Abstract：
:Effects of calyculin A, a potent inhibitor of protein phosphatases 1 and 2A, on X-ray cell killing and chromatin structure were studied using cultured mammalian cells (BHK21). Calyculin A at concentrations of 2.5-20 nM enhanced X-ray cell killing when exponentially growing BHK21 cells were treated with calyculin A for 30 min after X-irradiation. A 30-min treatment with this drug induced chromatin condensation transiently. These results suggest that the enhancement of X-ray cell killing by calyculin A is caused by the events associated with chromatin condensation. Protein phosphatase-targeting drugs may represent a new class of radiation sensitizers.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Nakamura K,Antoku Ssubject
Has Abstractpub_date
1994-04-15 00:00:00pages
2088-90issue
8eissn
0008-5472issn
1538-7445journal_volume
54pub_type
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