PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-Mediated Survival of Proneural Glioma Cells.

abstract：:Changes in the structure of the surface of mastocytoma cells were induced by hyperthermia and were investigated by means of cell electrophoresis. A decrease in the cell electrophoretic mobility was detected as early as 15 min after treatment at 42 degrees and progressed more rapidly under hypoxic conditions than under...

journal_title：Cancer research

authors： Sato C,Nakayama T,Kojima K,Nishimoto Y,Nakamura W

更新日期：1981-10-01 00:00:00

abstract：:The ability of four steroids and three bile acids to promote the appearance of hyperplastic foci and hyperplastic nodules initiated by diethylnitrosamine (DEN) in the liver of male Fischer rats was tested and compared with that of the known promoter phenobarbital (PB, 0.05%) as a standard value. Two weeks after a sing...

journal_title：Cancer research

authors： Cameron RG,Imaida K,Tsuda H,Ito N

更新日期：1982-06-01 00:00:00

abstract：:Creation of a nuclear export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying NPM1 mutations. Hereby, we clarify how these COOH-terminal alteration...

journal_title：Cancer research

authors： Bolli N,Nicoletti I,De Marco MF,Bigerna B,Pucciarini A,Mannucci R,Martelli MP,Liso A,Mecucci C,Fabbiano F,Martelli MF,Henderson BR,Falini B

更新日期：2007-07-01 00:00:00

abstract：:To define transcriptional dependencies of triple-negative breast cancer (TNBC), we identified transcription factors highly and specifically expressed in primary TNBCs and tested their requirement for cell growth in a panel of breast cancer cell lines. We found that EN1 (engrailed 1) is overexpressed in TNBCs and its d...

journal_title：Cancer research

authors： Peluffo G,Subedee A,Harper NW,Kingston N,Jovanović B,Flores F,Stevens LE,Beca F,Trinh A,Chilamakuri CSR,Papachristou EK,Murphy K,Su Y,Marusyk A,D'Santos CS,Rueda OM,Beck AH,Caldas C,Carroll JS,Polyak K

更新日期：2019-08-15 00:00:00

abstract：:Pregnant C3HeB/FeJ mice were treated with ethylnitrosourea (ENU) on one of gestation Days 10, 13, or 15 to determine if ENU treatment at different stages of gestation would result in qualitative or quantitative differences in lung tumors induced in the offspring. Lung tumors were counted and measured 6 mo after treatm...

journal_title：Cancer research

authors： Branstetter DG,Stoner GD,Budd C,Conran PB,Goldblatt PJ

更新日期：1988-01-15 00:00:00

abstract：:As with many types of cancer, cell motility is an important factor in the progression and metastasis of hepatocellular carcinomas (HCC). HCC is associated with significant fibrosis in the liver. The fibrotic microenvironment in the liver is characterized by an altered composition of the extracellular matrix (ECM) and ...

journal_title：Cancer research

authors： Yang C,Zeisberg M,Lively JC,Nyberg P,Afdhal N,Kalluri R

更新日期：2003-12-01 00:00:00

abstract：:The interaction of Adriamycin and pivaloyloxymethyl butyrate (AN-9) was investigated in IMR-32 neuroblastoma and MCF-7 breast adenocarcinoma cells. Adriamycin is a widely used anticancer drug, whereas AN-9 is an anticancer agent presently undergoing Phase II clinical trials. The anticancer activity of AN-9 has been at...

journal_title：Cancer research

authors： Cutts SM,Rephaeli A,Nudelman A,Hmelnitsky I,Phillips DR

更新日期：2001-11-15 00:00:00

abstract：:Cancer is a major health concern and a leading cause of mortality. The reliable identification of carcinogens and understanding of carcinogenicity has become a main focus of biomedical research and regulatory toxicology. While biomedical research applies cellular in vitro methods to uncover the underlying mechanisms c...

journal_title：Cancer research

authors： Stolz A,Becker M,Wistorf E,Ertych N

更新日期：2020-04-15 00:00:00

abstract：:An undifferentiated status and the epigenetic inactivation of tumor-suppressor genes are hallmarks of transformed cells. Promoter CpG island hypermethylation of differentiating genes, however, has rarely been reported. The Groucho homologue Transducin-like Enhancer of Split 1 (TLE1) is a multitasked transcriptional co...

journal_title：Cancer research

authors： Fraga MF,Berdasco M,Ballestar E,Ropero S,Lopez-Nieva P,Lopez-Serra L,Martín-Subero JI,Calasanz MJ,Lopez de Silanes I,Setien F,Casado S,Fernandez AF,Siebert R,Stifani S,Esteller M

更新日期：2008-06-01 00:00:00

abstract：:Tetrachloro(d,l-trans)-1,2-diaminocyclohexaneplatinum(IV) (tetraplatin) has been considered a prodrug which would be converted rapidly to dichloro(d,l-trans)-1,2-diaminocyclohexaneplatinum(II) [PtCl2(dach)] under physiological conditions. However, the biotransformations of tetraplatin have not been studied in detail. ...

journal_title：Cancer research

authors： Chaney SG,Gibbons GR,Wyrick SD,Podhasky P

更新日期：1991-02-01 00:00:00

abstract：:Because chronic intestinal inflammation is a risk factor for colorectal cancer, we hypothesized that genetic variants of inflammatory mediators, such as mannose-binding lectin 2 (MBL2), are associated with colon cancer susceptibility. Here, we report the association of 24 MBL2 single-nucleotide polymorphisms (SNP) and...

journal_title：Cancer research

authors： Zanetti KA,Haznadar M,Welsh JA,Robles AI,Ryan BM,McClary AC,Bowman ED,Goodman JE,Bernig T,Chanock SJ,Harris CC

更新日期：2012-03-15 00:00:00

abstract：:PD115934 (NSC 366140) is a soluble pyrazoloacridine derivative presently undergoing preclinical toxicology evaluation with the anticipation of Phase I human investigation. The agent displayed both human and murine solid tumor selectivity in vitro in a soft agar disk diffusion assay, relative to its activity against mu...

journal_title：Cancer research

authors： LoRusso P,Wozniak AJ,Polin L,Capps D,Leopold WR,Werbel LM,Biernat L,Dan ME,Corbett TH

更新日期：1990-08-15 00:00:00

abstract：:The incidence of skin cancer is on the rise, with over 1 million new cases yearly. Although it is known that squamous cell cancers (SCC) are caused by UV light, the mechanism(s) involved remains poorly understood. In vitro studies with epithelial cells or reports examining malignant skin lesions suggest that loss of E...

journal_title：Cancer research

authors： Brouxhon S,Kyrkanides S,O'Banion MK,Johnson R,Pearce DA,Centola GM,Miller JN,McGrath KH,Erdle B,Scott G,Schneider S,VanBuskirk J,Pentland AP

更新日期：2007-08-15 00:00:00

abstract：:Hypoxia drives malignant progression in part by promoting accumulation of the oncogenic transcription factor hypoxia inducible factor-1α (HIF-1α) in tumor cells. Tumor aggressiveness also relates to elevation of the cancer stem cell-associated membrane protein CD24, which has been causally implicated in tumor formatio...

journal_title：Cancer research

authors： Thomas S,Harding MA,Smith SC,Overdevest JB,Nitz MD,Frierson HF,Tomlins SA,Kristiansen G,Theodorescu D

更新日期：2012-11-01 00:00:00

abstract：:Adaptive therapy seeks to exploit intra-tumoral competition to avoid, or at least delay, the emergence of therapy resistance in cancer. Motivated by promising results in prostate cancer, there is growing interest in extending this approach to other neoplasms. As such, it is urgent to understand the characteristics of ...

journal_title：Cancer research

authors： Strobl MAR,West J,Viossat Y,Damaghi M,Robertson-Tessi M,Brown JS,Gatenby RA,Maini PK,Anderson ARA

更新日期：2020-11-10 00:00:00

abstract：:There is considerable evidence that sphingosine kinases play a key role in cancer progression, which might involve positive selection of cancer cells that have been provided with a survival and growth advantage as a consequence of overexpression of the enzyme. Therefore, inhibitors of sphingosine kinase represent a no...

journal_title：Cancer research

authors： Pyne S,Bittman R,Pyne NJ

更新日期：2011-11-01 00:00:00

abstract：:Although there is considerable knowledge of how DNA damage triggers cell cycle arrest, DNA repair, and apoptosis, little was known about its potential role in immune responses. Recently, we showed that genotoxic stress and stalled DNA replication forks induce the expression of ligands for the NKG2D receptor found in n...

journal_title：Cancer research

authors： Gasser S,Raulet DH

更新日期：2006-04-15 00:00:00

abstract：:We have analyzed the Fas-mediated death pathway in a panel of 11 Epstein-Barr virus (EBV)-negative and 10 EBV-positive Burkitt's lymphoma (BL) cell lines. We show that the increased expression of Fas in EBV-positive cell lines is mediated via LMP-1. Four of the 21 BL cell lines are readily responsive to Fas-mediated c...

journal_title：Cancer research

authors： Gutiérrez MI,Cherney B,Hussain A,Mostowski H,Tosato G,Magrath I,Bhatia K

更新日期：1999-02-01 00:00:00

abstract：:Cyclooxygenase, involved in tumor growth and angiogenesis, converts arachidonic acid to prostaglandin (PG)H(2), which is immediately converted to bioactive prostanoids including PGE(2), PGD(2), thromboxane (TX)A(2) and PGI(2). To test the hypothesis that changes in the prostanoid profile alter cancer growth, we transd...

journal_title：Cancer research

authors： Pradono P,Tazawa R,Maemondo M,Tanaka M,Usui K,Saijo Y,Hagiwara K,Nukiwa T

更新日期：2002-01-01 00:00:00

abstract：:O6-Alkylguanine, a DNA adduct formed by nitrosoureas, becomes the site of a point mutation during DNA synthesis by preferentially base mispairing with thymine rather than correctly base pairing with cytosine. To repair this adduct, cells contain a limited amount of O6-alkylguanine-DNA alkyltransferase (alkyltransferas...

journal_title：Cancer research

authors： Gerson SL,Trey JE,Miller K,Benjamin E

更新日期：1987-01-01 00:00:00

abstract：:Early phase evaluation of anticancer drugs has traditionally used toxicity (usually hematological) rather than efficacy end points to establish appropriate dosing schedules. To establish a biochemical efficacy end point for overcoming alkylguanine DNA alkyltransferase (AGT)-mediated tumor cell resistance to 1,3-bis(2-...

journal_title：Cancer research

authors： Spiro TP,Gerson SL,Liu L,Majka S,Haaga J,Hoppel CL,Ingalls ST,Pluda JM,Willson JK

更新日期：1999-05-15 00:00:00

abstract：:It has been claimed that the commercially available Ki-67 monoclonal antibody recognizes a nuclear antigen which is solely expressed in cycling cells. Therefore, at present, Ki-67 is increasingly used as a tool in evaluating growth fractions (GFs) of human tumors. Here we describe specific patterns in the expression a...

journal_title：Cancer research

authors： van Dierendonck JH,Keijzer R,van de Velde CJ,Cornelisse CJ

更新日期：1989-06-01 00:00:00

abstract：:Medulloblastoma is the most common malignant pediatric brain tumor and is one of the leading causes of cancer-related mortality in children. Treatment failure mainly occurs in children harboring metastatic tumors, which typically carry an isochromosome 17 or gain of 17q, a common hallmark of intermediate and high-risk...

journal_title：Cancer research

authors： Traenka C,Remke M,Korshunov A,Bender S,Hielscher T,Northcott PA,Witt H,Ryzhova M,Felsberg J,Benner A,Riester S,Scheurlen W,Grunewald TG,von Deimling A,Kulozik AE,Reifenberger G,Taylor MD,Lichter P,Butt E,Pfister SM

更新日期：2010-10-15 00:00:00

abstract：:The ability of culture dishes coated with an extracellular matrix (ECM) to act as a suitable substrate for human ovarian carcinoma cells in vitro has been examined. The plating efficiency on ECM was 30 to 80% (dispersed tumor cells from solid tumor tissue and effusions) with active proliferation of tumor cells being o...

journal_title：Cancer research

authors： Crickard K,Crickard U,Yoonessi M

更新日期：1983-06-01 00:00:00

abstract：:Expression of death-associated protein (DAP) kinase, a proapoptotic serine/threonine protein kinase, is frequently lost in human tumors. In a study of 134 primary breast cancer specimens hypermethylation of the DAP kinase gene was found in 13% of cases. A highly significant difference (P < 0.001) of DAP kinase inactiv...

journal_title：Cancer research

authors： Lehmann U,Celikkaya G,Hasemeier B,Länger F,Kreipe H

更新日期：2002-11-15 00:00:00

abstract：:Renal cell carcinoma is frequently infiltrated by cells of the immune system. This makes it important to understand interactions between cancer cells and immune cells so they can be manipulated to bring clinical benefit. Here, we analyze subsets and functions of T lymphocytes infiltrating renal cell tumors directly ex...

journal_title：Cancer research

authors： Attig S,Hennenlotter J,Pawelec G,Klein G,Koch SD,Pircher H,Feyerabend S,Wernet D,Stenzl A,Rammensee HG,Gouttefangeas C

更新日期：2009-11-01 00:00:00

abstract：:GW572016 (Lapatinib) is a tyrosine kinase inhibitor in clinical development for cancer that is a potent dual inhibitor of epidermal growth factor receptor (EGFR, ErbB-1) and ErbB-2. We determined the crystal structure of EGFR bound to GW572016. The compound is bound to an inactive-like conformation of EGFR that is ver...

journal_title：Cancer research

authors： Wood ER,Truesdale AT,McDonald OB,Yuan D,Hassell A,Dickerson SH,Ellis B,Pennisi C,Horne E,Lackey K,Alligood KJ,Rusnak DW,Gilmer TM,Shewchuk L

更新日期：2004-09-15 00:00:00

abstract：:DNA probes prepared from human O6-methylguanine-DNA methyltransferase complementary DNA were hybridized to mRNA isolated from human liver and fifteen human tumor cell lines proficient (Mer+) or deficient (Mer-) in transferase activity. Liver and Mer+ cells contained levels of transferase-specific mRNA that correlated ...

journal_title：Cancer research

authors： Fornace AJ Jr,Papathanasiou MA,Hollander MC,Yarosh DB

更新日期：1990-12-15 00:00:00

abstract：:Antitumor type I T-cell responses involving IFN-γ production are critical to control cancer, but the efficacy of this response is limited by a variety of immunosuppressive mechanisms that promote tumoral immune escape. One critical mechanism involves the accumulation of FOXP3(+) T regulatory cells (Treg), a class of s...

journal_title：Cancer research

authors： Redjimi N,Raffin C,Raimbaud I,Pignon P,Matsuzaki J,Odunsi K,Valmori D,Ayyoub M

更新日期：2012-09-01 00:00:00

abstract：:The in vitro growth rates of different classifications of human mammary epithelium were compared. Samples included 4 established breast cell lines and excised tissue or breast fluid cells originating WOMEN FOR 40 DIFFERENT AND comprising 3 classifications: normal, nonmalignant atypical, and malignant. Growth was quant...

journal_title：Cancer research

authors： Buehring GC,Williams RR

更新日期：1976-10-01 00:00:00