Neoplastic modulation of extracellular matrix: proteoglycan changes in the rabbit mesentery induced by V2 carcinoma cells.

abstract：:Genetic immunization of mice with dendritic cells (DCs) engineered to express a melanoma antigen generates antigen-specific, MHC-restricted, CD4-dependent protective immune responses. We wanted to determine the role of CD4 cells and CD40 ligation of MART-1 gene-modified DC in an animal model of immunotherapy for murin...

journal_title：Cancer research

authors： Ribas A,Butterfield LH,Amarnani SN,Dissette VB,Kim D,Meng WS,Miranda GA,Wang HJ,McBride WH,Glaspy JA,Economou JS

更新日期：2001-12-15 00:00:00

abstract：:Genes encoding the four principal polypeptide domains (N, A1-B1, A2-B2, and A3-B3) of carcinoembryonic antigen (CEA) were synthesized and expressed in Escherichia coli as fusion products with bacterial CMP-KDO synthetase (CKS). The four synthetic fusion proteins were purified in high yield and used as targets in Weste...

journal_title：Cancer research

authors： Hass GM,Bolling TJ,Kinders RJ,Henslee JG,Mandecki W,Dorwin SA,Shively JE

更新日期：1991-04-01 00:00:00

abstract：:For many solid tumors, surgical resection remains the gold standard and tumor-involved margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence imaging using molecular agents has shown promise for in situ imaging during resection. However, for cancers with difficult imaging conditions, surg...

journal_title：Cancer research

authors： Gao RW,Teraphongphom NT,van den Berg NS,Martin BA,Oberhelman NJ,Divi V,Kaplan MJ,Hong SS,Lu G,Ertsey R,Tummers WSFJ,Gomez AJ,Holsinger FC,Kong CS,Colevas AD,Warram JM,Rosenthal EL

更新日期：2018-09-01 00:00:00

abstract：:MYC exerts both positive and negative functions in cancer cells, such that its procancerous effects are unmasked only after its anticancer effects are blocked. Here we used multiple mouse models of lung adenocarcinoma to identify genetic events that can cooperate with MYC activation to promote the genesis of non-small...

journal_title：Cancer research

authors： Allen TD,Zhu CQ,Jones KD,Yanagawa N,Tsao MS,Bishop JM

更新日期：2011-03-15 00:00:00

abstract：:The receptor Notch1 plays an important role in malignant progression of many cancers, but its regulation is not fully understood. In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7-dependent proteasomal degradation of Notch1 by phosphorylating its intracellular domain (Notch1-IC) w...

journal_title：Cancer research

authors： Ann EJ,Kim MY,Yoon JH,Ahn JS,Jo EH,Lee HJ,Lee HW,Kang HG,Choi DW,Chun KH,Lee JS,Choi CY,Ferrando AA,Lee K,Park HS

更新日期：2016-08-15 00:00:00

abstract：:Cyclooxygenase-2 is a valid target for cancer prevention and treatment. This has been shown in preclinical and clinical cancer prevention studies by using a cyclooxygenase-2 inhibitor, celecoxib. When used in a randomized cancer prevention clinical trial on patients with the inherited autosomal dominant condition, fam...

journal_title：Cancer research

authors： Xiao Z,Luke BT,Izmirlian G,Umar A,Lynch PM,Phillips RK,Patterson S,Conrads TP,Veenstra TD,Greenwald P,Hawk ET,Ali IU

更新日期：2004-04-15 00:00:00

abstract：:Cells with a temperature-sensitive mutant of the v-abl oncoprotein (IC.DP) were treated with the anticancer drugs melphalan or hydroxyurea. At the restrictive temperature for v-ABL protein tyrosine kinase activity, drug-treated IC.DP cells died by apoptosis. In contrast, apoptotic cell death induced by either drug was...

journal_title：Cancer research

authors： Chapman RS,Whetton AD,Dive C

更新日期：1994-10-01 00:00:00

abstract：:Dietary factors can modify metabolic events involved in the initiation, promotion, or progression of tumors. To determine whether a high-sucrose diet has any effect on the development of enzyme-altered foci during the promotion step of chemical hepatocarcinogenesis in rats, 1-day-old Sprague-Dawley rats were given a s...

journal_title：Cancer research

authors： Hei TK,Sudilovsky O

更新日期：1985-06-01 00:00:00

abstract：:Increasing evidence argues that the success of an anticancer treatment may rely on immunoadjuvant side effects including the induction of immunogenic tumor cell death. Based on the assumption that this death mechanism is a similar prerequisite for the efficacy of an active immunotherapy using killed tumor cells, we ex...

journal_title：Cancer research

authors： Zappasodi R,Pupa SM,Ghedini GC,Bongarzone I,Magni M,Cabras AD,Colombo MP,Carlo-Stella C,Gianni AM,Di Nicola M

更新日期：2010-11-15 00:00:00

abstract：:The Inflammation and Cancer Think Tank Meeting was organized by the National Cancer Institute with the purpose of identifying research advances, gaps, and opportunities for the study and clinical application of the role of inflammation on tumorigenesis. The format of this meeting consisted of brief presentations that ...

journal_title：Cancer research

authors： Peek RM Jr,Mohla S,DuBois RN

更新日期：2005-10-01 00:00:00

abstract：:The presence of common genomic deletions in the 19q13 chromosomal region in neuroblastomas and gliomas strongly suggests the presence of a putative tumor suppressor gene for these neoplasms in this region that, despite much effort, has not yet been identified. In an attempt to address this issue, we compared the expre...

journal_title：Cancer research

authors： Alaminos M,Dávalos V,Ropero S,Setién F,Paz MF,Herranz M,Fraga MF,Mora J,Cheung NK,Gerald WL,Esteller M

更新日期：2005-04-01 00:00:00

abstract：:CUB domain-containing protein 1 (CDCP1) is a membrane protein that is highly expressed in several solid cancers. We reported previously that CDCP1 regulates anoikis resistance as well as cancer cell migration and invasion, although the underlying mechanisms have not been elucidated. In this study, we found that expres...

journal_title：Cancer research

authors： Miyazawa Y,Uekita T,Hiraoka N,Fujii S,Kosuge T,Kanai Y,Nojima Y,Sakai R

更新日期：2010-06-15 00:00:00

abstract：:We have investigated the antiproliferative and cytotoxic effects of selected enediynes against three Kaposi's sarcoma (KS) cell lines. The enediynes tested were found to be very potent in inhibiting the growth of KS cells. Treatment with concentrations of 10(-10) M or less were capable of producing 50% inhibition of g...

journal_title：Cancer research

authors： Corbeil J,Richman DD,Wrasidlo W,Nicolaou KC,Looney DJ

更新日期：1994-08-15 00:00:00

abstract：:Eight analogues of 2,5-bis(carboethoxyamino)-3,6-diaziridinyl-1,4-benzoquinone have been synthesized and tested for cytotoxicity against four different leukemic and lymphomic cell lines. For K562 and BSM cells, the toxicity could be correlated with the ease of reduction of the compounds as determined by the one-electr...

journal_title：Cancer research

authors： Dzielendziak A,Butler J,Hoey BM,Lea JS,Ward TH

更新日期：1990-04-01 00:00:00

abstract：:Checkpoint inhibitors like anti-PD1/PD-L1 have demonstrated significant therapeutic efficacy in a subset of patients partly through reinvigoration of CD8 T cells. However, their impact on myeloid cells remains largely unknown. Here, we report that anti-PD-L1 treatment favorably impacts the phenotype and function of tu...

journal_title：Cancer research

authors： Xiong H,Mittman S,Rodriguez R,Moskalenko M,Pacheco-Sanchez P,Yang Y,Nickles D,Cubas R

更新日期：2019-04-01 00:00:00

abstract：:Donor lymphocyte infusions (DLI) provide effective therapy for patients with multiple myeloma who have relapsed after allogeneic bone marrow transplantation. However, the immunological mechanisms of the graft-versus-myeloma (GVM) effect have not been defined, and the target antigens of this response have not been iden...

journal_title：Cancer research

authors： Orsini E,Bellucci R,Alyea EP,Schlossman R,Canning C,McLaughlin S,Ghia P,Anderson KC,Ritz J

更新日期：2003-05-15 00:00:00

abstract：:Synovial sarcomas are aggressive spindle cell sarcomas containing in some cases areas of epithelial differentiation. They consistently show a specific t(X;18;p11;q11), which usually represents either of two gene fusions, SYT-SSX1 or SYT-SSX2, encoding putative transcriptional proteins differing at 13 amino acid positi...

journal_title：Cancer research

authors： Ladanyi M,Antonescu CR,Leung DH,Woodruff JM,Kawai A,Healey JH,Brennan MF,Bridge JA,Neff JR,Barr FG,Goldsmith JD,Brooks JS,Goldblum JR,Ali SZ,Shipley J,Cooper CS,Fisher C,Skytting B,Larsson O

更新日期：2002-01-01 00:00:00

abstract：:Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-...

journal_title：Cancer research

authors： Chabottaux V,Sounni NE,Pennington CJ,English WR,van den Brûle F,Blacher S,Gilles C,Munaut C,Maquoi E,Lopez-Otin C,Murphy G,Edwards DR,Foidart JM,Noël A

更新日期：2006-05-15 00:00:00

abstract：:We report on the identification of autoantigens commonly recognized by sera from patients with breast cancer. We selected ten sera from patients with invasive ductal carcinoma (IDC) of the breast with high titer IgG autoantibodies for biopanning of a T7 phage breast cancer cDNA display library. A high throughput metho...

journal_title：Cancer research

authors： Fernández-Madrid F,Tang N,Alansari H,Granda JL,Tait L,Amirikia KC,Moroianu M,Wang X,Karvonen RL

更新日期：2004-08-01 00:00:00

abstract：:Local irradiation of tumors of rats bearing 3924A hepatomas resulted in more than a doubling of the putrescine levvel and nearly a doubling of spermidine concentration in the serum within 12 hr. Within 24 hr, the putrescine concentration had increased four-fold in the serum, along with a continued increase in the sper...

journal_title：Cancer research

authors： Russell DH,Looney WB,Kovacs CJ,Hopkins HA,Dattilo JW,Morris HP

更新日期：1976-02-01 00:00:00

abstract：:Snail is a key regulator of epithelial-mesenchymal transition (EMT), which is a major step in tumor metastasis. Although the induction of Snail transcription precedes EMT, posttranslational regulation, especially phosphorylation of Snail, is critical for determining Snail protein levels or stability, subcellular local...

journal_title：Cancer research

authors： Ryu KJ,Park SM,Park SH,Kim IK,Han H,Kim HJ,Kim SH,Hong KS,Kim H,Kim M,Yoon SJ,Asaithambi K,Lee KH,Park JY,Hah YS,Cho HJ,Yook JI,Yang JW,Ko GH,Lee G,Kang YJ,Hwangbo C,Kim KD,Park YJ,Yoo J

更新日期：2019-08-15 00:00:00

abstract：:CDC25A phosphatase activates multiple cyclin-dependent kinases (CDK) during cell cycle progression. Inactivation of CDC25A by ubiquitin-mediated degradation is a major mechanism of DNA damage-induced S-G(2) checkpoint. Although increased CDC25A expression has been reported in various human cancer tissues, it remains u...

journal_title：Cancer research

authors： Ray D,Terao Y,Nimbalkar D,Hirai H,Osmundson EC,Zou X,Franks R,Christov K,Kiyokawa H

更新日期：2007-07-15 00:00:00

abstract：:The mechanism of the previously reported cytotoxicity of liposomes containing plant phosphatidylinositol (PI) against numerous tumor cell lines was examined in detail by using liposomes containing synthetic PI specifically labeled either with radioactive myo-inositol, or in the sn-2 position with radioactive linoleic ...

journal_title：Cancer research

authors： Jett M,Chudzik J,Alving CR,Stanacev NZ

更新日期：1985-10-01 00:00:00

abstract：:A phosphorylation site was introduced into chimeric monoclonal antibody B72.3 (MAb-chB72.3) by site-specific mutation of the coding sequence. The phosphorylation site for the cAMP-dependent protein kinase was positioned at the carboxyl terminus of the heavy-chain constant region of MAb-chB72.3. The resultant modified ...

journal_title：Cancer research

authors： Lin L,Daugherty B,Schlom J,Pestka S

更新日期：1996-09-15 00:00:00

abstract：:The metastasizing MDAY-D2 tumor of DBA/2 mice disseminates in BALB/c allogeneic athymic nude (nu/nu) mice in a manner identical to that observed in the syngeneic host. Both the kinetics and organ distribution pattern of metastases from s.c. implants of MDAY-D2 are routinely predictable at any given tumor dose. BALB/c ...

journal_title：Cancer research

authors： Wiltrout RH,Frost P,Morrison MK,Kerbel RS

更新日期：1979-10-01 00:00:00

abstract：:Deregulation of translation initiation factors contributes to many pathogenic conditions, including cancer. Here, we report the definition of a novel regulatory pathway for translational initiation with possible therapeutic import in cancer. Specifically, we found that casein kinase 1ε (CK1ε) is highly expressed in br...

journal_title：Cancer research

authors： Shin S,Wolgamott L,Roux PP,Yoon SO

更新日期：2014-01-01 00:00:00

abstract：:Although mutated forms of ras are not associated with the majority of breast cancers (<5%), there is considerable experimental evidence that hyperactive Ras can promote breast cancer growth and development. Therefore, we determined whether Ras and Ras-responsive signaling pathways were activated persistently in nine w...

journal_title：Cancer research

authors： Eckert LB,Repasky GA,Ulkü AS,McFall A,Zhou H,Sartor CI,Der CJ

更新日期：2004-07-01 00:00:00

abstract：:Two continuous retinoblastoma cell lines were observed by scanning electron microscopy. Both cell lines spontaneously grow as a suspension of round cells in clusters, chains, and unique ring (rosette) formations. Scanning electron microscopy of suspension cells reveals some variation in the number and frequency of sur...

journal_title：Cancer research

authors： McFall RC,Nagy RM,Nagle BT,McGreevy LM

更新日期：1978-09-01 00:00:00

abstract：:Autotaxin (ATX) is an exoenzyme that potently induces tumor cell motility, and enhances experimental metastasis and angiogenesis. ATX was shown recently to be identical to serum lysophospholipase D activity, producing lysophosphatidic acid (LPA) from lyso-glycerophospholipids. LPA, itself a strong chemoattractant for ...

journal_title：Cancer research

authors： Clair T,Aoki J,Koh E,Bandle RW,Nam SW,Ptaszynska MM,Mills GB,Schiffmann E,Liotta LA,Stracke ML

更新日期：2003-09-01 00:00:00

abstract：:For patients with solid tumors, the tolerance of surrounding tissues often limits the dose of radiation that can be delivered. Thus, agents that preferentially increase the cytotoxic effects of radiation toward tumor cells would significantly alter the therapeutic ratio and improve patient survival. Using a high-throu...

journal_title：Cancer research

authors： Lally BE,Geiger GA,Kridel S,Arcury-Quandt AE,Robbins ME,Kock ND,Wheeler K,Peddi P,Georgakilas A,Kao GD,Koumenis C

更新日期：2007-09-15 00:00:00