A gene expression signature of genetic instability in colon cancer.

abstract：:Inflammatory pathways may mediate preparation of the "metastatic soil" in the lungs. Some of these pathways--activation and/or the recruitment of certain inflammatory cells--might depend on vascular endothelial growth factor receptor 1 (VEGFR1) activity. Thus, blocking the activity of VEGFR1 (or the interaction with i...

journal_title：Cancer research

authors： Duda DG,Jain RK

更新日期：2010-07-15 00:00:00

abstract：:In order to examine the effects of the overexpression of c-erbB-2 (HER-2, neu) on human bronchial epithelial cells, a human c-erbB-2 expression vector was introduced into the simian virus 40 large T-antigen-immortalized human bronchial epithelial cell line BEAS-2B. Isolation of multiple clonal cell lines after selecti...

journal_title：Cancer research

authors： Noguchi M,Murakami M,Bennett W,Lupu R,Hui F Jr,Harris CC,Gerwin BI

更新日期：1993-05-01 00:00:00

abstract：:Bortezomib (PS-341), a selective inhibitor of proteasome, induces apoptosis in various tumor cells, but its mechanism of action is unclear. Treatment with PS-341 induces apoptosis in SUDHL6 (DHL6), but not SUDHL4 (DHL4), lymphoma cells. Microarray analysis shows high RNA levels of heat shock protein-27 (Hsp27) in DHL4...

journal_title：Cancer research

authors： Chauhan D,Li G,Shringarpure R,Podar K,Ohtake Y,Hideshima T,Anderson KC

更新日期：2003-10-01 00:00:00

abstract：:Tumor relapses remain a serious problem after allogeneic stem cell transplantation (alloSCT), despite the long-term persistence of minor histocompatibility antigen (MiHA)-specific memory CD8(+) T cells specific for the tumor. We hypothesized that these memory T cells may lose their function over time in transplanted p...

journal_title：Cancer research

authors： Norde WJ,Maas F,Hobo W,Korman A,Quigley M,Kester MG,Hebeda K,Falkenburg JH,Schaap N,de Witte TM,van der Voort R,Dolstra H

更新日期：2011-08-01 00:00:00

abstract：:H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia mutated protein) phosphorylates H2AX in response to DNA double-strand breaks (DSBs). Whether DNA-dependent protein kinase (DNA-PK) plays any role in this response is unclear. Here, we show that H2...

journal_title：Cancer research

authors： Stiff T,O'Driscoll M,Rief N,Iwabuchi K,Löbrich M,Jeggo PA

更新日期：2004-04-01 00:00:00

abstract：:Tumors must manipulate the host vasculature to provide a blood supply adequate for their proliferation. Although tumors may arise as avascular masses, there is increasing evidence that some tumors begin to proliferate by first co-opting preexisting host blood vessels. By fluorescent vascular imaging, we provide eviden...

journal_title：Cancer research

authors： Lu W,Schroit AJ

更新日期：2005-02-01 00:00:00

abstract：:Microarray gene expression profiling is a powerful tool for generating molecular cancer classifications. However, elucidating biological insights from these large data sets has been challenging. Previously, we identified a gene expression-based classification of primary uveal melanomas that accurately predicts metasta...

journal_title：Cancer research

authors： Onken MD,Ehlers JP,Worley LA,Makita J,Yokota Y,Harbour JW

更新日期：2006-05-01 00:00:00

abstract：:Mesothelin is a cell-surface tumor-associated antigen expressed in several human cancers. The limited expression of mesothelin on normal tissues and its high expression in many cancers make it an attractive candidate for targeted therapies using monoclonal antibodies, immunoconjugates, and immunotoxins. Mesothelin is ...

journal_title：Cancer research

authors： Zhang Y,Chertov O,Zhang J,Hassan R,Pastan I

更新日期：2011-09-01 00:00:00

abstract：:Immunohistochemical localization of estrogen receptor (ER) using specific monoclonal anti-human estrogen receptor antibody, H222, with an immunoperoxidase technique was performed on fresh frozen tissue derived from 100 endometrial adenocarcinomas. Immunohistochemical evaluation incorporated both intensity and distribu...

journal_title：Cancer research

authors： Budwit-Novotny DA,McCarty KS,Cox EB,Soper JT,Mutch DG,Creasman WT,Flowers JL,McCarty KS Jr

更新日期：1986-10-01 00:00:00

abstract：:Metastatic prostate cancer continues to pose a difficult therapeutic challenge. Prostate cancer progression is associated with aberrant O-glycosylation of cancer cell surface receptors, but the functional impact of such events is uncertain. Here we report spontaneous metastasis of human prostate cancer xenografts that...

journal_title：Cancer research

authors： Tsai CH,Tzeng SF,Chao TK,Tsai CY,Yang YC,Lee MT,Hwang JJ,Chou YC,Tsai MH,Cha TL,Hsiao PW

更新日期：2016-10-01 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). We observed similar effects of EGCG in esophageal squamous cell carcinoma KYSE 150 cells and epide...

journal_title：Cancer research

authors： Hou Z,Sang S,You H,Lee MJ,Hong J,Chin KV,Yang CS

更新日期：2005-09-01 00:00:00

abstract：:Diethyldithiocarbamate (DDTC) has been shown to inhibit nephrotoxicity induced by cis-platinum (DDP) without inhibition of tumor response in the rat. We report here that DDTC at doses of 25-300 mg/kg inhibits DDP-induced nephrotoxicity and bone marrow toxicity in C57BL/6 X DBA/2F1 (hereafter called B6D2F1) mice, F344 ...

journal_title：Cancer research

authors： Bodenner DL,Dedon PC,Keng PC,Katz JC,Borch RF

更新日期：1986-06-01 00:00:00

abstract：:The lysyl oxidase (LOX) gene reverted Ras transformation of NIH 3T3 fibroblasts and tumor formation by gastric cancer cells, which frequently carry mutant RAS genes. The secreted lysyl oxidase proenzyme is processed to a propeptide (LOX-PP) and a functional enzyme (LOX). Unexpectedly, the tumor suppressor activity map...

journal_title：Cancer research

authors： Min C,Yu Z,Kirsch KH,Zhao Y,Vora SR,Trackman PC,Spicer DB,Rosenberg L,Palmer JR,Sonenshein GE

更新日期：2009-08-15 00:00:00

abstract：:We have cloned an alternatively spliced form of cyclin-dependent kinase (CDK) inhibitor p15 from human placenta. The alternative splice arises from an alternative 5' donor site in intron 1. An in-frame stop codon within the new exon, called exon 1beta, leads to translation of a Mr 10,000 protein identical to the NH2 t...

journal_title：Cancer research

authors： Tsubari M,Tiihonen E,Laiho M

更新日期：1997-07-15 00:00:00

abstract：:We compared L-phenylalanine mustard (L-PAM)-induced cytotoxicity and DNA cross-linking with and without a 42-h preincubation with the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO, 1 mM) in a human lymphoma cell line. The combination showed increased toxicity with a Do ratio of 1.6. L-PAM-induc...

journal_title：Cancer research

authors： Ducore JM,McNamara L

更新日期：1986-03-01 00:00:00

abstract：:The effect of heat on 1,4-dihydroxy-5,8-bis[2-[(2-hydroxyethyl)amino]ethylamino]-9, 10-anthracenedione dihydrochloride (DHAD; mitoxantrone, NSC 301739) cytotoxicity was studied in V79 Chinese hamster cells. An overnight exposure to the drug at 40 degrees C enhanced drug damage in chromosome aberrations, culture growth...

journal_title：Cancer research

authors： Yang SJ,Rafla S

更新日期：1985-08-01 00:00:00

abstract：:B16 melanoma cell variants were used to determine if the metastatic properties of these cells could be correlated to distinct plasma membrane, microsome, and mitochondrial membrane lipid compositions and membrane-bound enzyme activities in high- and low-metastatic cell variants, respectively. The high-metastatic B16-F...

journal_title：Cancer research

authors： Schroeder F,Gardiner JM

更新日期：1984-08-01 00:00:00

abstract：:Mutated ras genes are powerful transforming agents in vitro and are found in a wide variety of human tumors in vivo. We characterized the histopathology and p21 protein expression associated with tumorigenesis in line 69 transgenic mice carrying an activated, human c-Ha-ras gene on the Y-chromosome (A. C. Andres, C. A...

journal_title：Cancer research

authors： Nielsen LL,Discafani CM,Gurnani M,Tyler RD

更新日期：1991-07-15 00:00:00

abstract：:Sixteen steroids with different endocrine activities were administered to female rats for 6 or 7 days, in a broad range of doses. Liver growth was recorded by measuring weight and DNA contents and monooxygenase activity by assaying the turnover of five different substrates. According to their effects on these paramete...

journal_title：Cancer research

authors： Schulte-Hermann R,Ochs H,Bursch W,Parzefall W

更新日期：1988-05-01 00:00:00

abstract：:Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) has been reported to be overexpressed in lung cancer and in other cancers such as breast, pancreas, and liver. However, a mechanism linking hnRNP A2/B1 overexpression and progression to cancer has not yet been definitively established. To elucidate this mecha...

journal_title：Cancer research

authors： Tauler J,Zudaire E,Liu H,Shih J,Mulshine JL

更新日期：2010-09-15 00:00:00

abstract：:Gli signaling is critical for central nervous system development and is implicated in tumorigenesis. To monitor Gli signaling in gliomas in vivo, we created platelet-derived growth factor-induced gliomas in a Gli-luciferase reporter mouse. We find that Gli activation is found in gliomas and correlates with grade. In a...

journal_title：Cancer research

authors： Becher OJ,Hambardzumyan D,Fomchenko EI,Momota H,Mainwaring L,Bleau AM,Katz AM,Edgar M,Kenney AM,Cordon-Cardo C,Blasberg RG,Holland EC

更新日期：2008-04-01 00:00:00

abstract：:Prostate cancer is the most commonly diagnosed noncutaneous neoplasm and second most common cause of cancer-related mortality in western men. To investigate the mechanisms of prostate cancer development and progression, we did expression profiling of human prostate cancer and benign tissues. We show that the SOX4 is o...

journal_title：Cancer research

authors： Liu P,Ramachandran S,Ali Seyed M,Scharer CD,Laycock N,Dalton WB,Williams H,Karanam S,Datta MW,Jaye DL,Moreno CS

更新日期：2006-04-15 00:00:00

abstract：:A tetracosapeptide (peptide-24) corresponding to the amino-terminal sequence of the carcinoembryonic antigen (CEA) was synthesized and characterized. Antisera were produced to the peptide-24, and a radioimmunoassay was developed utilizing peptide-24 with a tyrosine residue on the amino-terminal end (Tyr-peptide-24). I...

journal_title：Cancer research

authors： Paul D,Flouret G,Tomita JT,Ranney K,Schenck J,Anderson B

更新日期：1981-06-01 00:00:00

abstract：:Thymidine phosphorylase (dThdPase)/platelet-derived endothelial cell growth factor is expressed at higher levels in a variety of human carcinomas than it is in adjacent normal tissue. The higher expression is associated with an increase of intratumoral microvessel density (IMVD) and an unfavorable patient prognosis. W...

journal_title：Cancer research

authors： Matsuura T,Kuratate I,Teramachi K,Osaki M,Fukuda Y,Ito H

更新日期：1999-10-01 00:00:00

abstract：:Rhabdomyosarcomas are the most frequent malignant soft tissue tumors of childhood; however, because current multimodality treatments fail to improve the poor survival rate of children with metastatic rhabdomyosarcoma, new treatments are required. We previously identified the gamma-subunit of the fetal acetylcholine re...

journal_title：Cancer research

authors： Gattenlöhner S,Marx A,Markfort B,Pscherer S,Landmeier S,Juergens H,Müller-Hermelink HK,Matthews I,Beeson D,Vincent A,Rossig C

更新日期：2006-01-01 00:00:00

abstract：:Protein kinase Ciota (PKCiota) is an oncogene required for maintenance of the transformed phenotype of non-small cell lung cancer cells. However, the role of PKCiota in lung tumor development has not been investigated. To address this question, we established a mouse model in which oncogenic Kras(G12D) is activated by...

journal_title：Cancer research

authors： Regala RP,Davis RK,Kunz A,Khoor A,Leitges M,Fields AP

更新日期：2009-10-01 00:00:00

abstract：:Human genes expressed exclusively in tumors and male germ line cells, such as those of the MAGE, BAGE, and GAGE families, encode antigens recognized by T lymphocytes, which are potentially useful for antitumor immunotherapy. To identify new genes of this type, we generated cDNA populations enriched in sequences expres...

journal_title：Cancer research

authors： Lucas S,De Smet C,Arden KC,Viars CS,Lethé B,Lurquin C,Boon T

更新日期：1998-02-15 00:00:00

abstract：:In this experiment, a segment of the left colon including the upper part of the rectum was transposed to the upper jejunum, and a segment of upper jejunum was transposed to the left colon of the same animal. In another group, the same colon and jejunum segments were transsected and reanastomosed in place. A third grou...

journal_title：Cancer research

authors： Celik C,Mittelman A,Paolini NS Jr,Lewis D,Evans JT

更新日期：1981-07-01 00:00:00

abstract：:Commercially available St. John's wort (Hypericum perforatum) preparations and some of their main constituents (hypericin, pseudohypericin, hyperforin, rutin, and quercetin) were examined for their potential to inhibit carcinogen activation by human cytochrome P450 1A1 (CYP1A1). We used a reconstituted system consisti...

journal_title：Cancer research

authors： Schwarz D,Kisselev P,Roots I

更新日期：2003-11-15 00:00:00

abstract：:Type 2 diabetes, which is mainly linked to obesity, is associated with increased incidence of liver cancer. We have previously found that in various models of obesity/diabetes, hyperinsulinemia maintains heightened hepatic expression of cyclin D1, suggesting a plausible mechanism linking diabetes and liver cancer prog...

journal_title：Cancer research

authors： Luo C,Liang J,Sharabi K,Hatting M,Perry EA,Tavares CDJ,Goyal L,Srivastava A,Bilodeau M,Zhu AX,Sicinski P,Puigserver P

更新日期：2020-08-15 00:00:00