A t(1;19) chromosome translocation in three cases of human malignant melanoma.

abstract：:Mutations that alter normal splice patterns and genomic rearrangements are common causes of hereditary diseases including hereditary nonpolyposis colorectal cancer. However, abnormal transcripts can be difficult to detect and interpret because splicing patterns are often heterogeneous even in normal cells. Standard te...

journal_title：Cancer research

authors： Nakagawa H,Yan H,Lockman J,Hampel H,Kinzler KW,Vogelstein B,De La Chapelle A

更新日期：2002-08-15 00:00:00

abstract：:Kras is a decisive oncogene in pancreatic ductal adenocarcinoma (PDAC). PIN1 is a key effector involved in the Kras/ERK axis, synergistically mediating various cellular events. However, the underlying mechanism by which PIN1 promotes the development of PDAC remains unclear. Here we sought to elucidate the effect of PI...

journal_title：Cancer research

authors： Liang C,Shi S,Liu M,Qin Y,Meng Q,Hua J,Ji S,Zhang Y,Yang J,Xu J,Ni Q,Li M,Yu X

更新日期：2019-01-01 00:00:00

abstract：:Pyrazine diazohydroxide (PZDH) is a novel antineoplastic agent that appears to form DNA adducts via the reactive pyrazine diazonium ion and produces substantial antitumor activity in preclinical models. We conducted a phase I trial to determine the maximally tolerated dose of PZDH that could be administered as a 5-min...

journal_title：Cancer research

authors： Vogelzang NJ,Mick R,Janisch L,Berezin F,Schilsky RL,Ratain MJ

更新日期：1994-01-01 00:00:00

abstract：:The ING family of proteins is involved in the regulation of diverse processes ranging from cell cycle and cellular senescence to apoptosis. These effects are most likely through activation of acetylation-dependent pathways that ultimately alter gene expression. Despite reports linking ING to p53 activation, the molecu...

journal_title：Cancer research

authors： Kataoka H,Bonnefin P,Vieyra D,Feng X,Hara Y,Miura Y,Joh T,Nakabayashi H,Vaziri H,Harris CC,Riabowol K

更新日期：2003-09-15 00:00:00

abstract：:cis-Diammine(1,1-cyclobutanedicarboxylato)platinum (CBDCA) is a nonnephrotoxic but myelosuppressive analogue of cisplatin (DDP) with greatly reduced protein binding and greatly increased renal excretion. Thus, CBDCA might produce undue toxicity in patients with decreased renal function. Twenty-two patients [14 females...

journal_title：Cancer research

authors： Egorin MJ,Van Echo DA,Tipping SJ,Olman EA,Whitacre MY,Thompson BW,Aisner J

更新日期：1984-11-01 00:00:00

abstract：:Untargeted effects of ionizing radiation (de novo effects in the unirradiated descendants or neighbors of irradiated cells) challenge widely held views about the mechanisms of radiation-induced DNA damage with implications for the health consequences of radiation exposures particularly in the context of the induction ...

journal_title：Cancer research

authors： Lorimore SA,McIlrath JM,Coates PJ,Wright EG

更新日期：2005-07-01 00:00:00

abstract：:A putative tumor suppressor gene, p53, has been shown to be altered in a variety of human tumor types. The primary mechanism of p53 inactivation is believed to be mutation of one allele followed by loss of the second allele. Malignant mesothelioma is a tumor that has been highly associated with exposure to asbestos fi...

journal_title：Cancer research

authors： Cote RJ,Jhanwar SC,Novick S,Pellicer A

更新日期：1991-10-01 00:00:00

abstract：:Members of cutaneous melanoma (CM) families with dysplastic nevi (DN) are at high risk of developing CM. Using a shuttle vector plasmid, pSP189, cell lines from three patients with CM plus DN were previously found to have elevated post-UV plasmid mutability. To investigate familial occurrence of this cellular phenotyp...

journal_title：Cancer research

authors： Moriwaki SI,Tarone RE,Tucker MA,Goldstein AM,Kraemer KH

更新日期：1997-10-15 00:00:00

abstract：:Copper plays an essential role in promoting angiogenesis. Tumors that become angiogenic acquire the ability to enter a phase of rapid growth and exhibit increased metastatic potential, the major cause of morbidity in cancer patients. We report that copper deficiency induced by tetrathiomolybdate (TM) significantly imp...

journal_title：Cancer research

authors： Pan Q,Kleer CG,van Golen KL,Irani J,Bottema KM,Bias C,De Carvalho M,Mesri EA,Robins DM,Dick RD,Brewer GJ,Merajver SD

更新日期：2002-09-01 00:00:00

abstract：:To identify genetic alterations underlying rectal carcinogenesis, we used global gene expression profiling of a series of 17 locally advanced rectal adenocarcinomas and 20 normal rectal mucosa biopsies on oligonucleotide arrays. A total of 351 genes were differentially expressed (P < 1.0e-7) between normal rectal muco...

journal_title：Cancer research

authors： Grade M,Ghadimi BM,Varma S,Simon R,Wangsa D,Barenboim-Stapleton L,Liersch T,Becker H,Ried T,Difilippantonio MJ

更新日期：2006-01-01 00:00:00

abstract：:Previous studies have shown that all-trans-retinoic acid fails to inhibit chemically induced transformation in 10T1/2 cells except at toxic levels, whereas retinol and many synthetic retinoids are potent inhibitors. In contrast, in many systems retinoic acid is a more effective modulator of differentiation and carcino...

journal_title：Cancer research

authors： Rundhaug J,Gubler ML,Sherman MI,Blaner WS,Bertram JS

更新日期：1987-11-01 00:00:00

abstract：:The effect of the AC33 tumor on protein synthesis in Lewis-Wistar rats was investigated under four different dietary regimens. The four diets used were: (a) 1.25 g amino acids plus 12.5 g glucose per day, (b) 1.25 g amino acids, (c) 1.25 g glucose per day, and (d) 12.5 g glucose per day. The rats were maintained on th...

journal_title：Cancer research

authors： Stein TP,Oram-Smith JC,Leskiw MJ,Wallace HW,Miller EE

更新日期：1976-11-01 00:00:00

abstract：:To improve tumor:tissue ratios in immunoscintigraphy, a three-step targeting method has been developed. The reagents used were (a) a radioactive, low molecular weight chelate prepared from ionic gallium and a phenolic polyaminocarboxylic acid, which can be labeled either with the single-photon emitter 67Ga or with the...

journal_title：Cancer research

authors： Schuhmacher J,Klivényi G,Matys R,Stadler M,Regiert T,Hauser H,Doll J,Maier-Borst W,Zöller M

更新日期：1995-01-01 00:00:00

abstract：:Antigens in human adult feces related to carcinoembryonic antigen (CEA) were analyzed with respect to their molecular masses, CEA domain compositions, and N-terminal amino acid sequences. By avoiding perchloric acid treatment, new fecal antigens related to CEA were identified. The fecal antigens revealed by Western bl...

journal_title：Cancer research

authors： Henslee JG,Vachula EJ,Paxton RJ,Matias MS,Shively JE,Rittenhouse HG,Tomita JT

更新日期：1992-08-01 00:00:00

abstract：:Breast cancer resistance protein (BCRP), also called ABCG2, confers resistance to anticancer agents such as 7-ethyl-10-hydroxycamptothecin (SN-38), mitoxantrone, and topotecan. We found previously that sulfated estrogens are physiologic substrates of BCRP. Flavonoids with weak estrogenic activities are called phytoest...

journal_title：Cancer research

authors： Imai Y,Tsukahara S,Asada S,Sugimoto Y

更新日期：2004-06-15 00:00:00

abstract：:Gonadotropin-releasing hormone-I (GnRH-I) is known to directly regulate prostate cancer cell proliferation. However, the role of GnRH-II in prostate cancer is unclear. Here, we investigated the effect of the GnRH-II antagonist trptorelix-1 (Trp-1) on growth of PC3 prostate cancer cells. Trp-1 induced growth inhibition...

journal_title：Cancer research

authors： Kim DK,Yang JS,Maiti K,Hwang JI,Kim K,Seen D,Ahn Y,Lee C,Kang BC,Kwon HB,Cheon J,Seong JY

更新日期：2009-02-01 00:00:00

abstract：:Metastasis is the primary cause of death from breast cancer. A xenograft model was used to identify genes potentially involved with metastasis, comparing expression in the poorly metastatic GI101A human breast cancer cell line and a highly metastatic variant, GILM2. cDNA microarray analyses of these isogenic variants ...

journal_title：Cancer research

authors： Kluger HM,Chelouche Lev D,Kluger Y,McCarthy MM,Kiriakova G,Camp RL,Rimm DL,Price JE

更新日期：2005-07-01 00:00:00

abstract：:Cancer may arise from a cancer stem/progenitor cell that shares characteristics with its normal counterpart. We report the reconstitution of the original human prostate cancer specimen from epithelial cell lines (termed HPET for human prostate epithelial/hTERT) derived from this sample. These tumors can be described i...

journal_title：Cancer research

authors： Gu G,Yuan J,Wills M,Kasper S

更新日期：2007-05-15 00:00:00

abstract：:Previous cytogenetic analysis has revealed frequent losses of chromosome 1p21-22 in human malignant mesothelioma, suggesting that the loss or inactivation of a tumor suppressor gene's) residing at this site may contribute to the tumorigenic conversion of mesothelial cells. To more precisely define the location of the ...

journal_title：Cancer research

authors： Lee WC,Balsara B,Liu Z,Jhanwar SC,Testa JR

更新日期：1996-10-01 00:00:00

abstract：:Cytochrome P450 aromatase (aromatase), a product of the CYP19 gene, catalyzes the synthesis of estrogens from androgens. Given the significance of estrogen synthesis in hormone-dependent breast carcinogenesis, it is important to elucidate the mechanisms that regulate CYP19 expression. The main objective of this study ...

journal_title：Cancer research

authors： Subbaramaiah K,Howe LR,Port ER,Brogi E,Fishman J,Liu CH,Hla T,Hudis C,Dannenberg AJ

更新日期：2006-05-15 00:00:00

abstract：:A murine monoclonal antibody 14.18 specifically recognizes disialoganglioside GD2, the major ganglioside expressed on the surface of human neuroblastoma cells. This monoclonal antibody (Mab) is of immunoglobulin G3 isotype, has an affinity constant (KA) of 3.5 X 10(8) M-1, and reacts preferentially with tumor cells an...

journal_title：Cancer research

authors： Mujoo K,Cheresh DA,Yang HM,Reisfeld RA

更新日期：1987-02-15 00:00:00

abstract：:Because efficient i.v. administration of interleukin 2 (IL-2) in tumor patients leads to severe cardiopulmonary side effects, we developed a new form of IL-2 application that allows activation of all IL-2-responsive immune cells directly at the tumor site. In five patients with T4N0M0 transitional cell carcinoma of th...

journal_title：Cancer research

authors： Huland E,Huland H

更新日期：1989-10-01 00:00:00

abstract：:The human papillomavirus (HPV) 16 E7 oncoprotein has been reported previously to stimulate DNA damage and to activate host cell DNA damage checkpoints. How HPV-16 E7 maintains proliferation despite activated DNA damage checkpoints is incompletely understood. Here, we provide evidence that cells expressing the HPV-16 E...

journal_title：Cancer research

authors： Spardy N,Covella K,Cha E,Hoskins EE,Wells SI,Duensing A,Duensing S

更新日期：2009-09-01 00:00:00

abstract：:The majority of BRCA1-associated breast cancers are basal cell-like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53-mutated tumors. At 0.5 mg/k...

journal_title：Cancer research

authors： Shafee N,Smith CR,Wei S,Kim Y,Mills GB,Hortobagyi GN,Stanbridge EJ,Lee EY

更新日期：2008-05-01 00:00:00

abstract：:Normal human cells can be transformed to anchorage-independent growth by transfection with DNA from MOLT-4 lymphoblasts, derived from a patient with acute lymphocytic leukemia. Cells were treated with polyethylene glycol 6000, and DNA was administered as a calcium phosphate coprecipitate . The transforming activity of...

journal_title：Cancer research

authors： Sutherland BM,Bennett PV

更新日期：1984-07-01 00:00:00

abstract：:Breast cancer-initiating cells have been recently identified in breast carcinoma as CD44+/CD24(-/low) cells, which exclusively retain tumorigenic activity and display stem cell-like properties. However, at present, direct evidence that breast cancer-initiating cells can be propagated in vitro is still lacking. We repo...

journal_title：Cancer research

authors： Ponti D,Costa A,Zaffaroni N,Pratesi G,Petrangolini G,Coradini D,Pilotti S,Pierotti MA,Daidone MG

更新日期：2005-07-01 00:00:00

abstract：:A phase I clinical trial with granulocyte-macrophage colony-stimulating factor tumor cell vaccines in patients with metastatic renal cell carcinoma (RCC) showed immune cell infiltration at vaccine sites and delayed-type hypersensitivity (DTH) responses to autologous tumor cells indicative of T-cell immunity. To furthe...

journal_title：Cancer research

authors： Zhou X,Jun DY,Thomas AM,Huang X,Huang LQ,Mautner J,Mo W,Robbins PF,Pardoll DM,Jaffee EM

更新日期：2005-02-01 00:00:00

abstract：:Phosphate ore mining and processing operations are associated with dusty conditions and potential exposure to gamma radiation and radon daughter products. Although most current measurements are within Occupational Safety and Health Administration (OSHA) guidelines, no measurements exist for the era preceding modern st...

journal_title：Cancer research

authors： Block G,Matanoski GM,Seltser R,Mitchell T

更新日期：1988-12-15 00:00:00

abstract：:The spontaneous sister chromatid exchanges (SCEs) and SCEs induced by 50 microM methyl methanesulfonate, 1 microM 4-nitroquinoline 1-oxide, and 5 microM 3-amino-1-methyl-5H-pyrido[4,3-b]indole were examined in phytohemagglutinin-activated peripheral lymphocytes from 53 healthy adult donors. The means of the mean spont...

journal_title：Cancer research

authors： Oikawa A,Sakai S,Horaguchi K,Tohda H

更新日期：1983-01-01 00:00:00

abstract：:Organic anion transporting polypeptide 1B3 (OATP1B3, SLCO1B3) is normally expressed in hepatocytes. In this study, we showed frequent overexpression of OATP1B3 in colorectal adenocarcinomas. Quantitative reverse transcription-PCR analysis of 17 colon tumors indicated tumoral overexpression of OATP1B3 by approximately ...

journal_title：Cancer research

authors： Lee W,Belkhiri A,Lockhart AC,Merchant N,Glaeser H,Harris EI,Washington MK,Brunt EM,Zaika A,Kim RB,El-Rifai W

更新日期：2008-12-15 00:00:00