Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11.

abstract：:Formalin-fixed, paraffin-embedded tissues from 108 cases of invasive carcinoma of the uterine cervix, consisting of 40 cases of adenocarcinoma, 44 cases of adenosquamous carcinoma, and, as a control, 24 cases of squamous cell carcinoma were examined for the presence of human papillomavirus (HPV) DNA by in situ hybridi...

journal_title：Cancer research

authors： Tase T,Okagaki T,Clark BA,Manias DA,Ostrow RS,Twiggs LB,Faras AJ

更新日期：1988-02-15 00:00:00

abstract：:The incidence, distribution, size, and histopathology of grossly visible colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed either a chemically defined fiber-free diet or a nutritionally and calorically equivalent diet containing a purified fiber component, microcrys...

journal_title：Cancer research

authors： Freeman HJ,Spiller GA,Kim YS

更新日期：1978-09-01 00:00:00

abstract：:Metformin, a biguanide widely used in the treatment of type II diabetes, clearly exhibits antineoplastic activity in experimental models and has been reported to reduce cancer incidence in diabetics. There are ongoing clinical trials to evaluate its antitumor properties, which may relate to its fundamental activity as...

journal_title：Cancer research

authors： Gravel SP,Hulea L,Toban N,Birman E,Blouin MJ,Zakikhani M,Zhao Y,Topisirovic I,St-Pierre J,Pollak M

更新日期：2014-12-15 00:00:00

abstract：:To analyze the distribution of radioactive carcinogens and [3H]thymidine between nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), we have developed a simple and rapid method for the separation of nDNA and mtDNA using gel electrophoresis of cell lysates. Using this method, we found that, when C3H10T 1/2 cells are expo...

journal_title：Cancer research

authors： Backer JM,Weinstein IB

更新日期：1982-07-01 00:00:00

abstract：:Intestinal radiation injury is dose limiting during abdominal and pelvic radiotherapy and critical for the outcome after accidental whole-body radiation exposure. The multifunctional cytokine, interleukin-11 (IL-11), ameliorates the intestinal radiation response, but its clinical use is hampered by severe toxicity aft...

journal_title：Cancer research

authors： Boerma M,Wang J,Burnett AF,Santin AD,Roman JJ,Hauer-Jensen M

更新日期：2007-10-01 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:Ependymomas and astrocytomas commonly have allelic losses of chromosome 22q, which suggests the presence of a glioma tumor suppressor gene on 22q. A candidate tumor suppressor gene on 22q is the neurofibromatosis 2 (NF2) gene since NF2 patients have an increased susceptibility to ependymomas and astrocytomas. Using si...

journal_title：Cancer research

authors： Rubio MP,Correa KM,Ramesh V,MacCollin MM,Jacoby LB,von Deimling A,Gusella JF,Louis DN

更新日期：1994-01-01 00:00:00

abstract：:We examined the DNA methylation pathway in an autochthonous murine prostate cancer model, transgenic adenocarcinoma of mouse prostate (TRAMP). We observed that, compared with strain-matched normal prostates, primary and metastatic TRAMP tumors display increased cytosine DNA methyltransferase (Dnmt) activity, Dnmt1 and...

journal_title：Cancer research

authors： Morey SR,Smiraglia DJ,James SR,Yu J,Moser MT,Foster BA,Karpf AR

更新日期：2006-12-15 00:00:00

abstract：:Although androgen ablation therapy is effective in treating primary prostate cancers, a significant number of patients develop incurable castration-resistant disease. Recent studies have suggested a potential synergy between vaccination and androgen ablation, yet the enhanced T-cell function is transient. Using a defi...

journal_title：Cancer research

authors： Tang S,Moore ML,Grayson JM,Dubey P

更新日期：2012-04-15 00:00:00

abstract：:Cytogenetic analyses of intraspecies human HeLa X fibroblast hybrid cell populations have provided tentative evidence for the correlation of loss of a single copy of chromosomes 11 and 14 with reexpression of tumorigenicity. In this study paired combinations of nontumorigenic and tumorigenic segregant HeLa X fibroblas...

journal_title：Cancer research

authors： Srivatsan ES,Benedict WF,Stanbridge EJ

更新日期：1986-12-01 00:00:00

abstract：:We report that tumor necrosis factor (TNF) alpha induced a strong antitumor immune reaction when it was produced in arteries leading to tumors by gene transfer in vivo. We used a mouse model carrying a sarcoma-180 tumor in the right footpad and injected the fusogenic liposomes encapsulating the human TNF-alpha gene in...

journal_title：Cancer research

authors： Mizuguchi H,Nakagawa T,Toyosawa S,Nakanishi M,Imazu S,Nakanishi T,Tsutsumi Y,Nakagawa S,Hayakawa T,Ijuhin N,Mayumi T

更新日期：1998-12-15 00:00:00

abstract：:The tumor microenvironment is characterized by regions of fluctuating and chronic hypoxia, low pH, and nutrient deprivation. It has been proposed that this unique tissue environment itself may constitute a major cause of the genetic instability seen in cancer. To investigate possible mechanisms by which the tumor micr...

journal_title：Cancer research

authors： Yuan J,Narayanan L,Rockwell S,Glazer PM

更新日期：2000-08-15 00:00:00

abstract：:The induction of phase 2 detoxifying enzymes, such as UDP-glucuronosyltransferases (UGTs), in response to an array of naturally occurring and synthetic agents, such as oltipraz (4-methyl-5-[2-pyrazinyl]-1,2-dithiole-3-thione), provides an effective means of protection against a variety of carcinogens. Transcription fa...

journal_title：Cancer research

authors： Iida K,Itoh K,Kumagai Y,Oyasu R,Hattori K,Kawai K,Shimazui T,Akaza H,Yamamoto M

更新日期：2004-09-15 00:00:00

abstract：:Metastasis-suppressing gene product CD82 and its analogue CD9 are considered to suppress the malignancy of various human cancers, although the rationale for this effect is unknown. The present study addresses phenotypic changes in Chinese hamster ovary mutant cell line ldlD deficient in UDP-Glc 4-epimerase and express...

journal_title：Cancer research

authors： Ono M,Handa K,Withers DA,Hakomori S

更新日期：1999-05-15 00:00:00

abstract：:Increasing the expression of c-FMS (colony-stimulating factor 1 receptor) by introduction of a transgene reduced the concentration of retinoic acid or 1,25-dihydroxy vitamin D3 needed to cause myeloid or monocytic cell differentiation and hypophosphorylation of the retinoblastoma tumor suppressor protein (RB) typicall...

journal_title：Cancer research

authors： Yen A,Sturgill R,Varvayanis S

更新日期：1997-05-15 00:00:00

abstract：:Overexpression of the adverse prognostic marker ERBB2 occurs in 30% of breast cancers; however, therapies targeting this gene have not proved to be as effective as was initially hoped. Transcriptional profiling meta-analyses have shown that there are approximately 150 genes co-overexpressed with ERBB2, suggesting that...

journal_title：Cancer research

authors： Kourtidis A,Jain R,Carkner RD,Eifert C,Brosnan MJ,Conklin DS

更新日期：2010-03-01 00:00:00

abstract：:Although radiotherapy (RT) decreases the incidence of locoregional recurrence in breast cancer, patients with triple-negative breast cancer (TNBC) have increased risk of local recurrence following breast-conserving therapy. The relationship between RT and local recurrence is unknown. Here, we tested the hypothesis tha...

journal_title：Cancer research

authors： Rafat M,Aguilera TA,Vilalta M,Bronsart LL,Soto LA,von Eyben R,Golla MA,Ahrari Y,Melemenidis S,Afghahi A,Jenkins MJ,Kurian AW,Horst KC,Giaccia AJ,Graves EE

更新日期：2018-08-01 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM) is a progressive destructive neoplasm of the lung associated with inactivating mutations in the TSC1 or TSC2 tumor suppressor genes. Cell or animal models that accurately reflect the pathology of LAM have been challenging to develop. Here, we generated a robust human cell model of LAM by...

journal_title：Cancer research

authors： Julian LM,Delaney SP,Wang Y,Goldberg AA,Doré C,Yockell-Lelièvre J,Tam RY,Giannikou K,McMurray F,Shoichet MS,Harper ME,Henske EP,Kwiatkowski DJ,Darling TN,Moss J,Kristof AS,Stanford WL

更新日期：2017-10-15 00:00:00

abstract：:Imatinib currently represents the standard treatment in the early chronic phase of chronic myelogenous leukemia (CML), thanks to the high percentage of cytogenetic complete remission achieved, but it is yet unclear to what extent it can eradicate leukemia. Therefore, different vaccination strategies have been suggeste...

journal_title：Cancer research

authors： Volpe G,Cignetti A,Panuzzo C,Kuka M,Vitaggio K,Brancaccio M,Perrone G,Rinaldi M,Prato G,Fava M,Geuna M,Pautasso M,Casnici C,Signori E,Tonon G,Tarone G,Marelli O,Fazio VM,Saglio G

更新日期：2007-06-01 00:00:00

abstract：:The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of their high sequence homology. Here we analyze the separate contributions o...

journal_title：Cancer research

authors： Oxford G,Owens CR,Titus BJ,Foreman TL,Herlevsen MC,Smith SC,Theodorescu D

更新日期：2005-08-15 00:00:00

abstract：:In spite of preclinical efficacy and recent randomized, controlled studies with adenoviral vectors expressing herpes simplex virus-1 thymidine kinase (HSV1-TK) showing statistically significant increases in survival, most clinical trials using single therapies have failed to provide major therapeutic breakthroughs. Be...

journal_title：Cancer research

authors： Ali S,King GD,Curtin JF,Candolfi M,Xiong W,Liu C,Puntel M,Cheng Q,Prieto J,Ribas A,Kupiec-Weglinski J,van Rooijen N,Lassmann H,Lowenstein PR,Castro MG

更新日期：2005-08-15 00:00:00

abstract：:Spy1A is a unique cell cycle activator known to mediate cell cycle progression and override the DNA damage response. This study focused on determining the role of this protein on postnatal mammary gland morphogenesis and neoplasia. Herein, we show that Spy1A levels are tightly regulated during mammary gland developmen...

journal_title：Cancer research

authors： Golipour A,Myers D,Seagroves T,Murphy D,Evan GI,Donoghue DJ,Moorehead RA,Porter LA

更新日期：2008-05-15 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) cells have constitutively high expression of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX) 2. These NSCLC cells also have increased prostaglandin expression (PGE2). Many lung cancers also express 12-lipoxygenase RNA and 12-lipoxygenase protein and biosynthesize 12(S)-hy...

journal_title：Cancer research

authors： Soriano AF,Helfrich B,Chan DC,Heasley LE,Bunn PA Jr,Chou TC

更新日期：1999-12-15 00:00:00

abstract：:2-Amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic amine present in pyrolysate products of meat and fish and has been shown to induce tumors in the colon, mammary gland, and possibly lymphatic system. Experiments were designed to examine the lymphoma-inducing capacity o...

journal_title：Cancer research

authors： Rao CV,Rivenson A,Zang E,Steele V,Kelloff G,Reddy BS

更新日期：1996-08-01 00:00:00

abstract：:The effects of 5-mercapto-2'-deoxyuridine (MUdr) on DNA synthesis in a primary murine spleen lymphocyte culture system stimulated by phytohemagglutinin (PHA) were studied. Inhibition of thymidine incorporation into acid insoluble nucleic acid material was 50% at 0.5 mM MUdR concentration, while inhibition of deoxyurid...

journal_title：Cancer research

authors： Bogyo D,Bardos TJ,Chmielewicz ZF

更新日期：1976-09-01 00:00:00

abstract：:Previous studies have shown that the invasion of V2 carcinoma cells in the rabbit mesentery is associated with marked extracellular matrix synthesis leading eventually to an overall increase in mesenteric mass. The purpose of the present study was to investigate the structural and biochemical composition of the extrac...

journal_title：Cancer research

authors： Iozzo RV,Müller-Glauser W

更新日期：1985-11-01 00:00:00

abstract：:Obesity enhances breast cancer risk in postmenopausal women and premenopausal women with genetic or familial risk factors. We have shown previously that within breast tissue, obesity increases macrophage-driven inflammation and promotes expansion of luminal epithelial cell populations that are hypothesized to be the c...

journal_title：Cancer research

authors： Chamberlin T,Clack M,Silvers C,Kuziel G,Thompson V,Johnson H,Arendt LM

更新日期：2020-10-15 00:00:00

abstract：:Elevated levels of TGFβ are a negative prognostic indicator for patients diagnosed with pancreatic cancer; as a result, the TGFβ pathway is an attractive target for therapy. However, clinical application of pharmacologic inhibition of TGFβ remains challenging because TGFβ has tumor suppressor functions in many epithel...

journal_title：Cancer research

authors： Ostapoff KT,Cenik BK,Wang M,Ye R,Xu X,Nugent D,Hagopian MM,Topalovski M,Rivera LB,Carroll KD,Brekken RA

更新日期：2014-09-15 00:00:00

abstract：:Retroviral and transposon-based mutagenesis screens in mice have been useful for identifying candidate cancer genes for some tumor types. However, many of the organs that exhibit the highest cancer rates in humans, including the prostate, have not previously been amenable to these approaches. This study shows for the ...

journal_title：Cancer research

authors： Rahrmann EP,Collier LS,Knutson TP,Doyal ME,Kuslak SL,Green LE,Malinowski RL,Roethe L,Akagi K,Waknitz M,Huang W,Largaespada DA,Marker PC

更新日期：2009-05-15 00:00:00

abstract：:This review portrays an updated overview about the possible tumor suppressive properties of the Rb2/p130 gene, the third member of the retinoblastoma (RB) family of genes, including RB itself and p107. After a brief analysis of the established structural and functional similarities among the three genes, the main purp...

journal_title：Cancer research

authors： Paggi MG,Giordano A

更新日期：2001-06-15 00:00:00