Abstract:
:Cyclooxygenase-2 is a valid target for cancer prevention and treatment. This has been shown in preclinical and clinical cancer prevention studies by using a cyclooxygenase-2 inhibitor, celecoxib. When used in a randomized cancer prevention clinical trial on patients with the inherited autosomal dominant condition, familial adenomatous polyposis, celecoxib proved efficacious. However, a remarkable heterogeneity in patients' responses to the chemopreventive effects of celecoxib was observed. Proteomic profiling of sera from these patients identified several markers, the expression of which was specifically modulated after treatment with celecoxib. A decision tree algorithm identified classifiers for response to celecoxib with relatively high sensitivity but moderate to low specificity. In particular, a spectral feature at m/z 16,961.4 was identified as a strong discriminator between response and nonresponse to celecoxib at the highest dose.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Xiao Z,Luke BT,Izmirlian G,Umar A,Lynch PM,Phillips RK,Patterson S,Conrads TP,Veenstra TD,Greenwald P,Hawk ET,Ali IUdoi
10.1158/0008-5472.can-03-3754subject
Has Abstractpub_date
2004-04-15 00:00:00pages
2904-9issue
8eissn
0008-5472issn
1538-7445journal_volume
64pub_type
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