An expression signature classifies chemotherapy-resistant pediatric osteosarcoma.

abstract：:Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic epigenetic alterations discovered in human cancers. DNA hypomethylation is postulated to occur very early in almost all human cancers, perhaps facilitating genetic instability and cancer initiation and progression. We therefore examined t...

journal_title：Cancer research

authors： Yegnasubramanian S,Haffner MC,Zhang Y,Gurel B,Cornish TC,Wu Z,Irizarry RA,Morgan J,Hicks J,DeWeese TL,Isaacs WB,Bova GS,De Marzo AM,Nelson WG

更新日期：2008-11-01 00:00:00

abstract：:ABBV-075 is a potent and selective BET family bromodomain inhibitor that recently entered phase I clinical trials. Comprehensive preclinical characterization of ABBV-075 demonstrated broad activity across cell lines and tumor models, representing a variety of hematologic malignancies and solid tumor indications. In mo...

journal_title：Cancer research

authors： Bui MH,Lin X,Albert DH,Li L,Lam LT,Faivre EJ,Warder SE,Huang X,Wilcox D,Donawho CK,Sheppard GS,Wang L,Fidanze S,Pratt JK,Liu D,Hasvold L,Uziel T,Lu X,Kohlhapp F,Fang G,Elmore SW,Rosenberg SH,McDaniel KF,Kati

更新日期：2017-06-01 00:00:00

abstract：:Peroxisome proliferators (PPs) act as nongenotoxic tumor promoters in rodents. Their hepatocarcinogenicity requires the presence of the PP-activated receptor alpha (PPARalpha); however, the exact role played by this transcription factor in the liver, more precisely in liver cell growth and differentiation, is not know...

journal_title：Cancer research

authors： Kaplanski C,Pauley CJ,Griffiths TG,Kawabata TT,Ledwith BJ

更新日期：2000-02-01 00:00:00

abstract：:Bortezomib is a proteasome inhibitor with proven efficacy in multiple myeloma and non-Hodgkin's lymphoma. This study reports the effects of bortezomib in B-cell lymphoma cell lines with differing sensitivity to bortezomib to investigate factors that influence sensitivity. Bortezomib induced a time- and concentration-d...

journal_title：Cancer research

authors： Strauss SJ,Higginbottom K,Jüliger S,Maharaj L,Allen P,Schenkein D,Lister TA,Joel SP

更新日期：2007-03-15 00:00:00

abstract：:SMYD3 methyltransferase is nearly undetectable in normal human tissues but highly expressed in several cancers, including breast cancer, although its contributions to pathogenesis in this setting are unclear. Here we report that histone H2A.Z.1 is a substrate of SMYD3 that supports malignancy. SMYD3-mediated dimethyla...

journal_title：Cancer research

authors： Tsai CH,Chen YJ,Yu CJ,Tzeng SR,Wu IC,Kuo WH,Lin MC,Chan NL,Wu KJ,Teng SC

更新日期：2016-10-15 00:00:00

abstract：:An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. We now show that two other human malignant T-lymphoid cell lines, CCRF-CEM and CCRF-HSB-2 also produce such a fac...

journal_title：Cancer research

authors： Uittenbogaart CH,Nishanian PG,Anisman DJ,Erikson TK,Fahey JL

更新日期：1986-03-01 00:00:00

abstract：:Cyclooxygenase-2 and prostaglandin E(2) (PGE(2)) levels are increased in colorectal cancers and a subset of adenomas. PGE(2) signaling through the EP4 receptor has previously been associated with colorectal tumorigenesis. However, changes in EP4 expression during adenoma to carcinoma progression have not been investig...

journal_title：Cancer research

authors： Chell SD,Witherden IR,Dobson RR,Moorghen M,Herman AA,Qualtrough D,Williams AC,Paraskeva C

更新日期：2006-03-15 00:00:00

abstract：:We recently reported on the pharmacokinetics in 14 cancer patients of the 19-9 antibody radiolabeled with 111In. We have now repeated this investigation in 18 cancer patients using the OC-125 antibody, in part to compare the in vivo behavior of two murine monoclonal antibodies of the same subclass administered as the ...

journal_title：Cancer research

authors： Hnatowich DJ,Gionet M,Rusckowski M,Siebecker DA,Roche J,Shealy D,Mattis JA,Wilson J,McGann J,Hunter RE

更新日期：1987-11-15 00:00:00

abstract：:Infection of the bone marrow-derived mast cell line PB-3c with a retrovirus carrying oncogenic c-Ha-ras or v-Ha-ras reduced the interleukin 3 (IL-3) growth requirement and induced a state of tumorigenicity. In contrast, normal c-Ha-ras had no effect on the IL-3 requirement of this cell line nor did the cells become tu...

journal_title：Cancer research

authors： Imber R,Fabbro D

更新日期：1991-01-15 00:00:00

abstract：:A series of purine nucleoside and dialdehyde analogues was studied to determine their potency as inhibitors of C-1300 murine neuroblastoma cell growth in tissue culture. Tumor cells were incubated with each analogue for 72 h, and the number of viable cells was determined at 24, 48, and 72 h. Dose-response curves were ...

journal_title：Cancer research

authors： Mirkin BL,O'Dea RF,Hogenkamp HP

更新日期：1987-07-15 00:00:00

abstract：:Seventeen young women with clinically confirmed mammary dysplasia and six age-matched controls were treated with alpha-tocopherol. Serum samples collected during the luteal phase of each woman at monthly intervals for the 4-month duration of the study were analyzed for serum luteinizing hormone, follicle-stimulating h...

journal_title：Cancer research

authors： Sundaram GS,London R,Margolis S,Wenk R,Lustgarten J,Nair PP,Goldstein P

更新日期：1981-09-01 00:00:00

abstract：:The sodium iodide symporter (NIS) is a classical iodide pump typically localized within the cell plasma membrane in thyroid cells, where NIS expression is believed to ensure success of mainstay radioiodide therapy in thyroid cancers. Although radioiodide uptake is generally reduced in thyroid cancer tissue, intracellu...

journal_title：Cancer research

authors： Feng F,Yehia L,Ni Y,Chang YS,Jhiang SM,Eng C

更新日期：2018-11-01 00:00:00

abstract：:Recent expression profile analyses revealed that lung adenocarcinomas can be divided into several subgroups with diverse pathological features. Because cellular heterogeneity of tumors can confound these analyses, we used laser capture microdissection and microarray expression analysis to characterize the molecular pr...

journal_title：Cancer research

authors： Miura K,Bowman ED,Simon R,Peng AC,Robles AI,Jones RT,Katagiri T,He P,Mizukami H,Charboneau L,Kikuchi T,Liotta LA,Nakamura Y,Harris CC

更新日期：2002-06-01 00:00:00

abstract：:The translation initiation factor eIF4E is an oncogene that is commonly overexpressed in primary breast cancers and metastases. In this article, we report that a pharmacologic inhibitor of eIF4E function, ribavirin, safely and potently suppresses breast tumor formation. Ribavirin administration blocked the growth of p...

journal_title：Cancer research

authors： Pettersson F,Del Rincon SV,Emond A,Huor B,Ngan E,Ng J,Dobocan MC,Siegel PM,Miller WH Jr

更新日期：2015-03-15 00:00:00

abstract：:Loss of heterozygosity (LOH) reduces genes to hemizygosity in cancer cells and presents an absolute difference between normal and cancer cells. The regions of LOH are usually much larger than the tumor suppressor gene, which is lost, and are expected to contain genes that are essential for cell survival. Single nucleo...

journal_title：Cancer research

authors： Fluiter K,ten Asbroek AL,van Groenigen M,Nooij M,Aalders MC,Baas F

更新日期：2002-04-01 00:00:00

abstract：:EBV-infected B-cell lymphomas are a potentially life-threatening complication in bone marrow and solid organ transplant recipients. Immunosuppressive drugs required to prevent allograft rejection also impair anti-EBV T-cell immunity, thereby increasing the risk of EBV-associated disease. Here we demonstrate that the i...

journal_title：Cancer research

authors： Nepomuceno RR,Balatoni CE,Natkunam Y,Snow AL,Krams SM,Martinez OM

更新日期：2003-08-01 00:00:00

abstract：:Comparison of the cell surface characteristics of the parental strain-specific TA3-St ascites cell (I) of the strain A mouse and the more allotransplantable TA3-St/ticol ascites cell (II), immunoselected for reduced absorption of anti-H-2a antibody from Cell I, revealed the following. Cell II, like Cell I, possessed n...

journal_title：Cancer research

authors： Codington JF,Das HR,Dalianis T,Klein G,Miller SC,Silber C,Lampert LA,Darby DM,Jeanloz RW

更新日期：1983-09-01 00:00:00

abstract：:Pentraxin-3 (PTX3) is a member of the pentraxin family of innate immune regulators, which includes C-reactive protein (CRP). PTX3 has been implicated in angiogenesis, proliferation, and immune escape in cancer. In the present study, we evaluated PTX3 tissue expression and serum concentration as a biomarker to discrimi...

journal_title：Cancer research

authors： Stallone G,Cormio L,Netti GS,Infante B,Selvaggio O,Fino GD,Ranieri E,Bruno F,Prattichizzo C,Sanguedolce F,Tortorella S,Bufo P,Grandaliano G,Carrieri G

更新日期：2014-08-15 00:00:00

abstract：:Homogeneously staining regions (HSRs) were found in hypodiploid cells (40%) of a subline of the human melanoma cell line, MeWo, (MeWo-C) but were absent from the hypotetraploid cells (60%). Another subline (MeWo-B) was also shown to contain two populations of cells, 70% hypodiploid and 30% hypotetraploid. None of the ...

journal_title：Cancer research

authors： Shtromas I,White BN,Holden JJ,Reimer DL,Roder JC

更新日期：1985-02-01 00:00:00

abstract：:The effects of an acidic condition (pH 6.5) on WAF1 gene expression and p53 accumulation was investigated in human glioblastoma cells with different p53 statuses. WAF1 and p53 accumulation after treatment in acidic conditions was observed in A-172 cells carrying the wild-type p53 gene but not in T98G cells carrying th...

journal_title：Cancer research

authors： Ohtsubo T,Wang X,Takahashi A,Ohnishi K,Saito H,Song CW,Ohnishi T

更新日期：1997-09-15 00:00:00

abstract：:Human mammary epithelial cells (HMEC) grown under standard cell culture conditions enter a growth phase referred to as selection, but a subpopulation is able to escape from arrest and continue to proliferate. These cells, called post-selection or variant HMECs, may be derived from progenitor cells found in normal mamm...

journal_title：Cancer research

authors： Hinshelwood RA,Huschtscha LI,Melki J,Stirzaker C,Abdipranoto A,Vissel B,Ravasi T,Wells CA,Hume DA,Reddel RR,Clark SJ

更新日期：2007-12-15 00:00:00

abstract：:Retinoic acid (RA)-treated HL-60 cells were used as a model to study differentiation of granulocytic leukemias. RA induces these cells to mature into granulocytes and to decrease growth. Mediators of these RA effects have not been identified definitively, but transforming growth factor-beta (TGF-beta) has been implica...

journal_title：Cancer research

authors： Nunes I,Kojima S,Rifkin DB

更新日期：1996-02-01 00:00:00

abstract：:The capacity of lymph nodes to eradicate cancer is a controversial issue. The purpose of this study was to determine the interplay between tumor growth and host resistance at early stages of lymph node metastasis. A metastasis model was made in the rat mesenteric lymph node, and migration of cancer cells was visualize...

journal_title：Cancer research

authors： Nagata H,Arai T,Soejima Y,Suzuki H,Ishii H,Hibi T

更新日期：2004-11-15 00:00:00

abstract：:The chemopreventive effects of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) on oral carcinogenesis induced by 4-nitroquinoline 1-oxide (4-NQO) was investigated in male F344 rats. Rats were given 20 ppm of 4-NQO in their drinking water for 8 weeks to induce oral neoplasms or preneoplasms. Animals were fed ...

journal_title：Cancer research

authors： Tanaka T,Makita H,Ohnishi M,Mori H,Satoh K,Hara A

更新日期：1995-09-15 00:00:00

abstract：:It is well known that normal human diploid fibroblasts undergo a significant, p53-dependent arrest in the G1 phase of the cell cycle after exposure to ionizing radiation. The presence and magnitude of a G1 arrest in human tumor cell lines, however, has been controversial, particularly in cells derived from solid tumor...

journal_title：Cancer research

authors： Nagasawa H,Keng P,Maki C,Yu Y,Little JB

更新日期：1998-05-01 00:00:00

abstract：:SGN-40 is a humanized IgG1 antihuman CD40 that is currently in a phase I clinical trial for the treatment of multiple myeloma. As surface CD40 expression on B-lineage cells is maintained from pro-B cells to plasma cells, SGN-40 may be applicable to treatment of other B-cell neoplasias, including non-Hodgkin's lymphoma...

journal_title：Cancer research

authors： Law CL,Gordon KA,Collier J,Klussman K,McEarchern JA,Cerveny CG,Mixan BJ,Lee WP,Lin Z,Valdez P,Wahl AF,Grewal IS

更新日期：2005-09-15 00:00:00

abstract：:Certain human tumors are extensively infiltrated by eosinophils and contain extracellular deposits of eosinophil peroxidase, which uses hydrogen peroxide as a substrate to produce highly toxic hypohalous acids. We hypothesized that J558L HI, an interleukin 5-transfected murine plasmacytoma that is infiltrated by numer...

journal_title：Cancer research

authors： Samoszuk MK,Wimley WC,Nguyen V

更新日期：1996-01-01 00:00:00

abstract：:The effect of overexpression of p21waf1 on drug sensitivity was studied in an osteosarcoma cell line (SaOs-2) lacking both p53 and functional retinoblastoma protein using a tetracycline (TC)-inducible expression system. p21waf1 expression was barely detectable in SaOS-2 cells incubated in the presence of TC. After TC ...

journal_title：Cancer research

authors： Li WW,Fan J,Hochhauser D,Bertino JR

更新日期：1997-06-01 00:00:00

abstract：:A founder allele in the CHEK2 gene (1100delC) has been associated with an elevated risk of breast cancer. This allele is responsible for the majority of CHEK2-associated breast cancers in women from northern European countries; however, within Europe, it seems to be rare in countries that are close to the Mediterranea...

journal_title：Cancer research

authors： Zhang S,Phelan CM,Zhang P,Rousseau F,Ghadirian P,Robidoux A,Foulkes W,Hamel N,McCready D,Trudeau M,Lynch H,Horsman D,De Matsuda ML,Aziz Z,Gomes M,Costa MM,Liede A,Poll A,Sun P,Narod SA

更新日期：2008-04-01 00:00:00

abstract：:Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. Here we applied whole-exome sequencing to 69 samples from 11 patients to resolve the genetic architecture of subclonal diversification. Spatial genomic diver...

journal_title：Cancer research

authors： Lin DC,Mayakonda A,Dinh HQ,Huang P,Lin L,Liu X,Ding LW,Wang J,Berman BP,Song EW,Yin D,Koeffler HP

更新日期：2017-05-01 00:00:00