Evidence for single-cell origin of 3-methylcholanthrene-induced fibrosarcomas in mice with cellular mosaicism.

Abstract:

:Fibrosarcomas produced by s.c. injection of 5 micrograms of 3-methylcholanthrene in Pgk-1a/Pgk-1b mice carrying X-chromosome inactivation mosaicism for the phosphoglycerate kinase (PGK-1) gene contained only one type of phosphoglycerate kinase in seven of eight cases (88%), as judged from its electrophoretic mobility, indicating the single-cell origin of the tumor.

journal_name

Cancer Res

journal_title

Cancer research

authors

Tanooka H,Tanaka K

subject

Has Abstract

pub_date

1982-05-01 00:00:00

pages

1856-8

issue

5

eissn

0008-5472

issn

1538-7445

journal_volume

42

pub_type

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