Abstract：
:The ability of the bovine C-type leukemia virus to induce syncytia formation in monolayer cell cultures has been used to develop a specific and simple infectivity assay for the virus. Using bovine embryonic spleen cells or human diploid embryonic lung cells as indicator cells, the results of the assay can be evaluated in 4 to 6 or 6 to 8 days, respectively. Pretreatment of the indicator cells with DEAE-dextran greatly increases the sensitivity of the assay. The assay is quantitative and can be applied as a direct method for the identification of bovine C-type leukemia virus-infected animals; it also provides a simple, and sensitive procedure for the detection and titration of virus-neutralizing antibodies.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Ferrer JF,Diglio CAsubject
Has Abstractpub_date
1976-03-01 00:00:00pages
1068-73issue
3eissn
0008-5472issn
1538-7445journal_volume
36pub_type
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