Serological markers of cancer and their applications in clinical trials.

abstract：:Our previous study showed that spleen cells from BALB/c mice bearing RL male 1 lymphoma inhibited the growth of RL male 1 lymphoma by the Winn-type adoptive transfer assay. Although this antitumor activity was mediated by the T-cell subset manifesting the surface phenotype of cytotoxic T-lymphocytes (CTLs), this antit...

journal_title：Cancer research

authors： Fuyama S,Yamamoto H,Fujii Y,Arai S

更新日期：1986-11-01 00:00:00

abstract：:Capsaicin (N-vanillyl-8-methyl-1-nonenamide) is a homovanillic acid derivative found in pungent fruits. Several investigators have reported the ability of capsaicin to inhibit events associated with the promotion of cancer. However, the effects of capsaicin on human leukemic cells have never been investigated. We inve...

journal_title：Cancer research

authors： Ito K,Nakazato T,Yamato K,Miyakawa Y,Yamada T,Hozumi N,Segawa K,Ikeda Y,Kizaki M

更新日期：2004-02-01 00:00:00

abstract：:In order to investigate the early cellular changes in liver associated with furan cholangiocarcinogenesis, young adult male Fischer 344 rats were administered furan by gavage once a day, 5 days a wk for 2 to 3 wk at doses ranging from 15 to 60 mg/kg of body weight per day. The most conspicuous feature observed in the ...

journal_title：Cancer research

authors： Elmore LW,Sirica AE

更新日期：1991-10-15 00:00:00

abstract：:Accurate normalization is an absolute prerequisite for correct measurement of gene expression. For quantitative real-time reverse transcription-PCR (RT-PCR), the most commonly used normalization strategy involves standardization to a single constitutively expressed control gene. However, in recent years, it has become...

journal_title：Cancer research

authors： Andersen CL,Jensen JL,Ørntoft TF

更新日期：2004-08-01 00:00:00

abstract：:Progression of the eukaryotic cell division cycle is regulated by a series of structurally related serine/threonine protein kinases known as cyclin-dependent kinases (CDKs). The D-type cyclin-dependent kinases, CDK4 and CDK6, have been strongly implicated in the control of G1 progression and the phosphorylation of the...

journal_title：Cancer research

authors： Li Y,Nichols MA,Shay JW,Xiong Y

更新日期：1994-12-01 00:00:00

abstract：:The mechanisms by which a primary tumor affects a selected distant organ before tumor cell arrival remain to be elucidated. This report shows that Gr-1+CD11b+ cells are significantly increased in lungs of mice bearing mammary adenocarcinomas before tumor cell arrival. In the premetastatic lungs, these immature myeloid...

journal_title：Cancer research

authors： Yan HH,Pickup M,Pang Y,Gorska AE,Li Z,Chytil A,Geng Y,Gray JW,Moses HL,Yang L

更新日期：2010-08-01 00:00:00

abstract：:The timing of bleomycin (BLM) administration after KMT-17 tumor inoculation was found to be important for optimizing its therapeutic effect on tumor-bearing rats. A remarkable therapeutic effect was observed when BLM (5 mg/kg/day) was administered i.p. for 5 days from the eighth day after tumor inoculation (Day 8 to D...

journal_title：Cancer research

authors： Morikawa K,Hosokawa M,Hamada J,Sugawara M,Kobayashi H

更新日期：1985-04-01 00:00:00

abstract：:The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tumorigenesis. Using ...

journal_title：Cancer research

authors： Ohm JE,Mali P,Van Neste L,Berman DM,Liang L,Pandiyan K,Briggs KJ,Zhang W,Argani P,Simons B,Yu W,Matsui W,Van Criekinge W,Rassool FV,Zambidis E,Schuebel KE,Cope L,Yen J,Mohammad HP,Cheng L,Baylin SB

更新日期：2010-10-01 00:00:00

abstract：:Potentiation of the EBV-specific CTL response by immunization with CTL epitopes has been proposed as a logical approach for immune-targeting nasopharyngeal carcinoma (NPC) cells in vivo. This approach will undoubtedly be influenced by the ability of these malignant cells to endogenously process and present target epit...

journal_title：Cancer research

authors： Khanna R,Busson P,Burrows SR,Raffoux C,Moss DJ,Nicholls JM,Cooper L

更新日期：1998-01-15 00:00:00

abstract：:Medulloblastoma is the most common malignant pediatric brain tumor and is one of the leading causes of cancer-related mortality in children. Treatment failure mainly occurs in children harboring metastatic tumors, which typically carry an isochromosome 17 or gain of 17q, a common hallmark of intermediate and high-risk...

journal_title：Cancer research

authors： Traenka C,Remke M,Korshunov A,Bender S,Hielscher T,Northcott PA,Witt H,Ryzhova M,Felsberg J,Benner A,Riester S,Scheurlen W,Grunewald TG,von Deimling A,Kulozik AE,Reifenberger G,Taylor MD,Lichter P,Butt E,Pfister SM

更新日期：2010-10-15 00:00:00

abstract：:The specific activity (dpm/mg protein) of the acid-soluble nuclear material extracted from spleens or lymph nodes (but not other tissues) of tumor-bearing BALB/c mice was approximately twice that of the corresponding tissues from tumor-free mice of the same age and sex following i.p. injection of L-[U-14C]lysine. Auto...

journal_title：Cancer research

authors： Mashburn LT

更新日期：1985-05-01 00:00:00

abstract：:More than 35 different partner genes with the mixed lineage leukemia (MLL) gene have been cloned from leukemia cells with translocations involving chromosome 11 band q23. In this study, we report on a novel fusion partner of the MLL gene, AF4p12, which we have identified as the human homologue to the furry gene of Dro...

journal_title：Cancer research

authors： Hayette S,Cornillet-Lefebvre P,Tigaud I,Struski S,Forissier S,Berchet A,Doll D,Gillot L,Brahim W,Delabesse E,Magaud JP,Rimokh R

更新日期：2005-08-01 00:00:00

abstract：:Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism. Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CA...

journal_title：Cancer research

authors： Fultang L,Gamble LD,Gneo L,Berry AM,Egan SA,De Bie F,Yogev O,Eden GL,Booth S,Brownhill S,Vardon A,McConville CM,Cheng PN,Norris MD,Etchevers HC,Murray J,Ziegler DS,Chesler L,Schmidt R,Burchill SA,Haber M,De Sant

更新日期：2019-02-01 00:00:00

abstract：:The majority of BRCA1-associated breast cancers are basal cell-like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53-mutated tumors. At 0.5 mg/k...

journal_title：Cancer research

authors： Shafee N,Smith CR,Wei S,Kim Y,Mills GB,Hortobagyi GN,Stanbridge EJ,Lee EY

更新日期：2008-05-01 00:00:00

abstract：:Specific progesterone binding by cultured human breast carcinoma T47D, MCF-7, and ZR75-1 cells was decreased 25-40% by epidermal growth factor (EGF), with a 50% effective dose of 0.1 nM EGF. Studies with the soluble and particulate fractions prepared after homogenization of T47D cells grown in glass roller bottles rev...

journal_title：Cancer research

authors： Sarup JC,Rao KV,Fox CF

更新日期：1988-09-15 00:00:00

abstract：:Sixteen patients with previously treated acute nonlymphocytic leukemia or chronic myelogenous leukemia in blast crisis were given one to three courses of esorubicin by continuous infusion over 48 h. Dosage levels extended from 35 to 85 mg/m2. Four patients showed partial responses of short duration. Nonhematological t...

journal_title：Cancer research

authors： Kreis W,Rottach C,Budman DR,Chan K,Schulman P,Allen SL,Weiselberg L,Vinciguerra V

更新日期：1988-10-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men in America. Currently, steroid receptor coactivators have been proposed to mediate the development and progression of prostate cancer, at times in a steroid-independent manner. Steroid receptor coactivator-3 (SRC-3, p/CIP, AIB1, ACTR, RAC3, and TRAM-1) is a member of th...

journal_title：Cancer research

authors： Zhou HJ,Yan J,Luo W,Ayala G,Lin SH,Erdem H,Ittmann M,Tsai SY,Tsai MJ

更新日期：2005-09-01 00:00:00

abstract：:ErbB2 and ErbB3, two members of the ErbB family, form a high-affinity heregulin coreceptor that elicits potent mitogenic and transforming signals, and clinical studies indicate that these receptors play an important role in tumor incidence and progression. To determine whether N-glycosylation is involved in the functi...

journal_title：Cancer research

authors： Yokoe S,Takahashi M,Asahi M,Lee SH,Li W,Osumi D,Miyoshi E,Taniguchi N

更新日期：2007-03-01 00:00:00

abstract：:PTEN phosphatase is a potent tumor suppressor that regulates multiple cellular functions. In the cytoplasm, PTEN dephosphorylates its primary lipid substrate, phosphatidylinositol 3,4,5-trisphosphate, to antagonize the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. It has also become increasingly evident ...

journal_title：Cancer research

authors： Gu T,Zhang Z,Wang J,Guo J,Shen WH,Yin Y

更新日期：2011-04-15 00:00:00

abstract：:Our recent studies have shown that the FoxM1B transcription factor is overexpressed in human glioma tissues and that the level of its expression correlates directly with glioma grade. However, whether FoxM1B plays a role in the early development of glioma (i.e., in transformation) is unknown. In this study, we found t...

journal_title：Cancer research

authors： Dai B,Pieper RO,Li D,Wei P,Liu M,Woo SY,Aldape KD,Sawaya R,Xie K,Huang S

更新日期：2010-04-01 00:00:00

abstract：:Standardized and reproducible preclinical models that recapitulate the dynamics of prostate cancer are urgently needed. We established a bank of transplantable patient-derived prostate cancer xenografts that capture the biologic and molecular heterogeneity currently confounding prognostication and therapy development....

journal_title：Cancer research

authors： Lin D,Wyatt AW,Xue H,Wang Y,Dong X,Haegert A,Wu R,Brahmbhatt S,Mo F,Jong L,Bell RH,Anderson S,Hurtado-Coll A,Fazli L,Sharma M,Beltran H,Rubin M,Cox M,Gout PW,Morris J,Goldenberg L,Volik SV,Gleave ME,Collins

更新日期：2014-02-15 00:00:00

abstract：:The enormous scope of natural human genetic variation is now becoming defined. To accurately annotate these variants, and to identify those with clinical importance, is often difficult to assess through functional assays. We explored systematic annotation by using homologous recombination to modify a native gene in he...

journal_title：Cancer research

authors： Hucl T,Rago C,Gallmeier E,Brody JR,Gorospe M,Kern SE

更新日期：2008-07-01 00:00:00

abstract：:Nm23-H1 has been identified as a metastasis suppressor gene, but its protein interactions have yet to be understood with any mechanistic clarity. In this study, we evaluated the proteomic spectrum of interactions made by Nm23-H1 in 4T1 murine breast cancer cells derived from tissue culture, primary mammary tumors, and...

journal_title：Cancer research

authors： Marino N,Marshall JC,Collins JW,Zhou M,Qian Y,Veenstra T,Steeg PS

更新日期：2013-10-01 00:00:00

abstract：:BRCA1 inactivation is a frequent event in basal-like breast carcinomas (BLC). However, BRCA1 can be inactivated by multiple mechanisms and determining its status is not a trivial issue. As an alternate approach, we profiled 65 BLC cases using single-nucleotide polymorphism arrays to define a signature of BRCA1-associa...

journal_title：Cancer research

authors： Popova T,Manié E,Rieunier G,Caux-Moncoutier V,Tirapo C,Dubois T,Delattre O,Sigal-Zafrani B,Bollet M,Longy M,Houdayer C,Sastre-Garau X,Vincent-Salomon A,Stoppa-Lyonnet D,Stern MH

更新日期：2012-11-01 00:00:00

abstract：:The purpose of this study was to investigate the immunobiological characteristics of the tumor-specific cell surface antigen expressed by the UV-induced murine fibrosarcoma, UV-2240. UV-2240 is classified as a regressor UV tumor because it is immunologically rejected by normal syngeneic mice but grows in immunocomprom...

journal_title：Cancer research

authors： Simcik WJ,Kripke ML,Sheu TL,LeGrue SJ

更新日期：1988-12-15 00:00:00

abstract：:Mouse polyclonal antibodies, raised against three regions of the human BRCA1 protein, were characterized and revealed BRCA1 as a 220-kDa nuclear phosphoprotein in normal cells. All three antisera recognize both in vitro-translated and recombinant, baculovirus-derived BRCA1, which co-migrate with BRCA1 from the human b...

journal_title：Cancer research

authors： Chen Y,Farmer AA,Chen CF,Jones DC,Chen PL,Lee WH

更新日期：1996-07-15 00:00:00

abstract：:We evaluated the cytotoxicity of the immunotoxin OKT1-SAP on fresh B-chronic lymphocytic leukemia (B-CLL) cells from 31 consecutive patients. OKT1-SAP comprised the OKT1 (CD5) monoclonal antibody disulfide linked to saporin-6 (SAP) ribosome-inactivating protein from the plant Saponaria officinalis. The effect of OKT1-...

journal_title：Cancer research

authors： Siena S,Bregni M,Formosa A,Brando B,Marenco P,Lappi DA,Bonadonna G,Gianni AM

更新日期：1989-06-15 00:00:00

abstract：:Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is normally expressed in hepatocytes. In this study, we showed frequent overexpression of OATP1B3 in colorectal adenocarcinomas. Quantitative reverse transcription-PCR analysis of 17 colon tumors indicated tumoral overexpression of OATP1B3 by approximately ...

journal_title：Cancer research

authors： Lee W,Belkhiri A,Lockhart AC,Merchant N,Glaeser H,Harris EI,Washington MK,Brunt EM,Zaika A,Kim RB,El-Rifai W

更新日期：2008-12-15 00:00:00

abstract：:We evaluated the effects of local X-irradiation on microscopic or small macroscopic primary melanomas in the feet of C57BL/6 mice and the subsequent development of spontaneous femoral lymph node (LN) metastases. Doses of 30, 40, 55, 62.5, or 72.5 Gy often cured the foot tumor and metastases to regional femoral lymph n...

journal_title：Cancer research

authors： Nathanson SD,Westrick P,Anaya P,Hetzel FW,Jacobsen G

更新日期：1989-08-15 00:00:00

abstract：:Tumorigenic activities of the (+)- and (-)-enantiomers of the diastereomeric, bay-region benzo(c)phenanthrene 3,4-diol-1,2-epoxides were evaluated in two mouse tumor models. In an initiation-promotion experiment on mouse skin, a single topical application of 10, 25, or 75 nmol of the compounds was followed by 20 weeks...

journal_title：Cancer research

authors： Levin W,Chang RL,Wood AW,Thakker DR,Yagi H,Jerina DM,Conney AH

更新日期：1986-05-01 00:00:00