Rate of generation of major karyotypic abnormalities in relationship to the metastatic potential of B16 murine melanoma.

abstract：:MEK inhibition is of interest in cancer drug development, but clinical activity in metastatic colorectal cancer (mCRC) has been limited. Preclinical studies demonstrated Wnt pathway overexpression in KRAS-mutant cell lines resistant to the MEK inhibitor, selumetinib. The combination of selumetinib and cyclosporin A, a...

journal_title：Cancer research

authors： Krishnamurthy A,Dasari A,Noonan AM,Mehnert JM,Lockhart AC,Leong S,Capasso A,Stein MN,Sanoff HK,Lee JJ,Hansen A,Malhotra U,Rippke S,Gustafson DL,Pitts TM,Ellison K,Davis SL,Messersmith WA,Eckhardt SG,Lieu CH

更新日期：2018-09-15 00:00:00

abstract：:To elucidate the role of cyclin E in cell growth and tumorigenesis in mammary epithelial cells, we have used retrovirus-mediated transduction to generate derivatives of the nontransformed HC11 mouse mammary epithelial cell line that stably express a human cyclin E cDNA (HU4). These derivatives expressed two distinct f...

journal_title：Cancer research

authors： Sgambato A,Han EK,Zhou P,Schieren I,Weinstein IB

更新日期：1996-03-15 00:00:00

abstract：:Translocations fusing the strong androgen-responsive gene, TMPRSS2, with ERG or other oncogenic ETS factors may facilitate prostate cancer development. Here, we studied 18 advanced prostate cancers for ETS factor alterations, using reverse transcription-PCR and DNA and RNA array technologies, and identified putative E...

journal_title：Cancer research

authors： Iljin K,Wolf M,Edgren H,Gupta S,Kilpinen S,Skotheim RI,Peltola M,Smit F,Verhaegh G,Schalken J,Nees M,Kallioniemi O

更新日期：2006-11-01 00:00:00

abstract：:Earlier studies have shown guanine arabinoside (ara-G) is an effective agent against growth of T-cell lines and freshly isolated human T-leukemic cells. However, poor water solubility of ara-G limits clinical use. 2-Amino-6-methoxypurine arabinoside (506U) is a water-soluble prodrug converted to ara-G by adenosine dea...

journal_title：Cancer research

authors： Lambe CU,Averett DR,Paff MT,Reardon JE,Wilson JG,Krenitsky TA

更新日期：1995-08-01 00:00:00

abstract：:Immune checkpoint inhibitors show great promise as therapy for advanced melanoma, heightening the need to determine the most effective use of these agents. Here, we report that programmed death-1(high) (PD-1(high)) tumor antigen (TA)-specific CD8(+) T cells present at periphery and at tumor sites in patients with adva...

journal_title：Cancer research

authors： Sun Z,Fourcade J,Pagliano O,Chauvin JM,Sander C,Kirkwood JM,Zarour HM

更新日期：2015-04-15 00:00:00

abstract：:Cytokine production and cytotoxicity for tumor cells are two important aspects of monocyte function and the inflammatory response against tumors and infectious agents. In the present studies we provide direct evidence at the mRNA and protein levels for the existence of autocrine tumor necrosis factor (TNF) and its imp...

journal_title：Cancer research

authors： Smith DM,Lackides GA,Epstein LB

更新日期：1990-06-01 00:00:00

abstract：:Surface-exposed proteins of vinblastine-sensitive human lymphoid cell line of leukemic origin (CCRF-CEM) were examined by the lactoperoxidase-catalyzed iodination and two-dimensional polyacrylamide gel electrophoresis methods. Spots which comigrate with bovine brain tubulin and rabbit muscle actin were prominently lab...

journal_title：Cancer research

authors： Rubin RW,Quillen M,Corcoran JJ,Ganapathi R,Krishan A

更新日期：1982-04-01 00:00:00

abstract：:The selective pressures leading to cancers with mutations in both KRAS and PIK3CA are unclear. Here, we show that somatic cell knockin of both KRAS G12V and oncogenic PIK3CA mutations in human breast epithelial cells results in cooperative activation of the phosphoinositide 3-kinase (PI3K) and mitogen-activated protei...

journal_title：Cancer research

authors： Wang GM,Wong HY,Konishi H,Blair BG,Abukhdeir AM,Gustin JP,Rosen DM,Denmeade SR,Rasheed Z,Matsui W,Garay JP,Mohseni M,Higgins MJ,Cidado J,Jelovac D,Croessmann S,Cochran RL,Karnan S,Konishi Y,Ota A,Hosokawa Y,Arga

更新日期：2013-06-01 00:00:00

abstract：:Previous studies have shown that PC12 cells undergo apoptosis (programmed cell death) when deprived of serum. In the present study, we examined the relationship of this death process to the cell cycle. PC12 cell populations synchronized at different, specific phases of the cell cycle exhibit similar kinetics of cell d...

journal_title：Cancer research

authors： Lindenboim L,Diamond R,Rothenberg E,Stein R

更新日期：1995-03-15 00:00:00

abstract：:Poly (ADP-ribose) glycohydrolase (PARG) is the main enzyme responsible for catabolism of poly (ADP-ribose) (PAR), synthesized by PARP. PARG dysfunction sensitizes certain cancer cells to alkylating agents and cisplatin by perturbing the DNA damage response. The gene mutations that sensitize cancer cells to PARG dysfun...

journal_title：Cancer research

authors： Sasaki Y,Fujimori H,Hozumi M,Onodera T,Nozaki T,Murakami Y,Ashizawa K,Inoue K,Koizumi F,Masutani M

更新日期：2019-08-01 00:00:00

abstract：:Tumorigenesis can arise from inappropriate activation of developmental genes in mature tissues. Here, we show that the developmental regulator Six1 is overexpressed in ovarian carcinoma cell lines (OCC) compared with normal ovarian surface epithelium. As observed in other cancers, Six1 overexpression in OCC leads to i...

journal_title：Cancer research

authors： Behbakht K,Qamar L,Aldridge CS,Coletta RD,Davidson SA,Thorburn A,Ford HL

更新日期：2007-04-01 00:00:00

abstract：:Although the cyclin-dependent kinases CDK4 and CDK6 play fundamental roles in cancer, the specific pathways and downstream targets by which they exert their tumorigenic effects remain elusive. In this study, we uncover distinct and novel functions for these kinases in regulating tumor formation and metastatic coloniza...

journal_title：Cancer research

authors： Dai M,Boudreault J,Wang N,Poulet S,Daliah G,Yan G,Moamer A,Burgos SA,Sabri S,Ali S,Lebrun JJ

更新日期：2020-12-28 00:00:00

abstract：:The levels of protooncogene RNA in matched bone marrow and peripheral blood cells obtained from patients with newly diagnosed acute myelogenous leukemia were compared. While the absolute amounts of c-myc RNA in the matched specimens are similar, the levels are not correlated. In contrast, while the levels of c-fos RNA...

journal_title：Cancer research

authors： Preisler HD,Sato H,Li YQ,Stein G,Stein J

更新日期：1987-07-15 00:00:00

abstract：:Using computerized pharmacy records from 1969 to 1973 for a cohort of 143,574 members of the Kaiser Permanente Medical Care Program, we have been testing associations of 215 drugs or drug groups with subsequent incidence of cancer at 56 sites. This paper presents findings with follow-up through 1984. There were 227 st...

journal_title：Cancer research

authors： Selby JV,Friedman GD,Fireman BH

更新日期：1989-10-15 00:00:00

abstract：:Human and mouse paralogues of the evolutionarily conserved mammalian HRAD9 and Mrad9 cell cycle checkpoint control genes have been isolated and called HRAD9B and Mrad9B, respectively. HRAD9B encodes a protein that is 414 amino acids long and is 55% similar and 35% identical to the HRAD9 gene product. The Mrad9B protei...

journal_title：Cancer research

authors： Hopkins KM,Wang X,Berlin A,Hang H,Thaker HM,Lieberman HB

更新日期：2003-09-01 00:00:00

abstract：:A bovine serum albumin-conjugated doxorubicin via the glutaraldehyde bridge (BSA-DXR conjugate) showed potent dose-dependent inhibition of cell growth against daunorubicin-resistant AH66 (AH66DR) cells as well as parental AH66 (AH66P) cells in vitro as compared to treatment with DXR or BSA-glutaraldehyde conjugate wit...

journal_title：Cancer research

authors： Ohkawa K,Hatano T,Yamada K,Joh K,Takada K,Tsukada Y,Matsuda M

更新日期：1993-09-15 00:00:00

abstract：:The mechanism whereby the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) is silenced in repair-deficient (Mer-) human tumor cells is unknown. The role of methylation of the 5' CpG island in MGMT gene suppression is controversial. Although we previously showed by restriction enzyme analysis that CpG m...

journal_title：Cancer research

authors： Qian XC,Brent TP

更新日期：1997-09-01 00:00:00

abstract：:In a recent study, we showed that the plant alkaloid camptothecin (CPT) and its derivatives 9-nitro-CPT (9NC) and 9-amino-CPT (9AC) inhibit growth of both human melanocytes (MEL cells) and their malignant counterparts, malignant melanoma (BRO) cells in vitro. This growth inhibition was accompanied by an increase in th...

journal_title：Cancer research

authors： Pantazis P,Early JA,Mendoza JT,DeJesus AR,Giovanella BC

更新日期：1994-02-01 00:00:00

abstract：:A total of 10 primary malignant lymphomas of the brain were examined for deletion, mutation, and 5' CpG island methylation of the p16 gene, which is a candidate tumor suppressor gene with CDK-inhibitory function. In Southern blot analysis, p16 gene deletion was suggested in nine cases, homozygously (five cases) or hem...

journal_title：Cancer research

authors： Zhang SJ,Endo S,Ichikawa T,Washiyama K,Kumanishi T

更新日期：1998-03-15 00:00:00

abstract：:Caspase-8 is a proapoptotic protease that suppresses neuroblastoma metastasis by inducing programmed cell death. Paradoxically, caspase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can promote metastasis when apoptosis is compromised. Migration is enhanced by caspase-8 recru...

journal_title：Cancer research

authors： Barbero S,Mielgo A,Torres V,Teitz T,Shields DJ,Mikolon D,Bogyo M,Barilà D,Lahti JM,Schlaepfer D,Stupack DG

更新日期：2009-05-01 00:00:00

abstract：:Heterotopic new bone formation was induced by implanting pieces of demineralized bone matrix in the abdominal wall of 22 growing Sprague-Dawley rats. The animals were divided into three groups and were given, 24 hr after initiation of the bone induction process, a single i.v. injection of methotrexate, 100 or 250 mg/k...

journal_title：Cancer research

authors： Nilsson OS,Bauer FC,Broström LA,Nilsonne U

更新日期：1984-04-01 00:00:00

abstract：:The endoplasmic reticulum (ER) has been posited as a potential anticancer target. The synthetic antitumor alkyl-lysophospholipid analogue edelfosine accumulates in the ER of solid tumor cells. This ER accumulation of the drug leads to the inhibition of phosphatidylcholine and protein synthesis, G(2)-M arrest, depletio...

journal_title：Cancer research

authors： Nieto-Miguel T,Fonteriz RI,Vay L,Gajate C,López-Hernández S,Mollinedo F

更新日期：2007-11-01 00:00:00

abstract：:Apoptosis is a mode of cell death that is carefully regulated based on cellular and environmental signals. The ability to modulate the individual cellular machinery and thereby to promote apoptosis is an important strategy in cancer therapy. It has previously been shown that overexpression of the transcription factor ...

journal_title：Cancer research

authors： Hunt KK,Deng J,Liu TJ,Wilson-Heiner M,Swisher SG,Clayman G,Hung MC

更新日期：1997-11-01 00:00:00

abstract：:Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb) trastuzumab. In a prospective, randomized phase III clinical trial ev...

journal_title：Cancer research

authors： Turcotte M,Allard D,Mittal D,Bareche Y,Buisseret L,José V,Pommey S,Delisle V,Loi S,Joensuu H,Kellokumpu-Lehtinen PL,Sotiriou C,Smyth MJ,Stagg J

更新日期：2017-10-15 00:00:00

abstract：:We investigated the prognostic value of p53 mutation type for 145 soft tissue sarcoma patients. In a PCR-SSCP-sequencing analysis, 15 mutations were identified: 10 non-frameshift (non-fs) and 5 frameshift (fs) mutations. Patients possessing non-fs mutations had a significantly poorer prognosis than patients without p5...

journal_title：Cancer research

authors： Taubert H,Meye A,Würl P

更新日期：1996-09-15 00:00:00

abstract：:Fischer X Copenhagen rats bearing Dunning R3327-AT tumors were treated with hematoporphyrin derivative and red light (630 nm from an argon-driven dye laser) alone or in combination with the hypoxic cell radiosensitizer, misonidazole (MISO). In vitro studies had suggested that hypoxia might significantly decrease the c...

journal_title：Cancer research

authors： Gonzalez S,Arnfield MR,Meeker BE,Tulip J,Lakey WH,Chapman JD,McPhee MS

更新日期：1986-06-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons, possible human breast carcinogens, are metabolized by cytochrome P4501A1 (CYP1A1) and glutathione S-transferase (GSTM1). A CYP1A1 polymorphism (isoleucine to valine substitution in exon 7) or the null allele for GSTM1 may affect the mutagenic potential of polycyclic aromatic hydrocarb...

journal_title：Cancer research

authors： Ambrosone CB,Freudenheim JL,Graham S,Marshall JR,Vena JE,Brasure JR,Laughlin R,Nemoto T,Michalek AM,Harrington A

更新日期：1995-08-15 00:00:00

abstract：:Stem cells are under strict regulation by both intrinsic factors and the microenvironment. There is increasing evidence that many cancers initiate through acquisition of genetic mutations (loss of intrinsic control) in stem cells or their progenitors, followed by alterations of the surrounding microenvironment (loss o...

journal_title：Cancer research

authors： Le LQ,Liu C,Shipman T,Chen Z,Suter U,Parada LF

更新日期：2011-07-01 00:00:00

abstract：:Estrogen exposure is considered a significant risk factor for breast cancer development. Estrogen receptor (ER) alpha is expressed at low levels in normal epithelia, and its expression is dramatically up-regulated as transformation progresses during mammary hyperplasia and adenocarcinoma development. The mechanism(s) ...

journal_title：Cancer research

authors： Sotgia F,Rui H,Bonuccelli G,Mercier I,Pestell RG,Lisanti MP

更新日期：2006-11-15 00:00:00

abstract：:Farnesol (FOH) and other isoprenoid alcohols induce apoptosis in various carcinoma cells and inhibit tumorigenesis in several in vivo models. However, the mechanisms by which they mediate their effects are not yet fully understood. In this study, we show that FOH is an effective inducer of apoptosis in several lung ca...

journal_title：Cancer research

authors： Joo JH,Liao G,Collins JB,Grissom SF,Jetten AM

更新日期：2007-08-15 00:00:00