Modulation of interferon receptor expression during combination beta ser-interferon and gamma-interferon treatment of human colon carcinoma cells.

abstract：:Complete and accurate DNA replication is fundamental to cellular proliferation and genome stability. Obstacles that delay, prevent, or terminate DNA replication cause the phenomena termed DNA replication stress. Cancer cells exhibit chronic replication stress due to the loss of proteins that protect or repair stressed...

journal_title：Cancer research

authors： Ubhi T,Brown GW

更新日期：2019-04-15 00:00:00

abstract：:In a search for the molecular basis of ABH status of tumors as correlated with malignancy, we studied various malignancy-related phenotypes of high H/Le(y)-expressing tumor cell lines in comparison with phenotypes of the same lines transfected with histo-blood group A or B genes. A and B gene transfectants, prepared i...

journal_title：Cancer research

authors： Ichikawa D,Handa K,Withers DA,Hakomori S

更新日期：1997-08-01 00:00:00

abstract：:The association between total serum cholesterol and triglycerides and the incidence rate of breast cancer has been examined in 242 incident cases of breast cancer that developed among 24,329 Norwegian women during 11-14 years of follow-up. At the time of lipid measurement they were between 35 and 51 years of age. Ther...

journal_title：Cancer research

authors： Vatten LJ,Foss OP

更新日期：1990-04-15 00:00:00

abstract：:Human epithelial cell lines derived from both carcinomatous and nomalignant tissues were characterized with respect to the presence and distribution of fibronectin by immunofluorescence microscopy. In cell lines derived from nonmalignant tissues or from primary carcinomas, fibronectin was found predominantly in an ext...

journal_title：Cancer research

authors： Smith HS,Riggs JL,Mosesson MW

更新日期：1979-10-01 00:00:00

abstract：:Sporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such as regional DNA hypermethylation and global DNA hypomethylation. Epidemiological and animal studies suggest that aberrant DNA methylation is associated with low dietary folate intake, which is aggravated by high alcohol intake. Th...

journal_title：Cancer research

authors： van Engeland M,Weijenberg MP,Roemen GM,Brink M,de Bruïne AP,Goldbohm RA,van den Brandt PA,Baylin SB,de Goeij AF,Herman JG

更新日期：2003-06-15 00:00:00

abstract：:Calyculin A, isolated from a marine sponge, has a novel spiro ketal skeleton. Structurally unrelated to okadaic acid, calyculin A bound to the okadaic acid receptors in particulate and soluble fractions of mouse skin. The biochemical and tumor-promoting activities of calyculin A were studied with those of okadaic acid...

journal_title：Cancer research

authors： Suganuma M,Fujiki H,Furuya-Suguri H,Yoshizawa S,Yasumoto S,Kato Y,Fusetani N,Sugimura T

更新日期：1990-06-15 00:00:00

abstract：:Elevated expression of Bmi-1 is associated with many cancers, including breast cancer. Here, we examined the oncogenic potential of Bmi-1 in MCF10A cells, a spontaneously immortalized, nontransformed strain of human mammary epithelial cells (HMEC). Bmi-1 overexpression alone in MCF10A cells did not result in oncogenic...

journal_title：Cancer research

authors： Datta S,Hoenerhoff MJ,Bommi P,Sainger R,Guo WJ,Dimri M,Band H,Band V,Green JE,Dimri GP

更新日期：2007-11-01 00:00:00

abstract：:More than 35 different partner genes with the mixed lineage leukemia (MLL) gene have been cloned from leukemia cells with translocations involving chromosome 11 band q23. In this study, we report on a novel fusion partner of the MLL gene, AF4p12, which we have identified as the human homologue to the furry gene of Dro...

journal_title：Cancer research

authors： Hayette S,Cornillet-Lefebvre P,Tigaud I,Struski S,Forissier S,Berchet A,Doll D,Gillot L,Brahim W,Delabesse E,Magaud JP,Rimokh R

更新日期：2005-08-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) tumor suppressor protein is expressed in neurons of the central nervous system and plays an important role during the neuronal differentiation of central nervous system progenitor cells. To elucidate the neuronal differentiating potential of VHL protein in neuroblastoma cells, we overexpressed ...

journal_title：Cancer research

authors： Murata H,Tajima N,Nagashima Y,Yao M,Baba M,Goto M,Kawamoto S,Yamamoto I,Okuda K,Kanno H

更新日期：2002-12-01 00:00:00

abstract：:Intentional bacterial infections can produce efficacious antitumor responses in mice, rats, dogs, and humans. However, low overall success rates and intense side effects prevent such approaches from being employed clinically. In this work, we titered bacteria and/or the proinflammatory cytokine TNFα in a set of establ...

journal_title：Cancer research

authors： Hatzikirou H,López Alfonso JC,Leschner S,Weiss S,Meyer-Hermann M

更新日期：2017-04-01 00:00:00

abstract：:Glioblastoma is the most aggressive primary brain tumor and responds poorly to currently available therapies. Transcriptomic characterization of glioblastoma has identified distinct molecular subtypes of glioblastoma. Gain-of-function alterations leading to enhanced platelet-derived growth factor (PDGF) signaling are ...

journal_title：Cancer research

authors： Rahme GJ,Zhang Z,Young AL,Cheng C,Bivona EJ,Fiering SN,Hitoshi Y,Israel MA

更新日期：2016-05-15 00:00:00

abstract：:One hundred seven Chinese patients with primary hepatocellular carcinoma (PHC) were compared with 107 hospital controls for the presence of hepatitis B surface antigen and smoking, drinking, and dietary habits. Eighty-two % of PHC cases were hepatitis B surface antigen positive compared to 18% of controls (relative ri...

journal_title：Cancer research

authors： Lam KC,Yu MC,Leung JW,Henderson BE

更新日期：1982-12-01 00:00:00

abstract：:The underlying mechanism regulating the expression of the cancer stem cell/tumor-initiating cell marker CD133/prominin-1 in cancer cells remains largely unclear, although knowledge of this mechanism would likely provide important biological information regarding cancer stem cells. Here, we found that the inhibition of...

journal_title：Cancer research

authors： Matsumoto K,Arao T,Tanaka K,Kaneda H,Kudo K,Fujita Y,Tamura D,Aomatsu K,Tamura T,Yamada Y,Saijo N,Nishio K

更新日期：2009-09-15 00:00:00

abstract：:Interleukin (IL) 6 was measured in the serum of 138 patients with metastatic renal carcinoma before the initiation of IL-2 treatment. IL-6 was detectable in 66 patients with renal cancer (48%) and in only 8 of 70 normal adults (11%). Serum C reactive protein (CRP) and IL-6 levels are correlated, suggesting that IL-6 i...

journal_title：Cancer research

authors： Blay JY,Negrier S,Combaret V,Attali S,Goillot E,Merrouche Y,Mercatello A,Ravault A,Tourani JM,Moskovtchenko JF

更新日期：1992-06-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease that is characterized by a particularly marked resistance to chemotherapy. We previously showed an association between decreased expression of BNIP3 and chemoresistance in PDAC cell lines. To further explore the molecular basis of chemoresistance in PDAC...

journal_title：Cancer research

authors： Mahon PC,Baril P,Bhakta V,Chelala C,Caulee K,Harada T,Lemoine NR

更新日期：2007-07-15 00:00:00

abstract：:Mice fed a diet containing 0.3 or 0.03% triethanolamine developed malignant tumors. Females showed a high incidence of tumors in lymphoid tissues, while this type was absent in males. Tumors in other tissues were produced at a considerable rate in both sexes, but no hepatoma was found. Triethanolamine was not mutageni...

journal_title：Cancer research

authors： Hoshino H,Tanooka H

更新日期：1978-11-01 00:00:00

abstract：:We describe two flow cytometric assays performed on populations of cells which have been stained with various fluorescent tracer molecules by the scrape-loading technique. One assay uses a simple one-color analysis on a flow cytometer by quantitating the fluorescence intensity of scrape-loaded lucifer yellow CH (LY) i...

journal_title：Cancer research

authors： Kavanagh TJ,Martin GM,el-Fouly MH,Trosko JE,Chang CC,Rabinovitch PS

更新日期：1987-11-15 00:00:00

abstract：:The chemotherapeutic effect of B859-35, the (-)-enantiomer of dihydropyrine 3-methyl-5-3-(4,4-diphenyl-1-piperidinyl)-propyl-1,4-dihydro-2,6-dimethy l-4- (3-nitrophenyl)-pyridine-3,5-dicarboxylate-hydrochloride (niguldipine), was tested on tumors induced in Syrian golden hamsters by N-nitrosodiethylamine (DEN). Periph...

journal_title：Cancer research

authors： Schuller HM,Correa E,Orloff M,Reznik GK

更新日期：1990-03-01 00:00:00

abstract：:The role of the immune system in tumor elimination has been shown to be increasingly ambiguous, as many tumors not only escape recognition by the adaptive immune response but also even prime the immune cells to promote tumor growth. This effect is achieved through a number of mechanisms, which include both direct inte...

journal_title：Cancer research

authors： Kareva I,Hahnfeldt P

更新日期：2013-05-01 00:00:00

abstract：:HER-2/neu (neu-N) transgenic mice, which express the nontransforming rat proto-oncogene, develop spontaneous focal mammary adenocarcinomas beginning at 5-6 months of age. The development and histology of these tumors bears a striking resemblance to what is seen in patients with breast cancer. We have characterized the...

journal_title：Cancer research

authors： Reilly RT,Gottlieb MB,Ercolini AM,Machiels JP,Kane CE,Okoye FI,Muller WJ,Dixon KH,Jaffee EM

更新日期：2000-07-01 00:00:00

abstract：:The study of two major risk factors in the development of hepatocellular carcinoma, namely persistent hepatitis virus infection and exposure to dietary aflatoxins, has been hampered by lack of an experimental system. To this end we have used a Pekin duck model to examine the effect of congenital duck hepatitis B virus...

journal_title：Cancer research

authors： Cova L,Wild CP,Mehrotra R,Turusov V,Shirai T,Lambert V,Jacquet C,Tomatis L,Trépo C,Montesano R

更新日期：1990-04-01 00:00:00

abstract：:Sputum samples obtained during the screening phase of a chemoprevention trial in heavy smokers were evaluated independently by trained cytotechnologists and classified for degree of cellular atypia according to the method of Saccommano et al. (G. Saccommano et al., Cancer (Phila.), 33: 256-270, 1974). The level of agr...

journal_title：Cancer research

authors： Browman GP,Arnold A,Levine MN,D'Souza T,Turner-Smith LM,Cayco R,Johnstone B,Birse R

更新日期：1990-02-15 00:00:00

abstract：:Melanoma is a disease characterized by lesions that activate ERK. Although 70% of cutaneous melanomas harbor activating mutations in the BRAF and NRAS genes, the alterations that drive tumor progression in the remaining 30% are largely undefined. Vemurafenib, a selective inhibitor of RAF kinases, has clinical utility ...

journal_title：Cancer research

authors： Nissan MH,Pratilas CA,Jones AM,Ramirez R,Won H,Liu C,Tiwari S,Kong L,Hanrahan AJ,Yao Z,Merghoub T,Ribas A,Chapman PB,Yaeger R,Taylor BS,Schultz N,Berger MF,Rosen N,Solit DB

更新日期：2014-04-15 00:00:00

abstract：:Variant cell lines that are sensitive to density-dependent inhibition of growth have been isolated from three of four SV40-transformed human fibroblast cell lines. Variants were isolated by plating the transformed cells at low density, by treating them with 5-fluorodeoxyuridine, or by growing them on glutaraldehyde-fi...

journal_title：Cancer research

authors： Rosenberg N,Schaeffer WI,Diamond L

更新日期：1975-08-01 00:00:00

abstract：:The partial pressure of oxygen (pO2) of FSaII tumors grown in the leg of C3H mice significantly improved when the tumors were heated by immersing the tumor-bearing legs in a water bath at 41.5 degrees C for 60 min. The tumor pO2 also substantially increased when the tumor-bearing mice breathed carbogen (95% O2:5% CO2)...

journal_title：Cancer research

authors： Griffin RJ,Okajima K,Barrios B,Song CW

更新日期：1996-12-15 00:00:00

abstract：:Placenta growth factor (PlGF) is a mitogen for endothelial cells that can potentiate the growth and permeabilizing effects on endothelium of vascular endothelial growth factor. Here we report that hypoxia induces the expression of both PlGF mRNA and protein in immortalized/transformed mouse embryonic fibroblasts (mEFs...

journal_title：Cancer research

authors： Green CJ,Lichtlen P,Huynh NT,Yanovsky M,Laderoute KR,Schaffner W,Murphy BJ

更新日期：2001-03-15 00:00:00

abstract：:The human melanoma cell line NEL-M1 proliferates in Ham's F-12 medium in the absence of serum, hormones, and growth factors. Culturing NEL-M1 cells in defined medium supplemented with insulin (5 micrograms/ml) and transferrin (5 micrograms/ml) results in a 94% increase in [3H]thymidine incorporation after 24 h and a 6...

journal_title：Cancer research

authors： DiSorbo DM

更新日期：1986-08-01 00:00:00

abstract：:We examined the role of constitutional genetic variation at the UDP-glucuronosyltransferase (UGT) 1A1 locus in breast cancer susceptibility. The UGT1A1 enzyme is a major UGT involved in estradiol glucuronidation. To date, four UGT1A1 variant alleles characterized by a variation in the number of TA from five through ei...

journal_title：Cancer research

authors： Guillemette C,Millikan RC,Newman B,Housman DE

更新日期：2000-02-15 00:00:00

abstract：:In vitro tests of tumor cell drug sensitivity have been suggested as a means of selecting more appropriate clinical strategies against human cancer and improving preclinical drug development. The lack of biotransformation in these in vitro assays precludes the meaningful assessment of several major chemotherapeutic ag...

journal_title：Cancer research

authors： Kirkwood JM,Marsh JC

更新日期：1983-07-01 00:00:00

abstract：:Overexpression of interleukin 6, a downstream target of the GBX2 homeobox gene, has been linked to the progression of prostate cancer. The Janus kinase-signal transducers and activators of transcription signaling pathway transmits interleukin 6-mediated signals from cell surface receptors to the target genes in the nu...

journal_title：Cancer research

authors： Ni Z,Lou W,Leman ES,Gao AC

更新日期：2000-03-01 00:00:00