Detection and biochemical characterization of antigens in human leukemic sera that cross-react with primate C-type viral proteins (Mr 30,000).

abstract：:In eight estrogen receptor (ER)-positive breast cancer cell lines (including three sublines of MCF-7) and five ER-negative breast lines, the action of the nonsteroidal antiestrogen, tamoxifen, was studied, and the concentrations of ER and antiestrogen binding site were measured. The concentration of antiestrogen bindi...

journal_title：Cancer research

authors： Reddel RR,Murphy LC,Hall RE,Sutherland RL

更新日期：1985-04-01 00:00:00

abstract：:The presence of succinyl-coenzyme A:acetoacetate CoA transferase (CoA transferase) (EC 2.8.3.5), an initiator of ketone body utilization in nonhepatic tissue, was examined in liver from normal, partly hepatectomized, neonatal, and tumor-bearing rats, as well as in a series of transplantable rat hepatomas ranging widel...

journal_title：Cancer research

authors： Fenselau A,Wallis K,Morris HP

更新日期：1975-09-01 00:00:00

abstract：:Paclitaxel (Taxol) is a chemotherapeutic agent that prevents disassembly of microtubular polymers, causing a growth arrest in the G2-M phase of the cell cycle and leading to apoptotic death. Paclitaxel has remarkable efficacy against fast-growing tumors but possesses major drawbacks, such as poor solubility and lack o...

journal_title：Cancer research

authors： Guillemard V,Saragovi HU

更新日期：2001-01-15 00:00:00

abstract：:In this study, we have exploited the power of insertional mutagenesis to elucidate tumor progression pathways in mice carrying two oncogenes (MYC/Runx2) that collaborate to drive early lymphoma development. Neonatal infection of these mice with Moloney murine leukemia virus resulted in accelerated tumor onset with ass...

journal_title：Cancer research

authors： Stewart M,Mackay N,Hanlon L,Blyth K,Scobie L,Cameron E,Neil JC

更新日期：2007-06-01 00:00:00

abstract：:The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like APOBEC3A and APOBEC3B have emerged as key mutation drivers in cancer. Here, we show that APOBEC3A and APOBEC3B activities impose a unique type of replication stress by inducing abasic sites at replication forks. In contrast to cells under other types ...

journal_title：Cancer research

authors： Buisson R,Lawrence MS,Benes CH,Zou L

更新日期：2017-09-01 00:00:00

abstract：:The effects of transforming growth factor-beta (TGF beta) on a human colon carcinoma cell line (MOSER) were investigated. TGF beta, at low concentrations (between 0.1 and 1.0 ng/ml), inhibited the proliferation of MOSER cells both in monolayer culture and soft agarose, in a dose-dependent manner. MOSER cells adapted t...

journal_title：Cancer research

authors： Hoosein NM,Brattain DE,McKnight MK,Levine AE,Brattain MG

更新日期：1987-06-01 00:00:00

abstract：:Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA. We found that lung adenoma/carcinoma spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth in which 8-oxoG was found to accumulate in the...

journal_title：Cancer research

authors： Sakumi K,Tominaga Y,Furuichi M,Xu P,Tsuzuki T,Sekiguchi M,Nakabeppu Y

更新日期：2003-03-01 00:00:00

abstract：:Aberrant FLT3 expression and/or mutation plays a significant role in leukemogenesis. This has prompted the development of selective small molecule tyrosine kinase inhibitors against FLT3. However, like most tyrosine kinase inhibitors, those against FLT3 are not completely specific and at the doses required to complete...

journal_title：Cancer research

authors： Piloto O,Levis M,Huso D,Li Y,Li H,Wang MN,Bassi R,Balderes P,Ludwig DL,Witte L,Zhu Z,Hicklin DJ,Small D

更新日期：2005-02-15 00:00:00

abstract：:Diets enriched in n-3 polyunsaturated fatty acids (n-3 PUFA) may protect against breast cancer but biochemical mechanisms are unclear. Our studies showed that the n-3 fatty acid docosahexaenoic acid (DHA) up-regulated syndecan-1 (SDC-1) in human breast cancer cells, and we tested the hypothesis that DHA-mediated up-re...

journal_title：Cancer research

authors： Sun H,Berquin IM,Owens RT,O'Flaherty JT,Edwards IJ

更新日期：2008-04-15 00:00:00

abstract：:Applications of mathematical modeling can improve outcome predictions of cancer therapy. Here we present a kinetic model incorporating effects of radiosensitivity, tumor repopulation, and dead-cell resolving on the analysis of tumor volume regression data of 80 cervical cancer patients (stages 1B2-IVA) who underwent r...

journal_title：Cancer research

authors： Huang Z,Mayr NA,Yuh WT,Lo SS,Montebello JF,Grecula JC,Lu L,Li K,Zhang H,Gupta N,Wang JZ

更新日期：2010-01-15 00:00:00

abstract：:CPT-11 [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin ] is a prodrug that is converted to the active metabolite SN-38 by carboxylesterases. In its active form, the drug inhibits topoisomerase I, causes DNA damage, and induces apoptosis. Data in this study show metabolism of CPT-11 to SN-38 (7-ethyl...

journal_title：Cancer research

authors： Danks MK,Morton CL,Pawlik CA,Potter PM

更新日期：1998-01-01 00:00:00

abstract：:We studied the effects of interleukin-1 alpha (IL-1) and interleukin-6 (IL-6) on MCF-7 breast cancer cells to determine whether these cytokines act additively/synergistically to alter cell growth and metabolism. We found that IL-1 alone (1000 units/ml) inhibited cell growth to a greater degree (83.8%) than IL-6 alone ...

journal_title：Cancer research

authors： Danforth DN Jr,Sgagias MK

更新日期：1993-04-01 00:00:00

abstract：:Liver X receptors function as central transcriptional regulators for lipid homeostasis, for which agonists have been developed as potential drugs for treatment of cardiovascular diseases and metabolic syndromes. Because dysregulation of lipid metabolism has been implicated in sex hormone-dependent cancers, we investig...

journal_title：Cancer research

authors： Fukuchi J,Kokontis JM,Hiipakka RA,Chuu CP,Liao S

更新日期：2004-11-01 00:00:00

abstract：:This set of experiments is the second of a series designed to explore alterations in cell dynamics and growth control of new populations of hepatocytes that appear to play a role in the carcinogenic process induced in the liver by chemical carcinogens. This is part of an ongoing study of the biochemical and molecular ...

journal_title：Cancer research

authors： Rotstein J,Sarma DS,Farber E

更新日期：1986-05-01 00:00:00

abstract：:T-cell infiltration of solid tumors is associated with improved prognosis and favorable responses to immunotherapy. Mechanisms that enable tumor infiltration of CD8+ T cells have not been defined, nor have drugs that assist this process been discovered. Here we address these issues with a focus on VE-cadherin, a major...

journal_title：Cancer research

authors： Zhao Y,Ting KK,Li J,Cogger VC,Chen J,Johansson-Percival A,Ngiow SF,Holst J,Grau G,Goel S,Muller T,Dejana E,McCaughan G,Smyth MJ,Ganss R,Vadas MA,Gamble JR

更新日期：2017-08-15 00:00:00

abstract：:Estrogen-related receptor alpha (ERRalpha) was identified as a gene related to estrogen receptor alpha (ERalpha) and belongs to a class of nuclear orphan receptors. ERRalpha binds to estrogen responsive element(s) (ERE) and is considered to be involved in modulation of estrogenic actions. However, biological significa...

journal_title：Cancer research

authors： Suzuki T,Miki Y,Moriya T,Shimada N,Ishida T,Hirakawa H,Ohuchi N,Sasano H

更新日期：2004-07-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) functions primarily as an inhibitory neurotransmitter in the mature central nervous system, and GABA/GABA receptors are also present in nonneural tissues, including cancer, but their precise function in nonneuronal or cancerous cells has thus far been poorly defined. Through the genome-w...

journal_title：Cancer research

authors： Takehara A,Hosokawa M,Eguchi H,Ohigashi H,Ishikawa O,Nakamura Y,Nakagawa H

更新日期：2007-10-15 00:00:00

abstract：:Three murine hybridomas (TMMR-1-3) were developed by repeated immunizations of mice with four different human osteosarcoma cell lines in an alternating sequence of inoculations. The monoclonal antibodies were screened for reactivities to cultured cell lines and tissue sections of osteosarcomas using flow cytometry and...

journal_title：Cancer research

authors： Tsai CC,McGuire MH,Mellitt RJ,Ritter RA 3rd,Xu JZ,Litwicki DJ,Roodman ST

更新日期：1990-01-01 00:00:00

abstract：:ZR-75-1, a human breast cancer cell line, has been grown in hormone-supplemented medium without serum. The factors required for optimal growth include 17beta-estradiol, insulin, transferrin, dexamethasone, and L-triiodothyronine. If estradiol, insulin, or L-triiodothyronine is omitted, cells cease division within 7 da...

journal_title：Cancer research

authors： Allegra JC,Lippman ME

更新日期：1978-11-01 00:00:00

abstract：:Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic drivers of medulloblastoma and CNS-PNET. Cross-species gene expressi...

journal_title：Cancer research

authors： Beckmann PJ,Larson JD,Larsson AT,Ostergaard JP,Wagner S,Rahrmann EP,Shamsan GA,Otto GM,Williams RL,Wang J,Lee C,Tschida BR,Das P,Dubuc AM,Moriarity BS,Picard D,Wu X,Rodriguez FJ,Rosemarie Q,Krebs RD,Molan AM,Dem

更新日期：2019-03-01 00:00:00

abstract：:Angiogenesis, the sprouting of new blood vessels from existing vessels, occurs in many physiological and pathological processes, including embryonic development, wound healing, and tumor growth. It is required for tumor growth because new blood vessel formation is necessary for tumors to expand beyond a minimum volume...

journal_title：Cancer research

authors： Millauer B,Longhi MP,Plate KH,Shawver LK,Risau W,Ullrich A,Strawn LM

更新日期：1996-04-01 00:00:00

abstract：:Murine fibrosarcoma UV-2237MM cells were implanted into different organs of syngeneic C3H/HeN mice. The resultant tumors were treated by i.v. administration of Adriamycin (ADR). Despite the high sensitivity of the fibrosarcoma cells to ADR in vitro, the established tumors growing in vivo exhibited marked differences i...

journal_title：Cancer research

authors： Staroselsky AN,Fan D,O'Brian CA,Bucana CD,Gupta KP,Fidler IJ

更新日期：1990-12-15 00:00:00

abstract：:In cell lines of human small cell carcinoma of the lung (SCCL) and in all subclones of one of the cell lines, cells were observed which completely interiorized other cells, leading to death of the interiorized cells and sometimes to complete autodestruction of the cultures. This phenomenon, which we have called "canni...

journal_title：Cancer research

authors： Brouwer M,de Ley L,Feltkamp CA,Elema J,Jongsma AP

更新日期：1984-07-01 00:00:00

abstract：:Combination treatment of SKCO1 human colon carcinoma cells with beta ser-interferon (IFN-beta ser) and gamma-interferon (IFN-gamma) results in a synergistic antiproliferative effect. The role of IFN-beta ser and IFN-gamma receptor modulation was investigated as a possible mechanism for this response. IFN-gamma (0.05-5...

journal_title：Cancer research

authors： Schiller JH,Bushmeyer SM,Ruzicka FJ,Princler GL,Faltynek CR,Borden EC

更新日期：1990-01-01 00:00:00

abstract：:To identify mechanisms of camptothecin (CPT) resistance and the relationship between CPT-resistant cells and other anticancer agents, a CPT-resistant cell line (CPT30) and its partial revertant cell line (CPT30R) were established from a human nasopharyngeal carcinoma cell line (HONE-1). CPT30 and CPT30R cells displaye...

journal_title：Cancer research

authors： Chang JY,Liu JF,Juang SH,Liu TW,Chen LT

更新日期：2002-07-01 00:00:00

abstract：:Elimination of both alleles of the gene that encodes the cyclin kinase inhibitor p21(WAF1/cip1) increases the frequency and size of intestinal tumors in Apc1638+/- mice that inherit a mutant allele of the Apc gene, and intermediate effects are seen if a single p21 allele is inactivated. The increased tumor formation i...

journal_title：Cancer research

authors： Yang WC,Mathew J,Velcich A,Edelmann W,Kucherlapati R,Lipkin M,Yang K,Augenlicht LH

更新日期：2001-01-15 00:00:00

abstract：:Pleural fluid from a child previously treated for rhabdomyosarcoma produced colonies in vitro. Cells from these colonies appeared to have the light and electron microscopic appearance of rhabdomyosarcoma cells. In this case, the malignant nature of the effusion had been suspected because of the patient's previous hist...

journal_title：Cancer research

authors： Altman AJ,Crussi FG,Rierden WJ,Baehner RL

更新日期：1975-07-01 00:00:00

abstract：:The HMGA1 protein is a major factor in chromatin architecture and gene control. It plays a critical role in neoplastic transformation. In fact, blockage of HMGA1 synthesis prevents rat thyroid cell transformation by murine transforming retroviruses, and an adenovirus carrying the HMGA1 gene in the antisense orientatio...

journal_title：Cancer research

authors： Fedele M,Fidanza V,Battista S,Pentimalli F,Klein-Szanto AJ,Visone R,De Martino I,Curcio A,Morisco C,Del Vecchio L,Baldassarre G,Arra C,Viglietto G,Indolfi C,Croce CM,Fusco A

更新日期：2006-03-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most frequent and incurable type of brain tumor of adults. Hypoxia has been shown to direct GBM toward a more aggressive and malignant state. Here we show that hypoxia increases Notch1 activation, which in turn induces the expression of transient receptor potential 6 (TRPC6) in pri...

journal_title：Cancer research

authors： Chigurupati S,Venkataraman R,Barrera D,Naganathan A,Madan M,Paul L,Pattisapu JV,Kyriazis GA,Sugaya K,Bushnev S,Lathia JD,Rich JN,Chan SL

更新日期：2010-01-01 00:00:00

abstract：:Cachexia is a life-threatening wasting syndrome lacking effective treatment, which arises in many cancer patients. Although ostensibly induced by multiple tumor-produced cytokines (tumorkines), their functional contribution to initiation and progression of this syndrome has proven difficult to determine. In this study...

journal_title：Cancer research

authors： Chen JL,Walton KL,Qian H,Colgan TD,Hagg A,Watt MJ,Harrison CA,Gregorevic P

更新日期：2016-09-15 00:00:00