Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment.

abstract：:Premature ovarian failure and reduced fecundity are well-documented consequences of cytotoxic chemotherapy used to treat patients with malignant diseases. To investigate the ability of different hormonal agents to block the effects of cyclophosphamide (CTX) on reproductive function, sexually mature female Long-Evans r...

journal_title：Cancer research

authors： Montz FJ,Wolff AJ,Gambone JC

更新日期：1991-04-15 00:00:00

abstract：:Cell division cycle 25B (Cdc25B) phosphatase controls entry into mitosis and regulates recovery from G2-M checkpoint-induced arrest. In the present study, we show that exposure of diploid mouse embryonic fibroblasts (MEF) to the ultimate carcinogen anti-benzo(a)pyrene (BP)-7,8-diol-9,10-epoxide (anti-BPDE) resulted in...

journal_title：Cancer research

authors： Srivastava SK,Bansal P,Oguri T,Lazo JS,Singh SV

更新日期：2007-10-01 00:00:00

abstract：:Benzidine, a human urinary bladder carcinogen, induces hepatic tumors in mice and rats. In this study, [3H]benzidine was administered in drinking water to mice for 1 week, and the covalent binding of the carcinogen to hepatic DNA was then determined. A single carcinogen:DNA adduct was detected which decreased in conce...

journal_title：Cancer research

authors： Martin CN,Beland FA,Roth RW,Kadlubar FF

更新日期：1982-07-01 00:00:00

abstract：:Cyclin-dependent kinase 2 activated by cyclin E is involved in the initiation of DNA replication and other S phase functions. Consistent with this role, cyclin E protein accumulates at the G1-S phase transition and declines during early S phase. This profile of expression is the result of periodic transcription and ub...

journal_title：Cancer research

authors： Spruck CH,Strohmaier H,Sangfelt O,Müller HM,Hubalek M,Müller-Holzner E,Marth C,Widschwendter M,Reed SI

更新日期：2002-08-15 00:00:00

abstract：:Gonadotropin-releasing hormone-I (GnRH-I) is known to directly regulate prostate cancer cell proliferation. However, the role of GnRH-II in prostate cancer is unclear. Here, we investigated the effect of the GnRH-II antagonist trptorelix-1 (Trp-1) on growth of PC3 prostate cancer cells. Trp-1 induced growth inhibition...

journal_title：Cancer research

authors： Kim DK,Yang JS,Maiti K,Hwang JI,Kim K,Seen D,Ahn Y,Lee C,Kang BC,Kwon HB,Cheon J,Seong JY

更新日期：2009-02-01 00:00:00

abstract：:Retinoic acid (RA) is a master epigenetic regulator that plays a pivotal role in both breast morphogenesis and development. Here, we show for the first time that RA, via the RA receptor alpha (RARalpha), epigenetically regulates in a concerted fashion the transcription of two RA-responsive genes, the RA receptor beta2...

journal_title：Cancer research

authors： Bistulfi G,Pozzi S,Ren M,Rossetti S,Sacchi N

更新日期：2006-11-01 00:00:00

abstract：:Increased activity, membrane association, and secretion of cathepsin B have been shown to correlate positively with invasiveness and the metastatic properties of many tumor entities. Cathepsin B is able to directly facilitate invasion by degrading extracellular matrix components or to indirectly facilitate invasion by...

journal_title：Cancer research

authors： Krueger S,Haeckel C,Buehling F,Roessner A

更新日期：1999-12-01 00:00:00

abstract：:To explore further the descriptive epidemiology of sarcomas of the uterus, we examined the distribution of marital status among 1479 white women diagnosed as having one of these tumors between January 1, 1973, and December 31, 1986, in 7 geographically defined areas of the United States. We estimated incidence rates b...

journal_title：Cancer research

authors： Schwartz SM,Weiss NS

更新日期：1990-03-15 00:00:00

abstract：:Inherited mutations of the human BRCA2 gene confer increased risks for developing breast, ovarian, and several other cancers. Unlike previously described Brca2 knockout mice that display predominantly embryonic lethal phenotypes, we developed mice with a homozygous germ-line deletion of Brca2 exon 27 that exhibit a mo...

journal_title：Cancer research

authors： McAllister KA,Bennett LM,Houle CD,Ward T,Malphurs J,Collins NK,Cachafeiro C,Haseman J,Goulding EH,Bunch D,Eddy EM,Davis BJ,Wiseman RW

更新日期：2002-02-15 00:00:00

abstract：:Two monoclonal antibodies, OC 125 and OC 133, bind to distinct determinants on the surface of human epithelial ovarian carcinoma cell lines. OC 125 and OC 133 recognize determinants on molecules with molecular weights greater than 200,000 and 80,000, respectively. When binding to four different cell lines was compared...

journal_title：Cancer research

authors： Masuho Y,Zalutsky M,Knapp RC,Bast RC Jr

更新日期：1984-07-01 00:00:00

abstract：:We have examined the implications of membrane-type matrix metalloproteinase (MT-MMP) for activation of the zymogen of MMP-2 (proMMP-2) in human gastric carcinoma. Northern blot analysis demonstrated exclusive expression of MT-MMP in the carcinoma tissues. Immunohistochemically, MT-MMP was colocalized in the carcinoma ...

journal_title：Cancer research

authors： Nomura H,Sato H,Seiki M,Mai M,Okada Y

更新日期：1995-08-01 00:00:00

abstract：:Oxidation of the vinyl halide carcinogen and hepatotoxin vinylidene chloride (VDC) by microsomal cytochrome P-450 yields 2,2-dichloroacetaldehyde, 2-chloroacetyl chloride, 2-chloroacetic acid, and 1,1-dichloroethylene oxide. The roles of these metabolites in covalent modification of proteins and reduced glutathione (G...

journal_title：Cancer research

authors： Liebler DC,Meredith MJ,Guengerich FP

更新日期：1985-01-01 00:00:00

abstract：:Uptake of actinomycin D (AD) was characterized in Ehrlich ascites tumor cells in vitro. The time course of uptake consists of an initial component that represents a unidirectional flux of AD into the cells, following which the net uptake rate falls to achieve a velocity that is constant over a 45-min interval of obser...

journal_title：Cancer research

authors： Bowen D,Goldman ID

更新日期：1975-11-01 00:00:00

abstract：:Although the aromatase inhibitor anastrozole has been shown to be very effective in the treatment of hormone-dependent postmenopausal breast cancer, some patients with advanced disease will develop resistance to treatment. To investigate therapeutic strategies to overcome resistance to anastrozole treatment, we have u...

journal_title：Cancer research

authors： Macedo LF,Sabnis GJ,Goloubeva OG,Brodie A

更新日期：2008-05-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a molecularly heterogeneous cancer that is difficult to treat. Despite the role it may play in tumor progression and response to therapy, microenvironmental (stromal) heterogeneity in TNBC has not been well characterized. To address this challenge, we investigated the transcript...

journal_title：Cancer research

authors： Saleh SMI,Bertos N,Gruosso T,Gigoux M,Souleimanova M,Zhao H,Omeroglu A,Hallett MT,Park M

更新日期：2017-09-01 00:00:00

abstract：:8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H) -one (mitozolomide) demonstrates curative action against a range of murine tumor model systems. At single doses of between 20 and 40 mg/kg, the latter of which approximates the 10% lethal dose value in mice, the compound elicited cures against the L121...

journal_title：Cancer research

authors： Hickman JA,Stevens MF,Gibson NW,Langdon SP,Fizames C,Lavelle F,Atassi G,Lunt E,Tilson RM

更新日期：1985-07-01 00:00:00

abstract：:The tumor-associated antigen MUC1 is overexpressed and underglycosylated in human adenocarcinomas of diverse origins, such as breast, ovary, and colon. We isolated and describe five human single-chain (sc) Fv antibodies specific for the MUC1 variable number of tandem repeats region isolated by in vitro selection from ...

journal_title：Cancer research

authors： Henderikx P,Kandilogiannaki M,Petrarca C,von Mensdorff-Pouilly S,Hilgers JH,Krambovitis E,Arends JW,Hoogenboom HR

更新日期：1998-10-01 00:00:00

abstract：:Between June 1977 and December 1979, 72 evaluable patients with childhood non-T-cell acute lymphoblastic leukemia were induced into complete remission using vincristine, prednisone, and doxorubicin. All received asparaginase consolidation and central nervous system prophylaxis with cranial irradiation and intrathecal ...

journal_title：Cancer research

authors： Sallan SE,Hitchcock-Bryan S,Gelber R,Cassady JR,Frei E 3rd,Nathan DG

更新日期：1983-11-01 00:00:00

abstract：:Multiple myeloma cells secrete more disulfide bond-rich proteins than any other mammalian cell. Thus, inhibition of protein disulfide isomerases (PDI) required for protein folding in the endoplasmic reticulum (ER) should increase ER stress beyond repair in this incurable cancer. Here, we report the mechanistically unb...

journal_title：Cancer research

authors： Vatolin S,Phillips JG,Jha BK,Govindgari S,Hu J,Grabowski D,Parker Y,Lindner DJ,Zhong F,Distelhorst CW,Smith MR,Cotta C,Xu Y,Chilakala S,Kuang RR,Tall S,Reu FJ

更新日期：2016-06-01 00:00:00

abstract：:The effect of schedule of drug administration on the biochemical and therapeutic effects of the combination of 1-beta-D-arabinofuranosylcytosine (ara-C) and asparaginase was investigated in vivo and in vitro using the murine leukemia L5178Y. Treatment of cells in vitro with either ara-C (10(-6) M) or asparaginase (0.5...

journal_title：Cancer research

authors： Schwartz SA,Morgenstern B,Capizzi RL

更新日期：1982-06-01 00:00:00

abstract：:A detailed analysis of the gamma-glutamylation of methotrexate has been conducted in primary cultures of rat hepatic parenchymal cells in monolayer culture. The rates of glutamylation are concentration dependent and saturable when measured over a 6-h period at concentrations between 2 and 50 microM. The removal of fol...

journal_title：Cancer research

authors： Galivan J,Pupons A,Rhee MS

更新日期：1986-02-01 00:00:00

abstract：:The human cytomegalovirus (HCMV), potentially associated with the development of malignancies, encodes the constitutively active chemokine receptor US28. Previously, we have shown that US28 expression induces an oncogenic phenotype both in vitro and in vivo. Microarray analysis revealed differential expression of gene...

journal_title：Cancer research

authors： Maussang D,Langemeijer E,Fitzsimons CP,Stigter-van Walsum M,Dijkman R,Borg MK,Slinger E,Schreiber A,Michel D,Tensen CP,van Dongen GA,Leurs R,Smit MJ

更新日期：2009-04-01 00:00:00

abstract：:Primary cell cultures derived from human skin epithelium metabolized benzo(a)pyrene to three classes of compounds: phenols, quinones, and dihydrodiols. The relative proportions of metabolites varied according to the skin donor but differed from the pattern of metabolites in rat liver microsome preparations. While appr...

journal_title：Cancer research

authors： Fox CH,Selkirk JK,Price FM,Croy RG,Sanford KK,Cottler-Fox M

更新日期：1975-12-01 00:00:00

abstract：:We have previously described a tumor model in which the influenza hemagglutinin protein (HA) expressed on the BALB/c-derived MT901 tumor line serves as an immunization-dependent tumor rejection antigen in normal syngeneic mice. Although the HA antigen in this model is clearly foreign to normal BALB/c mice, many tumor ...

journal_title：Cancer research

authors： Eck SC,Turka LA

更新日期：2001-04-01 00:00:00

abstract：:Thymus, spleen, and bone marrow of 1-month-old neonatally Moloney murine leukemia virus-inoculated mice have been transferred to 400-R-irradiated syngeneic recipients of the opposite sex. The donor or recipient origin of T-cell lymphomas arising in the host animal was identified by the sex chromosome marker. Spleen an...

journal_title：Cancer research

authors： Asjö B,Skoog L,Palminger I,Wiener F,Isaak D,Cerny J,Fenyö EM

更新日期：1985-03-01 00:00:00

abstract：:Human kallikrein 10 (hK10) is a secreted serine protease that is highly expressed in ovarian tissue. We hypothesized that hK10 might represent a novel serological marker for ovarian cancer. We quantified by immunoassay, hK10 in sera from 97 normal women (controls), 141 patients with benign gynecologic diseases, and 14...

journal_title：Cancer research

authors： Luo LY,Katsaros D,Scorilas A,Fracchioli S,Bellino R,van Gramberen M,de Bruijn H,Henrik A,Stenman UH,Massobrio M,van der Zee AG,Vergote I,Diamandis EP

更新日期：2003-02-15 00:00:00

abstract：:Many malignancies exhibit distinct patterns of metastasis that appear to be mediated by receptor/ligand-like interactions between tumor cells and organ-specific vascular endothelium. In order to study endothelial cell surface molecules involved in the binding of metastatic cells, we developed a perfusion method to iso...

journal_title：Cancer research

authors： Johnson RC,Augustin-Voss HG,Zhu DZ,Pauli BU

更新日期：1991-01-01 00:00:00

abstract：:Wnt ligand-driven tumor growth is inhibited by the soluble Wnt inhibitor Fzd8CRD, but the mechanism through which this effect is mediated is unknown. In the MMTV-Wnt1 mouse model, regression of mammary tumors by Fzd8CRD treatment coincides with an acute and strong induction of insulin-like growth factor (IGF)-binding ...

journal_title：Cancer research

authors： Liu BY,Soloviev I,Huang X,Chang P,Ernst JA,Polakis P,Sakanaka C

更新日期：2012-03-15 00:00:00

abstract：:Genetic instability has been recognized as a hallmark of human cancers. Retinoblastoma (Rb) tumor suppressor protein has an essential role in modulating cell cycle progression. However, there is no direct evidence supporting its role in maintaining genetic stability. Here, we developed a sensitive method to examine th...

journal_title：Cancer research

authors： Zheng L,Flesken-Nikitin A,Chen PL,Lee WH

更新日期：2002-05-01 00:00:00

abstract：:A molecular target associated with the progression of gastric cancer has not yet been uncovered. FBXW7 is a tumor suppressor gene transcriptionally controlled by p53 that plays a role in the regulation of cell cycle exit and reentry via c-Myc degradation. Few studies have addressed the clinical significance of FBXW7 e...

journal_title：Cancer research

authors： Yokobori T,Mimori K,Iwatsuki M,Ishii H,Onoyama I,Fukagawa T,Kuwano H,Nakayama KI,Mori M

更新日期：2009-05-01 00:00:00