Abstract：
:Although the t(2;13)(q35;q14) translocation has been found in most cases of the pediatric cancer alveolar rhabdomyosarcoma, several cases have been reported with a variant t(1;13)(p36;q14) translocation. Our findings indicate that this t(1;13) rearranges PAX7 on chromosome 1 and fuses it to FKHR on chromosome 13. This fusion results in a chimeric transcript consisting of 5' PAX7 and 3' FKHR regions, which is similar to the 5' PAX3-3' FKHR transcript formed by the t(2;13). The 5' PAX3 and PAX7 regions encode related DNA binding domains, and therefore we postulate that these translocations create similar chimeric transcription factors that alter expression of a common group of target genes.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Davis RJ,D'Cruz CM,Lovell MA,Biegel JA,Barr FGsubject
Has Abstractpub_date
1994-06-01 00:00:00pages
2869-72issue
11eissn
0008-5472issn
1538-7445journal_volume
54pub_type
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