Effects of endogenously activated transforming growth factor-beta on growth and differentiation of retinoic acid-treated HL-60 cells.

abstract：:Normal or immortal epithelial cells are sensitive to a form of apoptosis, commonly referred to as anoikis, which is induced by detachment from the extracellular matrix (ECM). In contrast, development of carcinomas is associated with acquisition of cellular resistance to anoikis. However, whether human cancer cells dep...

journal_title：Cancer research

authors： Frankel A,Rosen K,Filmus J,Kerbel RS

更新日期：2001-06-15 00:00:00

abstract：:The presence of common genomic deletions in the 19q13 chromosomal region in neuroblastomas and gliomas strongly suggests the presence of a putative tumor suppressor gene for these neoplasms in this region that, despite much effort, has not yet been identified. In an attempt to address this issue, we compared the expre...

journal_title：Cancer research

authors： Alaminos M,Dávalos V,Ropero S,Setién F,Paz MF,Herranz M,Fraga MF,Mora J,Cheung NK,Gerald WL,Esteller M

更新日期：2005-04-01 00:00:00

abstract：:The study of two major risk factors in the development of hepatocellular carcinoma, namely persistent hepatitis virus infection and exposure to dietary aflatoxins, has been hampered by lack of an experimental system. To this end we have used a Pekin duck model to examine the effect of congenital duck hepatitis B virus...

journal_title：Cancer research

authors： Cova L,Wild CP,Mehrotra R,Turusov V,Shirai T,Lambert V,Jacquet C,Tomatis L,Trépo C,Montesano R

更新日期：1990-04-01 00:00:00

abstract：:Sporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such as regional DNA hypermethylation and global DNA hypomethylation. Epidemiological and animal studies suggest that aberrant DNA methylation is associated with low dietary folate intake, which is aggravated by high alcohol intake. Th...

journal_title：Cancer research

authors： van Engeland M,Weijenberg MP,Roemen GM,Brink M,de Bruïne AP,Goldbohm RA,van den Brandt PA,Baylin SB,de Goeij AF,Herman JG

更新日期：2003-06-15 00:00:00

abstract：:In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling pathways contributing to angiogenic stimulation and tumor development. Characteristic features of tumor ischemia include hypoxia and glucose deprivation, leading to the activation of hypoxia-inducible factor-1-dependent signaling...

journal_title：Cancer research

authors： Drogat B,Auguste P,Nguyen DT,Bouchecareilh M,Pineau R,Nalbantoglu J,Kaufman RJ,Chevet E,Bikfalvi A,Moenner M

更新日期：2007-07-15 00:00:00

abstract：:We established a cisplatin-resistant human ovarian cancer cell line (HAC2/0.1) from the parent cell line (HAC2/P) by continuous exposure of HAC2/P to 0.1 microgram of cisplatin/ml. Drug sensitivity determined by colony assay revealed that HAC2/0.1 was 2.4 times as resistant to cisplatin as the parental cell line. HAC2...

journal_title：Cancer research

authors： Niimi S,Nakagawa K,Sugimoto Y,Nishio K,Fujiwara Y,Yokoyama S,Terashima Y,Saijo N

更新日期：1992-01-15 00:00:00

abstract：:Checkpoint pathways help cells maintain genomic integrity, delaying cell cycle progression in response to various risks of fidelity, such as genotoxic stresses, compromised DNA replication, and impaired spindle control. Cancer cells frequently exhibit genomic instability, and recent studies showed that checkpoint path...

journal_title：Cancer research

authors： Ray D,Terao Y,Fuhrken PG,Ma ZQ,DeMayo FJ,Christov K,Heerema NA,Franks R,Tsai SY,Papoutsakis ET,Kiyokawa H

更新日期：2007-02-01 00:00:00

abstract：:A cell line (NCE-G28) was established from the biopsy material of a human gliosarcoma of low histological differentiation. The initial cultures showed a mixed population of cells which in later stages became more uniform due to loss of slower growing constituents. The cells have been growing steadily for 20 months. A ...

journal_title：Cancer research

authors： Westphal M,Haensel M,Mueller D,Laas R,Kunzmann R,Rohde E,Koenig A,Hoelzel F,Herrmann HD

更新日期：1988-02-01 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumor in children. Osteosarcoma patients who respond poorly to chemotherapy are at a higher risk of relapse and adverse outcome. Therefore, it was the aim of this study to identify prognostic factors at the time of diagnosis to characterize the genes predictive of poor su...

journal_title：Cancer research

authors： Mintz MB,Sowers R,Brown KM,Hilmer SC,Mazza B,Huvos AG,Meyers PA,Lafleur B,McDonough WS,Henry MM,Ramsey KE,Antonescu CR,Chen W,Healey JH,Daluski A,Berens ME,Macdonald TJ,Gorlick R,Stephan DA

更新日期：2005-03-01 00:00:00

abstract：:The effect of dietary orotic acid (OA) in liver-pancreas carcinogenesis induced in female Syrian hamsters by N-Nitroso(2-hydroxypropyl) (2-oxopropyl)amine (HPOP) was evaluated. All animals infused with the carcinogen received the same doses. Results of the control group which received no OA or carcinogen were compared...

journal_title：Cancer research

authors： Kokkinakis DM,Albores-Saavedra J

更新日期：1994-10-15 00:00:00

abstract：:Using a microcytotoxicity assay we have studied the immune responses to the preneoplastic, hyperplastic alveolar nodule (HAN) lines D1 and D2 and to the mammary tumors arising spontaneously from them in BALB/c mice. Lymph node cells (LNC) from mice bearing HAN implants, or from mice whose implants had been removed gre...

journal_title：Cancer research

authors： Heppner GH,Kopp JS,Medina D

更新日期：1976-02-01 00:00:00

abstract：:Potentiation of the EBV-specific CTL response by immunization with CTL epitopes has been proposed as a logical approach for immune-targeting nasopharyngeal carcinoma (NPC) cells in vivo. This approach will undoubtedly be influenced by the ability of these malignant cells to endogenously process and present target epit...

journal_title：Cancer research

authors： Khanna R,Busson P,Burrows SR,Raffoux C,Moss DJ,Nicholls JM,Cooper L

更新日期：1998-01-15 00:00:00

abstract：:We have shown that a mutant derivative of Chinese hamster ovary CHO-K1 cells, ADR-5, which shows hypersensitivity to topoisomerase II (topo II)-inhibitory drugs, is cross-sensitive to the site-selective cyclic AMP analogue 8-chloro-cyclic AMP. We tested the hypothesis that overexpression of the type I alpha regulatory...

journal_title：Cancer research

authors： North PS,Davies SL,Ciardiello F,Damiano V,Bianco C,Pepe S,Bianco AR,Harris AL,Hickson ID,Tortora G

更新日期：1994-08-01 00:00:00

abstract：:We describe a method to postlabel, in vivo, biotinylated monoclonal antibodies pretargeted onto tumor deposits when most of the non-tumor-bound antibodies have already been cleared as avidin-bound complexes. The application of this principle to tumor detection by immunoscintigraphy was tested in 20 patients with histo...

journal_title：Cancer research

authors： Paganelli G,Magnani P,Zito F,Villa E,Sudati F,Lopalco L,Rossetti C,Malcovati M,Chiolerio F,Seccamani E

更新日期：1991-11-01 00:00:00

abstract：:The plasma of dogs afflicted with mammary carcinoma was perfused through chambers bearing Staphylococcus aureus Cowan strain I in an attempt to remove tumor-promoting, immunosuppressive immune complexes from the peripheral blood of these animals. In this canine model of spontaneous mammary carcinoma, reduction of brea...

journal_title：Cancer research

authors： Holohan TV,Phillips TM,Bowles C,Deisseroth A

更新日期：1982-09-01 00:00:00

abstract：:We previously found that a minor subfraction of the human genomic DNA, corresponding to 2500-3000 nonrepetitive sequences of 3 kilobases each and designated as tumor-activated DNA (TaDNA) was transcriptionally active in Burkitt's lymphoma cells and almost inactive in normal lymphocytes growing in vitro following integ...

journal_title：Cancer research

authors： Hanania N,Castagna M,Shaool D,Zeliszewski D,Harel J

更新日期：1985-12-01 00:00:00

abstract：:The intermediate filament protein Nestin serves as a biomarker for stem cells and has been used to identify subsets of cancer stem-like cells. However, the mechanistic contributions of Nestin to cancer pathogenesis are not understood. Here, we report that Nestin binds the hedgehog pathway transcription factor Gli3 to ...

journal_title：Cancer research

authors： Li P,Lee EH,Du F,Gordon RE,Yuelling LW,Liu Y,Ng JM,Zhang H,Wu J,Korshunov A,Pfister SM,Curran T,Yang ZJ

更新日期：2016-09-15 00:00:00

abstract：:Studies of V79-171 cells were undertaken to determine what extracellular or intracellular derivative of the drug WR-2721 is associated with radioprotection. The effect of preincubation at 23 +/- 1 degree C with WR-2721, and with derivatives of WR-2721 produced in medium containing alkaline phosphatase, upon survival o...

journal_title：Cancer research

authors： Smoluk GD,Fahey RC,Calabro-Jones PM,Aguilera JA,Ward JF

更新日期：1988-07-01 00:00:00

abstract：:Although neoplasia is caused by clonal proliferation of cells, the resulting tumors are frequently heterogeneous, being composed of both neoplastic and reactive cells. Therefore, identification of tumors as neoplastic processes is frequently obscured. We studied cutaneous angiofibroma, which is a tumor of unknown etio...

journal_title：Cancer research

authors： Vortmeyer AO,Böni R,Pack SD,Darling TN,Zhuang Z

更新日期：1999-01-15 00:00:00

abstract：:We studied the correlation between the formation of brain metastasis and the malignant growth potential of seven human melanoma cell lines, isolated from lymph node metastases (A375-SM, TXM-1, DM-4) or from brain metastases (TXM-13, TXM-18, TXM-34, TXM-40), and the potential of three variants of the mouse K-1735 melan...

journal_title：Cancer research

authors： Zhang RD,Price JE,Schackert G,Itoh K,Fidler IJ

更新日期：1991-04-15 00:00:00

abstract：:Human B-cell lymphomas are frequently associated with specific genetic changes caused by chromosomal translocations that activate proto-oncogenes. For lymphomas of mice expressing murine leukemia virus, mutagenic proviral insertions are thought to play a similar role. Here we report studies designed to determine wheth...

journal_title：Cancer research

authors： Shin MS,Fredrickson TN,Hartley JW,Suzuki T,Akagi K,Morse HC 3rd

更新日期：2004-07-01 00:00:00

abstract：:Membrane-type matrix metalloproteinases (MT-MMP) constitute a subfamily of six distinct membrane-associated MMPs. Although the contribution of MT1-MMP during different steps of cancer progression has been well documented, the significance of other MT-MMPs is rather unknown. We have investigated the involvement of MT4-...

journal_title：Cancer research

authors： Chabottaux V,Sounni NE,Pennington CJ,English WR,van den Brûle F,Blacher S,Gilles C,Munaut C,Maquoi E,Lopez-Otin C,Murphy G,Edwards DR,Foidart JM,Noël A

更新日期：2006-05-15 00:00:00

abstract：:Low income, poor diet, obesity, and a lack of exercise are interrelated lifestyle factors that can profoundly alter our biologic make up to increase cancer risk, growth, and development. We recently reported a potential mechanistic link between carbohydrate-derived metabolites and cancer, which may provide a biologic ...

journal_title：Cancer research

authors： Turner DP

更新日期：2015-05-15 00:00:00

abstract：:Tumor endothelial marker 8 (TEM8) is a recently described protein that is preferentially expressed within tumor endothelium. We have developed a fusion protein that targets TEM8 and disrupts tumor vasculature by promoting localized thrombosis. Fusion protein specificity and function were evaluated using Western blot a...

journal_title：Cancer research

authors： Fernando S,Fletcher BS

更新日期：2009-06-15 00:00:00

abstract：:Determining to what degree chemicals and environmental agents contribute to the development of cancer would be materially enhanced by the ability to distinguish chemically induced tumors from those that arise spontaneously. Using DNA fingerprinting as an assay, we investigated whether somatic DNA rearrangements are mo...

journal_title：Cancer research

authors： Ledwith BJ,Storer RD,Prahalada S,Manam S,Leander KR,van Zwieten MJ,Nichols WW,Bradley MO

更新日期：1990-09-01 00:00:00

abstract：:We review and compare statistical methods for the analysis of in vivo tumor growth experiments. The methods most commonly used are deficient in that they have either low power or misleading type I error rates. We propose a set of multivariate statistical modeling methods that correct these problems, illustrating their...

journal_title：Cancer research

authors： Heitjan DF,Manni A,Santen RJ

更新日期：1993-12-15 00:00:00

abstract：:Aggressive cancer cells typically show a high rate of energy-consuming anabolic processes driving the synthesis of lipids, proteins, and DNA. Here, we took advantage of the ability of the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside to increase the intracellular levels of AICA ribotide, an ...

journal_title：Cancer research

authors： Swinnen JV,Beckers A,Brusselmans K,Organe S,Segers J,Timmermans L,Vanderhoydonc F,Deboel L,Derua R,Waelkens E,De Schrijver E,Van de Sande T,Noël A,Foufelle F,Verhoeven G

更新日期：2005-03-15 00:00:00

abstract：:The clinical management of cutaneous melanoma would benefit significantly from a better understanding of the molecular changes that occur during melanocytic progression to a melanoma phenotype. To gain unique insights into this process, we developed a three-dimensional in vitro model that allows observations of normal...

journal_title：Cancer research

authors： Seftor EA,Brown KM,Chin L,Kirschmann DA,Wheaton WW,Protopopov A,Feng B,Balagurunathan Y,Trent JM,Nickoloff BJ,Seftor RE,Hendrix MJ

更新日期：2005-11-15 00:00:00

abstract：:The aim of this study was to evaluate the promoter methylation status and loss of heterozygosity (LOH) of the SEMA3B in non-small cell lung cancers (NSCLCs). We analyzed the methylation status of semaphorin 3B (SEMA3B) promoter and LOH at 3p21.3 in eight NSCLC cell lines and 27 primary tumors. Hypermethylation of SEMA...

journal_title：Cancer research

authors： Kuroki T,Trapasso F,Yendamuri S,Matsuyama A,Alder H,Williams NN,Kaiser LR,Croce CM

更新日期：2003-06-15 00:00:00

abstract：:Glutathione S-transferases have been purified to homogeneity from Chinese hamster liver. Three enzyme forms were separated and designated Forms I, II, and III in order of their elution from carboxymethylcellulose columns. The forms exhibit close physical similarities to glutathione S-transferases B (ligandin) of rat l...

journal_title：Cancer research

authors： Smith GJ,Ohl VS,Litwack G

更新日期：1980-06-01 00:00:00