Intravesical administration of radiolabeled antitumor monoclonal antibody in bladder carcinoma.

abstract：:Tumor relapses remain a serious problem after allogeneic stem cell transplantation (alloSCT), despite the long-term persistence of minor histocompatibility antigen (MiHA)-specific memory CD8(+) T cells specific for the tumor. We hypothesized that these memory T cells may lose their function over time in transplanted p...

journal_title：Cancer research

authors： Norde WJ,Maas F,Hobo W,Korman A,Quigley M,Kester MG,Hebeda K,Falkenburg JH,Schaap N,de Witte TM,van der Voort R,Dolstra H

更新日期：2011-08-01 00:00:00

abstract：:Epidemiological data have provided clues to the etiological factors involved in large bowel cancer development. High intake of dietary fat tends to promote colon carcinogenesis. Studies in metabolic epidemiology have shown that the high dietary fat affects the metabolic activity of gut bacteria as well as the levels o...

journal_title：Cancer research

authors： Reddy BS

更新日期：1981-09-01 00:00:00

abstract：:Streptavidin (SA)-biotin pretargeted radioimmunotherapy (PRIT) that targets CD20 in non-Hodgkin lymphoma (NHL) exhibits remarkable efficacy in model systems, but SA immunogenicity and interference by endogenous biotin may complicate clinical translation of this approach. In this study, we engineered a bispecific fusio...

journal_title：Cancer research

authors： Green DJ,Frayo SL,Lin Y,Hamlin DK,Fisher DR,Frost SH,Kenoyer AL,Hylarides MD,Gopal AK,Gooley TA,Orozco JJ,Till BG,O'Steen S,Orcutt KD,Wilbur DS,Wittrup KD,Press OW

更新日期：2016-11-15 00:00:00

abstract：:Endocannabinoids have been implicated in cancer. Increasing endogenous 2-arachidonoylglycerol (2-AG) by blocking its metabolism inhibits invasion of androgen-independent prostate cancer (PC-3 and DU-145) cells. Noladin ether (a stable 2-AG analog) and exogenous CB1 receptor agonists possess similar effects. Conversely...

journal_title：Cancer research

authors： Nithipatikom K,Endsley MP,Isbell MA,Falck JR,Iwamoto Y,Hillard CJ,Campbell WB

更新日期：2004-12-15 00:00:00

abstract：:Metabolic reprogramming of cancer cells and the tumor microenvironment are emerging as key factors governing tumor growth, metastasis, and response to therapies including immune checkpoint inhibitors. It has been recognized that rapidly proliferating cancer cells, tumor-infiltrating lymphocytes, and vascular endotheli...

journal_title：Cancer research

authors： Ngwa VM,Edwards DN,Philip M,Chen J

更新日期：2019-08-15 00:00:00

abstract：:A role for the immune system in controlling the progression of solid tumors has been established in several mouse models. However, the effect of immune responses and tumor escape on patient prognosis in the context of human cancer is poorly understood. Here, we investigate the cellular and molecular parameters that co...

journal_title：Cancer research

authors： Camus M,Tosolini M,Mlecnik B,Pagès F,Kirilovsky A,Berger A,Costes A,Bindea G,Charoentong P,Bruneval P,Trajanoski Z,Fridman WH,Galon J

更新日期：2009-03-15 00:00:00

abstract：:By using the newly developed adhesive tumor cell culture system, we analyzed the chromosomal constitutions of primary lung tumor and nonmalignant normal lung tissue from 10 previously untreated patients with non-small cell lung cancer. Chromosomal analyses were successfully carried out in banded chromosome preparation...

journal_title：Cancer research

authors： Lee JS,Pathak S,Hopwood V,Tomasovic B,Mullins TD,Baker FL,Spitzer G,Neidhart JA

更新日期：1987-12-01 00:00:00

abstract：:Immunologic targeting of the oncoprotein HER2/neu with monoclonal antibodies is an important component of current therapeutic strategies for patients with locally and systemically advanced breast cancer. Engineered antibodies targeting HER2 may have agonist or antagonist effects on HER2, but little is known about whet...

journal_title：Cancer research

authors： Montgomery RB,Makary E,Schiffman K,Goodell V,Disis ML

更新日期：2005-01-15 00:00:00

abstract：:Synovial sarcoma is a soft tissue malignancy characterized by the fusion of SS18 to either SSX1, SSX2, or SSX4 genes. SS18 and SSX are transcriptional cofactors involved in activation and repression of gene transcription, respectively. SS18 interacts with SWI/SNF, whereas SSX associates with the polycomb chromatin rem...

journal_title：Cancer research

authors： Lubieniecka JM,de Bruijn DR,Su L,van Dijk AH,Subramanian S,van de Rijn M,Poulin N,van Kessel AG,Nielsen TO

更新日期：2008-06-01 00:00:00

abstract：:The genetic alterations that occur during esophageal tumorigenesis have yet to be determined. We previously established a Wister rat carcinogenesis model of esophageal squamous cell carcinoma. To understand more about the molecular mechanisms during carcinogenesis, we produced esophageal neoplastic lesions by administ...

journal_title：Cancer research

authors： Nishida K,Mine S,Utsunomiya T,Inoue H,Okamoto M,Udagawa H,Hanai T,Mori M

更新日期：2005-01-15 00:00:00

abstract：:Recent reports suggest that expression of an activated c-Ha-ras oncogene is associated with cisplatin resistance in NIH-3T3 fibroblasts. To investigate the generality of these observations, cisplatin cytotoxicity was determined in a series of clonal Rat-1 fibroblast and rat ovarian surface epithelial (ROSE) cell lines...

journal_title：Cancer research

authors： Perez RP,Hamaguchi K,Tracey PA,Handel LM,Hamilton TC,Godwin AK

更新日期：1993-08-15 00:00:00

abstract：:Current standard of care for patients with pediatric acute lymphoblastic leukemia (ALL) is mainly effective, with high remission rates after treatment. However, the genetic perturbations that give rise to this disease remain largely undefined, limiting the ability to address resistant tumors or develop less toxic targ...

journal_title：Cancer research

authors： Ding LW,Sun QY,Tan KT,Chien W,Mayakonda A,Yeoh AEJ,Kawamata N,Nagata Y,Xiao JF,Loh XY,Lin DC,Garg M,Jiang YY,Xu L,Lim SL,Liu LZ,Madan V,Sanada M,Fernández LT,Hema Preethi SS,Lill M,Kantarjian HM,Kornblau SM,

更新日期：2017-01-15 00:00:00

abstract：:Genetic instability plays a central role in the development and progression of human cancer. Two major classes of genetic instability, microsatellite instability (MSI) and chromosome instability (microsatellite stable; MSS), are best understood in the context of colon cancer, where MSI tumors represent approximately 1...

journal_title：Cancer research

authors： Giacomini CP,Leung SY,Chen X,Yuen ST,Kim YH,Bair E,Pollack JR

更新日期：2005-10-15 00:00:00

abstract：:Cell adhesion and spreading is a crucial step in the metastatic cascade of cancer cells, and interruption of this step is considered to be a logical strategy for prevention and treatment of tumor metastasis. Emodin is the major active component of the rhizome of Rheum palmatum L., with known anticancer activities. Her...

journal_title：Cancer research

authors： Huang Q,Shen HM,Shui G,Wenk MR,Ong CN

更新日期：2006-06-01 00:00:00

abstract：:The secretion of transforming growth factors (TGFs) alpha and beta by normal, chemically transformed, and malignant rat liver epithelial cell lines was investigated. The WB-F344 normal cultured rat liver epithelial cell line does not secrete an epidermal growth factor-like (putatively TGF-alpha) activity, but several ...

journal_title：Cancer research

authors： Liu C,Tsao MS,Grisham JW

更新日期：1988-02-15 00:00:00

abstract：:Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with can...

journal_title：Cancer research

authors： Siolas D,Hannon GJ

更新日期：2013-09-01 00:00:00

abstract：:Long interspersed nuclear elements [LINE-1 (L1)] are abundant retrotransposons in mammalian genomes that remain silent under most conditions. Cellular stress signals activate L1, but the molecular mechanisms controlling L1 activation remain unclear. Evidence is presented here that benzo(a)pyrene (BaP), an environmenta...

journal_title：Cancer research

authors： Stribinskis V,Ramos KS

更新日期：2006-03-01 00:00:00

abstract：:Recent three genome-wide association studies have mapped a lung cancer susceptibility locus to chromosome 15q25 in Caucasians. However, the reported risk single nucleotide polymorphisms (SNPs) are extremely rare in Asians, arguing against any of these being causative variants. This study sought to identify other varia...

journal_title：Cancer research

authors： Wu C,Hu Z,Yu D,Huang L,Jin G,Liang J,Guo H,Tan W,Zhang M,Qian J,Lu D,Wu T,Lin D,Shen H

更新日期：2009-06-15 00:00:00

abstract：:Coded skin fibroblast cell strains from ataxia telangiectasia (AT) families and apparently normal individuals were obtained from two different sources. AT homozygous strains were clearly identified on the basis of marked hypersensitivity to cell killing by X-irradiation. AT heterozygotes were intermediate in their cyt...

journal_title：Cancer research

authors： Nagasawa H,Kraemer KH,Shiloh Y,Little JB

更新日期：1987-01-15 00:00:00

abstract：:Cancers are initiated as a result of changes that occur in the genome. Identification of gains and losses in the structure and expression of tumor-suppressor genes and oncogenes lies at the root of the understanding of cancer cell biology. Here, we show that the mitogen-activated protein kinase (MAPK) MKK3 suppresses ...

journal_title：Cancer research

authors： MacNeil AJ,Jiao SC,McEachern LA,Yang YJ,Dennis A,Yu H,Xu Z,Marshall JS,Lin TJ

更新日期：2014-01-01 00:00:00

abstract：:In this study, we have exploited the power of insertional mutagenesis to elucidate tumor progression pathways in mice carrying two oncogenes (MYC/Runx2) that collaborate to drive early lymphoma development. Neonatal infection of these mice with Moloney murine leukemia virus resulted in accelerated tumor onset with ass...

journal_title：Cancer research

authors： Stewart M,Mackay N,Hanlon L,Blyth K,Scobie L,Cameron E,Neil JC

更新日期：2007-06-01 00:00:00

abstract：:The activity of an endonuclease(s) acting on double-stranded, ultraviolet-irradiated, and 2-acetylaminofluorene-bound DNA but not on double-stranded undamaged DNA triples within two hr after partial hepatectomy. Although the activity drops between four and six hr after operation, it remains above levels measured in li...

journal_title：Cancer research

authors： Van Lancker JL,Tomura T

更新日期：1981-06-01 00:00:00

abstract：:Sensitivities to sister chromatid exchange (SCE) induction by chemicals of peripheral lymphocytes from 26 cancer patients were estimated under conditions identical to those for healthy humans which had been reported (Cancer Res., 43: 439-442, 1983). The sensitive individual was defined as one whose cells give a mean i...

journal_title：Cancer research

authors： Oikawa A,Horaguchi K,Sugawara R,Kikuchi J,Tohda H,Takahashi K,Wakui A,Yamauchi A,Nakada T

更新日期：1986-02-01 00:00:00

abstract：:Recently, we demonstrated that an androgen-regulated cell adhesion molecule, C-CAM, acts as a tumor suppressor in prostate cancer development. In this study, we further explored the possibility of applying C-CAM as a potential agent for developing prostate cancer gene therapy using an adenoviral delivery system. We fo...

journal_title：Cancer research

authors： Kleinerman DI,Zhang WW,Lin SH,Nguyen TV,von Eschenbach AC,Hsieh JT

更新日期：1995-07-01 00:00:00

abstract：:We recently reported that forced overexpression of the transcription factor E2F-1 in human HT-1080 fibrosarcoma cells resulted in corresponding high levels of thymidylate synthase (TS) and resistance to 5-fluoropyrimidines (D. Banerjee et al., Cancer Res., 58: 4292-4296, 1998). Because colorectal metastasis to the lun...

journal_title：Cancer research

authors： Banerjee D,Gorlick R,Liefshitz A,Danenberg K,Danenberg PC,Danenberg PV,Klimstra D,Jhanwar S,Cordon-Cardo C,Fong Y,Kemeny N,Bertino JR

更新日期：2000-05-01 00:00:00

abstract：:In summary, analysis of the P01 program indicates that differences exist in scores and funding requirements between purely basic and translational P01s; P01 funding has been stable and the P01 policies consistent; growth in average costs for P01s has lagged compared to R01s; P01 grantees have a higher success rate tha...

journal_title：Cancer research

authors： Broder S,Cushing M

更新日期：1993-02-01 00:00:00

abstract：:Suspensions of an oxygen-sensitive (MT-7) and of an oxygen-insensitive(M109) tumor cell line were injected i.v. into BALB/c mice. Exposure to 100% O2 after injection of the cells did not modify the initial arrest of either cell line in the lung. Exposure of animals given injections of MT-7 cells for 60 h to 100% oxyge...

journal_title：Cancer research

authors： Margaretten NC,Witschi H

更新日期：1988-05-15 00:00:00

abstract：:EWS encodes a ubiquitously expressed RNA binding protein with largely unknown function. In Ewing sarcoma family tumors (EFT), one allele is rearranged with an ETS gene. This is the first description of an EFT with a complete EWS deficiency in the presence of two copies of a rearranged chromosome 22 carrying an interst...

journal_title：Cancer research

authors： Kovar H,Jug G,Hattinger C,Spahn L,Aryee DN,Ambros PF,Zoubek A,Gadner H

更新日期：2001-08-15 00:00:00

abstract：:Chloroethylnitrosoureas (CNUs) are being used in the therapy of various neoplastic diseases, including skin cancer. Because secondary tumor formation is a serious threat in chemotherapy with these drugs, we explored whether and to what extent the DNA repair protein DNA-O6-methylguanine:protein-L-cysteine S-methyltrans...

journal_title：Cancer research

authors： Becker K,Gregel CM,Kaina B

更新日期：1997-08-15 00:00:00

abstract：:Although immunotherapies of tumors have demonstrated promise for altering the progression of malignancies, immunotherapies have been limited by an immunosuppressive tumor microenvironment (TME) that prevents infiltrating immune cells from performing their anticancer functions. Prominent among immunosuppressive cells a...

journal_title：Cancer research

authors： Cresswell GM,Wang B,Kischuk EM,Broman MM,Alfar RA,Vickman RE,Dimitrov DS,Kularatne SA,Sundaram CP,Singhal S,Eruslanov EB,Crist SA,Elzey BD,Ratliff TL,Low PS

更新日期：2020-11-17 00:00:00