Assessment of immune responses to tumors using cryostat sections of bronchogenic carcinoma.

abstract：:The mechanism of in vitro cytotoxicity by tumor necrosis serum (TNS) and a purified fraction was examined using sensitive L-M cells. Cell death was assessed by uptake of the dye trypan blue and/or by release of radiolabeled chromium. Cell killing was time and dose dependent. Cell survival was assessed by counting the ...

journal_title：Cancer research

authors： Kull FC Jr,Cuatrecasas P

更新日期：1981-12-01 00:00:00

abstract：:Gene targeting studies in mice have shown that the transcription factor Ikaros plays an essential role in lymphoid development and as a tumor suppressor in T cells, whereas the related gene Aiolos functions as a tumor suppressor in B cells. We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos...

journal_title：Cancer research

authors： Nakase K,Ishimaru F,Avitahl N,Dansako H,Matsuo K,Fujii K,Sezaki N,Nakayama H,Yano T,Fukuda S,Imajoh K,Takeuchi M,Miyata A,Hara M,Yasukawa M,Takahashi I,Taguchi H,Matsue K,Nakao S,Niho Y,Takenaka K,Shinagawa K,

更新日期：2000-08-01 00:00:00

abstract：:An in vivo model of human CD20+ B-lymphoma was established in severe combined immunodeficiency mice to test the ability of human neutralizing miniantibodies to CD55 and CD59 (MB55 and MB59) to enhance the therapeutic effect of rituximab. The miniantibodies contained single-chain fragment variables and the hinge-CH2-CH...

journal_title：Cancer research

authors： Macor P,Tripodo C,Zorzet S,Piovan E,Bossi F,Marzari R,Amadori A,Tedesco F

更新日期：2007-11-01 00:00:00

abstract：:Increasing the expression of c-FMS (colony-stimulating factor 1 receptor) by introduction of a transgene reduced the concentration of retinoic acid or 1,25-dihydroxy vitamin D3 needed to cause myeloid or monocytic cell differentiation and hypophosphorylation of the retinoblastoma tumor suppressor protein (RB) typicall...

journal_title：Cancer research

authors： Yen A,Sturgill R,Varvayanis S

更新日期：1997-05-15 00:00:00

abstract：:Epidemiological data have provided clues to the etiological factors involved in large bowel cancer development. High intake of dietary fat tends to promote colon carcinogenesis. Studies in metabolic epidemiology have shown that the high dietary fat affects the metabolic activity of gut bacteria as well as the levels o...

journal_title：Cancer research

authors： Reddy BS

更新日期：1981-09-01 00:00:00

abstract：:Sequential morphological changes occurring after brief carcinogen exposures of heterotopic tracheal transplants in rats were semiquantitatively studied. Tracheas were exposed to 7,12-dimethylbenz(a)anthracene for 1, 2, or 4 weeks, during which time means of 138, 152, and 160 microgram 7,12-dimethylbenz(a)anthracene, r...

journal_title：Cancer research

authors： Topping DC,Griesemer RA,Nettesheim P

更新日期：1979-12-01 00:00:00

abstract：:2-Amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic amine present in pyrolysate products of meat and fish and has been shown to induce tumors in the colon, mammary gland, and possibly lymphatic system. Experiments were designed to examine the lymphoma-inducing capacity o...

journal_title：Cancer research

authors： Rao CV,Rivenson A,Zang E,Steele V,Kelloff G,Reddy BS

更新日期：1996-08-01 00:00:00

abstract：:Steroid and xenobiotic receptor (SXR) or human pregnane X receptor (hPXR) has been shown to play an important role in the regulation of genes related to xenobiotic detoxification, such as cytochrome P450 3A4 and multidrug resistance gene 1. Cytochrome P450 enzymes, conjugation enzymes, and transporters are all conside...

journal_title：Cancer research

authors： Miki Y,Suzuki T,Kitada K,Yabuki N,Shibuya R,Moriya T,Ishida T,Ohuchi N,Blumberg B,Sasano H

更新日期：2006-01-01 00:00:00

abstract：:PD115934 (NSC 366140) is a soluble pyrazoloacridine derivative presently undergoing preclinical toxicology evaluation with the anticipation of Phase I human investigation. The agent displayed both human and murine solid tumor selectivity in vitro in a soft agar disk diffusion assay, relative to its activity against mu...

journal_title：Cancer research

authors： LoRusso P,Wozniak AJ,Polin L,Capps D,Leopold WR,Werbel LM,Biernat L,Dan ME,Corbett TH

更新日期：1990-08-15 00:00:00

abstract：:Many but not all of the cell surface antigens studied were released into tissue culture medium of human colorectal carcinoma and melanoma cells maintained in vitro. Two groups of monoclonal antibody-defined antigens are described. One group is composed of molecules that are released easily and in large quantitites int...

journal_title：Cancer research

authors： Steplewski Z,Chang TH,Herlyn M,Koprowski H

更新日期：1981-07-01 00:00:00

abstract：:Various hormones and growth factors are involved in the growth regulation of breast (tumor) cells. In this report we show for the first time that an analogue of the neuropeptide somatostatin (Sandostatin) can also influence the proliferation of human breast cancer cells (MCF-7), namely, in an inhibitory fashion. With ...

journal_title：Cancer research

authors： Setyono-Han B,Henkelman MS,Foekens JA,Klijn GM

更新日期：1987-03-15 00:00:00

abstract：:Abnormalities of chromosome 1, including trisomy for all or a portion of the long arm, have been frequently reported in many cancers. Anomalies of chromosome 19 are far less common, although a t(1;19)(q23;p13) translocation has been reported in association with pre-B-cell leukemia. We have observed a t(1;19)(q12;p13) ...

journal_title：Cancer research

authors： Parmiter AH,Balaban G,Herlyn M,Clark WH Jr,Nowell PC

更新日期：1986-03-01 00:00:00

abstract：:The roles played by cholesterol in cancer development and the potential of therapeutically targeting cholesterol homeostasis is a controversial area in the cancer community. Several epidemiologic studies report an association between cancer and serum cholesterol levels or statin use, while others suggest that there is...

journal_title：Cancer research

authors： Kuzu OF,Noory MA,Robertson GP

更新日期：2016-04-15 00:00:00

abstract：:Two opposing clusters of transcription factors (TF) have been associated with the differential risks of estrogen receptor positive or negative breast cancers, but the mechanisms underlying the opposing functions of the two clusters are undefined. In this study, we identified NFIB and YBX1 as novel interactors of the e...

journal_title：Cancer research

authors： Campbell TM,Castro MAA,de Oliveira KG,Ponder BAJ,Meyer KB

更新日期：2018-01-15 00:00:00

abstract：:Multiple myeloma is a cytogenetically/molecularly heterogeneous hematologic malignancy that remains mostly incurable, and the identification of a universal and relevant therapeutic target molecule is essential for the further development of therapeutic strategy. Herein, we identified that 3-phosphoinositide-dependent ...

journal_title：Cancer research

authors： Chinen Y,Kuroda J,Shimura Y,Nagoshi H,Kiyota M,Yamamoto-Sugitani M,Mizutani S,Sakamoto N,Ri M,Kawata E,Kobayashi T,Matsumoto Y,Horiike S,Iida S,Taniwaki M

更新日期：2014-12-15 00:00:00

abstract：:Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of ...

journal_title：Cancer research

authors： Teng MW,Ngiow SF,Ribas A,Smyth MJ

更新日期：2015-06-01 00:00:00

abstract：:In the present study, we examined hemodynamics in vasculogenic mimicry (VM) and angiogenesis of inflammatory breast cancer (IBC) xenografts (WIBC-9), having previously reported on the unique histological features and molecular basis of these processes (K. Shirakawa et al., Cancer Res., 61: 445-451, 2001). Histological...

journal_title：Cancer research

authors： Shirakawa K,Kobayashi H,Heike Y,Kawamoto S,Brechbiel MW,Kasumi F,Iwanaga T,Konishi F,Terada M,Wakasugi H

更新日期：2002-01-15 00:00:00

abstract：:The hypothesis that microvesicle-mediated miRNA transfer converts noncancer stem cells into cancer stem cells (CSC) leading to therapy resistance remains poorly investigated. Here we provide direct evidence supporting this hypothesis, by demonstrating how microvesicles derived from cancer-associated fibroblasts (CAF) ...

journal_title：Cancer research

authors： Sansone P,Berishaj M,Rajasekhar VK,Ceccarelli C,Chang Q,Strillacci A,Savini C,Shapiro L,Bowman RL,Mastroleo C,De Carolis S,Daly L,Benito-Martin A,Perna F,Fabbri N,Healey JH,Spisni E,Cricca M,Lyden D,Bonafé M,Bromb

更新日期：2017-04-15 00:00:00

abstract：:Iodine-131-labeled anti-CD45 antibody has been added to conventional hematopoietic stem cell transplant preparative regimens to deliver targeted radiation to hematopoietic tissues, with the goal of decreasing relapse rates without increasing toxicity. However, higher radiation doses could be delivered to leukemia cell...

journal_title：Cancer research

authors： Ruffner KL,Martin PJ,Hussell S,Nourigat C,Fisher DR,Bernstein ID,Matthews DC

更新日期：2001-07-01 00:00:00

abstract：:Mitochondria are the powerhouses of cells. Mitochondrial C-Raf is a potential cancer therapeutic target, as it regulates mitochondrial function and is localized to the mitochondria by its N-terminal domain. However, Raf inhibitor monotherapy can induce S338 phosphorylation of C-Raf (pC-Raf(S338)) and impede therapy. T...

journal_title：Cancer research

authors： Tsai YT,Chuang MJ,Tang SH,Wu ST,Chen YC,Sun GH,Hsiao PW,Huang SM,Lee HJ,Yu CP,Ho JY,Lin HK,Chen MR,Lin CC,Chang SY,Lin VC,Yu DS,Cha TL

更新日期：2015-09-01 00:00:00

abstract：:We have isolated a Chinese hamster ovary cell line, designated ADR-1, which exhibits hypersensitivity to a range of drugs which are thought to inhibit the action of the enzyme topoisomerase II. These include anthracyclines, other classes of intercalating agents, and the epipodophyllotoxin, etoposide. No significant se...

journal_title：Cancer research

authors： Robson CN,Hoban PR,Harris AL,Hickson ID

更新日期：1987-03-15 00:00:00

abstract：:Both 2-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (EC 4.1.1.17), and methylglyoxal bis(guanylhydrazone) (MGBG), a competitive inhibitor of S-adenosylmethionine decarboxylase (EC 4.1.1.50), strikingly stimulated melanotic expression of murine Cloudman S91 melanoma cells. The st...

journal_title：Cancer research

authors： Käpyaho K,Sinervirta R,Jänne J

更新日期：1985-04-01 00:00:00

abstract：:We have carried out a clinical trial in which patients with relapsed leukemia were treated with thymidine (dThd) prior to and concomitantly with the administration of 1-beta-D-arabinofuranosylcytosine (ara-C) in an effort to kinetically and biochemically modulate the leukemic cells with two objectives: (a) to increase...

journal_title：Cancer research

authors： Blumenreich MS,Chou TC,Andreeff M,Vale K,Clarkson BD,Young CW

更新日期：1984-02-01 00:00:00

abstract：:The molecular pathways driving mesenchymal glioblastoma (GBM) are still not well understood. We report here that truncated glioma-associated oncogene homolog 1 (tGLI1) is a tumor-specific transcription factor that facilitates GBM growth, is enriched in the mesenchymal subtype of GBM and glioma stem cells (GSC), and pr...

journal_title：Cancer research

authors： Rimkus TK,Carpenter RL,Sirkisoon S,Zhu D,Pasche BC,Chan MD,Lesser GJ,Tatter SB,Watabe K,Debinski W,Lo HW

更新日期：2018-05-15 00:00:00

abstract：:Radiation therapy combined with adjuvant hyperthermia has the potential to provide outstanding local-regional control for refractory disease. However, achieving therapeutic thermal dose can be problematic. In the current investigation, we used a chemistry-driven approach with the goal of designing and synthesizing nov...

journal_title：Cancer research

authors： Sekhar KR,Sonar VN,Muthusamy V,Sasi S,Laszlo A,Sawani J,Horikoshi N,Higashikubo R,Bristow RG,Borrelli MJ,Crooks PA,Lepock JR,Roti Roti JL,Freeman ML

更新日期：2007-01-15 00:00:00

abstract：:Human carcinoembryonic antigen (CEA) is an oncofetal glycoprotein overexpression of which by gastrointestinal carcinomas is well known. Expression of CEA in head and neck cancer (HNC) is not widely recognized. It is important to note that most of these studies used polyclonal antibodies that may have cross-reactivity ...

journal_title：Cancer research

authors： Kass ES,Greiner JW,Kantor JA,Tsang KY,Guadagni F,Chen Z,Clark B,De Pascalis R,Schlom J,Van Waes C

更新日期：2002-09-01 00:00:00

abstract：:Following DNA damage, human cells arrest primarily in the G(1) and G(2) phases of the cell cycle. Here, we show that after irradiation, human cancer cells with targeted deletion of PTEN or naturally occurring PTEN mutations can exert G(1) and G(2) arrests but are unable to arrest in size. Pharmacological inhibition of...

journal_title：Cancer research

authors： Lee C,Kim JS,Waldman T

更新日期：2004-10-01 00:00:00

abstract：:Antibodies to formalin-fixed, syngeneic melanoma cells were prepared in mice, purified by immunoaffinity chromatography, and tested for binding activity to viable melanoma cells. The radiolabeled antibodies detected congruent to 9 X 10(6) melanoma antigenic sites/cell. The calculated average association constant (Ka) ...

journal_title：Cancer research

authors： Winkelhake JL,Elcombe BM,Hodach A

更新日期：1979-08-01 00:00:00

abstract：:The existence of CD8+ CTLs that are capable of recognizing MHC class I-bound, human tumor-associated peptide antigens is now unequivocally documented in cancer patients. Thus far, the role of CD8+ T cells in tumor immunity has been predominantly viewed in terms of cytolytic ability as the prime mode of their function....

journal_title：Cancer research

authors： Chakraborty NG,Mukherji B

更新日期：1998-04-01 00:00:00

abstract：:Tasidotin (ILX-651), an orally active synthetic microtubule-targeted derivative of the marine depsipeptide dolastatin-15, is currently undergoing clinical evaluation for cancer treatment. Tasidotin inhibited proliferation of MCF7/GFP breast cancer cells with an IC(50) of 63 nmol/L and inhibited mitosis with an IC(50) ...

journal_title：Cancer research

authors： Ray A,Okouneva T,Manna T,Miller HP,Schmid S,Arthaud L,Luduena R,Jordan MA,Wilson L

更新日期：2007-04-15 00:00:00