Targeting tumor endothelial marker 8 in the tumor vasculature of colorectal carcinomas in mice.

abstract：:The Th2 cytokines interleukin (IL)-4 and -13 are acknowledged regulators of lymphocyte proliferation and activation. They have also been well studied in the regulation of various myeloid-derived populations in tumor biology. It has become clear, however, that both cytokines can have direct effects on epithelial tumor ...

journal_title：Cancer research

authors： Hallett MA,Venmar KT,Fingleton B

更新日期：2012-12-15 00:00:00

abstract：:Glioblastoma (GBM) is often treated with the cytotoxic drug temozolomide, but the disease inevitably recurs in a drug-resistant form after initial treatment. Here, we report that in GBM cells, even a modest decrease in the mismatch repair (MMR) components MSH2 and MSH6 have profound effects on temozolomide sensitivity...

journal_title：Cancer research

authors： McFaline-Figueroa JL,Braun CJ,Stanciu M,Nagel ZD,Mazzucato P,Sangaraju D,Cerniauskas E,Barford K,Vargas A,Chen Y,Tretyakova N,Lees JA,Hemann MT,White FM,Samson LD

更新日期：2015-08-01 00:00:00

abstract：:Genetic instability plays a central role in the development and progression of human cancer. Two major classes of genetic instability, microsatellite instability (MSI) and chromosome instability (microsatellite stable; MSS), are best understood in the context of colon cancer, where MSI tumors represent approximately 1...

journal_title：Cancer research

authors： Giacomini CP,Leung SY,Chen X,Yuen ST,Kim YH,Bair E,Pollack JR

更新日期：2005-10-15 00:00:00

abstract：:The present study was undertaken to investigate the role of plasminogen activator inhibitor type 1 (PAI-1) and activated protein C (APC) in the regulation of tumor cell invasion. PAI-1 was purified in active form from conditioned medium of human umbilical vein endothelial cells under denaturing conditions (4 M guanidi...

journal_title：Cancer research

authors： Kobayashi H,Moniwa N,Gotoh J,Sugimura M,Terao T

更新日期：1994-01-01 00:00:00

abstract：:Many epithelial tumors show deletion of the short arm of chromosome 8 that is related to aggressive disease or adverse prognosis. In undissected samples of urothelial cell carcinoma of the bladder, at least two regions of loss of heterozygosity (LOH) were identified previously within a small region of 8p11-p12. LOH an...

journal_title：Cancer research

authors： Adams J,Williams SV,Aveyard JS,Knowles MA

更新日期：2005-01-01 00:00:00

abstract：:Understanding molecular alterations in colorectal cancer (CRC) is needed to define new biomarkers and treatment targets. We used oligonucleotide microarrays to monitor gene expression of about 6,800 known genes and 35,000 expressed sequence tags (ESTs) on five pools (four to six samples in each pool) of total RNA from...

journal_title：Cancer research

authors： Birkenkamp-Demtroder K,Christensen LL,Olesen SH,Frederiksen CM,Laiho P,Aaltonen LA,Laurberg S,Sørensen FB,Hagemann R,ØRntoft TF

更新日期：2002-08-01 00:00:00

abstract：:Lymph node biopsies from 43 male homosexuals with persistent generalized lymphadenopathy and from ten acquired immunodeficiency syndrome patients, all with serum antibodies to human T-cell leukemia virus III, were studied with regard to histopathology, immunohistology, and T-cell subsets in cell suspensions. All acqui...

journal_title：Cancer research

authors： Biberfeld P,Porwit-Ksiazek A,Böttiger B,Morfeldt-Månsson L,Biberfeld G

更新日期：1985-09-01 00:00:00

abstract：:The effects of estrogens on the growth and enzyme activities for androgen synthesis in a mouse Leydig cell tumor line (T 124958-R) were studied. The s.c. implantation of a diethylstilbestrol pellet resulted in a marked enhancement of the tumor growth. 5 alpha-Reductase activity (nmol/g/h) in tumors rapidly grown in th...

journal_title：Cancer research

authors： Noguchi S,Nishizawa Y,Takatsuka D,Sato B,Matsumoto K

更新日期：1986-02-01 00:00:00

abstract：:Chemokines play the key role in initiating immune responses by regulating the attraction and homing of immune cells to the lymphoid and nonlymphoid tissues. CXCL14 is a chemokine that in tumors may act as chemoattractant for monocytes and dendritic cells (DC), which may modulate antitumor immune responses in certain c...

journal_title：Cancer research

authors： Song EY,Shurin MR,Tourkova IL,Gutkin DW,Shurin GV

更新日期：2010-06-01 00:00:00

abstract：:In human breast carcinomas, increased copy number of DNA sequences derived from the long arm of chromosome 20 (20q) has been commonly observed by both chromosome microdissection and comparative genomic hybridization. This chromosomal region is likely to contain one or more genes that are the biological targets of this...

journal_title：Cancer research

authors： Guan XY,Xu J,Anzick SL,Zhang H,Trent JM,Meltzer PS

更新日期：1996-08-01 00:00:00

abstract：:The purpose of these studies was to select in vitro tumor cells that were resistant to macrophage-mediated lysis. Seven different heterogeneous murine neoplasms (four fibrosarcomas, a melanoma, a rhabdomyosarcoma, and an osteogenic sarcoma) and one cloned line of a fibrosarcoma were incubated in vitro with syngeneic t...

journal_title：Cancer research

authors： Fogler WE,Fidler IJ

更新日期：1985-01-01 00:00:00

abstract：:Isoprenoid inhibitors are being evaluated as agents for the treatment of cancer. Their antitumor activity is attributed to inhibition of post-translational modification of Ras, which is crucial for its translocation and attachment to the plasma membrane, and ultimate involvement in signal transduction. However, whethe...

journal_title：Cancer research

authors： Efuet ET,Keyomarsi K

更新日期：2006-01-15 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI3K)/AKT pathway aberrations are common in cancer. By applying mass spectroscopy-based sequencing and reverse-phase protein arrays to 547 human breast cancers and 41 cell lines, we determined the subtype specificity and signaling effects of PIK3CA, AKT, and PTEN mutations and the effect...

journal_title：Cancer research

authors： Stemke-Hale K,Gonzalez-Angulo AM,Lluch A,Neve RM,Kuo WL,Davies M,Carey M,Hu Z,Guan Y,Sahin A,Symmans WF,Pusztai L,Nolden LK,Horlings H,Berns K,Hung MC,van de Vijver MJ,Valero V,Gray JW,Bernards R,Mills GB,Hennes

更新日期：2008-08-01 00:00:00

abstract：:New facets to Knudson's [corrected] "two-hit" hypothesis have been proposed recently in relation to adenomatous polyposis coli (APC): protein inactivation may be selected weakly, and the two hits may be interdependent. We reviewed published data on 165 sporadic and 102 familial adenomatous polyposis-associated colorec...

journal_title：Cancer research

authors： Cheadle JP,Krawczak M,Thomas MW,Hodges AK,Al-Tassan N,Fleming N,Sampson JR

更新日期：2002-01-15 00:00:00

abstract：:Progression of prostate cancer is believed to be dependent on angiogenesis induced by tumor cells. 3,3'-Diindolylmethane (DIM) has been shown to repress neovascularization in a Matrigel plug assay and inhibit cell proliferation, migration, invasion, and capillary tube formation of cultured human umbilical vein endothe...

journal_title：Cancer research

authors： Kong D,Li Y,Wang Z,Banerjee S,Sarkar FH

更新日期：2007-04-01 00:00:00

abstract：:The possible contribution of endocrine disrupters to human disease, particularly those compounds that modulate the estrogen receptor (ER), has recently drawn considerable attention. The tissue specificity of effects mediated by the ER is well recognized, although the mechanism of this specificity is not understood suf...

journal_title：Cancer research

authors： Hunter DS,Hodges LC,Vonier PM,Fuchs-Young R,Gottardis MM,Walker CL

更新日期：1999-07-01 00:00:00

abstract：:Epidemiological studies have shown that the regular consumption of red wine may in part account for the apparent compatibility of a high fat diet with a low incidence of coronary atherosclerosis. This phenomenon, commonly referred to as the French paradox, may be associated with red wine constituents that exhibit tumo...

journal_title：Cancer research

authors： Hsieh TC,Juan G,Darzynkiewicz Z,Wu JM

更新日期：1999-06-01 00:00:00

abstract：:Treatment of exponentially growing 9L monolayer cells with graded concentrations of methotrexate or 5-fluorouracil (5-FUra) resulted in approximately 95% cell kill, corresponding to the percentage of cells in this system labeled by autoradiography (98%). Additional cell kill could be obtained if 5-FUra was administere...

journal_title：Cancer research

authors： Weizsaecker M,Hoshino T,Deen DF,Kobayashi S

更新日期：1981-10-01 00:00:00

abstract：:This work confirms the previous observation that a single application of N-hydroxy-2-fluorenylacetamide or N-hydroxy-3-fluorenylacetamide to the mammary gland of the rat induced a high incidence of tumors, whereas the corresponding arylamides, N-2-fluorenylacetamide (2-FAA) and N-3-fluorenylacetamide, were only weakly...

journal_title：Cancer research

authors： Malejka-Giganti D,Rydell RE,Gutmann HR

更新日期：1977-01-01 00:00:00

abstract：:Thirty patients with lung cancer were studied using the leukocyte migration-inhibition assay. Cryostat sections of autologous and homologous carcinoma tissues and normal lung were used as antigens. Although no inhibition of migration was seen using autologous cancer tissues, seven of 30 patients (23%) demonstrated inh...

journal_title：Cancer research

authors： Erickson AD

更新日期：1980-10-01 00:00:00

abstract：:In an effort to achieve high concentrations of 5-fluorouracil (5-FUra) in the hepatic circulation while minimizing systemic exposure, several routes of intrahepatic administration were compared in the canine model. To ascertain these data, 5-FUra (30 mg/kg) was given as a bolus into either a systemic vein (femoral vei...

journal_title：Cancer research

authors： Didolkar MS,Covell DG,Jackson AJ,Walker AP,Kalidindi SR

更新日期：1984-11-01 00:00:00

abstract：:An unusual isozyme of lactate dehydrogenase, lactate dehydrogenase associated with Kirsten murine sarcoma virus (LDHk) was found in the sera of many patients with malignant tumors, while the sera of healthy persons had little or no such activity. This isozyme was detectable only when assayed in a nitrogen atmosphere, ...

journal_title：Cancer research

authors： Polonis VR,Anderson GR,Brzykcy J,Vladutiu AO,Manly KF

更新日期：1984-05-01 00:00:00

abstract：:Cancer metastasis is a leading cause of cancer morbidity and mortality. More needs to be learned about mechanisms that control this process. In particular, the role of chemokine receptors in metastasis remains controversial. Here, using a highly metastatic breast cancer (4T1) model, we show that lung metastasis is a f...

journal_title：Cancer research

authors： Olkhanud PB,Baatar D,Bodogai M,Hakim F,Gress R,Anderson RL,Deng J,Xu M,Briest S,Biragyn A

更新日期：2009-07-15 00:00:00

abstract：:Myeloma vaccines, based on dendritic cells pulsed with idiotype or tumor lysate, have been met with limited success, probably in part due to insufficient cross-priming of myeloma antigens. A powerful method to introduce myeloma-associated antigens into the cytosol of dendritic cells is protein transduction, a process ...

journal_title：Cancer research

authors： Batchu RB,Moreno AM,Szmania SM,Bennett G,Spagnoli GC,Ponnazhagan S,Barlogie B,Tricot G,van Rhee F

更新日期：2005-11-01 00:00:00

abstract：:An assay has been developed and measurements of aryl hydrocarbon [benzo(a)pyrene] hydroxylase have been made in peripheral blood monocytes from a human population. Treatment with benz(a)anthracene in cell culture increased aryl hydrocarbon hydroxylase activity from 6.5 to 37-fold in monocytes from each of 25 apparentl...

journal_title：Cancer research

authors： Bast RC Jr,Okuda T,Plotkin E,Tarone R,Rapp HJ,Gelboin HV

更新日期：1976-06-01 00:00:00

abstract：:Shorter alleles of a polymorphic [CAG](n) repeat in exon 1 of the androgen receptor (AR) have been associated with increased risk of prostate cancer and decreased risk of breast cancer. We prospectively assessed the association between the [CAG](n) repeat polymorphism in the androgen receptor and breast cancer risk am...

journal_title：Cancer research

authors： Haiman CA,Brown M,Hankinson SE,Spiegelman D,Colditz GA,Willett WC,Kantoff PW,Hunter DJ

更新日期：2002-02-15 00:00:00

abstract：:Antigens have been detected in 35 to 40% of sera from patients with leukemia that cross-react with the Mr 30,000 core proteins (p30) of baboon endogenous virus (BaEV) and/or of simian sarcoma-simian sarcoma-associated virus (SiSV) in a solid-phase enzyme immunoassay using anti-SiSV p30 and anti-BaEV p30 antisera. Thes...

journal_title：Cancer research

authors： Hehlmann R,Schetters H,Erfle V,Leib-Mösch C

更新日期：1983-01-01 00:00:00

abstract：:Although the concept that cancers originate from stem cells (SC) is becoming scientifically accepted, mechanisms by which SC contribute to tumor initiation and progression are largely unknown. For colorectal cancer (CRC), investigation of this problem has been hindered by a paucity of specific markers for identificati...

journal_title：Cancer research

authors： Huang EH,Hynes MJ,Zhang T,Ginestier C,Dontu G,Appelman H,Fields JZ,Wicha MS,Boman BM

更新日期：2009-04-15 00:00:00

abstract：:A chimeric CYCLIN D1-TROP2 mRNA was isolated from human ovarian and mammary cancer cells. The CYCLIN D1-TROP2 mRNA was shown to be a potent oncogene as it transforms naïve, primary cells in vitro and induces aggressive tumor growth in vivo in cooperation with activated RAS. Silencing of the chimeric mRNA inhibits the ...

journal_title：Cancer research

authors： Guerra E,Trerotola M,Dell' Arciprete R,Bonasera V,Palombo B,El-Sewedy T,Ciccimarra T,Crescenzi C,Lorenzini F,Rossi C,Vacca G,Lattanzio R,Piantelli M,Alberti S

更新日期：2008-10-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer syndrome characterized by early age of onset colorectal cancer (mean 45 years) as well as endometrial, urinary tract, and upper gastrointestinal adenocarcinomas. The HNPCC phenotype has been shown to segregate with germline mutations in ...

journal_title：Cancer research

authors： Weber TK,Conlon W,Petrelli NJ,Rodriguez-Bigas M,Keitz B,Pazik J,Farrell C,O'Malley L,Oshalim M,Abdo M,Anderson G,Stoler D,Yandell D

更新日期：1997-09-01 00:00:00