Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells.

abstract：:Early phase evaluation of anticancer drugs has traditionally used toxicity (usually hematological) rather than efficacy end points to establish appropriate dosing schedules. To establish a biochemical efficacy end point for overcoming alkylguanine DNA alkyltransferase (AGT)-mediated tumor cell resistance to 1,3-bis(2-...

journal_title：Cancer research

authors： Spiro TP,Gerson SL,Liu L,Majka S,Haaga J,Hoppel CL,Ingalls ST,Pluda JM,Willson JK

更新日期：1999-05-15 00:00:00

abstract：:This study examined the association between 17p allelic loss and p53 gene mutation in a series of 16 esophageal adenocarcinomas arising on a background of Barrett's esophagus. Two highly polymorphic dinucleotide repeat polymorphisms mapping to 17p13 were analyzed to assess the frequency of 17p allelic loss in these tu...

journal_title：Cancer research

authors： Gleeson CM,Sloan JM,McGuigan JA,Ritchie AJ,Russell SE

更新日期：1995-08-01 00:00:00

abstract：:MCT-1 is an oncogene that was initially identified in a human T cell lymphoma and has been shown to induce cell proliferation as well as activate survival-related pathways. MCT-1 contains the PUA domain, a recently described RNA-binding domain that is found in several tRNA and rRNA modification enzymes. Here, we estab...

journal_title：Cancer research

authors： Reinert LS,Shi B,Nandi S,Mazan-Mamczarz K,Vitolo M,Bachman KE,He H,Gartenhaus RB

更新日期：2006-09-15 00:00:00

abstract：:The mouse, dog, and monkey toxicity data on 30 drugs was retrospectively analyzed in comparison with the actual clinical dose schedules used in man. Animal dose schedules were converted to the human schedule and comparisons were made of the human dose versus the large animal toxic dose low, toxic dose high, and lethal...

journal_title：Cancer research

authors： Goldsmith MA,Slavik M,Carter SK

更新日期：1975-05-01 00:00:00

abstract：:Effective treatment of malignant carcinomas requires identification of proteins regulating epithelial cell proliferation. To this end, we compared gene expression profiles in murine colonocytes and their c-Myc-transformed counterparts, which possess enhanced proliferative potential. A surprisingly short list of deregu...

journal_title：Cancer research

authors： Thomas-Tikhonenko A,Viard-Leveugle I,Dews M,Wehrli P,Sevignani C,Yu D,Ricci S,el-Deiry W,Aronow B,Kaya G,Saurat JH,French LE

更新日期：2004-05-01 00:00:00

abstract：:H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia mutated protein) phosphorylates H2AX in response to DNA double-strand breaks (DSBs). Whether DNA-dependent protein kinase (DNA-PK) plays any role in this response is unclear. Here, we show that H2...

journal_title：Cancer research

authors： Stiff T,O'Driscoll M,Rief N,Iwabuchi K,Löbrich M,Jeggo PA

更新日期：2004-04-01 00:00:00

abstract：:Low-grade serous ovarian carcinoma (LGSOC) is a rare tumor subtype with high case fatality rates in patients with metastatic disease. There is a pressing need to develop effective treatments using newly available preclinical models for therapeutic discovery and drug evaluation. Here we use multiomics integration of wh...

journal_title：Cancer research

authors： Shrestha R,Llaurado Fernandez M,Dawson A,Hoenisch J,Volik S,Lin YY,Anderson S,Kim H,Haegert AM,Colborne S,Wong NKY,McConeghy B,Bell RH,Brahmbhatt S,Lee CH,DiMattia GE,Le Bihan S,Morin GB,Collins CC,Carey MS

更新日期：2021-01-13 00:00:00

abstract：:The evolution of immune blockades in tumors limits successful antitumor immunity, but the mechanisms underlying this process are not fully understood. Depletion of regulatory T cells (Treg), a T-cell subset that dampens excessive inflammatory and autoreactive responses, can allow activation of tumor-specific T cells. ...

journal_title：Cancer research

authors： Hindley JP,Jones E,Smart K,Bridgeman H,Lauder SN,Ondondo B,Cutting S,Ladell K,Wynn KK,Withers D,Price DA,Ager A,Godkin AJ,Gallimore AM

更新日期：2012-11-01 00:00:00

abstract：:The formation of a microvascular endothelium plays a critical role in the growth and metastasis of established tumors. The ability of a fragment from the first type III repeat of fibronectin (III(1C)), anastellin, to suppress tumor growth and metastasis in vivo has been reported to be related to its antiangiogenic pro...

journal_title：Cancer research

authors： Ambesi A,Klein RM,Pumiglia KM,McKeown-Longo PJ

更新日期：2005-01-01 00:00:00

abstract：:The supply of oxygen and nutrients to solid tumors is inefficient because cancer tissues have an inadequate number of microvessels, thus inducing the selective growth of the most aggressive cancer cells. This explains why many of the factors underlying a poor prognosis are induced in hypoxic/hypoglycemic conditions. A...

journal_title：Cancer research

authors： Raspaglio G,De Maria I,Filippetti F,Martinelli E,Zannoni GF,Prislei S,Ferrandina G,Shahabi S,Scambia G,Ferlini C

更新日期：2010-07-15 00:00:00

abstract：:OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function, and ...

journal_title：Cancer research

authors： Curti BD,Kovacsovics-Bankowski M,Morris N,Walker E,Chisholm L,Floyd K,Walker J,Gonzalez I,Meeuwsen T,Fox BA,Moudgil T,Miller W,Haley D,Coffey T,Fisher B,Delanty-Miller L,Rymarchyk N,Kelly T,Crocenzi T,Bernstein E,

更新日期：2013-12-15 00:00:00

abstract：:Vascular permeability factor (VPF) is one of the most potent known inducers of microvascular hyperpermeability; in addition, it is a selective endothelial cell growth factor, hence its alternate name, vascular endothelial growth factor. VPF exerts its actions on the microvasculature by interacting with specific endoth...

journal_title：Cancer research

authors： Brown LF,Berse B,Jackman RW,Tognazzi K,Manseau EJ,Senger DR,Dvorak HF

更新日期：1993-10-01 00:00:00

abstract：:The human inducible nitric oxide synthase (hiNOS) gene is regulated by nuclear factor kappaB (NF-kappaB) and has recently been shown to be a target of the Wnt/beta-catenin pathway. In this study, we tested the hypothesis that Wnt/beta-catenin signaling might regulate cytokine- or tumor necrosis factor alpha (TNFalpha)...

journal_title：Cancer research

authors： Du Q,Zhang X,Cardinal J,Cao Z,Guo Z,Shao L,Geller DA

更新日期：2009-05-01 00:00:00

abstract：:Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with can...

journal_title：Cancer research

authors： Siolas D,Hannon GJ

更新日期：2013-09-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a deadly and aggressive cancer. Understanding mechanisms that drive preneoplastic pancreatic lesions is necessary to improve early diagnostic and therapeutic strategies. Mutations and inactivation of activin-like kinase (ALK4) have been demonstrated to favor PDAC onset. Surpr...

journal_title：Cancer research

authors： Zhao Y,Wu Z,Chanal M,Guillaumond F,Goehrig D,Bachy S,Principe M,Ziverec A,Flaman JM,Collin G,Tomasini R,Pasternack A,Ritvos O,Vasseur S,Bernard D,Hennino A,Bertolino P

更新日期：2020-08-15 00:00:00

abstract：:Dilution end point loss of heterozygosity (LOH) analysis, a novel approach for the analysis of LOH, was used to evaluate allelic losses with the use of 21 highly polymorphic microsatellite markers at nine chromosomal sites most frequently affected in smoking-related non-small cell lung cancers. Allelotyping was done f...

journal_title：Cancer research

authors： Pan H,Califano J,Ponte JF,Russo AL,Cheng KH,Thiagalingam A,Nemani P,Sidransky D,Thiagalingam S

更新日期：2005-03-01 00:00:00

abstract：:It has been claimed that the commercially available Ki-67 monoclonal antibody recognizes a nuclear antigen which is solely expressed in cycling cells. Therefore, at present, Ki-67 is increasingly used as a tool in evaluating growth fractions (GFs) of human tumors. Here we describe specific patterns in the expression a...

journal_title：Cancer research

authors： van Dierendonck JH,Keijzer R,van de Velde CJ,Cornelisse CJ

更新日期：1989-06-01 00:00:00

abstract：:The antitumor effects of two immunotoxins were evaluated in vitro and in vivo against the human ovarian carcinoma cell line, OVCAR-3. The immunotoxins used were composed of recombinant ricin A chain (rRTA) covalently attached to a monoclonal antibody directed toward the human transferrin receptor (45412/rRTA, also cal...

journal_title：Cancer research

authors： Pearson JW,Hedrick E,Fogler WE,Bull RL,Ferris DK,Riggs CW,Wiltrout RH,Sivam G,Morgan AC,Groves E

更新日期：1990-10-01 00:00:00

abstract：:Antigens have been detected in 35 to 40% of sera from patients with leukemia that cross-react with the Mr 30,000 core proteins (p30) of baboon endogenous virus (BaEV) and/or of simian sarcoma-simian sarcoma-associated virus (SiSV) in a solid-phase enzyme immunoassay using anti-SiSV p30 and anti-BaEV p30 antisera. Thes...

journal_title：Cancer research

authors： Hehlmann R,Schetters H,Erfle V,Leib-Mösch C

更新日期：1983-01-01 00:00:00

abstract：:Mithramycin (MIT) and tolfenamic acid (TA) inhibit the activity of the transcription factor Sp1. In the present study, we investigated whether pancreatic cancer treatment with a combination of these compounds has a synergistic effect on Sp1 activity, tumor growth, and their underlying response mechanisms. Treatment of...

journal_title：Cancer research

authors： Jia Z,Gao Y,Wang L,Li Q,Zhang J,Le X,Wei D,Yao JC,Chang DZ,Huang S,Xie K

更新日期：2010-02-01 00:00:00

abstract：:It has been shown that the systemic administration of lymphokine-activated killer (LAK) cells with recombinant interleukin 2 (RIL-2) is effective in reducing the number of established pulmonary and hepatic metastases in murine models. Similarly, this modality of therapy has been proven effective against certain select...

journal_title：Cancer research

authors： Lafreniere R,Borkenhagen K,Bryant LD,Huchcroft S

更新日期：1989-05-01 00:00:00

abstract：:Oxidative stress exerted by superoxide-generating (redox-cycling) agents such as paraquat triggers the soxRS regulon of Escherichia coli. In this system, SoxR protein is the redox-sensitive activator of the soxS gene, the product of which then activates the approximately 10 promoters of this regulon. We found that 4-n...

journal_title：Cancer research

authors： Nunoshiba T,Demple B

更新日期：1993-07-15 00:00:00

abstract：:Cytosol estradiol receptor from MTW9-D (ovarian dependent) and MTW9-MtT (ovarian independent) rat mammary tumors were fractionated by chromatofocusing, a procedure which separates proteins on an ion-exchange column as a function of isoelectric point. Receptor from MTW9-D usually fractionated as three peaks with mean p...

journal_title：Cancer research

authors： Coufalik AH,Feldman M,Platica M,Toth L,Dreiling D,Hollander VP

更新日期：1983-11-01 00:00:00

abstract：:To identify molecular alterations involved in the initiation and progression of breast carcinomas, we analyzed the global gene expression profiles of normal mammary epithelial cells and in situ, invasive, and metastatic breast carcinomas using serial analysis of gene expression (SAGE). We identified sets of genes expr...

journal_title：Cancer research

authors： Porter DA,Krop IE,Nasser S,Sgroi D,Kaelin CM,Marks JR,Riggins G,Polyak K

更新日期：2001-08-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with proven efficacy in multiple myeloma and non-Hodgkin's lymphoma. This study reports the effects of bortezomib in B-cell lymphoma cell lines with differing sensitivity to bortezomib to investigate factors that influence sensitivity. Bortezomib induced a time- and concentration-d...

journal_title：Cancer research

authors： Strauss SJ,Higginbottom K,Jüliger S,Maharaj L,Allen P,Schenkein D,Lister TA,Joel SP

更新日期：2007-03-15 00:00:00

abstract：:A new DNA precipitation assay used together with the alkali unwinding assay may provide a rapid means of detecting DNA damage in addition to strand breaks based on the relative amount of damage measured by the two assays. X-rays, Adriamycin, 4-nitroquinoline-N-oxide, N-methyl-N'-nitrosoguanidine, bleomycin, RSU 1172, ...

journal_title：Cancer research

authors： Olive PL,Chan AP,Cu CS

更新日期：1988-11-15 00:00:00

abstract：:The Morris hepatocellular carcinoma 7777 is productive of extraordinarily high levels of the oncofetal protein, alpha-fetoprotein. Its chromosome composition was examined in detail since it represents the only near-diploid tumor of such productivity and has been reported to demonstrate a single unusual chromosomal alt...

journal_title：Cancer research

authors： Wolman SR,Cohen TI,Becker FF

更新日期：1977-08-01 00:00:00

abstract：:The pattern of proliferation of epithelial cells in esophageal epithelium was studied by means of [3H]deoxythymidine labeling of esophageal epithelium in subjects from Huixian, Henan Province, China, a high-risk geographical region for esophageal cancer. Comparisons were made among patterns of cell proliferation obser...

journal_title：Cancer research

authors： Wang LD,Lipkin M,Qui SL,Yang GR,Yang CS,Newmark HL

更新日期：1990-05-01 00:00:00

abstract：:The treatment of HeLa and HL-60 cells with various concentrations of pentakis(arizidino)thiatriazadiphosphorine oxide results in inhibition of growth and modification of cell cycle distribution. These phenomena were observed at 10(-4) M and 5 X 10(-5) M for HeLa cells and 10(-5) M and 5 X 10(-6) M for HL-60 cells. The...

journal_title：Cancer research

authors： Hecquet C,Nafziger J,Ronot X,Marie JP,Adolphe M

更新日期：1985-02-01 00:00:00

abstract：:The lysyl oxidase (LOX) gene reverted Ras transformation of NIH 3T3 fibroblasts and tumor formation by gastric cancer cells, which frequently carry mutant RAS genes. The secreted lysyl oxidase proenzyme is processed to a propeptide (LOX-PP) and a functional enzyme (LOX). Unexpectedly, the tumor suppressor activity map...

journal_title：Cancer research

authors： Min C,Yu Z,Kirsch KH,Zhao Y,Vora SR,Trackman PC,Spicer DB,Rosenberg L,Palmer JR,Sonenshein GE

更新日期：2009-08-15 00:00:00