The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

abstract：:KAI1 (CD82) belongs to the transmembrane 4 superfamily in which members have inhibitory effects on tumor cell motility and metastasis. During reverse transcription-PCR analysis, we found a splice variant of KAI1 (spliced-KAI1) in which exon 7 was deleted. This exon encodes the 28 amino acids that span from the distal ...

journal_title：Cancer research

authors： Lee JH,Seo YW,Park SR,Kim YJ,Kim KK

更新日期：2003-11-01 00:00:00

abstract：:Busulfan causes long-lasting defects in the hematopoietic stem cells and in the immune system of mice. We designed studies to determine whether chloramphenicol further damaged the already defective hematopoietic stem cells of mice that were pretreated with busulfan, and we unexpectedly observed that mice given injecti...

journal_title：Cancer research

authors： Robin E,Berman M,Bhoopalam N,Cohen H,Fried W

更新日期：1981-09-01 00:00:00

abstract：:Dissemination to draining lymph nodes is a frequent first step in prostate cancer metastasis. Although tumors metastasize to lymph nodes via the lymphatics, the importance of lymphangiogenesis in mediating the process remains controversial. Here, we inhibit intratumoral lymphangiogenesis in s.c. and surgical orthotopi...

journal_title：Cancer research

authors： Wong SY,Haack H,Crowley D,Barry M,Bronson RT,Hynes RO

更新日期：2005-11-01 00:00:00

abstract：:The tumor localization of various anti-CD5 immunotoxins (ITs) was studied in vivo in BALB/c nude mice bearing human ascitic Ichikawa tumor cells. Plasma and ascitic clearance of IT as well as the number of intact IT molecules taken up per tumor cell was measured with a highly sensitive immunoenzymometric assay. This a...

journal_title：Cancer research

authors： Rostaing-Capaillon O,Casellas P

更新日期：1990-05-15 00:00:00

abstract：:Induction of mRNA for BIK proapoptotic protein by doxorubicin or gamma-irradiation requires the DNA-binding transcription factor activity of p53. In MCF7 cells, pure antiestrogen fulvestrant also induces BIK mRNA and apoptosis. Here, we provide evidence that, in contrast to doxorubicin or gamma-irradiation, fulvestran...

journal_title：Cancer research

authors： Hur J,Bell DW,Dean KL,Coser KR,Hilario PC,Okimoto RA,Tobey EM,Smith SL,Isselbacher KJ,Shioda T

更新日期：2006-10-15 00:00:00

abstract：:The occurrence of spontaneous skin papillomas in Japanese newts (Cynops pyrrhogaster) from Niigata prefecture in Northern Japan was monitored over four seasons covering a period of 2 years. Of 13,613 newts, 249 were found to possess papillomas. The percentage of newts with papillomas was highest in autumn, ranging fro...

journal_title：Cancer research

authors： Asashima M,Komazaki S,Satou C,Oinuma T

更新日期：1982-09-01 00:00:00

abstract：:The study by Jaratlerdsiri and colleagues represents the first whole-genome sequencing study of prostate cancer from men in sub-Saharan Africa. Preliminary findings include a higher tumor mutation burden in these tumors compared with data from other available prostate cancer cohorts. Although larger studies are needed...

journal_title：Cancer research

authors： Huang FW

更新日期：2018-12-15 00:00:00

abstract：:In order to characterize the promoting activity of the peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,463), male F344 rats which received a single 150-mg/kg dose of diethylnitrosamine (DEN) were fed 0.1% WY-14,643 or 0.05% phenobarbital in the diet for 11, 22, or 54 wk. WY-14,6...

journal_title：Cancer research

authors： Cattley RC,Popp JA

更新日期：1989-06-15 00:00:00

abstract：:Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show that production of IL1β in primary breast cancer tumors is linked with advanced disease and originates from tumor-infiltrating CD11c+ myeloid cells. IL1β production is triggered by cancer cell membrane-derived TGFβ. Neutralizing TG...

journal_title：Cancer research

authors： Wu TC,Xu K,Martinek J,Young RR,Banchereau R,George J,Turner J,Kim KI,Zurawski S,Wang X,Blankenship D,Brookes HM,Marches F,Obermoser G,Lavecchio E,Levin MK,Bae S,Chung CH,Smith JL,Cepika AM,Oxley KL,Snipes GJ,B

更新日期：2018-09-15 00:00:00

abstract：:In the era of omics-driven research, it remains a common dilemma to stratify individual patients based on the molecular characteristics of their tumors. To improve molecular stratification of patients with breast cancer, we developed the Gaussian mixture model (GMM)-based classifier. This probabilistic classifier was ...

journal_title：Cancer research

authors： Prabakaran I,Wu Z,Lee C,Tong B,Steeman S,Koo G,Zhang PJ,Guvakova MA

更新日期：2019-07-01 00:00:00

abstract：:Interleukin 4 (IL-4) receptors were detected by a monoclonal antibody on tumor cells of 10 of 29 squamous cell carcinomas and 6 of 17 adenocarcinomas of the lung. None of the small cell carcinomas or carcinoid tumors stained. Parallel sections stained for epidermal growth factor receptors showed that all but 2 of the ...

journal_title：Cancer research

authors： Tungekar MF,Turley H,Dunnill MS,Gatter KC,Ritter MA,Harris AL

更新日期：1991-01-01 00:00:00

abstract：:Inflammation has increasingly been recognized as a critical component influencing tumor growth. Recent reports have revealed conflicting evidence for the role of Toll-like receptors (TLR) in modulating tumorigenesis. In our study, we implicate TLR3 in mediating immune surveillance with increased growth of implanted tr...

journal_title：Cancer research

authors： Chin AI,Miyahira AK,Covarrubias A,Teague J,Guo B,Dempsey PW,Cheng G

更新日期：2010-04-01 00:00:00

abstract：:Cell differentiation within stem cell lineages can check proliferative potential, but nodal pathways that can limit tumor growth are obscure. Here, we report that lung cancer cell populations generate phenotypic and oncogenic plasticity via a switch between differentiation programs controlled by SOX2 and SOX9, thus al...

journal_title：Cancer research

authors： Lin SC,Chou YT,Jiang SS,Chang JL,Chung CH,Kao YR,Chang IS,Wu CW

更新日期：2016-12-01 00:00:00

abstract：:Fourteen suspected hereditary nonpolyposis colorectal carcinoma cases with microsatellite unstable(microsatellite instability-high; MSI-H) tumors but no germ-line MSH2, MSH6, or MLH1 mutations were examined for hypermethylation of CpG sites in the critical promoter region of MLH1. The methylation patterns were determi...

journal_title：Cancer research

authors： Gazzoli I,Loda M,Garber J,Syngal S,Kolodner RD

更新日期：2002-07-15 00:00:00

abstract：:Activation of c-Met signaling and beta-catenin mutations are frequent genetic events observed in liver cancer development. Recently, we demonstrated that activated beta-catenin can cooperate with c-Met to induce liver cancer formation in a mouse model. Cyclin D1 (CCND1) is an important cell cycle regulator that is con...

journal_title：Cancer research

authors： Patil MA,Lee SA,Macias E,Lam ET,Xu C,Jones KD,Ho C,Rodriguez-Puebla M,Chen X

更新日期：2009-01-01 00:00:00

abstract：:Retinoids are promising agents for cancer chemoprevention and therapy. Nuclear retinoic acid receptors (RARs; RARalpha, -beta, and -gamma) and retinoid X receptors (RXRs; RXRalpha, -beta, and -gamma) are thought to mediate most of retinoids' effects on cell growth and differentiation. Because the majority of human non...

journal_title：Cancer research

authors： Sun SY,Yue P,Dawson MI,Shroot B,Michel S,Lamph WW,Heyman RA,Teng M,Chandraratna RA,Shudo K,Hong WK,Lotan R

更新日期：1997-11-01 00:00:00

abstract：:Biochemical quantitation of estrogen receptors has been used to predict prognosis in breast cancer. Immunocytochemical analysis of estrogen receptors correlates with biochemical analysis but has very few follow-up studies in the literature to validate it as a prognostic indicator. 257 patients were followed for up to ...

journal_title：Cancer research

authors： Kinsel LB,Szabo E,Greene GL,Konrath J,Leight GS,McCarty KS Jr

更新日期：1989-02-15 00:00:00

abstract：:Tissue survival responses to ionizing radiation are nonlinear with dose, rather yielding tissue-specific descending curves that impede straightforward analysis of biologic effects. Apoptotic cell death often occurs at low doses, while at clinically relevant intermediate doses, double-strand break misrepair yields mito...

journal_title：Cancer research

authors： Martin ML,Adileh M,Hsu KS,Hua G,Lee SG,Li C,Fuller JD,Rotolo JA,Bodo S,Klingler S,Haimovitz-Friedman A,Deasy JO,Fuks Z,Paty PB,Kolesnick RN

更新日期：2020-03-01 00:00:00

abstract：:Bropirimine (ABPP), a pyrimidinone, is currently under clinical trial for its antitumor potential. Bropirimine alone was marginally active against some experimental tumors such as B16 melanoma but was ineffective against others such as P388 or L1210 leukemia. However, it produced statistically significant synergistic ...

journal_title：Cancer research

authors： Li LH,DeKoning TF,Wallace TL

更新日期：1987-11-15 00:00:00

abstract：:Thirteen variables were evaluated for their significance in predicting the survival of 148 patients in a retrospective study with clinical Stage I cutaneous malignant melanoma. The variables studied were histological type, tumor thickness, level of invasion, mitotic activity, pigmentation type, existence of ulceration...

journal_title：Cancer research

authors： Hacene K,Le Doussal V,Brunet M,Lemoine F,Guerin P,Hebert H

更新日期：1983-06-01 00:00:00

abstract：:Despite considerable efforts to improve early detection of ovarian cancer, the majority of women at time of diagnosis will have metastatic disease. Understanding and targeting the molecular underpinnings of metastasis continues to be the principal challenge in the clinical management of ovarian cancer. Whereas the mul...

journal_title：Cancer research

authors： Hickson JA,Huo D,Vander Griend DJ,Lin A,Rinker-Schaeffer CW,Yamada SD

更新日期：2006-02-15 00:00:00

abstract：:Treatment of non-T/non-B human leukemic cell line REH with 5 X 10(-9) M 12-O-tetradecanoylphorbol-13-acetate (TPA) at 37 degrees resulted in their adherence to culture flasks by 24 to 36 hr and, after 72 hr, the entire surface of the flask/coverslips became covered with macrophage-like cells containing pseudopodia. Wr...

journal_title：Cancer research

authors： Srivastava BI,Koga M,Srivastava P

更新日期：1984-07-01 00:00:00

abstract：:An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. We now show that two other human malignant T-lymphoid cell lines, CCRF-CEM and CCRF-HSB-2 also produce such a fac...

journal_title：Cancer research

authors： Uittenbogaart CH,Nishanian PG,Anisman DJ,Erikson TK,Fahey JL

更新日期：1986-03-01 00:00:00

abstract：:Estrogen-related receptor alpha (ERRalpha) was identified as a gene related to estrogen receptor alpha (ERalpha) and belongs to a class of nuclear orphan receptors. ERRalpha binds to estrogen responsive element(s) (ERE) and is considered to be involved in modulation of estrogenic actions. However, biological significa...

journal_title：Cancer research

authors： Suzuki T,Miki Y,Moriya T,Shimada N,Ishida T,Hirakawa H,Ohuchi N,Sasano H

更新日期：2004-07-01 00:00:00

abstract：:The deregulated expression of cyclin E as measured by the overexpression of its low molecular weight (LMW) isoforms is a powerful predictor of poor outcome in patients with breast cancer. The mechanism by which these LMW forms give tumor cells a growth advantage is not known and is the subject of this article. In this...

journal_title：Cancer research

authors： Akli S,Zheng PJ,Multani AS,Wingate HF,Pathak S,Zhang N,Tucker SL,Chang S,Keyomarsi K

更新日期：2004-05-01 00:00:00

abstract：:Rational therapeutic approaches based on synthetic lethality may improve cancer management. On the basis of a high-throughput drug screen, we provide preclinical proof of concept that targeting the mitochondrial Hsp90 chaperone network (mtHsp90) and inhibition of Bcl-2, Bcl-xL, and Mcl-1 is sufficient to elicit synthe...

journal_title：Cancer research

authors： Karpel-Massler G,Ishida CT,Bianchetti E,Shu C,Perez-Lorenzo R,Horst B,Banu M,Roth KA,Bruce JN,Canoll P,Altieri DC,Siegelin MD

更新日期：2017-07-01 00:00:00

abstract：:Metabolite profiling using (1)H nuclear magnetic resonance (NMR) spectroscopy was used to investigate the metabolic changes associated with deletion of the gene for the transcriptional coactivator p300 in the human colon carcinoma cell line HCT116. Multivariate statistical methods were used to distinguish between meta...

journal_title：Cancer research

authors： Bundy JG,Iyer NG,Gentile MS,Hu DE,Kettunen M,Maia AT,Thorne NP,Brenton JD,Caldas C,Brindle KM

更新日期：2006-08-01 00:00:00

abstract：:A clone of a human gastric carcinoma cell line was used to determine whether cells which had survived a treatment with Melphalan would express altered survival responses when treated again with this agent 1 week or more later. Cells were treated for 1 h each week with 2 micrograms/ml (99% lethal dose). After the first...

journal_title：Cancer research

authors： Barranco SC,Townsend CM Jr,Weintraub B,Beasley EG,MacLean KK,Shaeffer J,Liu NH,Schellenberg K

更新日期：1990-06-15 00:00:00

abstract：:The oncogenic protein Ski associates with Smad proteins and counteracts their activation of gene expression and growth inhibition in response to transforming growth factor beta (TGF-beta). Here we show that Ski protein levels are increased in all 44 human melanoma tumor tissues analyzed in vivo. In addition, Ski subce...

journal_title：Cancer research

authors： Reed JA,Bales E,Xu W,Okan NA,Bandyopadhyay D,Medrano EE

更新日期：2001-11-15 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) plays critical roles in many biological processes and in tumorigenesis. Here, we show that two mutated EGFRs found in lung and other malignancies, EGFR-G719S and EGFR-L858R, could transform Ba/F3 cells to interleukin-3 (IL-3)-independent growth, in a ligand-independent manner, a...

journal_title：Cancer research

authors： Jiang J,Greulich H,Jänne PA,Sellers WR,Meyerson M,Griffin JD

更新日期：2005-10-01 00:00:00