,Matsuo K

更新日期：2012-10-01 00:00:00

abstract：:Hematoporphyrin [1,3,5,8-tetramethyl-2,4-bis(hydroxyethyl)-porphin-6,7-dipropio nic acid dihydrochloride derivative] (HPD) is a compound that was studied in a number of laboratories because of its cytocidal activity after activation by light. Modification of immune function seen during the photochemotherapeutic studie...

journal_title：Cancer research

authors： Canti G,Franco P,Marelli O,Ricci L,Nicolin A

更新日期：1984-04-01 00:00:00