Abstract：
:With normal human skin fibroblasts in culture, a transient decrease in queuine modification of tRNA precedes a phorbol ester tumor promoter-induced 5- to 10-fold increase in saturation density. Subsequently, an increase in the queuine content of cellular tRNA (to levels comparable to those in untreated cultures) precedes a decrease in saturation density. This reversal of the phorbol ester-induced alteration in tRNA modification occurs in the continued presence of the tumor promoter, and it parallels an increased ability of the cells to salvage queuine from catabolized endogenous tRNA. Addition of exogenous queuine concurrently with the tumor promoter at early passage significantly inhibits the increase in saturation density. The results suggest a role for the decrease in queuine modification of tRNA in mediating the phenotypic change induced by the tumor promoter.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Elliott MS,Katze JR,Trewyn RWsubject
Has Abstractpub_date
1984-08-01 00:00:00pages
3215-9issue
8eissn
0008-5472issn
1538-7445journal_volume
44pub_type
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