Senescent Stromal Cells Promote Cancer Resistance through SIRT1 Loss-Potentiated Overproduction of Small Extracellular Vesicles.

abstract：:Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA. We found that lung adenoma/carcinoma spontaneously developed in Ogg1 knockout mice approximately 1.5 years after birth in which 8-oxoG was found to accumulate in the...

journal_title：Cancer research

authors： Sakumi K,Tominaga Y,Furuichi M,Xu P,Tsuzuki T,Sekiguchi M,Nakabeppu Y

更新日期：2003-03-01 00:00:00

abstract：:Actinomycin D produces changes in the cell cycle kinetics of Chinese hamster (HA1) and mouse mammary tumor cells (EMT6) cultivated in vitro. There was a reduced rate of progression of the cells through S phase and a G2 arrest, the duration and degree of which were drug dose dependent. The lethal effects of the drug on...

journal_title：Cancer research

authors： Roots R,Smith KC

更新日期：1976-10-01 00:00:00

abstract：:The complement cascade is a part of the innate immune system that acts primarily to remove pathogens and injured cells. However, complement activation is also peculiarly associated with tumor progression. Here we report mechanistic insights into this association in multiple immunocompetent orthotopic models of lung ca...

journal_title：Cancer research

authors： Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA

更新日期：2018-01-01 00:00:00

abstract：:Arzoxifene ([6-hydroxy-3-[4-[2-(1-piperidinyl)-ethoxy]phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene) is a selective estrogen receptor modulator (SERM) that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. Arzoxifene...

journal_title：Cancer research

authors： Suh N,Glasebrook AL,Palkowitz AD,Bryant HU,Burris LL,Starling JJ,Pearce HL,Williams C,Peer C,Wang Y,Sporn MB

更新日期：2001-12-01 00:00:00

abstract：:Natural killer (NK) immune cells mediate antibody-dependent cellular cytotoxicity (ADCC) by aggregating FcγRIIIA/CD16, contributing significantly to the therapeutic effect of CD20 monoclonal antibodies (mAb). In this study, we show that CD16 ligation on primary human NK cells by the anti-CD20 mAb rituximab or ofatumum...

journal_title：Cancer research

authors： Capuano C,Romanelli M,Pighi C,Cimino G,Rago A,Molfetta R,Paolini R,Santoni A,Galandrini R

更新日期：2015-10-01 00:00:00

abstract：:Antigens in human adult feces related to carcinoembryonic antigen (CEA) were analyzed with respect to their molecular masses, CEA domain compositions, and N-terminal amino acid sequences. By avoiding perchloric acid treatment, new fecal antigens related to CEA were identified. The fecal antigens revealed by Western bl...

journal_title：Cancer research

authors： Henslee JG,Vachula EJ,Paxton RJ,Matias MS,Shively JE,Rittenhouse HG,Tomita JT

更新日期：1992-08-01 00:00:00

abstract：:Aberrant signal transduction has been implicated in malignant transformation, growth, and progression. This has led to the proposal to use inhibitors of signal transduction pathways to treat cancer. One approach to circumventing potential toxicity and improving efficacy would be to target pathways upon which cancer ce...

journal_title：Cancer research

authors： Kohn EC,Sandeen MA,Liotta LA

更新日期：1992-06-01 00:00:00

abstract：:KANSL2 is an integral subunit of the nonspecific lethal (NSL) chromatin-modifying complex that contributes to epigenetic programs in embryonic stem cells. In this study, we report a role for KANSL2 in regulation of stemness in glioblastoma (GBM), which is characterized by heterogeneous tumor stem-like cells associated...

journal_title：Cancer research

authors： Ferreyra Solari NE,Belforte FS,Canedo L,Videla-Richardson GA,Espinosa JM,Rossi M,Serna E,Riudavets MA,Martinetto H,Sevlever G,Perez-Castro C

更新日期：2016-09-15 00:00:00

abstract：:The progression from normal breast epithelium to a malignant phenotype may depend on changes in genetic events as well as failure of host mechanisms. Intermediate biomarkers are needed to more effectively identify malignant progression as well as to develop the potential for more specific treatments and prevention str...

journal_title：Cancer research

authors： Khanuja PS,Lehr JE,Soule HD,Gehani SK,Noto AC,Choudhury S,Chen R,Pienta KJ

更新日期：1993-07-15 00:00:00

abstract：:In the past 3 years, altered expression of the HEF1/CAS-L/NEDD9 scaffolding protein has emerged as contributing to cancer metastasis in multiple cancer types. However, whereas some studies have identified elevated NEDD9 expression as prometastatic, other work has suggested a negative role in tumor progression. We here...

journal_title：Cancer research

authors： Izumchenko E,Singh MK,Plotnikova OV,Tikhmyanova N,Little JL,Serebriiskii IG,Seo S,Kurokawa M,Egleston BL,Klein-Szanto A,Pugacheva EN,Hardy RR,Wolfson M,Connolly DC,Golemis EA

更新日期：2009-09-15 00:00:00

abstract：:Although altered expression of platelet-derived growth factor (PDGF)-A is a hallmark of many cancers, the importance of pro-PDGF-A conversion to PDGF-A in tumorigenesis and the cognate protease(s) is unknown. Pro-PDGF-A processing occurs at pairs of basic residues, likely involving the proprotein convertases (PCs). In...

journal_title：Cancer research

authors： Siegfried G,Khatib AM,Benjannet S,Chrétien M,Seidah NG

更新日期：2003-04-01 00:00:00

abstract：:We examined the effect of human interferon (HuIFN) -alpha and -beta on the proliferation and differentiation induced by dimethyl sulfoxide (DMSO) of HL-60 human promyelocytic leukemia cells into mature granulocytes. Neither HuIFN-alpha nor -beta, alone, from 1 to 1000 IU/ml, nor the homologous mock HuIFN preparations ...

journal_title：Cancer research

authors： Hamburger AW,White CP,Siebenlist RE,Sedmak JJ,Grossberg SE

更新日期：1985-11-01 00:00:00

abstract：:Expression of cyclooxygenase (COX)-2 protein in 4-nitroquinoline-1-oxide (4-NQO)-induced rat tongue lesions and the postinitiation chemopreventive potential of a selective COX-2 inhibitor, nimesulide (NIM), were examined in Fischer 344 male rats. NIM was administered in the diet at doses of 150, 300, and 600 ppm for 1...

journal_title：Cancer research

authors： Shiotani H,Denda A,Yamamoto K,Kitayama W,Endoh T,Sasaki Y,Tsutsumi N,Sugimura M,Konishi Y

更新日期：2001-02-15 00:00:00

abstract：:Cancer immunotherapy may become a major treatment backbone in many cancers over the next decade. There are numerous immune cell types found in cancers and many components of an immune reaction to cancer. Thus, the tumor has many strategies to evade an immune response. It has been proposed that four different types of ...

journal_title：Cancer research

authors： Teng MW,Ngiow SF,Ribas A,Smyth MJ

更新日期：2015-06-01 00:00:00

abstract：:Understanding molecular alterations in colorectal cancer (CRC) is needed to define new biomarkers and treatment targets. We used oligonucleotide microarrays to monitor gene expression of about 6,800 known genes and 35,000 expressed sequence tags (ESTs) on five pools (four to six samples in each pool) of total RNA from...

journal_title：Cancer research

authors： Birkenkamp-Demtroder K,Christensen LL,Olesen SH,Frederiksen CM,Laiho P,Aaltonen LA,Laurberg S,Sørensen FB,Hagemann R,ØRntoft TF

更新日期：2002-08-01 00:00:00

abstract：:Midkine is a heparin-binding growth factor highly expressed in various cancers, including neuroblastoma, the most common extracranial pediatric solid tumor. Prognosis of patients with neuroblastoma in which MYCN is amplified remains particularly poor. In this study, we used a MYCN transgenic model for neuroblastoma in...

journal_title：Cancer research

authors： Kishida S,Mu P,Miyakawa S,Fujiwara M,Abe T,Sakamoto K,Onishi A,Nakamura Y,Kadomatsu K

更新日期：2013-02-15 00:00:00

abstract：:Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated proteins that both function in tumor suppression. p16(INK4a) maintains the retinoblastoma protein in its growth-suppressive state through inhibition of cyclin D-dependent kinase activity, whereas ARF binds with MDM2 and stabilizes p53. T...

journal_title：Cancer research

authors： Yarbrough WG,Bessho M,Zanation A,Bisi JE,Xiong Y

更新日期：2002-02-15 00:00:00

abstract：:Exposure of Chinese hamster ovary cells to the enzyme inhibitors methylglyoxal bis(guanylhydrazone and alpha-difluoromethylornithine (DFMO) results in increased sensitivity to hyperthermia. While methylglyoxal bis(guanylhydrazone) demonstrates pronounced cytotoxicity at moderate extracellular concentrations, DFMO is t...

journal_title：Cancer research

authors： Fuller DJ,Gerner EW

更新日期：1982-12-01 00:00:00

abstract：:When human tumor xenotransplants into nude mice are used as experimental models, it is important to know whether their microvascular anatomy is rather host or tumor specific. Therefore a morphometric comparison of the vascular network in human squamous cell carcinomas and their xenotransplants was carried out. Biopsie...

journal_title：Cancer research

authors： Lauk S,Zietman A,Skates S,Fabian R,Suit HD

更新日期：1989-08-15 00:00:00

abstract：:This study identifies ataxia-telangiectasia mutated (ATM) as a further component of the complex signaling network of radiation-induced DNA damage in nontargeted bystander cells downstream of ataxia-telangiectasia and Rad3-related (ATR) and provides a rationale for molecular targeted modulation of these effects. In dir...

journal_title：Cancer research

authors： Burdak-Rothkamm S,Rothkamm K,Prise KM

更新日期：2008-09-01 00:00:00

abstract：:The pharmacokinetics of UCN-01 after administration as a 72- or 3-h infusion to cancer patients in initial Phase I trials displayed distinctive features that could not have been predicted from preclinical data. The distribution volumes (0.0796-0.158 liters/kg) and the systemic clearance (0.0407-0.252 ml/h/kg) were ext...

journal_title：Cancer research

authors： Fuse E,Tanii H,Kurata N,Kobayashi H,Shimada Y,Tamura T,Sasaki Y,Tanigawara Y,Lush RD,Headlee D,Figg WD,Arbuck SG,Senderowicz AM,Sausville EA,Akinaga S,Kuwabara T,Kobayashi S

更新日期：1998-08-01 00:00:00

abstract：:The effects of the dopamine agonist bromocriptine and antagonist haloperidol on the incidence and histology of colon tumors induced by azoxymethane and on the labeling index of colon mucosa were investigated in Wistar rats. Rats received weekly s.c. injections of 7.4 mg/kg of body weight azoxymethane for 10 weeks and ...

journal_title：Cancer research

authors： Iishi H,Baba M,Tatsuta M,Okuda S,Taniguchi H

更新日期：1991-11-15 00:00:00

abstract：:Recent in vitro studies of the epidermal growth factor receptor (EGFR) family have revealed complex signaling interactions involving the production of ligand-mediated heterodimers synergistic for the transformation of cells in vitro. In a series of 70 patients with childhood medulloblastoma, we have used immunohistoch...

journal_title：Cancer research

authors： Gilbertson RJ,Perry RH,Kelly PJ,Pearson AD,Lunec J

更新日期：1997-08-01 00:00:00

abstract：:The phosphatidylinositol 3'-kinase (PI3k)/protein kinase B (PKB/Akt) signal transduction pathway plays a critical role in mediating endothelial cell survival and function during oxidative stress. The role of the PI3k/Akt signaling pathway in promoting cell viability was studied in vascular endothelial cells treated wi...

journal_title：Cancer research

authors： Geng L,Tan J,Himmelfarb E,Schueneman A,Niermann K,Brousal J,Fu A,Cuneo K,Kesicki EA,Treiberg J,Hayflick JS,Hallahan DE

更新日期：2004-07-15 00:00:00

abstract：:Mortality surveys and death certificate studies have suggested an association between leukemia and farming. To investigate whether exposure to carcinogens in an agricultural setting is related to risk of leukemia, the authors conducted a population-based case-control interview study of 578 white men with leukemia and ...

journal_title：Cancer research

authors： Brown LM,Blair A,Gibson R,Everett GD,Cantor KP,Schuman LM,Burmeister LF,Van Lier SF,Dick F

更新日期：1990-10-15 00:00:00

abstract：:Oxidation of the vinyl halide carcinogen and hepatotoxin vinylidene chloride (VDC) by microsomal cytochrome P-450 yields 2,2-dichloroacetaldehyde, 2-chloroacetyl chloride, 2-chloroacetic acid, and 1,1-dichloroethylene oxide. The roles of these metabolites in covalent modification of proteins and reduced glutathione (G...

journal_title：Cancer research

authors： Liebler DC,Meredith MJ,Guengerich FP

更新日期：1985-01-01 00:00:00

abstract：:FoxP3 is a member of the forkhead family of transcription factors critically involved in the development and function of CD25(+) regulatory T cells (Treg). Until recently, FoxP3 expression was thought to be restricted to the T-cell lineage. However, using immunohistochemistry and flow cytometric analysis of human mela...

journal_title：Cancer research

authors： Ebert LM,Tan BS,Browning J,Svobodova S,Russell SE,Kirkpatrick N,Gedye C,Moss D,Ng SP,MacGregor D,Davis ID,Cebon J,Chen W

更新日期：2008-04-15 00:00:00

abstract：:Apoptosis is a critical early cellular event in the development of polycystic kidney disease (PKD) in humans and mice. In the SBM transgenic model of PKD, both apoptosis and proliferation are c-myc driven and are independent of p53 and Bcl-2 pathways. On the basis of recent evidence implicating the FasL/Fas pathway in...

journal_title：Cancer research

authors： Couillard M,Guillaume R,Tanji N,D'Agati V,Trudel M

更新日期：2002-04-15 00:00:00

abstract：:The c-Fes protein-tyrosine kinase exhibits strong expression in myeloid hematopoietic cells. Previous studies have shown that Fes induces differentiation in the chronic myelogenous leukemia-derived cell line K-562, suggesting that the Fes signal for differentiation is dominant to the Bcr-Abl signal for transformation ...

journal_title：Cancer research

authors： Lionberger JM,Smithgall TE

更新日期：2000-02-15 00:00:00

abstract：:Cytidine dialdehyde inhibited the growth of leukemia L1210 cells in culture at a 50% inhibitory concentration of 3.5 X 10(-5) M and, when administered i.p. at 200 mg/kg daily for 5 days, increased the mean survival of L1210 tumor-bearing mice by up to 171%. Given by the s.c. or i.v. routes, the compound was ineffectiv...

journal_title：Cancer research

authors： Kinahan JJ,Pavelic ZP,Leonard RJ,Bloch A,Grindey GB

更新日期：1980-03-01 00:00:00