Abstract：
:The biosynthesis, structure, and topology of a melanoma-associated antigen, previously defined with the monoclonal antibody NKI/C-3 was studied. A polyclonal rabbit antiserum was raised against the antigen with a broader reactivity than the previously used monoclonal antibody NKI/C-3. The antigen was shown to consist of a single protein backbone to which two or three N-linked glycans were added cotranslationally. Extensive further heterogeneity was generated in the Golgi compartment and was shown to be dependent on the presence of complex type sugars. Although the antigen is associated with melanomas, it was not codistributed with the tyrosinase activity associated with melanogenesis. The antigen did show codistribution with cathepsin D, which is a marker for lysosomal functions.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Gruters RA,Calafat J,Vennegoor CJ,Jansen H,Ploegh HLsubject
Has Abstractpub_date
1989-01-15 00:00:00pages
459-65issue
2eissn
0008-5472issn
1538-7445journal_volume
49pub_type
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