Abstract：
:Although there is considerable knowledge of how DNA damage triggers cell cycle arrest, DNA repair, and apoptosis, little was known about its potential role in immune responses. Recently, we showed that genotoxic stress and stalled DNA replication forks induce the expression of ligands for the NKG2D receptor found in natural killer cells and certain T cells, cell types that are able to attack tumor cells. Chronic activation of this response in tumor cells may contribute to immune recognition, but it also imposes a selection mechanism for immune escape and malignant progression. This unique arm of the DNA damage response may have implications for understanding therapeutic responses, many of which induce the DNA damage response, and for designing more effective regimens to treat cancer.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Gasser S,Raulet DHdoi
10.1158/0008-5472.CAN-05-4603subject
Has Abstractpub_date
2006-04-15 00:00:00pages
3959-62issue
8eissn
0008-5472issn
1538-7445pii
66/8/3959journal_volume
66pub_type
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