Promoter hypermethylation of the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype.

abstract：:A new form of therapy of experimental tumors, utilizing lymphokine-activated killer (LAK) cells and high doses of interleukin 2, has recently been applied in the treatment of human neoplasms. Severe side effects, suggestive of a diffuse vascular injury of unknown etiology, have prevented a more widespread application ...

journal_title：Cancer research

authors： Kotasek D,Vercellotti GM,Ochoa AC,Bach FH,White JG,Jacob HS

更新日期：1988-10-01 00:00:00

abstract：:Ionizing radiation (IR) and concomitant angiostatin (AS) produce greater than additive local antitumor effects. We examined whether prolonged AS treatment added to IR reduces proliferation of lung metastases from LLC primary tumors. Flank tumors were treated with 40 Gy with or without AS (25 mg/kg/day). IR plus a 14-d...

journal_title：Cancer research

authors： Gorski DH,Mauceri HJ,Salloum RM,Halpern A,Seetharam S,Weichselbaum RR

更新日期：2003-01-15 00:00:00

abstract：:The inactivation of the tumor suppressor gene p53 has been demonstrated in a variety of human tumors. In this study, we present a p53 gene analysis of 13 uterine carcinoma cell lines. Sequencing analysis of the entire coding region revealed mutations changing the p53 amino acid composition in all six endometrial carci...

journal_title：Cancer research

authors： Yaginuma Y,Westphal H

更新日期：1991-12-15 00:00:00

abstract：:Estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to inactive estrogen sulfates, whereas steroid sulfatase (STS) hydrolyzes estrone sulfate to estrone. Both EST and STS have been suggested to play important roles in regulating the in situ production of estrogens in human breast carcinoma tissu...

journal_title：Cancer research

authors： Suzuki T,Nakata T,Miki Y,Kaneko C,Moriya T,Ishida T,Akinaga S,Hirakawa H,Kimura M,Sasano H

更新日期：2003-06-01 00:00:00

abstract：:Initially isolated as the dominant suppressor of the mutant epidermal growth factor receptor (ellipse), the Dachshund gene plays a key role in metazoan development regulating the Retinal Determination Gene Network. Herein, the DACH1 gene was expressed in normal prostate epithelial cells with reduced expression in huma...

journal_title：Cancer research

authors： Wu K,Katiyar S,Witkiewicz A,Li A,McCue P,Song LN,Tian L,Jin M,Pestell RG

更新日期：2009-04-15 00:00:00

abstract：:Recent evidence from our laboratory and from others suggested that pretreatment with alpha-difluoromethylornithine (DFMO) sensitizes some human and rodent tumor cell lines to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Many human tumor cells are resistant to chloroethylnitrosourea-induced DNA interstrand cross-linkin...

journal_title：Cancer research

authors： Seidenfeld J,Barnes D,Block AL,Erickson LC

更新日期：1987-09-01 00:00:00

abstract：:Verapamil has been shown to enhance immunotoxin activity but only at concentrations that are too high for in vivo use. Therefore, four structural analogues of verapamil (D792, D595, D528, and Sz45) were evaluated for their ability to enhance the in vitro activity of immunotoxins made with either ricin A chain or Pseud...

journal_title：Cancer research

authors： Pirker R,FitzGerald DJ,Raschack M,Frank Z,Willingham MC,Pastan I

更新日期：1989-09-01 00:00:00

abstract：:Impaired glucose metabolism and hyperinsulinemia have been hypothesized to increase breast cancer risk. However, findings from observational studies relating blood concentrations of hyperinsulinemia markers to breast cancer risk have been inconsistent. We prospectively evaluated whether hemoglobin A1c (HbA1c) concentr...

journal_title：Cancer research

authors： Lin J,Ridker PM,Rifai N,Lee IM,Manson JE,Buring JE,Zhang SM

更新日期：2006-03-01 00:00:00

abstract：:CX3CR1+ macrophages in the intestinal lamina propria contribute to gut homeostasis through the immunomodulatory interleukin IL10, but there is little knowledge on how these cells or the CX3CR1 receptor may affect colorectal carcinogenesis. In this study, we show that CX3CR1-deficient mice fail to resolve gut inflammat...

journal_title：Cancer research

authors： Marelli G,Erreni M,Anselmo A,Taverniti V,Guglielmetti S,Mantovani A,Allavena P

更新日期：2017-08-15 00:00:00

abstract：:In the last decade, large-scale genomic studies in patients with hematologic malignancies identified recurrent somatic alterations in epigenetic modifier genes. Among these, the de novo DNA methyltransferase DNMT3A has emerged as one of the most frequently mutated genes in adult myeloid as well as lymphoid malignancie...

journal_title：Cancer research

authors： Venugopal K,Feng Y,Shabashvili D,Guryanova OA

更新日期：2021-01-15 00:00:00

abstract：:We previously demonstrated that mutational inactivation of transforming growth factor beta type II receptors (RIIs) is very common among the 13% of human colon cancers with microsatellite instability. These mutations principally cluster in the BAT-RII polyadenine sequence repeat. Among microsatellite stable (MSS) colo...

journal_title：Cancer research

authors： Grady WM,Myeroff LL,Swinler SE,Rajput A,Thiagalingam S,Lutterbaugh JD,Neumann A,Brattain MG,Chang J,Kim SJ,Kinzler KW,Vogelstein B,Willson JK,Markowitz S

更新日期：1999-01-15 00:00:00

abstract：:Male Wistar rats were given 50 mug of aflatoxin B1 twice a week for 4 weeks, and thereafter 75 mug twice a week for 10 weeks. Their livers were investigated histologically and histochemically for glycogen, RNA, fat, alkaline and acid phosphatases, adenosine triphosphatase, 5'-nucleotidase, glucose-6-phosphatase, gluco...

journal_title：Cancer research

authors： Kalengayi MM,Desmet VJ

更新日期：1975-10-01 00:00:00

abstract：:The toxicity and pharmacokinetics of cis-diamminedichloroplatinum (cisplatin) (90 mg/sq m) administered as a single 4-hr peritoneal dialysis, with or without concurrent i.v. infusion of sodium thiosulfate, 0.43 or 2.13 g/sq m/hr for 12 hr, were studied on 20 courses of treatment. When given without thiosulfate, the to...

journal_title：Cancer research

authors： Howell SB,Pfeifle CE,Wung WE,Olshen RA

更新日期：1983-03-01 00:00:00

abstract：:Our understanding of the cellular mechanisms governing carcinoma invasiveness and metastasis has evolved dramatically over the last several years. The previous emphasis on the epithelial-mesenchymal transition as a driver of the migratory properties of single cells has expanded with the observation that carcinoma cell...

journal_title：Cancer research

authors： VanderVorst K,Dreyer CA,Konopelski SE,Lee H,Ho HH,Carraway KL 3rd

更新日期：2019-04-15 00:00:00

abstract：:We studied N-myc RNA by in situ hybridization and S1 nuclease protection analysis in human fetal cerebrum, retina, lung, liver, and placenta during the second trimester. High levels of N-myc RNA were found in the early fetal cerebral germinal layer and the primordial cortex, with lower levels in the intermediate layer...

journal_title：Cancer research

authors： Grady EF,Schwab M,Rosenau W

更新日期：1987-06-01 00:00:00

abstract：:The cytotoxic effect of methotrexate (MTX) for mouse bone marrow cells has been studied by in vitro of the granulocyte precursor cell (CFU-C) in a medium containing dialyzed fetal calf serum and dialyzed L-cell supernatant. The formation of 50-cell colonies was inhibited to 50% of control by 10(-8) M MTX. Further incr...

journal_title：Cancer research

authors： Pinedo HM,Zaharko DS,Bull JM,Chabner BA

更新日期：1976-12-01 00:00:00

abstract：:Immune checkpoint therapies exhibit impressive efficacy in some patients with melanoma or lung cancer, but the lack of response in most cases presses the question of how general efficacy can be improved. In addressing this question, we generated a preclinical tumor model to study anti-PD-1 resistance by in vivo passag...

journal_title：Cancer research

authors： Wang X,Schoenhals JE,Li A,Valdecanas DR,Ye H,Zang F,Tang C,Tang M,Liu CG,Liu X,Krishnan S,Allison JP,Sharma P,Hwu P,Komaki R,Overwijk WW,Gomez DR,Chang JY,Hahn SM,Cortez MA,Welsh JW

更新日期：2017-02-15 00:00:00

abstract：:A transplantable mammary tumor derived from an outgrowth of nodule-like alveolar lesions induced by 7,12-dimethylbenz[a]anthracene in cultures of whole mammary gland was shown to produce a family of somatomedin-like polypeptides when cultured in vitro. Minced mammary tumor tissue as well as monolayer cultures of tumor...

journal_title：Cancer research

authors： Knauer DJ,Iyer AP,Banerjee MR,Smith GL

更新日期：1980-12-01 00:00:00

abstract：:Immunohistochemical localization of CA 125 using murine monoclonal antibody OC 125 was performed on fresh frozen tissue from 44 endometrial adenocarcinomas and 26 benign endometria. Immunohistochemical evaluation incorporated both intensity and distribution of staining (CA 125 HSCORE). Thirty-seven cancers (84%) and 2...

journal_title：Cancer research

authors： Berchuck A,Soisson AP,Clarke-Pearson DL,Soper JT,Boyer CM,Kinney RB,McCarty KS Jr,Bast RC Jr

更新日期：1989-04-15 00:00:00

abstract：:Breast cancer-initiating cells have been recently identified in breast carcinoma as CD44+/CD24(-/low) cells, which exclusively retain tumorigenic activity and display stem cell-like properties. However, at present, direct evidence that breast cancer-initiating cells can be propagated in vitro is still lacking. We repo...

journal_title：Cancer research

authors： Ponti D,Costa A,Zaffaroni N,Pratesi G,Petrangolini G,Coradini D,Pilotti S,Pierotti MA,Daidone MG

更新日期：2005-07-01 00:00:00

abstract：:For two decades, the antigen recognized by the Pathologische Anatomie Leiden-Endothelium (PAL-E) monoclonal antibody, a standard vascular endothelial cell marker, has remained elusive. Here, we used a combinatorial phage display-based approach ("epitope mapping") to select peptides binding to the original PAL-E antibo...

journal_title：Cancer research

authors： Jaalouk DE,Ozawa MG,Sun J,Lahdenranta J,Schlingemann RO,Pasqualini R,Arap W

更新日期：2007-10-15 00:00:00

abstract：:High levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, suggesting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. To test this hypothesis in vivo, we generated transgenic mice with widespread expression of Mdm4. Two independe...

journal_title：Cancer research

authors： Xiong S,Pant V,Suh YA,Van Pelt CS,Wang Y,Valentin-Vega YA,Post SM,Lozano G

更新日期：2010-09-15 00:00:00

abstract：:Clear cell renal carcinomas are most frequently characterized by loss of function of both copies of the von Hippel-Lindau (VHL) disease gene, suggesting that the VHL gene product plays an important role in regulating renal cell proliferation. To directly assess the function of the VHL gene product, we transfected the ...

journal_title：Cancer research

authors： Chen F,Kishida T,Duh FM,Renbaum P,Orcutt ML,Schmidt L,Zbar B

更新日期：1995-11-01 00:00:00

abstract：:Targeting dendritic cells in vivo by transcutaneous peptide immunization (TCI) represents an efficient immunization strategy to induce tumor-specific CTL because it reflects the physiologic conditions occurring during pathogen infection. Here we show that including a Th1 peptide in TCI can activate preexisting memory ...

journal_title：Cancer research

authors： Hosoi A,Takeda Y,Furuichi Y,Kurachi M,Kimura K,Maekawa R,Takatsu K,Kakimi K

更新日期：2008-05-15 00:00:00

abstract：:High levels of reactive oxygen species (ROS) present in human prostate epithelia are an important etiologic factor in prostate cancer (CaP) occurrence, recurrence, and progression. Androgen induces ROS production in the prostate by a yet unknown mechanism. Here, to the best of our knowledge, we report for the first ti...

journal_title：Cancer research

authors： Basu HS,Thompson TA,Church DR,Clower CC,Mehraein-Ghomi F,Amlong CA,Martin CT,Woster PM,Lindstrom MJ,Wilding G

更新日期：2009-10-01 00:00:00

abstract：:When newly hatched chicks are given injections of Rous sarcoma virus, a tumor develops at the site of injection. In spite of the presence of the virus in the blood, no other tumors are found distant from the site of inoculation during the life span of the animal (4-6 weeks). However, if a wound is made away from the p...

journal_title：Cancer research

authors： Martins-Green M,Boudreau N,Bissell MJ

更新日期：1994-08-15 00:00:00

abstract：:In vivo tumor inhibitory activity of polymorphonuclear leukocytes (PMN) treated in vitro with lymphokine(s) (LK) was investigated with Winn's assay. Culture supernatants of BALB/c mouse spleen cells incubated with a streptococcal preparation, OK-432, were used as an LK source. With the use of a [3H]uridine release ass...

journal_title：Cancer research

authors： Fujii Y,Kimura S,Arai S,Sendo F

更新日期：1987-11-15 00:00:00

abstract：:Bombesin (BBN), a 14 amino acid peptide, is an analogue of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRPrs) with high affinity and specificity. The GRPr is overexpressed on a variety of human cancer cells, including prostate, breast, lung, and pancreatic cancers. The specific aim of this study...

journal_title：Cancer research

authors： Smith CJ,Sieckman GL,Owen NK,Hayes DL,Mazuru DG,Kannan R,Volkert WA,Hoffman TJ

更新日期：2003-07-15 00:00:00

abstract：:The potential for enhancing antibody potency by increasing avidity was investigated using monoclonal IgG homodimers. Chemically linked dimers were made from a human-murine chimeric monoclonal IgG (ChiBR96) which strongly binds to a variety of breast, lung, ovary, and colon carcinomas. This monoclonal antibody is capab...

journal_title：Cancer research

authors： Wolff EA,Schreiber GJ,Cosand WL,Raff HV

更新日期：1993-06-01 00:00:00

abstract：:In eight estrogen receptor (ER)-positive breast cancer cell lines (including three sublines of MCF-7) and five ER-negative breast lines, the action of the nonsteroidal antiestrogen, tamoxifen, was studied, and the concentrations of ER and antiestrogen binding site were measured. The concentration of antiestrogen bindi...

journal_title：Cancer research

authors： Reddel RR,Murphy LC,Hall RE,Sutherland RL

更新日期：1985-04-01 00:00:00