Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance.

abstract：:The relative contribution of lymphocytes, macrophages, and granulocytes to the cell content of primary 3-methyl-cholanthrene-induced murine fibrosarcomas was determined at different stages in their progression by differential cell analysis on enzyme-derived single-cell suspensions. Furthermore, immunohistological anal...

journal_title：Cancer research

authors： Wood GW,Gollahon KA

更新日期：1978-07-01 00:00:00

abstract：:Inhibition of constitutive active signaling pathways, which are a characteristic phenomenon for many tumors, can be an effective therapeutic strategy. In contrast, oncogenic transcription factors, often activated by mutational events, are in general less amenable to small-molecule inhibition despite their obvious impo...

journal_title：Cancer research

authors： Amstutz R,Wachtel M,Troxler H,Kleinert P,Ebauer M,Haneke T,Oehler-Jänne C,Fabbro D,Niggli FK,Schäfer BW

更新日期：2008-05-15 00:00:00

abstract：:PD115934 (NSC 366140) is a soluble pyrazoloacridine derivative presently undergoing preclinical toxicology evaluation with the anticipation of Phase I human investigation. The agent displayed both human and murine solid tumor selectivity in vitro in a soft agar disk diffusion assay, relative to its activity against mu...

journal_title：Cancer research

authors： LoRusso P,Wozniak AJ,Polin L,Capps D,Leopold WR,Werbel LM,Biernat L,Dan ME,Corbett TH

更新日期：1990-08-15 00:00:00

abstract：:To identify mechanisms of camptothecin (CPT) resistance/toxicity, sublines from a human KB cell line were made resistant to CPT by continuous selection in increasing concentrations of CPT. Two CPT-resistant lines, 100 and 300, were 32- and 54-fold resistant to the growth-inhibitory properties of CPT compared to the KB...

journal_title：Cancer research

authors： Beidler DR,Chang JY,Zhou BS,Cheng YC

更新日期：1996-01-15 00:00:00

abstract：:The ability of cancer cells to evade apoptosis is dictated by a shift in the balance between proapoptotic and antiapoptotic gene expression programs. Monocyte chemotactic protein-induced protein 1 (MCPIP1) is a zinc-finger RNA binding protein with important roles in mediating inflammatory responses. Overexpression of ...

journal_title：Cancer research

authors： Lu W,Ning H,Gu L,Peng H,Wang Q,Hou R,Fu M,Hoft DF,Liu J

更新日期：2016-03-15 00:00:00

abstract：:The transcription factor nuclear factor-kappaB (NF-kappaB) is constitutively activated in many types of cancers and has been implicated in gene expression important for angiogenesis, tumor growth, progression, and metastasis. Here, we show that the NF-kappaB activator, IkappaB kinase-alpha (IKKalpha), but not IKKbeta,...

journal_title：Cancer research

authors： DeBusk LM,Massion PP,Lin PC

更新日期：2008-12-15 00:00:00

abstract：:Resistance to antineoplastic drugs is a major problem in the clinical management of cancer. Previous studies have demonstrated that the cytotoxicity of certain anticancer drugs is increased by lowering the glutathione (GSH) levels with buthionine sulfoximine (BSO), a specific inhibitor of gamma-glutamylcysteine synthe...

journal_title：Cancer research

authors： Dusre L,Mimnaugh EG,Myers CE,Sinha BK

更新日期：1989-02-01 00:00:00

abstract：:ABBV-075 is a potent and selective BET family bromodomain inhibitor that recently entered phase I clinical trials. Comprehensive preclinical characterization of ABBV-075 demonstrated broad activity across cell lines and tumor models, representing a variety of hematologic malignancies and solid tumor indications. In mo...

journal_title：Cancer research

authors： Bui MH,Lin X,Albert DH,Li L,Lam LT,Faivre EJ,Warder SE,Huang X,Wilcox D,Donawho CK,Sheppard GS,Wang L,Fidanze S,Pratt JK,Liu D,Hasvold L,Uziel T,Lu X,Kohlhapp F,Fang G,Elmore SW,Rosenberg SH,McDaniel KF,Kati

更新日期：2017-06-01 00:00:00

abstract：:The liver represents a major and frequently sole site of metastases for many types of cancer, particularly gastrointestinal cancers. We showed previously that coadministration of an engineered hepatic-targeting Listeria monocytogenes (LM) with a cancer vaccine enhanced the antitumor effect of vaccine-induced T cells s...

journal_title：Cancer research

authors： Yoshimura K,Laird LS,Chia CY,Meckel KF,Slansky JE,Thompson JM,Jain A,Pardoll DM,Schulick RD

更新日期：2007-10-15 00:00:00

abstract：:Nile blue derivatives have been shown to be potentially effective photosensitizers for photodynamic therapy of malignant tumors. Results of a previous study suggested that the high accumulation of these dyes in cells may be the result of dye aggregation, partition in membrane lipids, and/or sequestration in subcellula...

journal_title：Cancer research

authors： Lin CW,Shulok JR,Kirley SD,Cincotta L,Foley JW

更新日期：1991-05-15 00:00:00

abstract：:We are in an era where the potential exists for deriving comprehensive profiles of DNA alterations characterizing each form of human cancer. Such profiles would provide invaluable insight into mechanisms underlying the evolution of each tumor type and will provide molecular markers, which could radically improve cance...

journal_title：Cancer research

authors： Esteller M,Corn PG,Baylin SB,Herman JG

更新日期：2001-04-15 00:00:00

abstract：:Combination treatment of SKCO1 human colon carcinoma cells with beta ser-interferon (IFN-beta ser) and gamma-interferon (IFN-gamma) results in a synergistic antiproliferative effect. The role of IFN-beta ser and IFN-gamma receptor modulation was investigated as a possible mechanism for this response. IFN-gamma (0.05-5...

journal_title：Cancer research

authors： Schiller JH,Bushmeyer SM,Ruzicka FJ,Princler GL,Faltynek CR,Borden EC

更新日期：1990-01-01 00:00:00

abstract：:Myeloma vaccines, based on dendritic cells pulsed with idiotype or tumor lysate, have been met with limited success, probably in part due to insufficient cross-priming of myeloma antigens. A powerful method to introduce myeloma-associated antigens into the cytosol of dendritic cells is protein transduction, a process ...

journal_title：Cancer research

authors： Batchu RB,Moreno AM,Szmania SM,Bennett G,Spagnoli GC,Ponnazhagan S,Barlogie B,Tricot G,van Rhee F

更新日期：2005-11-01 00:00:00

abstract：:MicroRNAs are noncoding RNAs that inhibit the expression of their targets in a sequence-specific manner and play crucial roles during oncogenesis. Here we show that microRNA-7 (miR-7) inhibits p21-activated kinase 1 (Pak1) expression, a widely up-regulated signaling kinase in multiple human cancers, by targeting the 3...

journal_title：Cancer research

authors： Reddy SD,Ohshiro K,Rayala SK,Kumar R

更新日期：2008-10-15 00:00:00

abstract：:Exposures to carcinogens present in the diet, in cigarette smoke, or in the environment have been associated with increased risk of bladder and colorectal cancer. The aromatic amines and their metabolites, a class of carcinogen implicated in these exposures, can be N- or O-acetylated by the NAT1 and NAT2 enzymes. Acet...

journal_title：Cancer research

authors： Bell DA,Badawi AF,Lang NP,Ilett KF,Kadlubar FF,Hirvonen A

更新日期：1995-11-15 00:00:00

abstract：:It has been proposed that cross talk between integrin and growth factor receptor signaling such as ErbB2 (HER2) is required for activation of downstream effectors and ErbB2-mediated mammary tumorigenesis. Here we show that transforming growth factor beta (TGF-beta) induced focal adhesion kinase (FAK)-dependent cluster...

journal_title：Cancer research

authors： Wang SE,Xiang B,Zent R,Quaranta V,Pozzi A,Arteaga CL

更新日期：2009-01-15 00:00:00

abstract：:Gene transfer and expression of methotrexate (MTX)-resistant variants of dihydrofolate reductase (DHFR) in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive. We have previously demonstrated...

journal_title：Cancer research

authors： Belur LR,Boelk-Galvan D,Diers MD,McIvor RS,Zimmerman CL

更新日期：2001-02-15 00:00:00

abstract：:Cellular senescence is a potent tumor-suppressive program that prevents neoplastic events. Paradoxically, senescent cells develop an inflammatory secretome, termed the senescence-associated secretory phenotype, which is implicated in age-related pathologies including cancer. Here, we report that senescent cells active...

journal_title：Cancer research

authors： Han L,Long Q,Li S,Xu Q,Zhang B,Dou X,Qian M,Jiramongkol Y,Guo J,Cao L,Chin YE,Lam EW,Jiang J,Sun Y

更新日期：2020-08-15 00:00:00

abstract：:In order to test the contention that metastasis is a selective process and that therefore metastases might show a more restricted pattern of phenotypic and genotypic characteristics than primary tumors, we compared the expression of carcinoembryonic antigen, Ca 19-9, secretory component, serotonin, and mucin productio...

journal_title：Cancer research

authors： Arends JW,Schutte B,Wiggers T,Verstijnen CP,Blijham GH,Bosman FT

更新日期：1987-08-15 00:00:00

abstract：:We have studied the cellular expression of NB/70K, a glycoprotein proposed to be human ovarian tumor associated described previously. Analysis of cells bearing this antigen in malignant ascites shows expression in tumor cells of gynecological origin (ovarian, endometrial) and to a limited degree in breast cancer cells...

journal_title：Cancer research

authors： Bizzari JP,Mackillop WJ,Buick RN

更新日期：1983-02-01 00:00:00

abstract：:Somatic copy number variations (CNV) may drive cancer progression through both coding and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely unknown, especially for circular RNAs. By integrating bioinformatics analyses of alerted circRNAs and focal CNV in lung adenocarcinoma, we ident...

journal_title：Cancer research

authors： Qiu M,Xia W,Chen R,Wang S,Xu Y,Ma Z,Xu W,Zhang E,Wang J,Fang T,Hu J,Dong G,Yin R,Wang J,Xu L

更新日期：2018-06-01 00:00:00

abstract：:Mitomycin C (MMC) is an anticancer drug that requires reductive activation to exert its toxicity. MMC is known to cross-link DNA that contributes significantly to the cytotoxicity and consequent cell death. Cytosolic NADPH:quinone oxidoreductase 1 (NQO1) and microsomal enzymes have been shown to mediate MMC-induced DN...

journal_title：Cancer research

authors： Celli CM,Jaiswal AK

更新日期：2003-09-15 00:00:00

abstract：:Resistance of tumors to irradiation or chemotherapeutic agents is thought to be one of the reasons why patients who present with early malignancies may not be cured. Much is now known about the molecular mechanisms that underlie drug resistance, but until recently little was known about genetic contributions to radiat...

journal_title：Cancer research

authors： McKenna WG,Weiss MC,Endlich B,Ling CC,Bakanauskas VJ,Kelsten ML,Muschel RJ

更新日期：1990-01-01 00:00:00

abstract：:In vivo experiments performed with NIH (nu/nu, bg/bg, xid/xid) triple immunodeficient (TD) mice revealed the striking ability of i.v. injected B16-F1 and B16-F10 murine melanoma cells to colonize not only the lungs but also the liver of TD mice. Subsequently, B16 melanoma cell cultures, which express very low levels o...

journal_title：Cancer research

authors： Calorini L,Marozzi A,Byers HR,Waneck GL,Lee KW,Isselbacher KJ,Gattoni-Celli S

更新日期：1992-07-15 00:00:00

abstract：:Chromatin coregulators are important factors in tumorigenesis and cancer progression. ANCCA is an AAA+ ATPase and a bromodomain-containing nuclear coactivator for the estrogen and androgen receptors that is crucial for assembly of chromatin-modifying complexes and proliferation of hormone-responsive cancer cells. In t...

journal_title：Cancer research

authors： Kalashnikova EV,Revenko AS,Gemo AT,Andrews NP,Tepper CG,Zou JX,Cardiff RD,Borowsky AD,Chen HW

更新日期：2010-11-15 00:00:00

abstract：:Melanoma differentiation associated gene-7/interleukin-24 (Mda-7/IL-24), a novel member of the IL-10 family of cytokines, uniquely displays cancer-specific apoptosis-inducing activity. Positive results in ongoing phase I/II clinical trials have strengthened the possibility of its utilization as a cancer gene therapeut...

journal_title：Cancer research

authors： Sauane M,Lebedeva IV,Su ZZ,Choo HT,Randolph A,Valerie K,Dent P,Gopalkrishnan RV,Fisher PB

更新日期：2004-05-01 00:00:00

abstract：:We reported that NK4, composed of the N-terminal hairpin and subsequent four kringle domains of hepatocyte growth factor (HGF), acts as the competitive antagonist for HGF. We now provide the first evidence that NK4 inhibits tumor growth and metastasis as an angiogenesis inhibitor as well as an HGF antagonist. Administ...

journal_title：Cancer research

authors： Kuba K,Matsumoto K,Date K,Shimura H,Tanaka M,Nakamura T

更新日期：2000-12-01 00:00:00

abstract：:Cells of cloned lines of human squamous lung carcinomas elaborate large glycoproteins that are associated with their tumorigenic potential. Two groups of clones (called Le(a)-X-positive and Le(a)-X-negative) were studied that either do or do not express the Le(a)-X oligosaccharide associated with large glycoproteins a...

journal_title：Cancer research

authors： Stranahan PL,Howard RB,Pfenninger O,Cowen ME,Johnston MR,Pettijohn DE

更新日期：1992-05-15 00:00:00

abstract：:While more than 70% of breast cancers express estrogen receptor-α (ER+), endocrine therapies targeting these receptors often fail. The molecular mechanisms that underlie treatment resistance remain unclear. We investigated the potential role of glucose-regulated protein 78 (GRP78) in mediating estrogen resistance. Hum...

journal_title：Cancer research

authors： Cook KL,Shajahan AN,Wärri A,Jin L,Hilakivi-Clarke LA,Clarke R

更新日期：2012-07-01 00:00:00

abstract：:Human mammary and other carcinoma cells secrete and express on their cell surfaces complex, mucin-like glycoproteins (Mr greater than 10(6] that are recognized as tumor-associated antigens by a variety of monoclonal antibodies (MAbs). One such MAb, B72.3, has been extensively studied as to range of reactivity for a va...

journal_title：Cancer research

authors： Sheer DG,Schlom J,Cooper HL

更新日期：1988-12-01 00:00:00