Enhanced expression of the type II transforming growth factor beta receptor in human pancreatic cancer cells without alteration of type III receptor expression.

abstract：:Recent studies have shown that the Bcl-2 protein suppresses programmed cell death or apoptosis induced by a variety of stimuli including chemotherapeutic drugs. Because estrogen promotes the survival of estrogen-dependent breast cancer cells in vivo, we investigated whether estrogen might regulate levels of Bcl-2 gene...

journal_title：Cancer research

authors： Teixeira C,Reed JC,Pratt MA

更新日期：1995-09-01 00:00:00

abstract：:A novel monoclonal antibody was raised by immunization of mice with colorectal tumor cell lines. The fusion was screened by immunohistochemistry for binding to primary colorectal tumors. Subsequent analysis on primary disaggregated colorectal tumors show that the antibody recognizes a cell surface antigen expressed by...

journal_title：Cancer research

authors： Durrant LG,Harding SJ,Green NH,Buckberry LD,Parsons T

更新日期：2006-06-01 00:00:00

abstract：:SOX9 is a transcription factor that plays a critical role in the development of multiple tissues. We previously reported that SOX9 in normal human adult prostate was restricted to basal epithelium. SOX9 was also expressed in a subset of prostate cancer (PCa) cells and was increased in relapsed hormone-refractory PCa. ...

journal_title：Cancer research

authors： Wang H,Leav I,Ibaragi S,Wegner M,Hu GF,Lu ML,Balk SP,Yuan X

更新日期：2008-03-15 00:00:00

abstract：:Bisphosphonate (BP), a specific inhibitor of osteoclasts, has been widely used as a beneficial agent for the treatment of bone metastases in patients with breast cancer. It is well recognized that BP reduces osteolysis by promoting apoptosis in osteoclasts. However, recent animal and human data suggest that BPs not on...

journal_title：Cancer research

authors： Hiraga T,Williams PJ,Mundy GR,Yoneda T

更新日期：2001-06-01 00:00:00

abstract：:The effects of 5-mercapto-2'-deoxyuridine (MUdr) on DNA synthesis in a primary murine spleen lymphocyte culture system stimulated by phytohemagglutinin (PHA) were studied. Inhibition of thymidine incorporation into acid insoluble nucleic acid material was 50% at 0.5 mM MUdR concentration, while inhibition of deoxyurid...

journal_title：Cancer research

authors： Bogyo D,Bardos TJ,Chmielewicz ZF

更新日期：1976-09-01 00:00:00

abstract：:Oncogenic K-Ras mutation occurs frequently in several types of cancers, including pancreatic and lung cancers. Tumors with K-Ras mutation are resistant to chemotherapeutic drugs as well as molecular targeting agents. Although numerous approaches are ongoing to find effective ways to treat these tumors, there are still...

journal_title：Cancer research

authors： Fujita-Sato S,Galeas J,Truitt M,Pitt C,Urisman A,Bandyopadhyay S,Ruggero D,McCormick F

更新日期：2015-07-15 00:00:00

abstract：:The mechanism by which gonadotropin-releasing hormone (GnRH) agonists and antagonists inhibit tumor cell growth and proliferation is controversial. Direct mediation of the antitumor effects through the high-affinity GnRH receptors has been questioned because of the low level of expression of receptors on the tumor cel...

journal_title：Cancer research

authors： Kakar SS

更新日期：1998-10-15 00:00:00

abstract：:A role of the epidermal growth factor receptor (EGFR) family has been suggested in colon cancer etiology, progression, and/or severity. Our recently identified pan-erbB inhibitor EGFR-related protein (ERRP) targets EGFRs by attenuating their activation and subsequent signaling leading to cellular growth inhibition. In...

journal_title：Cancer research

authors： Schmelz EM,Xu H,Sengupta R,Du J,Banerjee S,Sarkar FH,Rishi AK,Majumdar AP

更新日期：2007-06-01 00:00:00

abstract：:ADAMTS metalloprotease family member ADAMTS9 maps to 3p14.2 and shows significant associations with the aerodigestive tract cancers esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). However, the functional impact of ADAMTS9 on cancer development has not been explored. In this study, we eval...

journal_title：Cancer research

authors： Lo PH,Lung HL,Cheung AK,Apte SS,Chan KW,Kwong FM,Ko JM,Cheng Y,Law S,Srivastava G,Zabarovsky ER,Tsao SW,Tang JC,Stanbridge EJ,Lung ML

更新日期：2010-07-01 00:00:00

abstract：:Patients with lung cancer often present with metastatic disease and therefore have a very poor prognosis. The recent discovery of several novel ROS receptor tyrosine kinase molecular alterations in non-small cell lung cancer (NSCLC) presents a therapeutic opportunity for the development of new targeted treatment strat...

journal_title：Cancer research

authors： Jun HJ,Johnson H,Bronson RT,de Feraudy S,White F,Charest A

更新日期：2012-08-01 00:00:00

abstract：:The Morris hepatocellular carcinoma 7777 is productive of extraordinarily high levels of the oncofetal protein, alpha-fetoprotein. Its chromosome composition was examined in detail since it represents the only near-diploid tumor of such productivity and has been reported to demonstrate a single unusual chromosomal alt...

journal_title：Cancer research

authors： Wolman SR,Cohen TI,Becker FF

更新日期：1977-08-01 00:00:00

abstract：:Loss of function of the tumor suppressor protein p53 represents a very frequent event in human carcinogenesis, but the molecular mechanisms linking impaired p53 activity to increased cell malignancy are still incompletely understood. p53 is normally involved in both cell cycle control and the induction of cell death a...

journal_title：Cancer research

authors： Pani G,Bedogni B,Anzevino R,Colavitti R,Palazzotti B,Borrello S,Galeotti T

更新日期：2000-08-15 00:00:00

abstract：:The degree of heterogeneity among cancer stem cells (CSC) remains ill-defined and may hinder effective anti-CSC therapy. Evaluation of oral cancers for such heterogeneity identified two compartments within the CSC pool. One compartment was detected using a reporter for expression of the H3K4me3 demethylase JARID1B to ...

journal_title：Cancer research

authors： Facompre ND,Harmeyer KM,Sole X,Kabraji S,Belden Z,Sahu V,Whelan K,Tanaka K,Weinstein GS,Montone KT,Roesch A,Gimotty PA,Herlyn M,Rustgi AK,Nakagawa H,Ramaswamy S,Basu D

更新日期：2016-09-15 00:00:00

abstract：:An epitope region, located at amino acid residues 173-180 (EAAA-GIQW), of a human cell proliferation-associated nucleolar antigen, P120, has been defined by mutational analysis and competition assays. A synthetic peptide corresponding to this epitope region completely blocks the binding of the anti-P120 antibody to Es...

journal_title：Cancer research

authors： Valdez BC,Busch RK,Larson RG,Busch H

更新日期：1990-05-01 00:00:00

abstract：:To better understand the events occurring during immunotherapy of liver metastases with effector cells, we have developed a clinically relevant animal model in which both effector-tumor cell interactions and survival can be evaluated. A cell line of human gastric carcinoma (HR) metastatic to the liver has been establi...

journal_title：Cancer research

authors： Yasumura S,Lin WC,Hirabayashi H,Vujanovic NL,Herberman RB,Whiteside TL

更新日期：1994-07-15 00:00:00

abstract：:A megakaryoblastic cell line, termed T-33, was established from the peripheral blood of a patient with Philadelphia chromosome-positive chronic myelogenous leukemia in megakaryoblastic crisis. T-33 cells have been maintained in RPMI 1640 medium containing 10% fetal calf serum in a single cell suspension with a doublin...

journal_title：Cancer research

authors： Tange T,Nakahara K,Mitani K,Yamasaki I,Yasuda H,Tanaka F,Mizuguchi M,Oda H,Yatomi Y,Takanashi R

更新日期：1988-11-01 00:00:00

abstract：:Little is known about the genetic changes underlying invasive tumor growth in bladder cancer. Because alterations that are linked to invasive tumor growth may be detectable in minimally invasive (stage pT1) but not in noninvasive (stage pTa) tumors, we searched for genetic differences between 28 pTa and 28 papillary p...

journal_title：Cancer research

authors： Richter J,Jiang F,Görög JP,Sartorius G,Egenter C,Gasser TC,Moch H,Mihatsch MJ,Sauter G

更新日期：1997-07-15 00:00:00

abstract：:Human T-cell leukemia virus type 1 oncoprotein Tax is a transcriptional regulator that interacts with a large number of host cell factors. Here, we report the novel characterization of the interaction of Tax with a human cell protein named Tax1-binding protein 1 (TAX1BP1). We show that TAX1BP1 is a nuclear receptor co...

journal_title：Cancer research

authors： Chin KT,Chun AC,Ching YP,Jeang KT,Jin DY

更新日期：2007-02-01 00:00:00

abstract：:Recently, we have shown that the p53 tumor suppressor gene product can inhibit expression of the bcl-2 gene. In this report, we explored the molecular basis for p53-mediated down-regulation of bcl-2 gene expression using a cotransfection approach involving p53 expression plasmids and chloramphenicol acetyltransferase ...

journal_title：Cancer research

authors： Miyashita T,Harigai M,Hanada M,Reed JC

更新日期：1994-06-15 00:00:00

abstract：:Human papillomavirus (HPV) type 18 DNA was introduced into epithelial cell strains derived from normal and cancer tissues of human prostatectomy specimens by the lipofection transfection method. Two cell lines were established: PZ-HPV-7 (transfected normal cell) and CA-HPV-10 (transfected cancer-derived cell). These l...

journal_title：Cancer research

authors： Weijerman PC,König JJ,Wong ST,Niesters HG,Peehl DM

更新日期：1994-11-01 00:00:00

abstract：:Interleukin-2-based regimens of biological therapy have shown some clinical promise for the treatment of kidney cancer in humans, although the mechanisms responsible for tumor regression occurring in these patients remain unclear. Preclinical insight into these mechanisms is limited by a paucity of orthotopic animal m...

journal_title：Cancer research

authors： Gruys ME,Back TC,Subleski J,Wiltrout TA,Lee JK,Schmidt L,Watanabe M,Stanyon R,Ward JM,Wigginton JM,Wiltrout RH

更新日期：2001-08-15 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) is constitutively activated in many types of cancers and has been implicated in gene expression important for angiogenesis, tumor growth, progression, and metastasis. Here, we show that the NF-kappaB activator, IkappaB kinase-alpha (IKKalpha), but not IKKbeta,...

journal_title：Cancer research

authors： DeBusk LM,Massion PP,Lin PC

更新日期：2008-12-15 00:00:00

abstract：:We examined the therapeutic effect of lipopolysaccharide (LPS), a differentiation inducer, in combination with daunomycin, an antileukemia drug possessing differentiation-inducing potential, on a rat myelomonocytic leukemia (c-WRT-7). c-WRT-7 cells were found to differentiate into macrophage-like cells and to lose the...

journal_title：Cancer research

authors： Fujii Y,Yuki N,Takeichi N,Kobayashi H,Miyazaki T

更新日期：1987-03-15 00:00:00

abstract：:Currently, no curative therapy for metastatic prostate cancer exists. Causing prostate cancer cells to express functionally active sodium iodide symporter (NIS) would enable those cells to concentrate iodide from plasma and might offer the ability to treat prostate cancer with radioiodine. Therefore, the aim of our st...

journal_title：Cancer research

authors： Spitzweg C,Zhang S,Bergert ER,Castro MR,McIver B,Heufelder AE,Tindall DJ,Young CY,Morris JC

更新日期：1999-05-01 00:00:00

abstract：:MYC exerts both positive and negative functions in cancer cells, such that its procancerous effects are unmasked only after its anticancer effects are blocked. Here we used multiple mouse models of lung adenocarcinoma to identify genetic events that can cooperate with MYC activation to promote the genesis of non-small...

journal_title：Cancer research

authors： Allen TD,Zhu CQ,Jones KD,Yanagawa N,Tsao MS,Bishop JM

更新日期：2011-03-15 00:00:00

abstract：:Patients receiving cytotoxic drugs are at an increased risk of bacterial infection. Drug-induced leukopenia may be responsible for depression of host defenses; however, there is little information concerning the qualitative effects, if any, of cytotoxic agents on granulocyte antibacterial activity. Since methotrexate ...

journal_title：Cancer research

authors： Hyams JS,Donaldson MH,Metcalf JA,Root RK

更新日期：1978-03-01 00:00:00

abstract：:ErbB2 and ErbB3, two members of the ErbB family, form a high-affinity heregulin coreceptor that elicits potent mitogenic and transforming signals, and clinical studies indicate that these receptors play an important role in tumor incidence and progression. To determine whether N-glycosylation is involved in the functi...

journal_title：Cancer research

authors： Yokoe S,Takahashi M,Asahi M,Lee SH,Li W,Osumi D,Miyoshi E,Taniguchi N

更新日期：2007-03-01 00:00:00

abstract：:The pool sizes of purine nucleotides, nucleosides, and nucleobases were measured in the host tissues liver, skeletal muscle, and blood of Ehrlich ascites tumor-bearing mice during the different periods of tumor growth. There were large differences of tissue concentrations of these metabolites between control animals, ...

journal_title：Cancer research

authors： Siems WG,Grune T,Schmidt H,Tikhonov YV,Pimenov AM

更新日期：1993-11-01 00:00:00

abstract：:Pathways relevant to cancer are well known to overlap with fetal development, as reflected in reactivation of embryonic genes in tumors. However, molecular evidence for this notion has gathered in piecemeal fashion, and systematic approaches have rarely been applied to gauge the extent and global characteristics of th...

journal_title：Cancer research

authors： Hu M,Shivdasani RA

更新日期：2005-10-01 00:00:00

abstract：:The homologous proteins p68 and p72 are members of the DEAD box family of RNA helicases. Here, we show that expression of both of these helicases strongly increases during the polyp-->adenoma-->adenocarcinoma transition in the colon. Furthermore, p68 and p72 form complexes with beta-catenin and promote the ability of ...

journal_title：Cancer research

authors： Shin S,Rossow KL,Grande JP,Janknecht R

更新日期：2007-08-15 00:00:00