Farnesol-induced apoptosis in human lung carcinoma cells is coupled to the endoplasmic reticulum stress response.

abstract：:Although polyamines are well recognized for their critical involvement in cell growth, the cell cycle specificity of this requirement has not yet been characterized with respect to the newly delineated regulatory pathways. We recently reported that polyamine analogues having close structural and functional similaritie...

journal_title：Cancer research

authors： Kramer DL,Vujcic S,Diegelman P,Alderfer J,Miller JT,Black JD,Bergeron RJ,Porter CW

更新日期：1999-03-15 00:00:00

abstract：:Chromatin coregulators are important factors in tumorigenesis and cancer progression. ANCCA is an AAA+ ATPase and a bromodomain-containing nuclear coactivator for the estrogen and androgen receptors that is crucial for assembly of chromatin-modifying complexes and proliferation of hormone-responsive cancer cells. In t...

journal_title：Cancer research

authors： Kalashnikova EV,Revenko AS,Gemo AT,Andrews NP,Tepper CG,Zou JX,Cardiff RD,Borowsky AD,Chen HW

更新日期：2010-11-15 00:00:00

abstract：:The relationship between natural cell-mediated cytotoxicity (NCMC) and antibody-dependent cell-mediated cytotoxicity (ADCC) was examined in an Epstein-Barr virus-infected target cell system. The total ADCC reactivity to Epstein-Barr virus-infected target cells varied considerably with different effector cells, indicat...

journal_title：Cancer research

authors： Takasugi M,Mickey MR,Levine PH

更新日期：1982-04-01 00:00:00

abstract：:We have shown previously that IgM from Ehrlich tumor (ET)-immunized mice, recognizing ET cell surface carbohydrates, protects control mice to a subsequent tumor challenge. The factors involved in such IgM-mediated protection were unknown, since it was independent of complement activation. Here, we have extended these ...

journal_title：Cancer research

authors： Gil J,Alvarez R,Viñuela JE,Ruiz de Morales JG,Bustos A,De la Concha EG,Subiza JL

更新日期：1990-11-15 00:00:00

abstract：:The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers. Although radioiodide uptake is generally reduced in thyroid cancer tissue, intracellu...

journal_title：Cancer research

authors： Feng F,Yehia L,Ni Y,Chang YS,Jhiang SM,Eng C

更新日期：2018-11-01 00:00:00

abstract：:The antimetastatic activity of Nocardia rubra cell wall skeleton (N-CWS) with or without cyclophosphamide was examined in an experimental model of pulmonary metastasis induced by Lewis lung carcinoma in C57BL/6 mice. Lewis lung carcinoma cells were implanted into the footpads of mice, and the implanted tumors were rem...

journal_title：Cancer research

authors： Kagawa K,Yamashita T,Tsubura E,Yamamura Y

更新日期：1984-02-01 00:00:00

abstract：:Earlier studies (Baeckström et al., J. Biol. Chem., 266: 21537-21547, 1991) have revealed that the colon carcinoma cell line COLO 205 produces two different proteins carrying the carcinoma-associated sialyl-Le(a) carbohydrate epitope. One is the MUC1 mucin apoprotein, and the other protein is smaller and has not been ...

journal_title：Cancer research

authors： Baeckström D,Nilsson O,Price MR,Lindholm L,Hansson GC

更新日期：1993-02-15 00:00:00

abstract：:The capacity of lymph nodes to eradicate cancer is a controversial issue. The purpose of this study was to determine the interplay between tumor growth and host resistance at early stages of lymph node metastasis. A metastasis model was made in the rat mesenteric lymph node, and migration of cancer cells was visualize...

journal_title：Cancer research

authors： Nagata H,Arai T,Soejima Y,Suzuki H,Ishii H,Hibi T

更新日期：2004-11-15 00:00:00

abstract：:Inactivating effects caused by vincristine alone or in combination with another mitotic inhibitor, 1-propargyl-5-chloropyrimidin-2-one, were studied as loss of colony-forming ability in exponentially growing or synchronized populations of the human cell line NHIK 3025. Treatment with 4 ng vincristine per ml(4.3 nM) in...

journal_title：Cancer research

authors： Wibe E

更新日期：1980-06-01 00:00:00

abstract：:The metabolites, transporters, and enzymes involved in choline metabolism are regarded as biomarkers for disease progression in a variety of cancers, but their in vivo detection is not ideal. Both magnetic resonance spectroscopy [MRS using chemical shift imaging (CSI) total choline (tCho)] and C-choline positron emiss...

journal_title：Cancer research

authors： Wehrl HF,Schwab J,Hasenbach K,Reischl G,Tabatabai G,Quintanilla-Martinez L,Jiru F,Chughtai K,Kiss A,Cay F,Bukala D,Heeren RM,Pichler BJ,Sauter AW

更新日期：2013-03-01 00:00:00

abstract：:We have studied the effects of partial polyamine depletion, induced by treatment with alpha-difluoromethylornithine (DFMO) on cell cycle phase distributions in five cultured human carcinoma cell lines. We used flow cytometry of cells stained with chromomycin-A3 and computer analysis to measure phase distributions of t...

journal_title：Cancer research

authors： Seidenfeld J,Block AL,Komar KA,Naujokas MF

更新日期：1986-01-01 00:00:00

abstract：:Bleomycin treatment produced dose-dependent changes in lung collagen content and in several measurable histopathological parameters. NIH/Swiss mice were treated twice weekly for 6 weeks with bleomycin, 0, 1, 20, or 40 mg/kg s.c. The two highest doses produced mortalities of 35 and 100%, respectively, as well as loss o...

journal_title：Cancer research

authors： Sikic BI,Young DM,Mimnaugh EG,Gram TE

更新日期：1978-03-01 00:00:00

abstract：:Despite their extensive clinical and pathologic heterogeneity, all malignant germ cell tumors (GCT) are thought to originate from primordial germ cells. However, no common biological abnormalities have been identified to date. We profiled 615 microRNAs (miRNA) in pediatric malignant GCTs, controls, and GCT cell lines ...

journal_title：Cancer research

authors： Palmer RD,Murray MJ,Saini HK,van Dongen S,Abreu-Goodger C,Muralidhar B,Pett MR,Thornton CM,Nicholson JC,Enright AJ,Coleman N,Children's Cancer and Leukaemia Group.

更新日期：2010-04-01 00:00:00

abstract：:The receptor Notch1 plays an important role in malignant progression of many cancers, but its regulation is not fully understood. In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7-dependent proteasomal degradation of Notch1 by phosphorylating its intracellular domain (Notch1-IC) w...

journal_title：Cancer research

authors： Ann EJ,Kim MY,Yoon JH,Ahn JS,Jo EH,Lee HJ,Lee HW,Kang HG,Choi DW,Chun KH,Lee JS,Choi CY,Ferrando AA,Lee K,Park HS

更新日期：2016-08-15 00:00:00

abstract：:Although the cyclin-dependent kinases CDK4 and CDK6 play fundamental roles in cancer, the specific pathways and downstream targets by which they exert their tumorigenic effects remain elusive. In this study, we uncover distinct and novel functions for these kinases in regulating tumor formation and metastatic coloniza...

journal_title：Cancer research

authors： Dai M,Boudreault J,Wang N,Poulet S,Daliah G,Yan G,Moamer A,Burgos SA,Sabri S,Ali S,Lebrun JJ

更新日期：2020-12-28 00:00:00

abstract：:Cells lacking the tumor suppressor gene LKB1/STK11 alter their metabolism to match the demands of accelerated growth, leaving them highly vulnerable to stress. However, targeted therapy for LKB1-deficient cancers has yet to be reported. In both Kras/p53/Lkb1 cell lines and a genetically engineered mouse model of Kras/...

journal_title：Cancer research

authors： Liu Y,Li Y,Wang X,Liu F,Gao P,Quinn MM,Li F,Merlino AA,Benes C,Liu Q,Gray NS,Wong KK

更新日期：2017-09-15 00:00:00

abstract：:The presence of immunosuppressive macrophages that become activated in the tumor microenvironment constitutes a major factor responsible for tumor growth and malignancy. In line with this knowledge, we report here that macrophage proliferation is a significant feature of advanced stages of cancer. Moreover, we have fo...

journal_title：Cancer research

authors： Giurisato E,Lonardi S,Telfer B,Lussoso S,Risa-Ebrí B,Zhang J,Russo I,Wang J,Santucci A,Finegan KG,Gray NS,Vermi W,Tournier C

更新日期：2020-08-15 00:00:00

abstract：:Stromal cell-derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 are implicated in the pathogenesis and prognosis of acute myelogenous leukemia (AML). Cellular microparticles, submicron vesicles shed from the plasma membrane of various cells, are also associated with human pathology. In the present study, we invest...

journal_title：Cancer research

authors： Kalinkovich A,Tavor S,Avigdor A,Kahn J,Brill A,Petit I,Goichberg P,Tesio M,Netzer N,Naparstek E,Hardan I,Nagler A,Resnick I,Tsimanis A,Lapidot T

更新日期：2006-11-15 00:00:00

abstract：:This report describes the application of a new approach, the universal response surface approach, to the quantitative assessment of drug interaction, i.e., the determination of synergism, antagonism, additivity, potentiation, inhibition, and coalitive action. The specific drug combination and experimental growth syste...

journal_title：Cancer research

authors： Greco WR,Park HS,Rustum YM

更新日期：1990-09-01 00:00:00

abstract：:In this issue of Cancer Research, Rozeveld and colleagues present intriguing evidence of the importance of lipid droplets and hormone-sensitive lipase (HSL) in regulating the aggressive nature of pancreatic cancer. Initially demonstrating a dependency of preloaded lipids on an invasive phenotype, the authors then esta...

journal_title：Cancer research

authors： Man J,Pajic M,Joshua AM

更新日期：2020-11-15 00:00:00

abstract：:Regulation of c-myc expression is known to be sensitive to a variety of mitogenic stimuli in various cell types. Since estrogen is a well documented mitogen of estrogen-responsive human breast cancer (HBC) cells, we studied the influence of estradiol and its antagonist tamoxifen on the expression of c-myc in HBC cell ...

journal_title：Cancer research

authors： Dubik D,Dembinski TC,Shiu RP

更新日期：1987-12-15 00:00:00

abstract：:Cancers are initiated as a result of changes that occur in the genome. Identification of gains and losses in the structure and expression of tumor-suppressor genes and oncogenes lies at the root of the understanding of cancer cell biology. Here, we show that the mitogen-activated protein kinase (MAPK) MKK3 suppresses ...

journal_title：Cancer research

authors： MacNeil AJ,Jiao SC,McEachern LA,Yang YJ,Dennis A,Yu H,Xu Z,Marshall JS,Lin TJ

更新日期：2014-01-01 00:00:00

abstract：:Specific progesterone binding by cultured human breast carcinoma T47D, MCF-7, and ZR75-1 cells was decreased 25-40% by epidermal growth factor (EGF), with a 50% effective dose of 0.1 nM EGF. Studies with the soluble and particulate fractions prepared after homogenization of T47D cells grown in glass roller bottles rev...

journal_title：Cancer research

authors： Sarup JC,Rao KV,Fox CF

更新日期：1988-09-15 00:00:00

abstract：:Galectin-3, a beta-galactoside binding protein, plays a significant role in cell to extracellular matrix interactions. Despite its extracellular expression, the precise physiological mechanisms that trigger its release from the intracellular milieu have not been characterized. The present analyses were, therefore, don...

journal_title：Cancer research

authors： Zhu WQ,Ochieng J

更新日期：2001-03-01 00:00:00

abstract：:Thirty-one patients with metastatic hormone-refractory prostatic adenocarcinoma were investigated scintigraphically with the 111In-labeled somatostatin analogue [DTPA-D-Phe1]-octreotide (OctreoScan) and with 99mTc-labeled HDP. In vitro somatostatin receptor autoradiography was performed on biopsies obtained from eight...

journal_title：Cancer research

authors： Nilsson S,Reubi JC,Kalkner KM,Laissue JA,Horisberger U,Olerud C,Westlin JE

更新日期：1995-12-01 00:00:00

abstract：:Whether the apparent efficacy of a specific kinase inhibitor is attributable solely to inhibition of its primary target, or to combined inhibition of additional unidentified kinases, is a critical issue in cancer therapy. We used a chemical genetic approach to generate a selective inhibitor of v-erbB [a transforming a...

journal_title：Cancer research

authors： Fan QW,Specht KM,Zhang C,Goldenberg DD,Shokat KM,Weiss WA

更新日期：2003-12-15 00:00:00

abstract：:Retinoic acid (RA)-treated HL-60 cells were used as a model to study differentiation of granulocytic leukemias. RA induces these cells to mature into granulocytes and to decrease growth. Mediators of these RA effects have not been identified definitively, but transforming growth factor-beta (TGF-beta) has been implica...

journal_title：Cancer research

authors： Nunes I,Kojima S,Rifkin DB

更新日期：1996-02-01 00:00:00

abstract：:We have previously reported that rodent tumor cell lines secrete a potent vascular permeability factor with a molecular weight of 34,000-42,000 (Senger et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science (Wash. DC), 219: 983-985, 1983). This tumor-secreted vas...

journal_title：Cancer research

authors： Senger DR,Perruzzi CA,Feder J,Dvorak HF

更新日期：1986-11-01 00:00:00

abstract：:The major transmission route for Kaposi sarcoma-associated herpesvirus (KSHV) infection is the oral cavity through saliva. Kaposi sarcoma (KS) frequently occurs in the oral cavity in HIV-positive individuals and is often the first presenting sign of AIDS. However, the oral target cells for KSHV infection and the cellu...

journal_title：Cancer research

authors： Li Y,Zhong C,Liu D,Yu W,Chen W,Wang Y,Shi S,Yuan Y

更新日期：2018-01-01 00:00:00

abstract：:The timing of bleomycin (BLM) administration after KMT-17 tumor inoculation was found to be important for optimizing its therapeutic effect on tumor-bearing rats. A remarkable therapeutic effect was observed when BLM (5 mg/kg/day) was administered i.p. for 5 days from the eighth day after tumor inoculation (Day 8 to D...

journal_title：Cancer research

authors： Morikawa K,Hosokawa M,Hamada J,Sugawara M,Kobayashi H

更新日期：1985-04-01 00:00:00