High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development.

abstract：:The immune reactivity to partially purified Thomsen-Friedenreich antigen was investigated in patients with lung cancer. The modified method of original leukocyte adherence inhibition test, termed superoxide assay-leukocyte adherence inhibition test, was used to detect the reactivity. The coded peripheral mononuclear c...

journal_title：Cancer research

authors： Ichinose Y,Yagawa K,Kaku M,Hara N,Ohta M

更新日期：1985-09-01 00:00:00

abstract：:The initiation and promotion of cancer is thought to result from a series of genetic mutations, some of which may be inherited. Our analysis of 337 lung cancer families suggested that, after allowing for an individual's pack-years of tobacco use, the pattern of disease was best explained by Mendelian codominant inheri...

journal_title：Cancer research

authors： Sellers TA,Potter JD,Bailey-Wilson JE,Rich SS,Rothschild H,Elston RC

更新日期：1992-05-01 00:00:00

abstract：:Applications of mathematical modeling can improve outcome predictions of cancer therapy. Here we present a kinetic model incorporating effects of radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis of tumor volume regression data of 80 cervical cancer patients (stages 1B2-IVA) who underwent r...

journal_title：Cancer research

authors： Huang Z,Mayr NA,Yuh WT,Lo SS,Montebello JF,Grecula JC,Lu L,Li K,Zhang H,Gupta N,Wang JZ

更新日期：2010-01-15 00:00:00

abstract：:Breast carcinomas < or = 1 cm in size (T1a,b) are being detected more frequently as a result of screening. Because traditional prognostic parameters are either lacking (tumor size) or rare (nodal metastases), a marker(s) is needed to identify the subset of patients who could benefit from adjuvant therapy. A retrospect...

journal_title：Cancer research

authors： Tan P,Cady B,Wanner M,Worland P,Cukor B,Magi-Galluzzi C,Lavin P,Draetta G,Pagano M,Loda M

更新日期：1997-04-01 00:00:00

abstract：:HER-2/neu (neu-N) transgenic mice, which express the nontransforming rat proto-oncogene, develop spontaneous focal mammary adenocarcinomas beginning at 5-6 months of age. The development and histology of these tumors bears a striking resemblance to what is seen in patients with breast cancer. We have characterized the...

journal_title：Cancer research

authors： Reilly RT,Gottlieb MB,Ercolini AM,Machiels JP,Kane CE,Okoye FI,Muller WJ,Dixon KH,Jaffee EM

更新日期：2000-07-01 00:00:00

abstract：:We have investigated the effect of a combined chemoimmunotherapy protocol with liposomal muramyl tripeptide phosphatidylethanolamine (MTP-PE), 5-fluorouracil (5-FU), and 5-formyltetrahydrofolate (leucovorin) on the growth of hepatic metastases using carcinoma H-59, a liver-homing subline of the Lewis lung carcinoma (P...

journal_title：Cancer research

authors： Asao T,Shibata HR,Batist G,Brodt P

更新日期：1992-11-15 00:00:00

abstract：:Cell aggregation is frequently impaired during the growth of primary tumors and the formation of metastatic lesions. Cell aggregation depends on cell-cell adhesion; however, no rigorous approach exists to monitor and quantify it accurately in the absence of the confounding factors of cell-substrate adhesion and the re...

journal_title：Cancer research

authors： Saias L,Gomes A,Cazales M,Ducommun B,Lobjois V

更新日期：2015-06-15 00:00:00

abstract：:Mice lacking N-acetylglucosaminyltransferase III (GlcNAc-TIII) exhibit slightly but significantly retarded liver tumor progression after a single injection of 10 micro g/g diethylnitrosamine (DEN) and continued administration of phenobarbital (PB) in drinking water. A key question is whether the absence of GlcNAc-TIII...

journal_title：Cancer research

authors： Yang X,Tang J,Rogler CE,Stanley P

更新日期：2003-11-15 00:00:00

abstract：:The bryostatins are a group of macrocyclic lactones isolated from the marine bryozoan Bugula neritina. Bryostatin 1, like the phorbol esters, activates protein kinase C; however, it partially inhibits the phorbol ester induced differentiation of the human promyelocytic leukemic cell line HL-60. We compared the phospho...

journal_title：Cancer research

authors： Warren BS,Kamano Y,Pettit GR,Blumberg PM

更新日期：1988-11-01 00:00:00

abstract：:Human cancer cells maintain telomeres by telomerase activity (TA) or by alternative lengthening of telomeres (ALT). We proposed to define the prevalence of the two telomere maintenance mechanisms (TMM), to assess their association with histology, and to compare their prognostic relevance in a series of 93 patients wit...

journal_title：Cancer research

authors： Costa A,Daidone MG,Daprai L,Villa R,Cantù S,Pilotti S,Mariani L,Gronchi A,Henson JD,Reddel RR,Zaffaroni N

更新日期：2006-09-01 00:00:00

abstract：:The immunoreceptor NKG2D originally identified in natural killer (NK) cells recognizes ligands that are upregulated on tumor cells. Expression of NKG2D ligands (NKG2DL) is induced by the DNA damage response (DDR), which is often activated constitutively in cancer cells, revealing them to NK cells as a mechanism of imm...

journal_title：Cancer research

authors： Lam AR,Bert NL,Ho SS,Shen YJ,Tang LF,Xiong GM,Croxford JL,Koo CX,Ishii KJ,Akira S,Raulet DH,Gasser S

更新日期：2014-04-15 00:00:00

abstract：:It has long been known that complex interactions occur between tumors and normal host immune cells. The human melanoma cell line A375 has been used previously as an indicator cell for tumor cell cytotoxicity mediated by monocytes. During other studies on this tumor cell line, we noted that the conditioned media harves...

journal_title：Cancer research

authors： Sabatini M,Chavez J,Mundy GR,Bonewald LF

更新日期：1990-05-01 00:00:00

abstract：:Two newly synthesized nitrosoureido sugars have been evaluated for their antitumor activity and diabetogenic potential in a number of in vitro and in vivo preclinical tumor model systems. 2-Amino-2-deoxy-N'-methyl-N'-nitrosoureido-1,3,4,6-tetra-O-acetyl-alpha- D- mannopyranose (MAZ), a lipophilic mannosamine derivativ...

journal_title：Cancer research

authors： Bernacki RJ,Wilson GL,Mossman BT,Angelino N,Kanter PM,Korytnyk W

更新日期：1985-02-01 00:00:00

abstract：:Estrogen-related receptor alpha (ERRalpha) was identified as a gene related to estrogen receptor alpha (ERalpha) and belongs to a class of nuclear orphan receptors. ERRalpha binds to estrogen responsive element(s) (ERE) and is considered to be involved in modulation of estrogenic actions. However, biological significa...

journal_title：Cancer research

authors： Suzuki T,Miki Y,Moriya T,Shimada N,Ishida T,Hirakawa H,Ohuchi N,Sasano H

更新日期：2004-07-01 00:00:00

abstract：:T-cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T-cell metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources often renders T cells dysfunctional. Environmental stress produces ep...

journal_title：Cancer research

authors： Koss B,Shields BD,Taylor EM,Storey AJ,Byrum SD,Gies AJ,Washam CL,Choudhury SR,Hyun Ahn J,Uryu H,Williams JB,Krager KJ,Chiang TC,Mackintosh SG,Edmondson RD,Aykin-Burns N,Gajewski TF,Wang GG,Tackett AJ

更新日期：2020-11-01 00:00:00

abstract：:Mitomycin C (MMC) is an anticancer drug that requires reductive activation to exert its toxicity. MMC is known to cross-link DNA that contributes significantly to the cytotoxicity and consequent cell death. Cytosolic NADPH:quinone oxidoreductase 1 (NQO1) and microsomal enzymes have been shown to mediate MMC-induced DN...

journal_title：Cancer research

authors： Celli CM,Jaiswal AK

更新日期：2003-09-15 00:00:00

abstract：:In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling pathways contributing to angiogenic stimulation and tumor development. Characteristic features of tumor ischemia include hypoxia and glucose deprivation, leading to the activation of hypoxia-inducible factor-1-dependent signaling...

journal_title：Cancer research

authors： Drogat B,Auguste P,Nguyen DT,Bouchecareilh M,Pineau R,Nalbantoglu J,Kaufman RJ,Chevet E,Bikfalvi A,Moenner M

更新日期：2007-07-15 00:00:00

abstract：:Unlike the growth factor dependence of normal cells, cancer cells can maintain growth factor-independent glycolysis and survival through expression of oncogenic kinases, such as BCR-Abl. Although targeted kinase inhibition can promote cancer cell death, therapeutic resistance develops frequently, and further mechanist...

journal_title：Cancer research

authors： Mason EF,Zhao Y,Goraksha-Hicks P,Coloff JL,Gannon H,Jones SN,Rathmell JC

更新日期：2010-10-15 00:00:00

abstract：:We investigated the effects of somatostatin analogues and a synthetic bombesin/gastrin-releasing peptide (GRP) antagonist on the growth of the human malignant glioma cell lines U-87MG and U-373MG transplanted to nude mice or cultured in vitro. Nude mice bearing s.c. implanted U-87MG or U-373MG tumors were treated for ...

journal_title：Cancer research

authors： Pinski J,Schally AV,Halmos G,Szepeshazi K,Groot K

更新日期：1994-11-15 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumor in children. Osteosarcoma patients who respond poorly to chemotherapy are at a higher risk of relapse and adverse outcome. Therefore, it was the aim of this study to identify prognostic factors at the time of diagnosis to characterize the genes predictive of poor su...

journal_title：Cancer research

authors： Mintz MB,Sowers R,Brown KM,Hilmer SC,Mazza B,Huvos AG,Meyers PA,Lafleur B,McDonough WS,Henry MM,Ramsey KE,Antonescu CR,Chen W,Healey JH,Daluski A,Berens ME,Macdonald TJ,Gorlick R,Stephan DA

更新日期：2005-03-01 00:00:00

abstract：:Ewing sarcoma is a rare but aggressive disease most common in young adults. This cancer is driven by a unique chimeric fusion oncogene but targeted strategies have been elusive. Here we report the identification of the protein kinase PKC-ß (PRKCB) as a disease-specific druggable target for treatment of Ewing sarcoma. ...

journal_title：Cancer research

authors： Surdez D,Benetkiewicz M,Perrin V,Han ZY,Pierron G,Ballet S,Lamoureux F,Rédini F,Decouvelaere AV,Daudigeos-Dubus E,Geoerger B,de Pinieux G,Delattre O,Tirode F

更新日期：2012-09-01 00:00:00

abstract：:Virion antigens of feline leukemia virus are associated with HLA antigens in the membrane of human cells infected with the virus. Feline leukemia virus produced by these cells incorporates host membrane antigens into the virion envelope, making the virus susceptible to lysis by antisera directed to HLA or to uninfecte...

journal_title：Cancer research

authors： Azocar J,Essex M

更新日期：1979-09-01 00:00:00

abstract：:Cyclooxygenase-2 and prostaglandin E(2) (PGE(2)) levels are increased in colorectal cancers and a subset of adenomas. PGE(2) signaling through the EP4 receptor has previously been associated with colorectal tumorigenesis. However, changes in EP4 expression during adenoma to carcinoma progression have not been investig...

journal_title：Cancer research

authors： Chell SD,Witherden IR,Dobson RR,Moorghen M,Herman AA,Qualtrough D,Williams AC,Paraskeva C

更新日期：2006-03-15 00:00:00

abstract：:The homologous proteins p68 and p72 are members of the DEAD box family of RNA helicases. Here, we show that expression of both of these helicases strongly increases during the polyp-->adenoma-->adenocarcinoma transition in the colon. Furthermore, p68 and p72 form complexes with beta-catenin and promote the ability of ...

journal_title：Cancer research

authors： Shin S,Rossow KL,Grande JP,Janknecht R

更新日期：2007-08-15 00:00:00

abstract：:Antisera raised against human lymphoid glucocorticoid receptors were used in combination with the glucocorticoid receptor affinity label [3H]dexamethasone 21-mesylate [( 3H]DM) to identify the glucocorticoid receptors of the human B-lymphoblastoid cell line IM-9 and the human T-cell leukemic cell line CEM-C7. Antisera...

journal_title：Cancer research

authors： Harmon JM,Eisen HJ,Brower ST,Simons SS Jr,Langley CL,Thompson EB

更新日期：1984-10-01 00:00:00

abstract：:Cancer stem-like cells (CSC) in hepatocellular carcinoma (HCC) are thought to mediate therapeutic resistance and poor survival outcomes, but their intrinsic and extrinsic control is not well understood. In this study, we found that the chromatin modification factor LSD1 is highly expressed in HCC CSC where it decrease...

journal_title：Cancer research

authors： Liu C,Liu L,Chen X,Cheng J,Zhang H,Zhang C,Shan J,Shen J,Qian C

更新日期：2018-02-15 00:00:00

abstract：:An animal lectin purified from loach (Misgurnus anguillicaudatus) eggs induced release of cytotoxin from fresh bone marrow cells from mice, although the other lectins tested, wheat germ agglutinin, concanavalin A, and phytohemagglutinin did not. The cytotoxin released from bone marrow cells was a heat-labile protein w...

journal_title：Cancer research

authors： Okutomi T,Nakajima Y,Sakakibara F,Kawauchi H,Yamazaki M

更新日期：1987-01-01 00:00:00

abstract：:The secretion of transforming growth factors (TGFs) alpha and beta by normal, chemically transformed, and malignant rat liver epithelial cell lines was investigated. The WB-F344 normal cultured rat liver epithelial cell line does not secrete an epidermal growth factor-like (putatively TGF-alpha) activity, but several ...

journal_title：Cancer research

authors： Liu C,Tsao MS,Grisham JW

更新日期：1988-02-15 00:00:00

abstract：:The intermediate filament protein Nestin serves as a biomarker for stem cells and has been used to identify subsets of cancer stem-like cells. However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood. Here, we report that Nestin binds the hedgehog pathway transcription factor Gli3 to ...

journal_title：Cancer research

authors： Li P,Lee EH,Du F,Gordon RE,Yuelling LW,Liu Y,Ng JM,Zhang H,Wu J,Korshunov A,Pfister SM,Curran T,Yang ZJ

更新日期：2016-09-15 00:00:00

abstract：:The concept that different leukemias are developmentally distinct and, like in normal hematopoiesis, generated by restricted populations of cells named leukemia-initiating cells (LIC), is becoming more established. These cancer stem-like cells have been assumed to have unique properties, including the capability of se...

journal_title：Cancer research

authors： Tamiro F,Weng AP,Giambra V

更新日期：2021-01-07 00:00:00