Perivascular cells harboring multiple endocrine neoplasia type 1 alterations are neoplastic cells in angiofibromas.

Abstract:

:Although neoplasia is caused by clonal proliferation of cells, the resulting tumors are frequently heterogeneous, being composed of both neoplastic and reactive cells. Therefore, identification of tumors as neoplastic processes is frequently obscured. We studied cutaneous angiofibroma, which is a tumor of unknown etiology. Combined analysis using immunohistochemistry, selective tissue microdissection, fluorescence in situ hybridization, sequencing analysis, and deletion analysis of the multiple endocrine neoplasia type 1 locus succeeded in the identification of a population of genetically altered, neoplastic cells in these tumors. This approach may be valuable in the future in identifying the etiology of other tumors of unknown etiology.

journal_name

Cancer Res

journal_title

Cancer research

authors

Vortmeyer AO,Böni R,Pack SD,Darling TN,Zhuang Z

subject

Has Abstract

pub_date

1999-01-15 00:00:00

pages

274-8

issue

2

eissn

0008-5472

issn

1538-7445

journal_volume

59

pub_type

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