Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability.

abstract：:The effect of sodium taurocholate on the biliary export of stable mutagenic phenolic glucuronide metabolites of benzo(a)pyrene from livers of corn oil- or 3-methylcholanthrene-treated rats was studied using a nonrecirculating perfusion system. Sterile bile samples were collected every 4 min and assayed for mutagens us...

journal_title：Cancer research

authors： Kari FW,Kauffman FC,Thurman RG

更新日期：1985-04-01 00:00:00

abstract：:Patients with disseminated Ewing's family of tumors (ESFT) often experience drug-resistant relapse. We hypothesize that targeting minimal residual disease with the cytotoxic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR; fenretinide) may decrease relapse. We determined the following: (a) 4-HPR cytotoxicity against 12...

journal_title：Cancer research

authors： Batra S,Reynolds CP,Maurer BJ

更新日期：2004-08-01 00:00:00

abstract：:The accumulated literature suggests that altering the immune capacities of animals or humans seldom has detectable effects on tumor incidence nor, it seems, does the growth of an untransplanted tumor, either spontaneous or induced, immunize the host against the growth of a subsequent implant of that tumor. These obser...

journal_title：Cancer research

authors： Prehn RT

更新日期：1994-02-15 00:00:00

abstract：:Hypoxia drives malignant progression in part by promoting accumulation of the oncogenic transcription factor hypoxia inducible factor-1α (HIF-1α) in tumor cells. Tumor aggressiveness also relates to elevation of the cancer stem cell-associated membrane protein CD24, which has been causally implicated in tumor formatio...

journal_title：Cancer research

authors： Thomas S,Harding MA,Smith SC,Overdevest JB,Nitz MD,Frierson HF,Tomlins SA,Kristiansen G,Theodorescu D

更新日期：2012-11-01 00:00:00

abstract：:Anguidine is a fungal metabolite with antitumor activity in a murine colon cancer model. Because of disappointing results in clinical trials, we analyzed the lethal and cytokinetic effects of anguidine on cultured human colon cancer cells. The studies revealed a moderate reduction in survival only after prolonged drug...

journal_title：Cancer research

authors： Dosik GM,Barlogie B,Johnston DA,Murphy WK,Drewinko B

更新日期：1978-10-01 00:00:00

abstract：:A HeLa cell line synchronized by double thymidine block and mitotic shake off was shown to have a characteristic surface morphology for each of the different cell cycle stages. Inhibitors of cell multiplication were used to arrest cells in specific cell cycle phases, and these cells had a surface morphology similar to...

journal_title：Cancer research

authors： Lundgren E,Roos G

更新日期：1976-11-01 00:00:00

abstract：:Cells obtained from N-nitrosomethylurea-induced rat mammary tumors were grown in vitro using the soft-agar clonogenic assay technique. Their growth was studied in regular media containing serum as well as in media lacking serum, but to which insulin was added. Deletion of serum from the media resulted in a mean decrea...

journal_title：Cancer research

authors： Arafah BM,Griffin P,Gordon NH,Pearson OH

更新日期：1984-12-01 00:00:00

abstract：:Estrogen-related receptor alpha (ERRalpha) was identified as a gene related to estrogen receptor alpha (ERalpha) and belongs to a class of nuclear orphan receptors. ERRalpha binds to estrogen responsive element(s) (ERE) and is considered to be involved in modulation of estrogenic actions. However, biological significa...

journal_title：Cancer research

authors： Suzuki T,Miki Y,Moriya T,Shimada N,Ishida T,Hirakawa H,Ohuchi N,Sasano H

更新日期：2004-07-01 00:00:00

abstract：:Advocates bring unique and important viewpoints to the cancer research process, ensuring that scientific and medical advances are patient-centered and relevant. In this article, we discuss the benefits of engaging advocates in cancer research and underscore ways in which both the scientific and patient communities can...

journal_title：Cancer research

authors： Salamone JM,Lucas W,Brundage SB,Holloway JN,Stahl SM,Carbine NE,London M,Greenwood N,Goyes R,Chisholm DC,Price E,Carlin R,Winarsky S,Baker KB,Maues J,Shajahan-Haq AN

更新日期：2018-10-15 00:00:00

abstract：:Mitochondria are the powerhouses of cells. Mitochondrial C-Raf is a potential cancer therapeutic target, as it regulates mitochondrial function and is localized to the mitochondria by its N-terminal domain. However, Raf inhibitor monotherapy can induce S338 phosphorylation of C-Raf (pC-Raf(S338)) and impede therapy. T...

journal_title：Cancer research

authors： Tsai YT,Chuang MJ,Tang SH,Wu ST,Chen YC,Sun GH,Hsiao PW,Huang SM,Lee HJ,Yu CP,Ho JY,Lin HK,Chen MR,Lin CC,Chang SY,Lin VC,Yu DS,Cha TL

更新日期：2015-09-01 00:00:00

abstract：:A number of studies have shown that the extracellular pH (pHe) in cancers is typically lower than that in normal tissue and that an acidic pHe promotes invasive tumor growth in primary and metastatic cancers. Here, we investigate the hypothesis that increased systemic concentrations of pH buffers reduce intratumoral a...

journal_title：Cancer research

authors： Silva AS,Yunes JA,Gillies RJ,Gatenby RA

更新日期：2009-03-15 00:00:00

abstract：:Two murine monoclonal antibodies, 2H6G5 (IgM) and 4A9E10 (IgG3), were obtained by using either cultured human hepatocellular carcinoma cells (PLC/PRF/5) or the acidic glycolipid mixture prepared from the same cells as immunogens. The antigen in PLC/PRF/5 cell membranes recognized by both antibodies was identified as a...

journal_title：Cancer research

authors： Hiraiwa N,Iida N,Ishizuka I,Itai S,Shigeta K,Kannagi R,Fukuda Y,Imura H

更新日期：1988-12-01 00:00:00

abstract：:Activation of protein kinase Cbeta (PKCbeta) has been repeatedly implicated in tumor-induced angiogenesis. The PKCbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses angiogenesis and was advanced for clinical development based upon this antiangiogenic activity. Activation of PKCbeta has now also been impl...

journal_title：Cancer research

authors： Graff JR,McNulty AM,Hanna KR,Konicek BW,Lynch RL,Bailey SN,Banks C,Capen A,Goode R,Lewis JE,Sams L,Huss KL,Campbell RM,Iversen PW,Neubauer BL,Brown TJ,Musib L,Geeganage S,Thornton D

更新日期：2005-08-15 00:00:00

abstract：:Small-molecule inhibitors of PARP1/2, such as olaparib, have been proposed to serve as a synthetic lethal therapy for cancers that harbor BRCA1 or BRCA2 mutations. Indeed, in clinical trials, PARP1/2 inhibitors elicit sustained antitumor responses in patients with germline BRCA gene mutations. In hypothesizing that ad...

journal_title：Cancer research

authors： Bajrami I,Frankum JR,Konde A,Miller RE,Rehman FL,Brough R,Campbell J,Sims D,Rafiq R,Hooper S,Chen L,Kozarewa I,Assiotis I,Fenwick K,Natrajan R,Lord CJ,Ashworth A

更新日期：2014-01-01 00:00:00

abstract：:Monoclonal antibodies (Mabs) against human ovarian mucinous and serous carcinoma were obtained by the Mab technique. Their reactivities against human tumors were tested by indirect immunofluorescence. One of the Mabs, named 4C7, derived from the spleen cells of mice immunized with mucinous carcinoma line OVA-1, reacte...

journal_title：Cancer research

authors： Tsuji Y,Suzuki T,Nishiura H,Takemura T,Isojima S

更新日期：1985-05-01 00:00:00

abstract：:Expression of the alpha6beta4 integrin is associated with poor patient prognosis and reduced survival in a variety of human cancers. In recent years, a limited number of in vivo studies have examined the contribution of this integrin receptor to cancer progression and they have revealed that the alpha6beta4 integrin p...

journal_title：Cancer research

authors： Dutta U,Shaw LM

更新日期：2008-11-01 00:00:00

abstract：:Small cell lung cancer (SCLC) produces several neuroendocrine peptides, including gastrin-releasing peptide (GRP), the mammalian equivalent of bombesin. There is some evidence to support the suggestion that GRP is an autocrine regulator of SCLC growth. Therefore, we have tested the effect of bombesin and two antagonis...

journal_title：Cancer research

authors： Layton JE,Scanlon DB,Soveny C,Morstyn G

更新日期：1988-09-01 00:00:00

abstract：:Targeting cancer cell metabolism is a new promising strategy to fight cancer. Metformin, a widely used antidiabetic agent, exerts antitumoral and antiproliferative action. In this study, the addition of metformin to 2-deoxyglucose (2DG) inhibited mitochondrial respiration and glycolysis in prostate cancer cells leadin...

journal_title：Cancer research

authors： Ben Sahra I,Laurent K,Giuliano S,Larbret F,Ponzio G,Gounon P,Le Marchand-Brustel Y,Giorgetti-Peraldi S,Cormont M,Bertolotto C,Deckert M,Auberger P,Tanti JF,Bost F

更新日期：2010-03-15 00:00:00

abstract：:Calyculin A, isolated from a marine sponge, has a novel spiro ketal skeleton. Structurally unrelated to okadaic acid, calyculin A bound to the okadaic acid receptors in particulate and soluble fractions of mouse skin. The biochemical and tumor-promoting activities of calyculin A were studied with those of okadaic acid...

journal_title：Cancer research

authors： Suganuma M,Fujiki H,Furuya-Suguri H,Yoshizawa S,Yasumoto S,Kato Y,Fusetani N,Sugimura T

更新日期：1990-06-15 00:00:00

abstract：:Metformin may reduce the progression of head and neck squamous cell carcinoma (HNSCC); however, whether metformin acts by altering the host metabolism or targets cancer-initiating cells remains poorly understood. This gap in knowledge has prevented the stratification of patient populations who are most likely to benef...

journal_title：Cancer research

authors： Wu X,Yeerna H,Goto Y,Ando T,Wu VH,Zhang X,Wang Z,Amornphimoltham P,Murphy AN,Tamayo P,Chen Q,Lippman SM,Gutkind JS

更新日期：2019-09-01 00:00:00

abstract：:c-myc expression, amplification, and rearrangement were studied in neoplastic hepatic nodules of rats after diethylnitrosamine treatment, in hepatocellular carcinomas induced by N-methyl-N-nitrosourea, and in tumorigenic liver cell lines derived from rat hepatocytes transformed by diethylnitrosamine in vivo. Steady-st...

journal_title：Cancer research

authors： Suchy BK,Sarafoff M,Kerler R,Rabes HM

更新日期：1989-12-01 00:00:00

abstract：:Retinoids that regulate cell growth, differentiation, and apoptosis have shown promising results in preclinical studies and in a few clinical trials of cancer chemoprevention and therapy. However, the clinical use of retinoids is limited by resistance of certain malignant cells to their antitumor effects and by side e...

journal_title：Cancer research

authors： Chun KH,Benbrook DM,Berlin KD,Hong WK,Lotan R

更新日期：2003-07-01 00:00:00

abstract：:The cyanomorpholino derivative of doxorubicin (MRA-CN) is a DNA intercalator and alkylator that is a highly potent cytotoxin, non-cross-resistant in multidrug-resistant cells, and noncardiotoxic in comparison with doxorubicin. To further examine mechanisms of action and resistance to MRA-CN, a cell line resistant to M...

journal_title：Cancer research

authors： Lau DH,Lewis AD,Ehsan MN,Sikic BI

更新日期：1991-10-01 00:00:00

abstract：:The levels of serum thymic factor(s) (STF), of Thy-1.2 positivity of splenocytes [as measured by their azathioprine (AZ) sensitivity], and of Thy-1.2-positive "spontaneous" spleen rosette-forming cells (SSRFCs), as well as the presence of infectious virus in the thymus, were assessed as a function of time after virus ...

journal_title：Cancer research

authors： Tonietti G,Rossi GB,Del Gobbo V,Accinni L,Ranucci A,Titti F,Premrov MG,Garaci E

更新日期：1983-09-01 00:00:00

abstract：:Hematopoietic progenitor kinase 1 (HPK1) regulates stress responses, proliferation, and apoptosis in hematopoietic cells. In this study, we examined the expression, regulation, and functions of HPK1 in pancreatic ductal adenocarcinomas (PDA). We found that loss of HPK1 protein expression correlated significantly with ...

journal_title：Cancer research

authors： Wang H,Song X,Logsdon C,Zhou G,Evans DB,Abbruzzese JL,Hamilton SR,Tan TH,Wang H

更新日期：2009-02-01 00:00:00

abstract：:An assay using a bimane derivative has been developed to detect free glutathione (GSH) in individual viable cells by flow cytometry. Monochlorobimane [syn-(ClCH2CH3)-1,5-diazabicycla[3.30]acta-3,6-diene-2,8-dio ne], itself nonfluorescent, reacts with GSH to form a highly fluorescent derivative. High pressure liquid ch...

journal_title：Cancer research

authors： Rice GC,Bump EA,Shrieve DC,Lee W,Kovacs M

更新日期：1986-12-01 00:00:00

abstract：:The invasive transformation of A-459 lung epithelial carcinoma cells has been linked to the autocrine regulation of malignant phenotypic changes by transforming growth factor beta (TGF-beta). Here we demonstrate, using stable 13C glucose isotopes, that the transformed phenotype is characterized by decreased CO2 produc...

journal_title：Cancer research

authors： Boros LG,Torday JS,Lim S,Bassilian S,Cascante M,Lee WN

更新日期：2000-03-01 00:00:00

abstract：:Pheochromocytomas are tumors originating from chromaffin cells, the large majority of which are sporadic neoplasms. The genetic and molecular events determining their tumorigenesis continue to remain unknown. On the other hand, RET germ-line mutations cause the inheritance of familial tumors in multiple endocrine neop...

journal_title：Cancer research

authors： Le Hir H,Colucci-D'Amato LG,Charlet-Berguerand N,Plouin PF,Bertagna X,de Franciscis V,Thermes C

更新日期：2000-03-01 00:00:00

abstract：:Interleukin-6 (IL-6) and the subsequent Janus-activated kinase (JAK)-dependent signaling pathways play a critical role in the pathogenesis of multiple myeloma. Here, we compared the sensitivity and specificity of a novel pan-JAK inhibitor, tetracyclic pyridone 6 (P6), with that of AG490 in a panel of myeloma-derived c...

journal_title：Cancer research

authors： Pedranzini L,Dechow T,Berishaj M,Comenzo R,Zhou P,Azare J,Bornmann W,Bromberg J

更新日期：2006-10-01 00:00:00

abstract：:We tested the influence of recombinant human interleukin (rhIL)-l3 and rhIL-4 on clonal growth of human breast cancer cell lines. rhIL-13 and rhIL-4 inhibited clonal growth of three of nine lines to approximately 50% of controls (ED50, 0.5 ng/ml). rhIl-13 reduced [3H]thymidine incorporation in all three cell lines: tw...

journal_title：Cancer research

authors： Serve H,Oelmann E,Herweg A,Oberberg D,Serve S,Reufi B,Mücke C,Minty A,Thiel E,Berdel WE

更新日期：1996-08-01 00:00:00