Isolation of a prostate carcinoma cell proliferation-inhibiting factor from human seminal plasma and its similarity to transforming growth factor beta.

abstract：:Slow-clearing, tumor-targeting proteins such as monoclonal antibodies typically exhibit high tumor accumulation but low tissue contrast, whereas intermediate-sized proteins such as scFvs show faster clearance but only moderate tumor accumulation. For both, tumor targeting does not seem to improve further above an opti...

journal_title：Cancer research

authors： Zahnd C,Kawe M,Stumpp MT,de Pasquale C,Tamaskovic R,Nagy-Davidescu G,Dreier B,Schibli R,Binz HK,Waibel R,Plückthun A

更新日期：2010-02-15 00:00:00

abstract：:Hexose uptake during the progression of neoplasia in rat tracheal epithelial cells was studied by measuring the uptake of 2-deoxy[3H]glucose (2-dGlc) in nontumorigenic (C-18) and tumorigenic (T-8, 1000-WT) rat tracheal epithelial cell lines with varying degrees of cell association as well as in: normal primary cell cu...

journal_title：Cancer research

authors： Wasilenko WJ,Marchok AC

更新日期：1984-07-01 00:00:00

abstract：:Transcription factor p53 and phosphatase PTEN are two tumor suppressors that play essential roles in suppression of carcinogenesis. However, the mechanisms by which p53 mediates anticancer activity and the relationship between p53 and PTEN are not well understood. In the present study, we found that pretreatment of mo...

journal_title：Cancer research

authors： Wang J,Ouyang W,Li J,Wei L,Ma Q,Zhang Z,Tong Q,He J,Huang C

更新日期：2005-08-01 00:00:00

abstract：:We previously showed that introduction of a normal, neomycin-tagged human chromosome 11 reduces the metastatic capacity of MDA-MB-435 (435) human breast carcinoma cells by 70-90% without affecting tumorigenicity, suggesting the presence of one or more metastasis suppressor genes encoded on human chromosome 11. To iden...

journal_title：Cancer research

authors： Seraj MJ,Samant RS,Verderame MF,Welch DR

更新日期：2000-06-01 00:00:00

abstract：:Mandibular condyles of late embryonic NMRI mice were used to study the effect of the FBR murine osteosarcoma virus in an in vitro tissue culture system. Chondroprogenitor cells and chondroblastic cells present in the condylar tissue normally undergo rapid differentiation in vitro which results in an advanced stage of ...

journal_title：Cancer research

authors： Schmidt J,Livne E,Erfle V,Gössner W,Silbermann M

更新日期：1986-06-01 00:00:00

abstract：:Metastases from prostatic adenocarcinoma (prostate cancer) are characterized by their predilection for bone and typical osteoblastic features. An in vitro model of bone metastases from prostate cancer was developed using a bicompartment coculture system of mouse osteoblasts and human prostate cancer cells. In this mod...

journal_title：Cancer research

authors： Yang J,Fizazi K,Peleg S,Sikes CR,Raymond AK,Jamal N,Hu M,Olive M,Martinez LA,Wood CG,Logothetis CJ,Karsenty G,Navone NM

更新日期：2001-07-15 00:00:00

abstract：:Tumor associated AUA1 monoclonal antibody and 11.4.1. nonspecific monoclonal antibody, which does not react with human tissues, were radiolabeled with 111In and administered intravesically to 23 patients undergoing cystoscopy for bladder carcinoma. The antibody solution remained in the bladder for 1 h and then was was...

journal_title：Cancer research

authors： Bamias A,Keane P,Krausz T,Williams G,Epenetos AA

更新日期：1991-01-15 00:00:00

abstract：:Physical activity is defined as bodily movement due to skeletal muscle contraction that results in quantifiable energy expenditure. Both epidemiological and laboratory data indicate that the level of physical activity in which an individual engages may affect cancer risk. Exercise is distinguished from other types of ...

journal_title：Cancer research

authors： Thompson HJ

更新日期：1994-04-01 00:00:00

abstract：:The estrogen receptor (ER) is a nuclear protein with a hormone- and a DNA-binding domain. We examined the DNA binding of ER in MCF-7 cells and 79 primary breast cancers by gel mobility shift assay using as a probe the estrogen response element (ERE). The mobility shift assay showed saturable, specific binding of ER to...

journal_title：Cancer research

authors： Foster BD,Cavener DR,Parl FF

更新日期：1991-07-01 00:00:00

abstract：:Over the past 10 years, the Tumor Microenvironment Network (TMEN), supported by the NCI (Bethesda, MD), has promoted collaborative research with the explicit goal of fostering multi-institutional and transdisciplinary groups that are capable of addressing complex issues involving the tumor microenvironment. The main g...

journal_title：Cancer research

authors： DeClerck YA,Pienta KJ,Woodhouse EC,Singer DS,Mohla S

更新日期：2017-03-01 00:00:00

abstract：:The effect of hydrocortisone on blood-borne tumor metastasis was studied in an i.v. inoculation experiment with Ehrlich hypotetraploid clone 1, Ehrlich hypotetraploid stock, and Ehrlich hyperdiploid stock tumors. The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced me...

journal_title：Cancer research

authors： Kodama M,Kodama T

更新日期：1975-04-01 00:00:00

abstract：:The class of folate antimetabolites typified by (6R)-dideazatetrahydrofolate (lometrexol, DDATHF) are specific inhibitors of de novo purine synthesis because of potent inhibition of glycinamide ribonucleotide formyltransferase (GART) but do not induce detectable levels of DNA strand breaks. As such, they are a test ca...

journal_title：Cancer research

authors： Bronder JL,Moran RG

更新日期：2002-09-15 00:00:00

abstract：:Cyclophosphamide treatment of adult male rats leads to sustained decreases in several liver microsomal cytochrome P450 (CYP) activities, including CYP 2C11-catalyzed cyclophosphamide activation, via a process that is associated with a feminization of the overall pattern of liver enzyme expression (G. A. LeBlanc and D....

journal_title：Cancer research

authors： Chang TK,Waxman DJ

更新日期：1993-06-01 00:00:00

abstract：:Alkyl-lysophospholipids have been shown to possess antitumoral activity in animal and in human tumors. Among them, racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine (ET-18-OCH3) had an antimetastatic effect in experimental tumors. We investigated the effect of ET-18-OCH3 on invasion of MO4 mouse fibrosarcoma ce...

journal_title：Cancer research

authors： Storme GA,Berdel WE,van Blitterswijk WJ,Bruyneel EA,De Bruyne GK,Mareel MM

更新日期：1985-01-01 00:00:00

abstract：:We have evaluated immunohistochemical characteristics of tumors and the infiltrating cells in patients treated with various immunotherapy regimens. Forty-eight patients with advanced malignancies were treated with high dose i.v. recombinant interleukin-2 alone or in combination with cyclophosphamide, recombinant tumor...

journal_title：Cancer research

authors： Rubin JT,Elwood LJ,Rosenberg SA,Lotze MT

更新日期：1989-12-15 00:00:00

abstract：:High levels of reactive oxygen species (ROS) present in human prostate epithelia are an important etiologic factor in prostate cancer (CaP) occurrence, recurrence, and progression. Androgen induces ROS production in the prostate by a yet unknown mechanism. Here, to the best of our knowledge, we report for the first ti...

journal_title：Cancer research

authors： Basu HS,Thompson TA,Church DR,Clower CC,Mehraein-Ghomi F,Amlong CA,Martin CT,Woster PM,Lindstrom MJ,Wilding G

更新日期：2009-10-01 00:00:00

abstract：:Hypoxia initiates numerous intracellular signaling pathways important in regulating cell proliferation, differentiation, and death. In this study, we investigated the pathway that hypoxia uses to activate Akt and inactivate glycogen synthase kinase-3 (GSK-3), two proteins the functions of which are important in cell s...

journal_title：Cancer research

authors： Chen EY,Mazure NM,Cooper JA,Giaccia AJ

更新日期：2001-03-15 00:00:00

abstract：:A series of purine nucleoside and dialdehyde analogues was studied to determine their potency as inhibitors of C-1300 murine neuroblastoma cell growth in tissue culture. Tumor cells were incubated with each analogue for 72 h, and the number of viable cells was determined at 24, 48, and 72 h. Dose-response curves were ...

journal_title：Cancer research

authors： Mirkin BL,O'Dea RF,Hogenkamp HP

更新日期：1987-07-15 00:00:00

abstract：:Bifunctional alkylating agents are known to cross-link DNA by simultaneously alkylating two guanine residues located on opposite strands. Despite this apparent requirement for bifunctionality, 1-(2-chloroethyl)-1-nitrosoureas bearing a single alkylating function were found to cross-link DNA in vitro. Cross-linking was...

journal_title：Cancer research

authors： Kohn KW

更新日期：1977-05-01 00:00:00

abstract：:It has been suggested that oxygen-carrying blood substitutes, perfluorochemical (PFC) emulsions, can increase blood flow and oxygen delivery to poorly perfused tumor regions. Local cerebral blood flow was measured in male Wistar rats bearing intracranial Walker 256 tumor with and without blood-PFC exchange using [14C]...

journal_title：Cancer research

authors： Hiraga S,Klubes P,Owens ES,Cysyk RL,Blasberg RG

更新日期：1987-06-15 00:00:00

abstract：:The Fas receptor ligand FasL regulates immune cell levels by inducing apoptosis of Fas receptor-positive cells. Here, we studied the impact of host FasL on tumor development in mice. Genetically targeting FasL in naïve mice increased myeloid cell populations, but, in marked contrast, it reduced the levels of myeloid-d...

journal_title：Cancer research

authors： Peyvandi S,Buart S,Samah B,Vétizou M,Zhang Y,Durrieu L,Polrot M,Chouaib S,Benihoud K,Louache F,Karray S

更新日期：2015-10-15 00:00:00

abstract：:DNA methyltransferase 1 (DNMT1)-deficient mice are tumor-prone, and this has been proposed to result from the induction of genomic instability. To address whether loss of DNMT1, or the related protein DNMT3b, results in genomic instability in human cancer cells, we used a near-diploid human colorectal cancer cell line...

journal_title：Cancer research

authors： Karpf AR,Matsui S

更新日期：2005-10-01 00:00:00

abstract：:HER-2/neu (neu-N) transgenic mice, which express the nontransforming rat proto-oncogene, develop spontaneous focal mammary adenocarcinomas beginning at 5-6 months of age. The development and histology of these tumors bears a striking resemblance to what is seen in patients with breast cancer. We have characterized the...

journal_title：Cancer research

authors： Reilly RT,Gottlieb MB,Ercolini AM,Machiels JP,Kane CE,Okoye FI,Muller WJ,Dixon KH,Jaffee EM

更新日期：2000-07-01 00:00:00

abstract：:Glioblastoma is an aggressive brain tumor characterized by an abnormal blood vasculature that is hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis in this setting by modulating cell-cell and cell-matrix adhesion of endothelial cells. Tissue microarray analysis demonstrated that vascular ...

journal_title：Cancer research

authors： Langenkamp E,Zhang L,Lugano R,Huang H,Elhassan TE,Georganaki M,Bazzar W,Lööf J,Trendelenburg G,Essand M,Pontén F,Smits A,Dimberg A

更新日期：2015-11-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) produce angiogenic factors and in breast cancer are associated with high vascular grade and poor survival. TAMs preferentially migrate to hypoxic areas within tumors and strongly express hypoxia-inducible factor (HIF)-2 alpha. This study examined whether HIF-2 alpha was involved in ...

journal_title：Cancer research

authors： Leek RD,Talks KL,Pezzella F,Turley H,Campo L,Brown NS,Bicknell R,Taylor M,Gatter KC,Harris AL

更新日期：2002-03-01 00:00:00

abstract：:A novel method for high-efficiency and region- controlled in vivo gene transfer was developed by combining in vivo electroporation and intraarterial plasmid DNA injection. A mammalian expression plasmid for the Escherichia coli lacZ gene (driven with a SV40 early promoter) was injected into the internal carotid artery...

journal_title：Cancer research

authors： Nishi T,Yoshizato K,Yamashiro S,Takeshima H,Sato K,Hamada K,Kitamura I,Yoshimura T,Saya H,Kuratsu J,Ushio Y

更新日期：1996-03-01 00:00:00

abstract：:Occurrence of estrone, estradiol, and testosterone glucuronyltranferase activities was tested in a well-differentiated hepatoma, Reuber H35. Transferase activities for estrone and estradiol were found in the hepatoma. The Michaelis-Menten kinetics of these two microsomal glucuronyltransferase activities were similar i...

journal_title：Cancer research

authors： Gessner T

更新日期：1977-07-01 00:00:00

abstract：:CD44 is an integral membrane glycoprotein that functions as a receptor for the extracellular matrix glycan, hyaluronan. Here we report that CD44 is a novel biomarker for non-small cell lung tumors, squamous metaplasia of the lung, and activated type II pneumocytes. We have examined the expression of CD44 in 12 human l...

journal_title：Cancer research

authors： Penno MB,August JT,Baylin SB,Mabry M,Linnoila RI,Lee VS,Croteau D,Yang XL,Rosada C

更新日期：1994-03-01 00:00:00

abstract：:Neuronal pentraxins (NPTX) and their corresponding receptors (NPTXR) have been studied as synapse-associated proteins in the nervous system, but their role in cancer is largely unknown. By applying a multidisciplinary, high-throughput proteomic approach, we have recently identified a peptide ligand motif for targeted ...

journal_title：Cancer research

authors： Bartolini A,Di Paolo D,Noghero A,Murgia D,Sementa AR,Cilli M,Pasqualini R,Arap W,Bussolino F,Ponzoni M,Pastorino F,Marchiò S

更新日期：2015-10-15 00:00:00

abstract：:We recently reported the transcription patterns of human papillomavirus (HPV) type 18 sequences in human cervical carcinoma cell lines. The open reading frames (ORFs) E6* and E6 represent the 5'-terminal cistrons in HPV18 mRNAs. ORF E6* was assumed to be specific for HPV types associated with genital carcinomas. To id...

journal_title：Cancer research

authors： Schneider-Gädicke A,Kaul S,Schwarz E,Gausepohl H,Frank R,Bastert G

更新日期：1988-06-01 00:00:00