The need for a search for a proximal pathogenic principle of human AIDS.

abstract：:The difficulty to dissect a complex phenotype of established malignant cells to several critical transcriptional programs greatly impedes our understanding of the malignant transformation. The genetic elements required to transform some primary human cells to a tumorigenic state were described in several recent studie...

journal_title：Cancer research

authors： Milyavsky M,Tabach Y,Shats I,Erez N,Cohen Y,Tang X,Kalis M,Kogan I,Buganim Y,Goldfinger N,Ginsberg D,Harris CC,Domany E,Rotter V

更新日期：2005-06-01 00:00:00

abstract：:A methylcholanthrene-induced fibrosarcoma (3AM) and several of its clones were evaluated for pulmonary metastasis, growth rate, and chromosome composition. Heterogeneity was observed in the three parameters, and no correlation was found between growth rate and metastatic potential. Furthermore, three clones (10, 34, a...

journal_title：Cancer research

authors： Wang N,Yu SH,Liener IE,Hebbel RP,Eaton JW,McKhann CF

更新日期：1982-03-01 00:00:00

abstract：:Sleep fragmentation (SF) is a highly prevalent condition and a hallmark of sleep apnea, a condition that has been associated with increased cancer incidence and mortality. In this study, we examined the hypothesis that sleep fragmentation promotes tumor growth and progression through proinflammatory TLR4 signaling. In...

journal_title：Cancer research

authors： Hakim F,Wang Y,Zhang SX,Zheng J,Yolcu ES,Carreras A,Khalyfa A,Shirwan H,Almendros I,Gozal D

更新日期：2014-03-01 00:00:00

abstract：:Patients receiving cytotoxic drugs are at an increased risk of bacterial infection. Drug-induced leukopenia may be responsible for depression of host defenses; however, there is little information concerning the qualitative effects, if any, of cytotoxic agents on granulocyte antibacterial activity. Since methotrexate ...

journal_title：Cancer research

authors： Hyams JS,Donaldson MH,Metcalf JA,Root RK

更新日期：1978-03-01 00:00:00

abstract：:The presence of common genomic deletions in the 19q13 chromosomal region in neuroblastomas and gliomas strongly suggests the presence of a putative tumor suppressor gene for these neoplasms in this region that, despite much effort, has not yet been identified. In an attempt to address this issue, we compared the expre...

journal_title：Cancer research

authors： Alaminos M,Dávalos V,Ropero S,Setién F,Paz MF,Herranz M,Fraga MF,Mora J,Cheung NK,Gerald WL,Esteller M

更新日期：2005-04-01 00:00:00

abstract：:DNA polymerase beta (Polbeta) is a DNA repair protein that functions in base excision repair and meiosis. The enzyme has deoxyribose phosphate lyase and polymerase activity, but it is error prone because it bears no proofreading activity. Errors in DNA repair can lead to the accumulation of mutations and consequently ...

journal_title：Cancer research

authors： Fotiadou P,Henegariu O,Sweasy JB

更新日期：2004-06-01 00:00:00

abstract：:The cultivated mushroom of commerce in the Western hemisphere, Agaricus bisporus, was given p.o. to randomly bred Swiss mice for 3 days and was followed by semisynthetic diet for 4 days each week for life. The mice were 6 weeks old at the beginning of the experiment. As a result of treatment, tumors were induced in th...

journal_title：Cancer research

authors： Toth B,Erickson J

更新日期：1986-08-01 00:00:00

abstract：:Radiation exposure is related to risk of numerous types of cancer, but relatively little is known about its effect on risk of multiple primary cancers. Using follow-up data through 2002 from 77,752 Japanese atomic bomb survivors, we identified 14,048 participants diagnosed with a first primary cancer, of whom 1,088 we...

journal_title：Cancer research

authors： Li CI,Nishi N,McDougall JA,Semmens EO,Sugiyama H,Soda M,Sakata R,Hayashi M,Kasagi F,Suyama A,Mabuchi K,Davis S,Kodama K,Kopecky KJ

更新日期：2010-09-15 00:00:00

abstract：:The linear chromosomes of vertebrates terminate in telomeres that consist of a tandemly repeated hexameric sequence, 5'TTAGGG3'. Telomeres form a protective loop structure (t-loop), which is thought to prevent them from being recognized as a double-strand break. Approximately 10% of human tumors prevent shortening of ...

journal_title：Cancer research

authors： Fasching CL,Neumann AA,Muntoni A,Yeager TR,Reddel RR

更新日期：2007-08-01 00:00:00

abstract：:Systemic cisplatin-based chemotherapy cures > or =90% of patients with metastatic germ cell tumors (GCTs). The biological basis of this exquisite chemo-sensitivity and the resistant phenotype encountered in 10-15% of patients with GCT is yet unclear. A defective mismatch repair pathway leading to microsatellite instab...

journal_title：Cancer research

authors： Mayer F,Gillis AJ,Dinjens W,Oosterhuis JW,Bokemeyer C,Looijenga LH

更新日期：2002-05-15 00:00:00

abstract：:Perineural invasion is a common feature of pancreatic ductal adenocarcinoma (PDAC). Here, we investigated the effect of perineural invasion on the microenvironment and how this affects PDAC progression. Transcriptome expression profiles of PDAC tissues with different perineural invasion status were compared, and the i...

journal_title：Cancer research

authors： Yang MW,Tao LY,Jiang YS,Yang JY,Huo YM,Liu DJ,Li J,Fu XL,He R,Lin C,Liu W,Zhang JF,Hua R,Li Q,Jiang SH,Hu LP,Tian GA,Zhang XX,Niu N,Lu P,Shi J,Xiao GG,Wang LW,Xue J,Zhang ZG,Sun YW

更新日期：2020-05-15 00:00:00

abstract：:UDP-N-acetylglucosamine: beta-D-mannoside beta-1,4-N-acetylglucosaminyl-transferase III (GnT-III) is a key enzyme in the branching of asparagine-linked oligosaccharides, which are present in surface membrane proteins of various tissues and in secretory glycoproteins. The activity of GnT-III was assayed in 2 human hepa...

journal_title：Cancer research

authors： Miyoshi E,Nishikawa A,Ihara Y,Hayashi N,Fusamoto H,Kamada T,Taniguchi N

更新日期：1994-04-01 00:00:00

abstract：:In our previous studies carried out on inbred rats of the Sprague-Dawley strain (L. Gross and Y. Dreyfuss, Proc. Natl. Acad. Sci. USA, 76: 5910-5913, 1979), the tumor incidence was increased following irradiation (150 rads, 5 times, at weekly intervals), from 22 to 93% in females and from 5 to 59% in males. Experiment...

journal_title：Cancer research

authors： Gross L,Dreyfuss Y,Faraggiana T

更新日期：1988-05-01 00:00:00

abstract：:Breast cancer-initiating cells have been recently identified in breast carcinoma as CD44+/CD24(-/low) cells, which exclusively retain tumorigenic activity and display stem cell-like properties. However, at present, direct evidence that breast cancer-initiating cells can be propagated in vitro is still lacking. We repo...

journal_title：Cancer research

authors： Ponti D,Costa A,Zaffaroni N,Pratesi G,Petrangolini G,Coradini D,Pilotti S,Pierotti MA,Daidone MG

更新日期：2005-07-01 00:00:00

abstract：:Anti-idiotypic monoclonal antibodies (MoAbs) were prepared in a syngeneic system against anti-carcinoembryonic antigen (CEA) MoAb 5B3 (IgG1), which reacted with a carbohydrate moiety on CEA, and MoAb MA208 (IgG1), which reacted with a peptide on CEA. Anti-idiotypic MoAb T3-503 and T4-202 recognized the private idiotyp...

journal_title：Cancer research

authors： Tsujisaki M,Imai K,Tokuchi S,Hanzawa Y,Ishida T,Kitagawa H,Hinoda Y,Yachi A

更新日期：1991-05-15 00:00:00

abstract：:To test the hypothesis that genetic instability correlates with malignant potential, we compared the rate of generation of marker chromosomal abnormalities in clones of B16 F1 and B16 F10 murine melanoma. These rates were estimated through an adaptation of fluctuation analysis of Luria and Delbruck (S. E. Luria and M....

journal_title：Cancer research

authors： Kendal WS,Wang RY,Hsu TC,Frost P

更新日期：1987-07-15 00:00:00

abstract：:The pharmacokinetics of UCN-01 after administration as a 72- or 3-h infusion to cancer patients in initial Phase I trials displayed distinctive features that could not have been predicted from preclinical data. The distribution volumes (0.0796-0.158 liters/kg) and the systemic clearance (0.0407-0.252 ml/h/kg) were ext...

journal_title：Cancer research

authors： Fuse E,Tanii H,Kurata N,Kobayashi H,Shimada Y,Tamura T,Sasaki Y,Tanigawara Y,Lush RD,Headlee D,Figg WD,Arbuck SG,Senderowicz AM,Sausville EA,Akinaga S,Kuwabara T,Kobayashi S

更新日期：1998-08-01 00:00:00

abstract：:Antitumor type I T-cell responses involving IFN-γ production are critical to control cancer, but the efficacy of this response is limited by a variety of immunosuppressive mechanisms that promote tumoral immune escape. One critical mechanism involves the accumulation of FOXP3(+) T regulatory cells (Treg), a class of s...

journal_title：Cancer research

authors： Redjimi N,Raffin C,Raimbaud I,Pignon P,Matsuzaki J,Odunsi K,Valmori D,Ayyoub M

更新日期：2012-09-01 00:00:00

abstract：:Although the t(2;13)(q35;q14) translocation has been found in most cases of the pediatric cancer alveolar rhabdomyosarcoma, several cases have been reported with a variant t(1;13)(p36;q14) translocation. Our findings indicate that this t(1;13) rearranges PAX7 on chromosome 1 and fuses it to FKHR on chromosome 13. This...

journal_title：Cancer research

authors： Davis RJ,D'Cruz CM,Lovell MA,Biegel JA,Barr FG

更新日期：1994-06-01 00:00:00

abstract：:Helicobacter pylori-induced gastritis is the strongest singular risk factor for gastric adenocarcinoma. Matrix metalloproteinase-7 (MMP-7) is a proteolytic enzyme that can modify the intestinal microbial replicative niche as well as affect tumorigenesis, and H. pylori stimulates expression of MMP-7 in gastric epitheli...

journal_title：Cancer research

authors： Ogden SR,Noto JM,Allen SS,Patel DA,Romero-Gallo J,Washington MK,Fingleton B,Israel DA,Lewis ND,Wilson KT,Chaturvedi R,Zhao Z,Shyr Y,Peek RM Jr

更新日期：2010-01-01 00:00:00

abstract：:The glutathione transferase (GST) isoenzyme profile was determined in two human tumor cell lines, U1690 derived from a small cell lung cancer and U1810 derived from a non-small cell lung cancer. U1810 cells are 3.2-fold more resistant to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) than are U1690 cells, a finding ascri...

journal_title：Cancer research

authors： Berhane K,Hao XY,Egyházi S,Hansson J,Ringborg U,Mannervik B

更新日期：1993-09-15 00:00:00

abstract：:A naturally occurring human antibody potentiates dendritic cell function on cross-linking B7-DC (PD-L2), supporting robust T-cell responses in vitro. Moreover, treatment of dendritic cells with B7-DC cross-linking antibody resulted in secretion of interleukin-12, suggesting a TH1 polarization of this response. Here we...

journal_title：Cancer research

authors： Radhakrishnan S,Nguyen LT,Ciric B,Flies D,Van Keulen VP,Tamada K,Chen L,Rodriguez M,Pease LR

更新日期：2004-07-15 00:00:00

abstract：:Immunotherapy for breast cancer using cytotoxic T cells (CTL) is hindered by the lack of well-characterized breast cancer antigens that are expressed in most breast tumor cells and recognized by CD8+ CTL. A recently described breast tissue differentiation antigen, NY-BR-1, is expressed in >80% breast tumors and elicit...

journal_title：Cancer research

authors： Wang W,Epler J,Salazar LG,Riddell SR

更新日期：2006-07-01 00:00:00

abstract：:Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient cha...

journal_title：Cancer research

authors： Peres LC,Mallen AR,Townsend MK,Poole EM,Trabert B,Allen NE,Arslan AA,Dossus L,Fortner RT,Gram IT,Hartge P,Idahl A,Kaaks R,Kvaskoff M,Magliocco AM,Merritt MA,Quirós JR,Tjonneland A,Trichopoulou A,Tumino R,van Gils

更新日期：2019-10-15 00:00:00

abstract：:We have recently found that human pancreatic adenocarcinomas exhibit strong immunostaining for the three mammalian transforming growth factor beta (TGF-beta) isoforms. These important growth-regulating polypeptides bind to a number of proteins, including the type I TGF-beta receptor (T beta R-I), type II TGF-beta rece...

journal_title：Cancer research

authors： Friess H,Yamanaka Y,Büchler M,Berger HG,Kobrin MS,Baldwin RL,Korc M

更新日期：1993-06-15 00:00:00

abstract：:Protein synthesis is a vital cellular process that regulates growth and metabolism. It is controlled via signaling networks in response to environmental changes, including the presence of nutrients, mitogens, or starvation. The phosphorylation state of proteins involved in translation initiation is a limiting factor t...

journal_title：Cancer research

authors： Grzmil M,Hemmings BA

更新日期：2012-08-15 00:00:00

abstract：:alphaVbeta3 integrin complexes are overexpressed in the growing, invading margins of human glioblastoma multiforme (GBM) and in the GBM vasculature, suggesting a key role for alphaVbeta3 in GBM growth and invasion. The function of alphaVbeta3 complexes in tumor formation, however, has been challenged by studies showin...

journal_title：Cancer research

authors： Kanamori M,Vanden Berg SR,Bergers G,Berger MS,Pieper RO

更新日期：2004-04-15 00:00:00

abstract：:7-Hydroxystaurosporine (UCN-01) is a protein kinase inhibitor that is under development as an anticancer agent in the United States and Japan. Long-term exposure of human A549 non-small cell lung cancer cells to UCN-01 furnished cells (A549/UCN) with acquired resistance against UCN-01. In this study, the sensitivity o...

journal_title：Cancer research

authors： Sugiyama K,Akiyama T,Shimizu M,Tamaoki T,Courage C,Gescher A,Akinaga S

更新日期：1999-09-01 00:00:00

abstract：:We have used immunoprecipitation of radioactivity from labeled cell membrane preparations to study further the association between the histocompatibility-2 (H-2) peptides and a tumor-associated embryonic antigen (Ag I) on the surface of L-cells. Since earlier studies had shown that Ag I and H-2 co-cap on L-cells, the ...

journal_title：Cancer research

authors： Gooding LR

更新日期：1976-09-01 00:00:00

abstract：:Activation of apoptosis is believed to be critical for the role of p53 as a tumor suppressor. Here, we report a new mouse strain carrying a human p53 transgene in the mouse p53-null background. Expression of human p53 in these mice was comparable with wild-type murine p53; however, transactivation, induction of apopto...

journal_title：Cancer research

authors： Dudgeon C,Kek C,Demidov ON,Saito S,Fernandes K,Diot A,Bourdon JC,Lane DP,Appella E,Fornace AJ Jr,Bulavin DV

更新日期：2006-03-15 00:00:00