Hematoporphyrin derivative rescue from toxicity caused by chemotherapy or radiation in a murine leukemia model (L1210).

abstract：:We have examined the properties of the estrogen receptor and progesterone receptor in MDA-MB-134 human breast cells and have evaluated the effects of estrogen on cell proliferation and progesterone receptor levels in these cells as indices of hormonal sensitivity. These cells contain high levels of estrogen receptor (...

journal_title：Cancer research

authors： Reiner GC,Katzenellenbogen BS

更新日期：1986-03-01 00:00:00

abstract：:The effect of 0.0001 to 10 muM 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1 muM dexamethasone on cell proliferation was studied by measuring cell densities in control and drug-treated rat glioma (strain C6) monolayer cultures. When C6 cultures were exposed to 0.01 to 10 muM BCNU, the growth rates decreased for 2 ...

journal_title：Cancer research

authors： Grasso RJ,Johnson CE,Boler RK,Moore NA

更新日期：1977-02-01 00:00:00

abstract：:A major objective of the emerging field of exercise-oncology research is to determine the efficacy of, and biological mechanisms by which, aerobic exercise affects cancer incidence, progression, and/or metastasis. There is a strong inverse association between self-reported exercise and the primary incidence of several...

journal_title：Cancer research

authors： Ashcraft KA,Peace RM,Betof AS,Dewhirst MW,Jones LW

更新日期：2016-07-15 00:00:00

abstract：:Tumor suppressor p53-dependent apoptosis is thought to be one of the most important tumor-suppressive functions in human tumorigenesis. However, whether the major mechanism underlying the p53-dependent apoptosis is transactivation dependent or independent remains unclear. Using 179 mutant p53s with diverse transcripti...

journal_title：Cancer research

authors： Kakudo Y,Shibata H,Otsuka K,Kato S,Ishioka C

更新日期：2005-03-15 00:00:00

abstract：:The aggressive biology of human pancreatic adenocarcinoma has been linked with overexpression of vascular endothelial growth factor (VEGF). Constitutive activation of the transcription factor Sp1 plays a critical role in VEGF overexpression. Recent studies indicated that celecoxib, a selective cyclooxygenase-2 inhibit...

journal_title：Cancer research

authors： Wei D,Wang L,He Y,Xiong HQ,Abbruzzese JL,Xie K

更新日期：2004-03-15 00:00:00

abstract：:We have examined the implications of membrane-type matrix metalloproteinase (MT-MMP) for activation of the zymogen of MMP-2 (proMMP-2) in human gastric carcinoma. Northern blot analysis demonstrated exclusive expression of MT-MMP in the carcinoma tissues. Immunohistochemically, MT-MMP was colocalized in the carcinoma ...

journal_title：Cancer research

authors： Nomura H,Sato H,Seiki M,Mai M,Okada Y

更新日期：1995-08-01 00:00:00

abstract：:The failure and/or toxicity of conventional therapies for many types of human cancers underscore the need for development of safe and effective alternative treatments. Toward this goal, we describe the direct oncolytic activity of RNA-based vectors derived from poliovirus, termed replicons, which are genetically incap...

journal_title：Cancer research

authors： Ansardi DC,Porter DC,Jackson CA,Gillespie GY,Morrow CD

更新日期：2001-12-01 00:00:00

abstract：:Tumor cell-derived selectin ligands mediate contact to the endothelium, platelets, and leukocytes through binding to selectins that facilitates metastasis. Here, we describe the mechanism of how endogenous (non-tumor derived) selectin ligands contribute to metastasis using α(1,3)fucosyltransferase 7 (Fuc-TVII(-/-))-de...

journal_title：Cancer research

authors： Hoos A,Protsyuk D,Borsig L

更新日期：2014-02-01 00:00:00

abstract：:Applications of mathematical modeling can improve outcome predictions of cancer therapy. Here we present a kinetic model incorporating effects of radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis of tumor volume regression data of 80 cervical cancer patients (stages 1B2-IVA) who underwent r...

journal_title：Cancer research

authors： Huang Z,Mayr NA,Yuh WT,Lo SS,Montebello JF,Grecula JC,Lu L,Li K,Zhang H,Gupta N,Wang JZ

更新日期：2010-01-15 00:00:00

abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

journal_title：Cancer research

authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

更新日期：1991-04-15 00:00:00

abstract：:Connexins are tumor suppressors, and human breast connexin 26 (Cx26) and connexin 43 (Cx43) gap junctions are often down-regulated in breast cancer. We previously showed that Cx26 and Cx43 overexpressed in MDA-MB-231 breast cancer cells inhibited tumor growth in vivo but not in two-dimensional cultures. In the current...

journal_title：Cancer research

authors： McLachlan E,Shao Q,Wang HL,Langlois S,Laird DW

更新日期：2006-10-15 00:00:00

abstract：:Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poorly understood. Here we show that intratumoral copper levels influence PD-L1 exp...

journal_title：Cancer research

authors： Voli F,Valli E,Lerra L,Kimpton K,Saletta F,Giorgi FM,Mercatelli D,Rouaen JRC,Shen S,Murray JE,Ahmed-Cox A,Cirillo G,Mayoh C,Beavis PA,Haber M,Trapani JA,Kavallaris M,Vittorio O

更新日期：2020-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF)-C is a lymphangiogenic factor implicated in lymphatic metastasis. In this study, we investigated the role of the type I insulin-like growth factor receptor (IGF-IR) in the regulation of VEGF-C expression. We used Lewis lung carcinoma subline M-27 cells transfected with human I...

journal_title：Cancer research

authors： Tang Y,Zhang D,Fallavollita L,Brodt P

更新日期：2003-03-15 00:00:00

abstract：:By applying a new and highly sensitive assay for measuring N-hydroxy metabolites, the biochemical properties of the microsomal N-hydroxylase from control and 3-methylcholanthrene-treated rat and hamster liver have been analyzed, and the following conclusions have been drawn. (a) Due to a difference in enzyme affinity,...

journal_title：Cancer research

authors： Razzouk C,Mercier M,Roberfroid M

更新日期：1980-10-01 00:00:00

abstract：:Prognostic tests for patients with early-stage lung cancer may provide needed guidance on postoperative surveillance and therapeutic decisions. We used a novel strategy to develop and validate a prognostic classifier for early-stage lung cancer. Specifically, we focused on 42 genes with roles in lung cancer or cancer ...

journal_title：Cancer research

authors： Akagi I,Okayama H,Schetter AJ,Robles AI,Kohno T,Bowman ED,Kazandjian D,Welsh JA,Oue N,Saito M,Miyashita M,Uchida E,Takizawa T,Takenoshita S,Skaug V,Mollerup S,Haugen A,Yokota J,Harris CC

更新日期：2013-07-01 00:00:00

abstract：:Neuroblastoma cells accumulate ascorbic acid and iron. It was hypothesized that these features could be exploited for sensitizing neuroblastoma cells for therapy in combination with reactive oxygen intermediates. In the present study the effects of 6-hydroxydopamine (6-OHDA) and H2O2 on metabolic parameters critical f...

journal_title：Cancer research

authors： Bruchelt G,Schraufstätter IU,Niethammer D,Cochrane CG

更新日期：1991-11-15 00:00:00

abstract：:The antitumor activity of IFN-alpha is well established. However, the role of the plasmacytoid dendritic cell (PDC), the major producer of IFN-alpha upon viral infection, in tumor biology is unknown. We sought to study the presence and function of PDC in a human solid tumor. Here, we demonstrate that PDCs infiltrate t...

journal_title：Cancer research

authors： Hartmann E,Wollenberg B,Rothenfusser S,Wagner M,Wellisch D,Mack B,Giese T,Gires O,Endres S,Hartmann G

更新日期：2003-10-01 00:00:00

abstract：:The effect of the AC33 tumor on protein synthesis in Lewis-Wistar rats was investigated under four different dietary regimens. The four diets used were: (a) 1.25 g amino acids plus 12.5 g glucose per day, (b) 1.25 g amino acids, (c) 1.25 g glucose per day, and (d) 12.5 g glucose per day. The rats were maintained on th...

journal_title：Cancer research

authors： Stein TP,Oram-Smith JC,Leskiw MJ,Wallace HW,Miller EE

更新日期：1976-11-01 00:00:00

abstract：:The purpose of this study was to investigate the immunobiological characteristics of the tumor-specific cell surface antigen expressed by the UV-induced murine fibrosarcoma, UV-2240. UV-2240 is classified as a regressor UV tumor because it is immunologically rejected by normal syngeneic mice but grows in immunocomprom...

journal_title：Cancer research

authors： Simcik WJ,Kripke ML,Sheu TL,LeGrue SJ

更新日期：1988-12-15 00:00:00

abstract：:The XC infectious center assay was used to study the nature of the lymphoid cells producing N-tropic C-type viruses in preleukemic AKR mice. Viral production by thymic cell suspensions was very low and was possibly due to contaminating cells. Production at least 100-fold higher was found in spleen cells and was probab...

journal_title：Cancer research

authors： Gisselbrecht S,Blaineau C,Hurot MA,Pozo F,Levy JP

更新日期：1978-04-01 00:00:00

abstract：:One hundred seven Chinese patients with primary hepatocellular carcinoma (PHC) were compared with 107 hospital controls for the presence of hepatitis B surface antigen and smoking, drinking, and dietary habits. Eighty-two % of PHC cases were hepatitis B surface antigen positive compared to 18% of controls (relative ri...

journal_title：Cancer research

authors： Lam KC,Yu MC,Leung JW,Henderson BE

更新日期：1982-12-01 00:00:00

abstract：:Inhibition of constitutive active signaling pathways, which are a characteristic phenomenon for many tumors, can be an effective therapeutic strategy. In contrast, oncogenic transcription factors, often activated by mutational events, are in general less amenable to small-molecule inhibition despite their obvious impo...

journal_title：Cancer research

authors： Amstutz R,Wachtel M,Troxler H,Kleinert P,Ebauer M,Haneke T,Oehler-Jänne C,Fabbro D,Niggli FK,Schäfer BW

更新日期：2008-05-15 00:00:00

abstract：:The sonic hedgehog (SHH) receptor Patched 1 (Ptch1) is critical for embryonic development, and its loss is linked to tumorigenesis. Germ line inactivation of one copy of Ptch1 predisposes to basal cell carcinoma and medulloblastoma in mouse and man. In many cases, medulloblastoma arising from perturbations of Ptch1 fu...

journal_title：Cancer research

authors： Lee Y,Miller HL,Russell HR,Boyd K,Curran T,McKinnon PJ

更新日期：2006-07-15 00:00:00

abstract：:Ionizing radiation (IR) and concomitant angiostatin (AS) produce greater than additive local antitumor effects. We examined whether prolonged AS treatment added to IR reduces proliferation of lung metastases from LLC primary tumors. Flank tumors were treated with 40 Gy with or without AS (25 mg/kg/day). IR plus a 14-d...

journal_title：Cancer research

authors： Gorski DH,Mauceri HJ,Salloum RM,Halpern A,Seetharam S,Weichselbaum RR

更新日期：2003-01-15 00:00:00

abstract：:A prominent feature of glioblastoma is its resistance to death from Fas pathway activation. In this study, we explored the modulation of Fas-induced glioblastoma death with chemotherapeutic agents. Camptothecin significantly increased the glioblastoma cell death response to Fas receptor activation regardless of p53 st...

journal_title：Cancer research

authors： Xia S,Rosen EM,Laterra J

更新日期：2005-06-15 00:00:00

abstract：:Multiple DNA microsatellites with frequent loss of heterozygosity (LOH) in melanomas have been demonstrated. The finding that free DNA is enriched in blood of melanoma patients prompted studies to determine whether tumor-specific DNA, such as DNA microsatellites exhibiting LOH, can be detected in blood and have clinic...

journal_title：Cancer research

authors： Fujiwara Y,Chi DD,Wang H,Keleman P,Morton DL,Turner R,Hoon DS

更新日期：1999-04-01 00:00:00

abstract：:The effects of estrogens on the growth and enzyme activities for androgen synthesis in a mouse Leydig cell tumor line (T 124958-R) were studied. The s.c. implantation of a diethylstilbestrol pellet resulted in a marked enhancement of the tumor growth. 5 alpha-Reductase activity (nmol/g/h) in tumors rapidly grown in th...

journal_title：Cancer research

authors： Noguchi S,Nishizawa Y,Takatsuka D,Sato B,Matsumoto K

更新日期：1986-02-01 00:00:00

abstract：:A major challenge in treating cancer is the difficulty of bringing therapy to poorly perfused areas of solid tumors, which are often most resistant to chemotherapy and radiation. GRP94 is a chaperone protein localized in the endoplasmic reticulum with antiapoptotic properties. We report here that in vitro the proximal...

journal_title：Cancer research

authors： Reddy RK,Dubeau L,Kleiner H,Parr T,Nichols P,Ko B,Dong D,Ko H,Mao C,DiGiovanni J,Lee AS

更新日期：2002-12-15 00:00:00

abstract：:UV radiation is a potent DNA-damaging agent and a known inducer of skin cancer in experimental animals. To elucidate the role of oncogenes in UV carcinogenesis, we analyzed UV-induced murine skin tumors for mutations in codon 12, 13, or 61 of Ha-ras, Ki-ras, and N-ras oncogenes by amplification of genomic tumor DNAs b...

journal_title：Cancer research

authors： Pierceall WE,Kripke ML,Ananthaswamy HN

更新日期：1992-07-15 00:00:00

abstract：:The FLT3 gene is mutated by an internal tandem duplication (ITD) in 20-25% of adults with acute myeloid leukemia (AML). We studied 82 adults <60 years of age with primary AML and normal cytogenetics, who received uniform high-dose therapy and found FLT3 ITD in 23 (28%) patients. When the 23 FLT3 ITD+ cases were compar...

journal_title：Cancer research

authors： Whitman SP,Archer KJ,Feng L,Baldus C,Becknell B,Carlson BD,Carroll AJ,Mrózek K,Vardiman JW,George SL,Kolitz JE,Larson RA,Bloomfield CD,Caligiuri MA

更新日期：2001-10-01 00:00:00