Oncogene addiction.

abstract：:CXCL16 is a new member of the chemokine superfamily, which exists in a transmembrane as well as a soluble form. Its receptor CXCR6 is detected on CD4(+) T cells, CD8(+) T cells, and natural killer T cells. Here, we report a significant correlation of CXCL16 expression by tumor cells with the infiltration of T cells an...

journal_title：Cancer research

authors： Hojo S,Koizumi K,Tsuneyama K,Arita Y,Cui Z,Shinohara K,Minami T,Hashimoto I,Nakayama T,Sakurai H,Takano Y,Yoshie O,Tsukada K,Saiki I

更新日期：2007-05-15 00:00:00

abstract：:Malignant ascites is a common complication in the late stages of epithelial ovarian cancer (EOC) that greatly diminishes the quality of life of patients. Malignant ascites is a known consequence of vascular dysfunction, but current approved treatments are not effective in preventing fluid accumulation. In this study, ...

journal_title：Cancer research

authors： Moughon DL,He H,Schokrpur S,Jiang ZK,Yaqoob M,David J,Lin C,Iruela-Arispe ML,Dorigo O,Wu L

更新日期：2015-11-15 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most frequent and incurable type of brain tumor of adults. Hypoxia has been shown to direct GBM toward a more aggressive and malignant state. Here we show that hypoxia increases Notch1 activation, which in turn induces the expression of transient receptor potential 6 (TRPC6) in pri...

journal_title：Cancer research

authors： Chigurupati S,Venkataraman R,Barrera D,Naganathan A,Madan M,Paul L,Pattisapu JV,Kyriazis GA,Sugaya K,Bushnev S,Lathia JD,Rich JN,Chan SL

更新日期：2010-01-01 00:00:00

abstract：:It has been postulated that the expression of the ribonucleoprotein telomerase is necessary to overcome cellular senescence and that malignant tumors must express telomerase to maintain their immortality. In most human adult tissues, telomerase activity is not detected. In contrast, several murine tissues express vari...

journal_title：Cancer research

authors： Bednarek A,Budunova I,Slaga TJ,Aldaz CM

更新日期：1995-10-15 00:00:00

abstract：:The effects of quinacrine, an antimetabolite which intercalates into DNA, on the ultrastructure of interphase nuclei and on RNA turnover were studied in primary cultures of rat hepatocytes. Procedures included ultrastructural cytochemical staining for ribonucleoprotein and DNA, autoradiography, and measurement of labe...

journal_title：Cancer research

authors： Leduc EH,Bernhard W,Viron A,Fain J,Puvion E

更新日期：1981-07-01 00:00:00

abstract：:Obesity is associated with increased cancer incidence and mortality. We have previously found that obesity in children is associated with a 50% increased recurrence of acute lymphoblastic leukemia (ALL) in high-risk patients. We have therefore developed novel in vivo and in vitro preclinical models to study the mechan...

journal_title：Cancer research

authors： Behan JW,Yun JP,Proektor MP,Ehsanipour EA,Arutyunyan A,Moses AS,Avramis VI,Louie SG,Butturini A,Heisterkamp N,Mittelman SD

更新日期：2009-10-01 00:00:00

abstract：:Primary solid tumors were mechanically and/or enzymatically disassociated, and the resulting suspensions of single cells and small clumps of cells were seeded onto three different substrates, i.e., tissue culture plastic, rat smooth muscle cells (SMCs), and SMC-derived extracellular matrix. Tests of the relative effec...

journal_title：Cancer research

authors： Bogenmann E,Mark C,Isaacs H,Neustein HB,De Clerck YA,Laug WE,Jones PA

更新日期：1983-03-01 00:00:00

abstract：:SIRT6 is a SIR2 family member that regulates multiple molecular pathways involved in metabolism, genomic stability, and aging. It has been proposed previously that SIRT6 is a tumor suppressor in cancer. Here, we challenge this concept by presenting evidence that skin-specific deletion of SIRT6 in the mouse inhibits sk...

journal_title：Cancer research

authors： Ming M,Han W,Zhao B,Sundaresan NR,Deng CX,Gupta MP,He YY

更新日期：2014-10-15 00:00:00

abstract：:Infiltrating macrophages are a key component of inflammation during tumorigenesis, but the direct evidence of such linkage remains unclear. We report here that persistent coculturing of immortalized prostate epithelial cells with macrophages, without adding any carcinogens, induces prostate tumorigenesis and that indu...

journal_title：Cancer research

authors： Fang LY,Izumi K,Lai KP,Liang L,Li L,Miyamoto H,Lin WJ,Chang C

更新日期：2013-09-15 00:00:00

abstract：:We report on the identification of autoantigens commonly recognized by sera from patients with breast cancer. We selected ten sera from patients with invasive ductal carcinoma (IDC) of the breast with high titer IgG autoantibodies for biopanning of a T7 phage breast cancer cDNA display library. A high throughput metho...

journal_title：Cancer research

authors： Fernández-Madrid F,Tang N,Alansari H,Granda JL,Tait L,Amirikia KC,Moroianu M,Wang X,Karvonen RL

更新日期：2004-08-01 00:00:00

abstract：:Virtually all patients with chronic myelogenous leukemia (CML) express an aberrant protein (p210 Bcr-Abl) that contains NH2-terminal sequences from Bcr fused to COOH-terminal sequences from Abl. In a yeast two-hybrid screen, we have identified TSG101 as a binding partner for Bcr. Because TSG101 is a subunit of the mam...

journal_title：Cancer research

authors： Olabisi OO,Mahon GM,Kostenko EV,Liu Z,Ozer HL,Whitehead IP

更新日期：2006-06-15 00:00:00

abstract：:Mitomycin C requires bioreduction in order to exert its cytotoxic action. Activation of mitomycin C to an electrophile was equally supported by NADPH and NADH in EMT6 tumor cell sonicates under hypoxia. No alkylation was observed under aerobic conditions. Purified NADH:cytochrome b5 reductase catalyzed the reduction o...

journal_title：Cancer research

authors： Hodnick WF,Sartorelli AC

更新日期：1993-10-15 00:00:00

abstract：:Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular and clinicopathologic criteria. Using methylated in tumor (MINT) markers 1, 2, 12, and 31, we stratified 77 primary CRC...

journal_title：Cancer research

authors： Whitehall VL,Wynter CV,Walsh MD,Simms LA,Purdie D,Pandeya N,Young J,Meltzer SJ,Leggett BA,Jass JR

更新日期：2002-11-01 00:00:00

abstract：:Chicken chondrocytes isolated from 11-day-old chicken vertebrate cartilage were transformed by Rous sarcoma virus ts LA24 of the Prague strain as well as by the wild-type Prague strain of Rous sarcoma virus. The morphology of chondrocytes transformed by Rous sarcoma virus ts LA 24 was dependent on the temperature, and...

journal_title：Cancer research

authors： Okayama M,Yoshimura M,Muto M,Chi J,Roth S,Kaji A

更新日期：1977-03-01 00:00:00

abstract：:The cells' ability to proliferate in response to growth factor stimulation is significantly altered during cancer progression. To investigate the mechanisms underlying these alterations in prostate cancer, the role and expression of beta1A integrin and type 1 insulin-like growth factor receptor (IGF-IR), known to cont...

journal_title：Cancer research

authors： Goel HL,Breen M,Zhang J,Das I,Aznavoorian-Cheshire S,Greenberg NM,Elgavish A,Languino LR

更新日期：2005-08-01 00:00:00

abstract：:Centrosome amplification is a hallmark of virtually all types of cancers, including solid tumors and hematologic malignancies. Cancer cells with extra centrosomes use centrosome clustering (CC) to allow for successful division. Because normal cells do not rely on this mechanism, CC is regarded as a promising target to...

journal_title：Cancer research

authors： Konotop G,Bausch E,Nagai T,Turchinovich A,Becker N,Benner A,Boutros M,Mizuno K,Krämer A,Raab MS

更新日期：2016-11-15 00:00:00

abstract：:The effect of intravesical Bacillus Calmette-Guérin (BCG; Pasteur strain) treatment on the frequency of implantation and growth rate of the murine transitional cell carcinoma of the bladder, MBT-2, was studied. MBT-2 cells were instilled into the bladder immediately after electrocauterization, and BCG instillations (4...

journal_title：Cancer research

authors： Shapiro A,Ratliff TL,Oakley DM,Catalona WJ

更新日期：1983-04-01 00:00:00

abstract：:Liver X receptors function as central transcriptional regulators for lipid homeostasis, for which agonists have been developed as potential drugs for treatment of cardiovascular diseases and metabolic syndromes. Because dysregulation of lipid metabolism has been implicated in sex hormone-dependent cancers, we investig...

journal_title：Cancer research

authors： Fukuchi J,Kokontis JM,Hiipakka RA,Chuu CP,Liao S

更新日期：2004-11-01 00:00:00

abstract：:We have recently identified a new gene, interleukin-17 receptor-like (IL-17RL), which is expressed in normal prostate and prostate cancer. This investigation is focused on the role of IL-17RL in prostate cancer. We found that IL-17RL was expressed at significantly higher levels in several androgen-independent prostate...

journal_title：Cancer research

authors： You Z,Shi XB,DuRaine G,Haudenschild D,Tepper CG,Lo SH,Gandour-Edwards R,de Vere White RW,Reddi AH

更新日期：2006-01-01 00:00:00

abstract：:In a previous study, we found that the small-molecule epidermal growth factor receptor (EGFR) inhibitor gefitinib (ZD1839, Iressa) blocked cell proliferation at biologically relevant concentrations in approximately one third (6 of 17) of human bladder cancer cell lines examined. Here, we studied the effects of gefitin...

journal_title：Cancer research

authors： Shrader M,Pino MS,Lashinger L,Bar-Eli M,Adam L,Dinney CP,McConkey DJ

更新日期：2007-02-15 00:00:00

abstract：:The nucleus has been shown to be a site for the inositol lipid cycle that can be affected by treatment of quiescent cells with growth factors such as insulin-like growth factor I (IGF-I). Indeed, the exposure of Swiss 3T3 cells to IGF-I results in a rapid and transient increase in nuclear phospholipase C (PLC) beta1 a...

journal_title：Cancer research

authors： Manzoli L,Billi AM,Rubbini S,Bavelloni A,Faenza I,Gilmour RS,Rhee SG,Cocco L

更新日期：1997-06-01 00:00:00

abstract：:To determine the role of the transcription factor signal transducer and activator of transcription (STAT) 1 on endothelial cell function, human umbilical vein endothelial cells (HUVEC) were treated with IFN-gamma, a potent activator of STAT1. IFN-gamma inhibited cell growth and tube formation of HUVECs. Although the p...

journal_title：Cancer research

authors： Battle TE,Lynch RA,Frank DA

更新日期：2006-04-01 00:00:00

abstract：:Active-specific immunotherapy with dendritic cells loaded with peptide derived from the melanoma antigen, gp100, failed to mediate regression of established B16F10 melanoma in normal mice. Dendritic cell vaccination induced activation and subsequent deletion of adoptively transferred naive CD8+ T-cell receptor transge...

journal_title：Cancer research

authors： Wang LX,Li R,Yang G,Lim M,O'Hara A,Chu Y,Fox BA,Restifo NP,Urba WJ,Hu HM

更新日期：2005-11-15 00:00:00

abstract：:Reduced expression of neural cell adhesion molecule (NCAM) has been implicated in the progression to tumor malignancy in cancer patients. Previously, we have shown that the loss of NCAM function causes the formation of lymph node metastasis in a transgenic mouse model of pancreatic beta cell carcinogenesis (Rip1Tag2)....

journal_title：Cancer research

authors： Crnic I,Strittmatter K,Cavallaro U,Kopfstein L,Jussila L,Alitalo K,Christofori G

更新日期：2004-12-01 00:00:00

abstract：:The mouse breast cancer cell lines 4T1, 4T07, and 67NR are highly tumorigenic but vary in metastatic potential: 4T1 widely disseminates, resulting in secondary tumors in the lung, liver, bone, and brain; 4T07 spreads to the lung and liver but is unable to establish metastatic nodules; 67NR is unable to metastasize. Th...

journal_title：Cancer research

authors： Manka D,Spicer Z,Millhorn DE

更新日期：2005-12-15 00:00:00

abstract：:Many epithelial tumors show deletion of the short arm of chromosome 8 that is related to aggressive disease or adverse prognosis. In undissected samples of urothelial cell carcinoma of the bladder, at least two regions of loss of heterozygosity (LOH) were identified previously within a small region of 8p11-p12. LOH an...

journal_title：Cancer research

authors： Adams J,Williams SV,Aveyard JS,Knowles MA

更新日期：2005-01-01 00:00:00

abstract：:Monoclonal antibody SM 92 is involved in the immunophenotype of gastrointestinal and liver cells, SM 43 in ovarian cells, and SM 13 in lung cells. Based on a study of 61 breast adenocarcinoma patients, we found that tumors reacting with SM 92 appear associated with liver metastases, SM 43 with ovarian metastases, and ...

journal_title：Cancer research

authors： Gioanni JC,Mazeau C,Zanghellini E,Hecht F,Gugenheim J,Crafa F,Granon C,Namer M,Ettore F,Schneider M

更新日期：1994-10-15 00:00:00

abstract：:Given the prevalence of Ras mutations in human cancer, it is critical to understand the effector pathways downstream of oncogenic Ras leading to transformation. To directly assess the requirement for Rac1 in K-ras-induced tumorigenesis, we employed a model of lung cancer in which an oncogenic allele of K-ras could be ...

journal_title：Cancer research

authors： Kissil JL,Walmsley MJ,Hanlon L,Haigis KM,Bender Kim CF,Sweet-Cordero A,Eckman MS,Tuveson DA,Capobianco AJ,Tybulewicz VL,Jacks T

更新日期：2007-09-01 00:00:00

abstract：:Elongation factor-2 kinase (eEF-2 kinase), also known as Ca(2+)/calmodulin-dependent kinase III, regulates protein synthesis by controlling the rate of peptide chain elongation. The activity of eEF-2 kinase is increased in glioblastoma and other malignancies, yet its role in neoplasia is uncertain. Recent evidence sug...

journal_title：Cancer research

authors： Wu H,Yang JM,Jin S,Zhang H,Hait WN

更新日期：2006-03-15 00:00:00

abstract：:Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1) is a member of the CEA family of immunoglobulin-like adhesion molecules with two major splice variants, CEACAM1(a)-4L and CEACAM1(b)-4S, differing in the length of their COOH-terminal cytoplasmic tail. Both forms are down-regulated in prostate a...

journal_title：Cancer research

authors： Laurie NA,Comegys MM,Carreiro MP,Brown JF,Flanagan DL,Brilliant KE,Hixson DC

更新日期：2005-12-01 00:00:00