A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor.

abstract：:The detection of tumor suppressor gene promoter methylation in sputum-derived exfoliated cells predicts early lung cancer. Here, we identified genetic determinants for this epigenetic process and examined their biologic effects on gene regulation. A two-stage approach involving discovery and replication was used to as...

journal_title：Cancer research

authors： Leng S,Stidley CA,Liu Y,Edlund CK,Willink RP,Han Y,Landi MT,Thun M,Picchi MA,Bruse SE,Crowell RE,Van Den Berg D,Caporaso NE,Amos CI,Siegfried JM,Tesfaigzi Y,Gilliland FD,Belinsky SA

更新日期：2012-02-01 00:00:00

abstract：:alpha-Interferon (IFN-alpha) induced unique ultrastructural alterations in peripheral blood and splenic hairy cell leukemia (HCL) cells (14 of 20 cases) treated in vitro. To further investigate the effects of B-cell growth factor (BCGF) and IFN-alpha on target hairy cells (HCs), we utilized immunogold labeling in conj...

journal_title：Cancer research

authors： Gamliel H,Brownstein BH,Gurfel D,Wu SH,Rosner MC,Golomb HM

更新日期：1990-07-01 00:00:00

abstract：:Structural analysis of the sugar chains of human chorionic gonadotropin (hCG) has revealed that abnormal biantennary structures appear specifically on hCG in the urine of choriocarcinoma patients. However, the enzymatic and molecular mechanisms of the biosynthesis of abnormal biantennary sugar chains have not yet been...

journal_title：Cancer research

authors： Takamatsu S,Oguri S,Minowa MT,Yoshida A,Nakamura K,Takeuchi M,Kobata A

更新日期：1999-08-15 00:00:00

abstract：:A two-stage genome-wide association study (GWAS) of the Cancer Genetic Markers of Susceptibility (CGEMS) initiative identified single nucleotide polymorphisms (SNP) in 150 regions across the genome that may be associated with prostate cancer (PCa) risk. We filtered these results to identify 43 independent SNPs where t...

journal_title：Cancer research

authors： Hsu FC,Sun J,Wiklund F,Isaacs SD,Wiley KE,Purcell LD,Gao Z,Stattin P,Zhu Y,Kim ST,Zhang Z,Liu W,Chang BL,Walsh PC,Duggan D,Carpten JD,Isaacs WB,Grönberg H,Xu J,Zheng SL

更新日期：2009-04-01 00:00:00

abstract：:The tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced specific changes in the cell surface glycoprotein profile of K562 human leukemic cells. TPA-treated K562 cells were examined by cell surface labeling followed by immunoprecipitation with anti-glycophorin antiserum or anti-K562 antis...

journal_title：Cancer research

authors： Fukuda M

更新日期：1981-11-01 00:00:00

abstract：:Irinotecan hydrochloride (CPT-11), an antitumor camptothecin derivative, causes severe forms of diarrhea clinically. We characterized CPT-11-induced diarrhea histologically and enzymologically and assessed the relationships between intestinal toxicity and the activity of the enzymes that play a key role in the major m...

journal_title：Cancer research

authors： Takasuna K,Hagiwara T,Hirohashi M,Kato M,Nomura M,Nagai E,Yokoi T,Kamataki T

更新日期：1996-08-15 00:00:00

abstract：:Patients with long-standing ulcerative colitis (UC) are at increased risk for colon cancer. These cancers are thought to arise from preexisting dysplasia in a field of abnormal cells that often exhibits aneuploidy and p53 abnormalities. Using dual color fluorescence in situ hybridization with centromere probes and loc...

journal_title：Cancer research

authors： Rabinovitch PS,Dziadon S,Brentnall TA,Emond MJ,Crispin DA,Haggitt RC,Bronner MP

更新日期：1999-10-15 00:00:00

abstract：:Malignant and uninvolved human breast tissues were maintained in organ culture for 3 to 6 days. Under these conditions, the three-dimensional glandular architecture is maintained with the least disruption of tissue integrity. The biosynthesis and release of glycoproteins were studied by using the incorporation of [14C...

journal_title：Cancer research

authors： Gendler SJ,Dermer GB,Silverman LM,Tökés ZA

更新日期：1982-11-01 00:00:00

abstract：:The in vitro growth rates of different classifications of human mammary epithelium were compared. Samples included 4 established breast cell lines and excised tissue or breast fluid cells originating WOMEN FOR 40 DIFFERENT AND comprising 3 classifications: normal, nonmalignant atypical, and malignant. Growth was quant...

journal_title：Cancer research

authors： Buehring GC,Williams RR

更新日期：1976-10-01 00:00:00

abstract：:Nucleolar antigens of normal rat liver, regenerating liver, and Novikoff ascites hepatoma cells were transplanted in vitro from polyadenylic acid-containing messenger RNAs isolated from the respective tissues and immunoprecipitated with specific antinucleolar antibodies and Protein A. By two-dimensional gel electropho...

journal_title：Cancer research

authors： Satoh K,Busch H

更新日期：1983-05-01 00:00:00

abstract：:The effects of quinacrine, an antimetabolite which intercalates into DNA, on the ultrastructure of interphase nuclei and on RNA turnover were studied in primary cultures of rat hepatocytes. Procedures included ultrastructural cytochemical staining for ribonucleoprotein and DNA, autoradiography, and measurement of labe...

journal_title：Cancer research

authors： Leduc EH,Bernhard W,Viron A,Fain J,Puvion E

更新日期：1981-07-01 00:00:00

abstract：:Pyruvate kinase isozymes were studied in normal brain tissue (both fetal and adult) and in meningiomas and malignant gliomas. In fetal brain five different forms could be detected by electrophoresis (K4, K3M, K2M2, KM3, and M4). In adult brain the M4-type, K3M hybrid, and K4-type are present; the M isozyme is largely ...

journal_title：Cancer research

authors： van Veelen CW,Verbiest H,Vlug AM,Rijksen G,Staal GE

更新日期：1978-12-01 00:00:00

abstract：:An epidemic of a malignant neoplasm occurs in northern pike, Esox lucius L., from the Aland Islands of Finland. The neoplasm is morphologically similar to other pike hemic tumors reported in other areas of the world. Pike normal tissues showed evolutionary conservation with the mammalian intermediate filament proteins...

journal_title：Cancer research

authors： Thompson JS,Kostiala AA

更新日期：1990-09-01 00:00:00

abstract：:Systemic delivery of anticancer agents is accompanied by many unwanted side effects that can be mitigated by encapsulation of antineoplastic agents. However, encapsulation necessitates a technique for controlled delivery to the cancerous tissue. We have developed a novel drug delivery system that releases drug from st...

journal_title：Cancer research

authors： Nelson JL,Roeder BL,Carmen JC,Roloff F,Pitt WG

更新日期：2002-12-15 00:00:00

abstract：:We analyzed the mRNA expression of the FHIT gene by reverse transcription-PCR (RT-PCR) in 54 cases of acute lymphoblastic leukemia (ALL; 11 cases of T-cell ALL [T-ALL] and 43 cases of non-T-ALL) and 40 cases of acute myeloid leukemia (AML). In 46% of the ALL cases and 55% of the AML cases, FHIT expression was absent o...

journal_title：Cancer research

authors： Iwai T,Yokota S,Nakao M,Nakazawa N,Taniwaki M,Kimura T,Sonoda Y,Kaneko H,Okuda T,Azuma H,Oka T,Takeda T,Watanabe A,Kikuta A,Asami K,Sekine I,Matsushita T,Tsuchiya T,Mimaya J,Koizumi S,Ohta S,Miyake M,Takaue Y

更新日期：1998-11-15 00:00:00

abstract：:A model for medulloblastoma-like primitive neuroectodermal tumors was established in rat using retrovirally transduced SV40 large T antigen (LT) as an inducing agent (O. D. Wiestler et al., Brain Pathol., 2: 47-59, 1992). A cell line isolated from such a tumor and clonal derivatives thereof were biologically and molec...

journal_title：Cancer research

authors： Salewski H,Bayer TA,Eidhoff U,Preuss U,Weggen S,Scheidtmann KH

更新日期：1999-04-15 00:00:00

abstract：:Factors affecting the expression of carcinoembryonic antigen (CEA) at the surface of in vitro human colon carcinoma cells were determined using 125I-labeled antibodies. Binding of specific anti-CEA antibodies resulted in polar redistribution of CEA, followed by endocytosis of most of the CEA-anti-CEA complexes. These ...

journal_title：Cancer research

authors： Rosenthal KL,Tompkins WA,Rawls WE

更新日期：1980-12-01 00:00:00

abstract：:There is little information on early molecular events in the development of N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis and of the effects of chemopreventive agents on these events. In this study, we identified genes in rat esophagus that were differentially expressed in response to short-te...

journal_title：Cancer research

authors： Reen RK,Dombkowski AA,Kresty LA,Cukovic D,Mele JM,Salagrama S,Nines R,Stoner GD

更新日期：2007-07-01 00:00:00

abstract：:Options for skin cancer treatment currently include surgery, radiotherapy, topical chemotherapy, cryosurgery, curettage, and electrodessication. Although effective, surgery is costly and unsuitable for certain patients. Radiotherapy can leave a poor cosmetic effect, and current chemotherapy is limited by low cure rate...

journal_title：Cancer research

authors： Ogbourne SM,Suhrbier A,Jones B,Cozzi SJ,Boyle GM,Morris M,McAlpine D,Johns J,Scott TM,Sutherland KP,Gardner JM,Le TT,Lenarczyk A,Aylward JH,Parsons PG

更新日期：2004-04-15 00:00:00

abstract：:Cancer cells contain multiple genetic and epigenetic abnormalities. Despite this complexity, their growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon, called "oncogene addiction," provides a rationale for molecular targeted therapy. The efficacy of this strategy require...

journal_title：Cancer research

authors： Weinstein IB,Joe A

更新日期：2008-05-01 00:00:00

abstract：:Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with diethylnitrosamine, as measured by the appearance of foci of resistant hepatocytes that stain for gamma-glutamyl transpeptidase and that are presumptive preneoplastic lesions in the rat. Wi...

journal_title：Cancer research

authors： Ying TS,Sarma DS,Farber E

更新日期：1981-06-01 00:00:00

abstract：:Successful treatment of many patients with osteosarcoma requires more effective chemotherapy. Since new agents are needed, we have developed an immunotoxin using TP-3, an IgG2b mAb which recognizes human and canine osteosarcomas and budding capillaries of tumors. The plant hemitoxin, pokeweed antiviral protein (PAP), ...

journal_title：Cancer research

authors： Anderson PM,Meyers DE,Hasz DE,Covalcuic K,Saltzman D,Khanna C,Uckun FM

更新日期：1995-03-15 00:00:00

abstract：:The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing evidence also indicates that IAPs also modulate cell division, cell cycle progression, and signal transduction pathways. As our basic understanding of IAPs has inc...

journal_title：Cancer research

authors： Schimmer AD

更新日期：2004-10-15 00:00:00

abstract：:Integrin alpha(5)beta(1) is overexpressed on endothelial cells of tumor vessels and is uniformly and rapidly accessible to antibodies in the bloodstream. Here, we determined whether antibodies rapidly gain access to integrin overexpressed on the abluminal (basolateral) surface of endothelial cells through vascular lea...

journal_title：Cancer research

authors： Magnussen A,Kasman IM,Norberg S,Baluk P,Murray R,McDonald DM

更新日期：2005-04-01 00:00:00

abstract：:Phosphoglucose isomerase (PGI) is a multifunctional enzyme that functions in glucose metabolism as a glycolytic enzyme catalyzing an interconversion between glucose and fructose inside the cell, while it acts as cytokine outside the cell, with properties that include autocrine motility factor (AMF)-regulating tumor ce...

journal_title：Cancer research

authors： Niinaka Y,Harada K,Fujimuro M,Oda M,Haga A,Hosoki M,Uzawa N,Arai N,Yamaguchi S,Yamashiro M,Raz A

更新日期：2010-11-15 00:00:00

abstract：:A truncating allele of the cell cycle checkpoint kinase CHK2 is present in 1% of the population, conferring a moderate increase in breast cancer risk, and inactivation of chk2 enhances mammary tumorigenesis in mice with targeted inactivation of brca1. We used the mouse mammary tumor virus (MMTV) promoter to target exp...

journal_title：Cancer research

authors： Kwak EL,Kim S,Zhang J,Cardiff RD,Schmidt EV,Haber DA

更新日期：2006-02-15 00:00:00

abstract：:The aim of this study was to evaluate to what extent tumor necrosis factor alpha (TNF-alpha) and interleukin 1 may explain the development of experimental cancer cachexia. For this purpose, C57BL/6J mice bearing a transplantable low differentiated rapidly growing tumor were passively immunized every other day with rab...

journal_title：Cancer research

authors： Gelin J,Moldawer LL,Lönnroth C,Sherry B,Chizzonite R,Lundholm K

更新日期：1991-01-01 00:00:00

abstract：:During the development of neoplasia, epithelial tissues undergo biochemical and structural changes that can manifest in tissue fluorescence. There have been several reports on different in vivo fluorescence characteristics between normal and precancerous (dysplastic) tissues. However, it has been difficult to identify...

journal_title：Cancer research

authors： Georgakoudi I,Jacobson BC,Müller MG,Sheets EE,Badizadegan K,Carr-Locke DL,Crum CP,Boone CW,Dasari RR,Van Dam J,Feld MS

更新日期：2002-02-01 00:00:00

abstract：:Cell adhesion and spreading is a crucial step in the metastatic cascade of cancer cells, and interruption of this step is considered to be a logical strategy for prevention and treatment of tumor metastasis. Emodin is the major active component of the rhizome of Rheum palmatum L., with known anticancer activities. Her...

journal_title：Cancer research

authors： Huang Q,Shen HM,Shui G,Wenk MR,Ong CN

更新日期：2006-06-01 00:00:00

abstract：:Melanoma differentiation associated gene-7/interleukin-24 (Mda-7/IL-24), a novel member of the IL-10 family of cytokines, uniquely displays cancer-specific apoptosis-inducing activity. Positive results in ongoing phase I/II clinical trials have strengthened the possibility of its utilization as a cancer gene therapeut...

journal_title：Cancer research

authors： Sauane M,Lebedeva IV,Su ZZ,Choo HT,Randolph A,Valerie K,Dent P,Gopalkrishnan RV,Fisher PB

更新日期：2004-05-01 00:00:00