Identification of human leukemic glucocorticoid receptors using affinity labeling and anti-human glucocorticoid receptor antibodies.

abstract：:Frontline anticancer therapies such as chemotherapy and irradiation often slow tumor growth, but tumor regrowth and spread to distant sites usually occurs after the conclusion of treatment. We recently showed that macrophages could be used to deliver large quantities of a hypoxia-regulated, prostate-specific oncolytic...

journal_title：Cancer research

authors： Muthana M,Rodrigues S,Chen YY,Welford A,Hughes R,Tazzyman S,Essand M,Morrow F,Lewis CE

更新日期：2013-01-15 00:00:00

abstract：:Vascular endothelial growth factor D has recently been linked to the control of lymphangiogenesis and lymphatic metastasis. The molecular determinants regulating vegf-D gene transcription, however, have not yet been identified. After isolation of 2 kb of 5'-flanking DNA of the human vegf-D gene, we identified a novel,...

journal_title：Cancer research

authors： Schäfer G,Wissmann C,Hertel J,Lunyak V,Höcker M

更新日期：2008-01-15 00:00:00

abstract：:Anti-inflammatory drugs and antibiotics alter the risk of breast cancer in women, but roles for bacteria and inflammation in breast malignancies are poorly understood. A recent study in mice suggests that intestinal bacteria can trigger mammary carcinoma. The mechanisms involved in this effect suggest that dysregulate...

journal_title：Cancer research

authors： Rao VP,Poutahidis T,Fox JG,Erdman SE

更新日期：2007-02-01 00:00:00

abstract：:Dicer1 functions as a tumor suppressor in mouse models. In humans, somatic mutations are associated with many cancers in adults, and patients with DICER1 syndrome with DICER1 germline mutations are susceptible to childhood cancers. Dicer is phosphorylated by the ERK-MAP kinase pathway and because this pathway is activ...

journal_title：Cancer research

authors： Aryal NK,Pant V,Wasylishen AR,Rimel BJ,Baseler L,El-Naggar AK,Mutch DG,Goodfellow PJ,Arur S,Lozano G

更新日期：2019-05-15 00:00:00

abstract：:To investigate the mechanism of action of the antineoplastic drug estramustine, we compared its effects on human prostate cancer cells with those of vinblastine. At their respective concentrations that result in 50% inhibition of clonogenic growth, both drugs caused an accumulation of cells blocked at mitosis and simi...

journal_title：Cancer research

authors： Dahllöf B,Billström A,Cabral F,Hartley-Asp B

更新日期：1993-10-01 00:00:00

abstract：:The supply of oxygen and nutrients to solid tumors is inefficient because cancer tissues have an inadequate number of microvessels, thus inducing the selective growth of the most aggressive cancer cells. This explains why many of the factors underlying a poor prognosis are induced in hypoxic/hypoglycemic conditions. A...

journal_title：Cancer research

authors： Raspaglio G,De Maria I,Filippetti F,Martinelli E,Zannoni GF,Prislei S,Ferrandina G,Shahabi S,Scambia G,Ferlini C

更新日期：2010-07-15 00:00:00

abstract：:A direct ligand-banding radioassay for methotrexate (MTX) has been developed using dihydrofolate reductase, contained in the lysate of L1210 leukemia cells, as the binding determinant. The procedure is a two-phase reaction system where standard MTX concentrations or the sample being assayed in incubated with the reage...

journal_title：Cancer research

authors： Arons E,Rothenberg SP,Costa MD,Fischer C,Iqbal MP

更新日期：1975-08-01 00:00:00

abstract：:In the present study, we examined hemodynamics in vasculogenic mimicry (VM) and angiogenesis of inflammatory breast cancer (IBC) xenografts (WIBC-9), having previously reported on the unique histological features and molecular basis of these processes (K. Shirakawa et al., Cancer Res., 61: 445-451, 2001). Histological...

journal_title：Cancer research

authors： Shirakawa K,Kobayashi H,Heike Y,Kawamoto S,Brechbiel MW,Kasumi F,Iwanaga T,Konishi F,Terada M,Wakasugi H

更新日期：2002-01-15 00:00:00

abstract：:Oxygen derived free radicals and peroxides result from many antitumor treatments, including radiation and anthracyclines. Doxorubicin cardiotoxicity is thought to result from free radical induced lipid peroxidation. The heart has less active detoxification enzymes than does the liver and depends on selenium dependent ...

journal_title：Cancer research

authors： Batist G,Norton J,Katki AG,Wagman L,Ferrans VJ,Maher M,Myers CE

更新日期：1985-11-01 00:00:00

abstract：:Although a Chinese hamster V79 cell-based assay for inhibitors of metabolic cooperation is currently available, the development of a human cell-based assay is desirable in order to avoid inappropriate extrapolation from animal cells to human cells. Cells derived from a human teratocarcinoma cell line (designated PA-1)...

journal_title：Cancer research

authors： Kavanagh TJ,Chang CC,Trosko JE

更新日期：1986-03-01 00:00:00

abstract：:DRAIC is a 1.7 kb spliced long noncoding RNA downregulated in castration-resistant advanced prostate cancer. Decreased DRAIC expression predicts poor patient outcome in prostate and seven other cancers, while increased DRAIC represses growth of xenografted tumors. Here, we show that cancers with decreased DRAIC expres...

journal_title：Cancer research

authors： Saha S,Kiran M,Kuscu C,Chatrath A,Wotton D,Mayo MW,Dutta A

更新日期：2020-03-01 00:00:00

abstract：:Deletion of the chromosome 5q [del(5q)] is one of the most common cytogenetic abnormalities observed in patients with de novo myelodysplastic syndromes (MDS) and therapy-related MDS or acute myeloid leukemia (t-MDS/tAML). Emerging evidence indicates that activation of the Wnt/β-catenin pathway contributes to the devel...

journal_title：Cancer research

authors： Li L,Sheng Y,Li W,Hu C,Mittal N,Tohyama K,Seba A,Zhao YY,Ozer H,Zhu T,Qian Z

更新日期：2017-08-01 00:00:00

abstract：:3,3',5-Triiodo-L-thyronine (200 microgram/100 g) is shown to be a potent liver parenchymal cell mitogen in the rat, and thyroidectomy is seen to severely inhibit hepatocyte proliferation in regenerating rat liver. Taken together, these observations point to a crucial role for the iodothyronine in liver cell hyperplasi...

journal_title：Cancer research

authors： Short J,Klein K,Kibert L,Ove P

更新日期：1980-07-01 00:00:00

abstract：:Busulfan (1,4-butanediol dimethanesulfonate, BU) is relatively unique among other standard chemotherapy compounds in its ability to deplete noncycling primitive stem cells in the host and consequently to allow for high levels of long-term, donor-type engraftment after bone marrow transplantation (BMT). Such a property...

journal_title：Cancer research

authors： Westerhof GR,Ploemacher RE,Boudewijn A,Blokland I,Dillingh JH,McGown AT,Hadfield JA,Dawson MJ,Down JD

更新日期：2000-10-01 00:00:00

abstract：:The discovery of somatic mutations in EGFR and development of EGFR tyrosine kinase inhibitors (TKI) have revolutionized treatment for lung cancer. However, resistance to TKIs emerges in almost all patients and currently no effective treatment is available. Here, we show that β-catenin is essential for development of E...

journal_title：Cancer research

authors： Nakayama S,Sng N,Carretero J,Welner R,Hayashi Y,Yamamoto M,Tan AJ,Yamaguchi N,Yasuda H,Li D,Soejima K,Soo RA,Costa DB,Wong KK,Kobayashi SS

更新日期：2014-10-15 00:00:00

abstract：:Cyclins and cyclin-dependent kinases regulate the cell cycle. Cyclin A has a dual role in cell proliferation. It is essential in the S phase for DNA replication, and it is also involved in G2-M-phase transition, signifying actively dividing cells. The expression of cyclin A was determined by immunohistochemistry in pa...

journal_title：Cancer research

authors： Huuhtanen RL,Blomqvist CP,Böhling TO,Wiklund TA,Tukiainen EJ,Virolainen M,Tribukait B,Andersson LC

更新日期：1999-06-15 00:00:00

abstract：:Using the technique of premature chromosome condensation, which permits the visual inspection of interphase chromatin, we have shown previously that 28 hr after exposure to 6-thioguanine (TG) specific and drastic morphological changes in the chromosomes of Chinese hamster ovary fibroblasts in the G2 phase of the cell ...

journal_title：Cancer research

authors： Maybaum J,Mandel HG

更新日期：1983-08-01 00:00:00

abstract：:The ability of glucocorticoids (GCs) to induce death in lymphoid-origin cells is the basis for their frequent use in the therapy of various human hematological malignancies. However, the occurrence of primary or secondary GC resistance limits their clinical usefulness. Prior investigations into the mechanism of GC res...

journal_title：Cancer research

authors： Geley S,Hartmann BL,Hala M,Strasser-Wozak EM,Kapelari K,Kofler R

更新日期：1996-11-01 00:00:00

abstract：:The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing evidence also indicates that IAPs also modulate cell division, cell cycle progression, and signal transduction pathways. As our basic understanding of IAPs has inc...

journal_title：Cancer research

authors： Schimmer AD

更新日期：2004-10-15 00:00:00

abstract：:Postpartum mammary gland involution is a tissue remodeling event that occurs in all mammals in the absence of nursing or after weaning to return the gland to the pre-pregnant state. The tissue microenvironment created by involution has proven to be tumor promotional. Here we report that the GPI-linked protein semaphor...

journal_title：Cancer research

authors： Elder AM,Tamburini BAJ,Crump LS,Black SA,Wessells VM,Schedin PJ,Borges VF,Lyons TR

更新日期：2018-11-15 00:00:00

abstract：:Nineteen transplantable tumor lines were established from individual spontaneous mammary tumors of the DBA/2 Ha-DD mouse. Of these lines, 5 were classified as fast growing, 8 as medium growing, and 6 as slow growing, based on the time required for the tumors to reach a size of 10 mm in average diameter and on the aver...

journal_title：Cancer research

authors： Hosokawa M,Orsini F,Mihich E

更新日期：1975-10-01 00:00:00

abstract：:Cancer cell motility has been associated with metastatic potential of sublines of the Dunning R-3227 rat prostatic adenocarcinoma model. However, three sublines of high motility lacked the capacity for metastasis. In all previous works, motility has been studied upon plastic and only upon attached cells at least 18 h ...

journal_title：Cancer research

authors： Mohler JL,Levy F,Sharief Y

更新日期：1991-12-15 00:00:00

abstract：:Colorectal cancers with widespread CpG island methylation display a number of distinct clinicopathological features, and it has been suggested that the condition has an inheritable genetic component. To address this possibility, histories of cancer were obtained from 562 individuals undergoing curative surgery for uns...

journal_title：Cancer research

authors： Ward RL,Williams R,Law M,Hawkins NJ

更新日期：2004-10-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is characterized by therapeutic resistance for which the basis is poorly understood. Here, we report that the DNA and p53-binding protein ATDC/TRIM29, which is highly expressed in PDAC, plays a critical role in DNA damage signaling and radioresistance in pancreatic cancer cells....

journal_title：Cancer research

authors： Wang L,Yang H,Palmbos PL,Ney G,Detzler TA,Coleman D,Leflein J,Davis M,Zhang M,Tang W,Hicks JK,Helchowski CM,Prasad J,Lawrence TS,Xu L,Yu X,Canman CE,Ljungman M,Simeone DM

更新日期：2014-03-15 00:00:00

abstract：:Inactivation of p16INK4 tumor suppressor gene function is frequently observed in breast cancer. We examined p16INK4 expression in human mammary epithelial cell (HMEC) cultures established from four normal donors. Normal HMECs divide a limited number of times before proliferation ceases in a state referred to as select...

journal_title：Cancer research

authors： Huschtscha LI,Noble JR,Neumann AA,Moy EL,Barry P,Melki JR,Clark SJ,Reddel RR

更新日期：1998-08-15 00:00:00

abstract：:Centrosome amplification is a hallmark of virtually all types of cancers, including solid tumors and hematologic malignancies. Cancer cells with extra centrosomes use centrosome clustering (CC) to allow for successful division. Because normal cells do not rely on this mechanism, CC is regarded as a promising target to...

journal_title：Cancer research

authors： Konotop G,Bausch E,Nagai T,Turchinovich A,Becker N,Benner A,Boutros M,Mizuno K,Krämer A,Raab MS

更新日期：2016-11-15 00:00:00

abstract：:Tasidotin (ILX-651), an orally active synthetic microtubule-targeted derivative of the marine depsipeptide dolastatin-15, is currently undergoing clinical evaluation for cancer treatment. Tasidotin inhibited proliferation of MCF7/GFP breast cancer cells with an IC(50) of 63 nmol/L and inhibited mitosis with an IC(50) ...

journal_title：Cancer research

authors： Ray A,Okouneva T,Manna T,Miller HP,Schmid S,Arthaud L,Luduena R,Jordan MA,Wilson L

更新日期：2007-04-15 00:00:00

abstract：:Integration of the human papillomavirus (HPV) genome into the host genome is associated with the disruption of the HPV E2 gene and with amplification and rearrangement of the viral and flanking cellular sequences. Molecular characterization of the genomic structures of coamplified HPV sequences and oncogenes provides ...

journal_title：Cancer research

authors： Herrick J,Conti C,Teissier S,Thierry F,Couturier J,Sastre-Garau X,Favre M,Orth G,Bensimon A

更新日期：2005-02-15 00:00:00

abstract：:The activated RAS/RAF cascade plays a crucial role in lung cancer, but is also known to induce cellular senescence, a major barrier imposed on tumor cells early in tumorigenesis. MYC is a key factor in suppression of RAS/BRAF(V600E)-induced senescence in vitro. However, it is still unclear whether MYC has the same rol...

journal_title：Cancer research

authors： Tabor V,Bocci M,Alikhani N,Kuiper R,Larsson LG

更新日期：2014-08-15 00:00:00

abstract：:Ether phospholipids are analogues of the naturally occurring 2-lyso-phosphatidylcholine that have been reported to have in vitro/in vivo antitumor activity. Their antiproliferative effect has been found against a variety of animal and human tumor cell lines. We have characterized the cytostatic activity of two ether p...

journal_title：Cancer research

authors： Principe P,Sidoti C,Braquet P

更新日期：1992-05-01 00:00:00