Abstract：
:EWS encodes a ubiquitously expressed RNA binding protein with largely unknown function. In Ewing sarcoma family tumors (EFT), one allele is rearranged with an ETS gene. This is the first description of an EFT with a complete EWS deficiency in the presence of two copies of a rearranged chromosome 22 carrying an interstitial EWS-FLI1 translocation. Absence of EWS protein suggested that it is dispensable for EFT growth. By sequencing of EWS cDNA from unrelated EFTs, we excluded inactivation of EWS as a general mechanism in EFT pathogenesis. Rather, EWS was found to be uniformly expressed in two splicing variants of similar abundancy, EWSalpha and EWSbeta, which differ in a single amino acid. Three EWS negative cell lines were established, which will serve as valuable models to study normal and aberrant EWS function upon reintroduction into the tumor cells.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Kovar H,Jug G,Hattinger C,Spahn L,Aryee DN,Ambros PF,Zoubek A,Gadner Hsubject
Has Abstractpub_date
2001-08-15 00:00:00pages
5992-7issue
16eissn
0008-5472issn
1538-7445journal_volume
61pub_type
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