Abstract：
:Glutathione S-transferases have been purified to homogeneity from Chinese hamster liver. Three enzyme forms were separated and designated Forms I, II, and III in order of their elution from carboxymethylcellulose columns. The forms exhibit close physical similarities to glutathione S-transferases B (ligandin) of rat liver and epsilon of humam liver. However, enzyme kinetic analysis indicates that the hamster enzymes exhibit similar Km values but higher Vmax values towards common substrates compared with the rat and human forms. These differences, which explain the increased enzymic activities of hamster glutathione S-transferases in vivo and in vitro, appear to be related to slight differences in the peptide composition of hamster liver glutathione S-transferases compared to the rat and human enzymes.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Smith GJ,Ohl VS,Litwack Gsubject
Has Abstractpub_date
1980-06-01 00:00:00pages
1787-90issue
6eissn
0008-5472issn
1538-7445journal_volume
40pub_type
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