Abstract:
:Although neoplasia is caused by clonal proliferation of cells, the resulting tumors are frequently heterogeneous, being composed of both neoplastic and reactive cells. Therefore, identification of tumors as neoplastic processes is frequently obscured. We studied cutaneous angiofibroma, which is a tumor of unknown etiology. Combined analysis using immunohistochemistry, selective tissue microdissection, fluorescence in situ hybridization, sequencing analysis, and deletion analysis of the multiple endocrine neoplasia type 1 locus succeeded in the identification of a population of genetically altered, neoplastic cells in these tumors. This approach may be valuable in the future in identifying the etiology of other tumors of unknown etiology.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Vortmeyer AO,Böni R,Pack SD,Darling TN,Zhuang Zsubject
Has Abstractpub_date
1999-01-15 00:00:00pages
274-8issue
2eissn
0008-5472issn
1538-7445journal_volume
59pub_type
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