Expression of a transfected H-2Kb gene in B16 cells correlates with suppression of liver metastases in triple immunodeficient mice.

abstract：:The majority of patients with colon cancer will develop advanced disease, with the liver being the most common site of metastatic disease. Patients with increased numbers of tumor-infiltrating lymphocytes in primary colon tumors and liver metastases have improved outcomes. However, the molecular factors that could emp...

journal_title：Cancer research

authors： Qiao G,Qin J,Kunda N,Calata JF,Mahmud DL,Gann P,Fu YX,Rosenberg SA,Prabhakar BS,Maker AV

更新日期：2017-04-15 00:00:00

abstract：:Fibroblast growth factor receptor 1 (FGFR1) is frequently amplified and highly expressed in lobular carcinomas of the breast. In this report, we evaluated the biological activity of FGFR1 in a wide range of in vitro assays. Conditional activation of FGFR1 in the nontransformed MCF10A human mammary cell line, MCF10A, r...

journal_title：Cancer research

authors： Xian W,Pappas L,Pandya D,Selfors LM,Derksen PW,de Bruin M,Gray NS,Jonkers J,Rosen JM,Brugge JS

更新日期：2009-03-15 00:00:00

abstract：:DNA damage response (DDR) pathways maintain genomic stability. A 657del5 mutation of NBS1, a key DDR component, causing the rare cancer-predisposing Nijmegen breakage syndrome has been reported nearly exclusively in Slavic populations. In this study, we describe the first identification in a Japanese population of an ...

journal_title：Cancer research

authors： Ebi H,Matsuo K,Sugito N,Suzuki M,Osada H,Tajima K,Ueda R,Takahashi T

更新日期：2007-12-01 00:00:00

abstract：:The antitumor activity of combination therapy with recombinant tumor necrosis-alpha (rhTNF-alpha) and recombinant interleukin-2 (rhIL-2) was assessed against established immunogenic (MCA-106) and nonimmunogenic (MCA-102) sarcomas at both s.c. and visceral (hepatic) sites. C57BL/6 (B6) mice were treated with a single i...

journal_title：Cancer research

authors： McIntosh JK,Mulé JJ,Merino MJ,Rosenberg SA

更新日期：1988-07-15 00:00:00

abstract：:Multiple myeloma cells secrete more disulfide bond-rich proteins than any other mammalian cell. Thus, inhibition of protein disulfide isomerases (PDI) required for protein folding in the endoplasmic reticulum (ER) should increase ER stress beyond repair in this incurable cancer. Here, we report the mechanistically unb...

journal_title：Cancer research

authors： Vatolin S,Phillips JG,Jha BK,Govindgari S,Hu J,Grabowski D,Parker Y,Lindner DJ,Zhong F,Distelhorst CW,Smith MR,Cotta C,Xu Y,Chilakala S,Kuang RR,Tall S,Reu FJ

更新日期：2016-06-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) can mediate antitumor effects by indirect mechanisms involving antiangiogenesis and up-regulation of the cellular immune response rather than by direct tumor cell destruction. From mAbs raised by immunization of rats with transformed murine endothelial cells, a mAb (EOL4G8) was selected fo...

journal_title：Cancer research

authors： Melero I,Gabari I,Corbí AL,Relloso M,Mazzolini G,Schmitz V,Rodriguez-Calvillo M,Tirapu I,Camafeita E,Albar JP,Prieto J

更新日期：2002-06-01 00:00:00

abstract：:Use of steroid biosynthesis inhibitors to suppress estrogen production is a logical strategy in the treatment of women with hormone-dependent breast cancer. The clinical availability of aminoglutethimide as an inhibitor of cytochrome P-450-mediated steroid hydroxylations prompted study of the precise pharmacological a...

journal_title：Cancer research

authors： Santen RJ,Santner SJ,Tilsen-Mallett N,Rosen HR,Samojlik E,Veldhuis JD

更新日期：1982-08-01 00:00:00

abstract：:Clonal variants of mouse epidermal JB6 cells that are genetically susceptible (P+) or resistant (P-) to tumor promoter-induced neoplastic transformation exhibit differential activator protein-1 (AP-1) response. Transactivation of AP-1 appears to be necessary but not sufficient to promote transformation in JB6 cells. I...

journal_title：Cancer research

authors： Hsu TC,Nair R,Tulsian P,Camalier CE,Hegamyer GA,Young MR,Colburn NH

更新日期：2001-05-15 00:00:00

abstract：:Gene-targeted mice that contain a His6-tagged mouse c-Myc cDNA, Myc(His), inserted head to head into different sites of the mouse immunoglobulin heavy-chain locus, Igh, mimic the chromosomal T(12;15)(Igh-Myc) translocation that results in the activation of Myc in the great majority of mouse plasmacytomas. Mice carryin...

journal_title：Cancer research

authors： Park SS,Shaffer AL,Kim JS,duBois W,Potter M,Staudt LM,Janz S

更新日期：2005-09-01 00:00:00

abstract：:High expression of VEGFC predicts adverse prognosis in acute myeloid leukemia (AML). We therefore explored VEGFC-targeting efficacy as an AML therapy using a VEGFC mAb. VEGFC antibody therapy enforced myelocytic differentiation of clonal CD34+ AML blasts. Treatment of CD34+ AML blasts with the antibody reduced expansi...

journal_title：Cancer research

authors： Kampen KR,Scherpen FJG,Mahmud H,Ter Elst A,Mulder AB,Guryev V,Verhagen HJMP,De Keersmaecker K,Smit L,Kornblau SM,De Bont ESJM

更新日期：2018-10-15 00:00:00

abstract：:The ShcA adaptor protein transduces oncogenic signals downstream of receptor tyrosine kinases. We show here that breast tumors engage the ShcA pathway to increase their metabolism. ShcA signaling enhanced glucose catabolism through glycolysis and oxidative phosphorylation, rendering breast cancer cells critically depe...

journal_title：Cancer research

authors： Im YK,Najyb O,Gravel SP,McGuirk S,Ahn R,Avizonis DZ,Chénard V,Sabourin V,Hudson J,Pawson T,Topisirovic I,Pollak M,St-Pierre J,Ursini-Siegel J

更新日期：2018-09-01 00:00:00

abstract：:Bleomycin treatment produced dose-dependent changes in lung collagen content and in several measurable histopathological parameters. NIH/Swiss mice were treated twice weekly for 6 weeks with bleomycin, 0, 1, 20, or 40 mg/kg s.c. The two highest doses produced mortalities of 35 and 100%, respectively, as well as loss o...

journal_title：Cancer research

authors： Sikic BI,Young DM,Mimnaugh EG,Gram TE

更新日期：1978-03-01 00:00:00

abstract：:Astrocytoma, the most common brain tumor in humans, is usually malignant and virtually incurable. Two types of malignant astrocytomas can be distinguished histopathologically: anaplastic astrocytoma and glioblastoma multiforme. Studies using DNA markers that detect restriction fragment length polymorphisms have shown ...

journal_title：Cancer research

authors： Fults D,Pedone CA,Thomas GA,White R

更新日期：1990-09-15 00:00:00

abstract：:With normal human skin fibroblasts in culture, a transient decrease in queuine modification of tRNA precedes a phorbol ester tumor promoter-induced 5- to 10-fold increase in saturation density. Subsequently, an increase in the queuine content of cellular tRNA (to levels comparable to those in untreated cultures) prece...

journal_title：Cancer research

authors： Elliott MS,Katze JR,Trewyn RW

更新日期：1984-08-01 00:00:00

abstract：:The simultaneous distribution of monoclonal 131I-labeled anti-carcinoembryonic antigen (CEA) immunoglobulin (IgG) (NP-2) or 131I-labeled irrelevant myeloma IgG (Ag8) and [3H]thymidine was studied in hamsters bearing transplants of the GW-39 human colon carcinoma by qualitative double-tracer whole-body autoradiography....

journal_title：Cancer research

authors： Fand I,Sharkey RM,Primus FJ,Cohen SA,Goldenberg DM

更新日期：1987-04-15 00:00:00

abstract：:We describe a method to postlabel, in vivo, biotinylated monoclonal antibodies pretargeted onto tumor deposits when most of the non-tumor-bound antibodies have already been cleared as avidin-bound complexes. The application of this principle to tumor detection by immunoscintigraphy was tested in 20 patients with histo...

journal_title：Cancer research

authors： Paganelli G,Magnani P,Zito F,Villa E,Sudati F,Lopalco L,Rossetti C,Malcovati M,Chiolerio F,Seccamani E

更新日期：1991-11-01 00:00:00

abstract：:To elucidate the role of cyclin E in cell growth and tumorigenesis in mammary epithelial cells, we have used retrovirus-mediated transduction to generate derivatives of the nontransformed HC11 mouse mammary epithelial cell line that stably express a human cyclin E cDNA (HU4). These derivatives expressed two distinct f...

journal_title：Cancer research

authors： Sgambato A,Han EK,Zhou P,Schieren I,Weinstein IB

更新日期：1996-03-15 00:00:00

abstract：:Since the sodium salt of ascorbic acid (AA) promoted two-stage urinary bladder carcinogenesis in rats, whereas AA itself did not, the roles of the urinary sodium ion concentration and pH on urinary bladder carcinogenesis were investigated. Male F344 rats were given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine in their ...

journal_title：Cancer research

authors： Fukushima S,Shibata MA,Shirai T,Tamano S,Ito N

更新日期：1986-04-01 00:00:00

abstract：:Alterations in expression of or responsiveness to transforming growth factor beta (TGF-beta) are frequently found in human and animal epithelial cancers and are though to be important for loss of growth control in the neoplastic cell. We show here that keratinocyte cell lines from mice with a targeted deletion of the ...

journal_title：Cancer research

authors： Glick AB,Weinberg WC,Wu IH,Quan W,Yuspa SH

更新日期：1996-08-15 00:00:00

abstract：:In cell lines of human small cell carcinoma of the lung (SCCL) and in all subclones of one of the cell lines, cells were observed which completely interiorized other cells, leading to death of the interiorized cells and sometimes to complete autodestruction of the cultures. This phenomenon, which we have called "canni...

journal_title：Cancer research

authors： Brouwer M,de Ley L,Feltkamp CA,Elema J,Jongsma AP

更新日期：1984-07-01 00:00:00

abstract：:Although a majority of malignant testicular Leydig cell tumors induced in the mouse by chronic estrogenization remain dependent upon estrogen stimulation for growth during early transplant generations, we have observed tumors of two lines, no longer growth dependent upon estrogen, that regressed when hosts bearing pal...

journal_title：Cancer research

authors： Huseby RA

更新日期：1983-11-01 00:00:00

abstract：:Monoclonal antibodies (McAbs) to human bladder carcinoma were generated by fusion of NS-1 mouse myeloma cells with spleen cells from BALB/c mice immunized with either cultured human bladder cancer cells or cells obtained from a fresh surgically removed bladder tumor. Four hybridomas which reacted strongly with bladder...

journal_title：Cancer research

authors： Young DA,Prout GR Jr,Lin CW

更新日期：1985-09-01 00:00:00

abstract：:NGR-TNF is a derivative of TNF-α that targets tumor blood vessels and enhances penetration of chemotherapeutic drugs. Because of this property, NGR-TNF is being tested in combination with chemotherapy in various phase II and III clinical trials. Here we report that chromogranin A (CgA), a protein present in variable a...

journal_title：Cancer research

authors： Dondossola E,Gasparri AM,Colombo B,Sacchi A,Curnis F,Corti A

更新日期：2011-09-01 00:00:00

abstract：:Three groups of 6 to 8-week-old male mice with transplanted C57BL/6 X DBA/2F1 tumor were irradiated by a single dose of 60Co localized on the tumor in association with i.p. injections of lyophilized Bacillus Calmette-Guérin. When the animals were sacrificed, tumor parameters (weight, surface area, and volume) were det...

journal_title：Cancer research

authors： Dubois JB,Serrou B

更新日期：1976-05-01 00:00:00

abstract：:Macrophage migration inhibition responses of mice immunized with mutant polyoma viruses or with cells transformed and/or infected by them have been studied. The macrophage migration inhibition reaction revealed individual differences. In several cases, mice immunized with a mutant virus responded preferentially or exc...

journal_title：Cancer research

authors： Szigeti R,Dalianis T,Ramqvist T,Ito Y,Klein G

更新日期：1984-03-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpes virus (KSHV) contributes to the pathogenesis of Kaposi's sarcoma and primary effusion lymphomas. KSHV encodes a G protein-coupled receptor (KSHV-GPCR) that signals constitutively and transforms NIH3T3 cells. Here, we show that KSHV-GPCR transformation requires activation of the small...

journal_title：Cancer research

authors： Dadke D,Fryer BH,Golemis EA,Field J

更新日期：2003-12-15 00:00:00

abstract：:We have reported previously that the PTEN COOH-terminal 33 amino acids play a role in the maintenance of PTEN protein stability (Tolkacheva and Chan, Oncogene, 19: 680-689, 2000). By site-directed mutagenesis, we identified two threonine residues within this COOH-terminal region at codon 382 and 383 that may be target...

journal_title：Cancer research

authors： Tolkacheva T,Boddapati M,Sanfiz A,Tsuchida K,Kimmelman AC,Chan AM

更新日期：2001-07-01 00:00:00

abstract：:Neuroblastomas are extremely aggressive, although heterogeneous, cancers with a poor prognosis upon metastasis. Some evidence has suggested a correlative silencing of caspase-8 with MYCN amplification in neuroblastoma. A prognostic effect of this silencing, however, has been disputed. We report here hitherto undescrib...

journal_title：Cancer research

authors： Finlay D,Vuori K

更新日期：2007-12-15 00:00:00

abstract：:Early diagnosis of lung cancer based on conventional screening procedures has been unable thus far to decrease lung cancer mortality. We explored the possibility of using microsatellite instability in the detection and screening of early phases of lung carcinogenesis. We studied tumor, histopathologically normal bronc...

journal_title：Cancer research

authors： Miozzo M,Sozzi G,Musso K,Pilotti S,Incarbone M,Pastorino U,Pierotti MA

更新日期：1996-05-15 00:00:00

abstract：:Methotrexate [(+) amethopterin, L-MTX] has two carboxyl groups in its structure and is eliminated mainly by excretion into urine and bile. To investigate the biliary excretion mechanism of L-MTX, we performed in vivo and in vitro studies using mutant rats, Eisai hyperbilirubinemic rats (EHBRs), whose canalicular multi...

journal_title：Cancer research

authors： Masuda M,I'izuka Y,Yamazaki M,Nishigaki R,Kato Y,Ni'inuma K,Suzuki H,Sugiyama Y

更新日期：1997-08-15 00:00:00